CD24 (original) (raw)

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Mammalian protein found in Homo sapiens

CD24
Identifiers
Aliases CD24, CD24A, CD24 molecule
External IDs OMIM: 600074; MGI: 88323; GeneCards: CD24; OMA:CD24 - orthologs
Gene location (Human)Chromosome 6 (human)Chr.Chromosome 6 (human)[1]Chromosome 6 (human)Genomic location for CD24Genomic location for CD24Band6q21Start106,969,831 bp[1]End106,975,627 bp[1]
Gene location (Mouse)Chromosome 10 (mouse)Chr.Chromosome 10 (mouse)[2]Chromosome 10 (mouse)Genomic location for CD24Genomic location for CD24Band10 B2|10 23.01 cMStart43,454,280 bp[2]End43,460,261 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inrenal medullabronchial epithelial cellmucosa of colonmucosa of sigmoid colonoral cavityparotid glandgingival epitheliumepithelium of nasopharynxmucosa of ileumpancreatic epithelial cellTop expressed infetal liver hematopoietic progenitor cellcrypt of lieberkuhn of small intestinesuperior cervical ganglionepithelium of stomachhuman fetusmedial ganglionic eminenceepithelium of lensparotid glandtibiofemoral jointbloodMore reference expression dataBioGPSn/a
Gene ontologyMolecular function protein tyrosine kinase activator activity signal transducer activity protein binding protein kinase binding Cellular component membrane plasma membrane cell surface anchored component of external side of plasma membrane membrane raft anchored component of membrane intracellular anatomical structure Biological process response to hypoxia regulation of MAPK cascade positive regulation of MAP kinase activity regulation of cytokine-mediated signaling pathway positive regulation of cytosolic calcium ion concentration chemokine receptor transport out of membrane raft T cell costimulation regulation of phosphorylation Wnt signaling pathway negative regulation of transforming growth factor beta3 production cell activation immune response-regulating cell surface receptor signaling pathway response to estrogen respiratory burst intrinsic apoptotic signaling pathway glomerular parietal epithelial cell differentiation cell adhesion glomerular visceral epithelial cell differentiation cholesterol homeostasis regulation of epithelial cell differentiation response to molecule of bacterial origin cell migration B cell receptor transport into membrane raft positive regulation of nephron tubule epithelial cell differentiation positive regulation of activated T cell proliferation positive regulation of protein tyrosine kinase activity cell-cell adhesion Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez10013394112484EnsemblENSG00000272398ENSMUSG00000047139UniProtP25063P24807RefSeq (mRNA)NM_001291737NM_001291738NM_001291739NM_013230NM_001359084NM_009846RefSeq (protein)NP_001278666NP_001278667NP_001278668NP_037362NP_001346013NP_033976Location (UCSC)Chr 6: 106.97 – 106.98 MbChr 10: 43.45 – 43.46 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene.[5] CD24 is a cell adhesion molecule.

CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils[6] and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. The protein also contributes to a wide range of downstream signaling networks and is crucial for neural development.[7] Cross-linking of CD24 on the surface of neutrophils induces apoptosis,[8] and this appears to be defective in sepsis.[8] CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined.[_citation needed_]

Researchers have identified CD24 as a novel cell surface marker that flags anastasis in melanoma cells, a process where cells that have initiated apoptosis can recover and survive1[9]. This discovery highlights CD24’s role in marking apoptotic subpopulations that exhibit metabolic activity and proliferative capacities, contributing to melanoma’s resilience and potential metastasis.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000272398 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047139 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hough MR, Rosten PM, Sexton TL, Kay R, Humphries RK (July 1994). "Mapping of CD24 and homologous sequences to multiple chromosomal loci". Genomics. 22 (1): 154–61. doi:10.1006/geno.1994.1356. PMID 7959762.
  6. ^ Elghetany MT, Patel J (December 2002). "Assessment of CD24 expression on bone marrow neutrophilic granulocytes: CD24 is a marker for the myelocytic stage of development". American Journal of Hematology. 71 (4): 348–9. doi:10.1002/ajh.10176. PMID 12447971. S2CID 39674808.
  7. ^ Gilliam DT, Menon V, Bretz NP, Pruszak J (March 2017). "The CD24 surface antigen in neural development and disease". Neurobiology of Disease. 99: 133–144. doi:10.1016/j.nbd.2016.12.011. PMID 27993646. S2CID 3492300.
  8. ^ a b Parlato M, Souza-Fonseca-Guimaraes F, Philippart F, Misset B, Adib-Conquy M, Cavaillon JM (March 2014). "CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis". Journal of Immunology. 192 (5): 2449–59. doi:10.4049/jimmunol.1301055. PMID 24501201. S2CID 45838206.
  9. ^ Vasileva MH, Bennemann A, Zachmann K, Schön MP, Frank J, Ulaganathan VK (August 2024). "CD24 flags anastasis in melanoma cells". Apoptosis. doi:10.1007/s10495-024-01990-1. PMID 39136818.