CEP164 (original) (raw)

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Protein-coding gene in the species Homo sapiens

CEP164
Identifiers
Aliases	CEP164, NPHP15, centrosomal protein 164
External IDs	OMIM: 614848; MGI: 2384878; HomoloGene: 51110; GeneCards: CEP164; OMA:CEP164 - orthologs
Gene location (Human)Chr.Chromosome 11 (human)[1]Band11q23.3Start117,314,557 bp[1]End117,413,266 bp[1]
Gene location (Mouse)Chr.Chromosome 9 (mouse)[2]Band9|9 A5.2Start45,678,244 bp[2]End45,739,989 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inspermtendon of biceps brachiisural nervenippleright uterine tubebronchial epithelial cellvisceral pleuraleft testisparietal pleuraright testisTop expressed inneural layer of retinasecondary oocyteRostral migratory streaminternal carotid arteryzygotespermatidexternal carotid arteryureterspermatocyteprimary oocyteMore reference expression dataBioGPSn/a
Gene ontologyMolecular function protein binding Cellular component ciliary transition fiber cytoplasm centriole cytosol centrosome cytoskeleton nucleus nucleoplasm extracellular space nuclear speck intracellular membrane-bounded organelle Biological process cell division cell cycle cell projection organization G2/M transition of mitotic cell cycle DNA repair cellular response to DNA damage stimulus cilium assembly ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez22897214552EnsemblENSG00000110274ENSMUSG00000043987UniProtQ9UPV0Q5DU05RefSeq (mRNA)NM_001271933NM_014956NM_001081373RefSeq (protein)NP_001258862NP_055771n/aLocation (UCSC)Chr 11: 117.31 – 117.41 MbChr 9: 45.68 – 45.74 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene.[5][6]Its function appears two be twofold: CEP164 is required for primary cilium formation.[7] Furthermore, it is an important component in the response to DNA damage by UV light.[8][9]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110274 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043987 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: centrosomal protein 164kDa".
6. ^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
7. ^ Graser, S.; Stierhof, Y. -D.; Lavoie, S. B.; Gassner, O. S.; Lamla, S.; Le Clech, M.; Nigg, E. A. (2007). "Cep164, a novel centriole appendage protein required for primary cilium formation". The Journal of Cell Biology. 179 (2): 321–30. doi:10.1083/jcb.200707181. PMC 2064767. PMID 17954613.
8. ^ Sivasubramaniam, S.; Sun, X.; Pan, Y. -R.; Wang, S.; Lee, E. Y. -H. P. (2008). "Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1". Genes & Development. 22 (5): 587–600. doi:10.1101/gad.1627708. PMC 2259029. PMID 18283122.
9. ^ Pan, YR; Lee, EY (2009). "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity". Cell Cycle. 8 (4): 655–64. doi:10.4161/cc.8.4.7844. PMID 19197159.

• Human CEP164 genome location and CEP164 gene details page in the UCSC Genome Browser.

• Graser S, Stierhof YD, Lavoie SB, et al. (2007). "Cep164, a novel centriole appendage protein required for primary cilium formation". J. Cell Biol. 179 (2): 321–30. doi:10.1083/jcb.200707181. PMC 2064767. PMID 17954613.

• Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function". J. Cell Biol. 129 (6): 1617–28. doi:10.1083/jcb.129.6.1617. PMC 2291169. PMID 7790358.

• Casenghi M, Meraldi P, Weinhart U, et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Dev. Cell. 5 (1): 113–25. doi:10.1016/S1534-5807(03)00193-X. PMID 12852856.

• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

• Mayor T, Stierhof YD, Tanaka K, et al. (2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837–46. doi:10.1083/jcb.151.4.837. PMC 2169446. PMID 11076968.

• Sivasubramaniam S, Sun X, Pan YR, et al. (2008). "Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1". Genes Dev. 22 (5): 587–600. doi:10.1101/gad.1627708. PMC 2259029. PMID 18283122.

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

• Petretti C, Savoian M, Montembault E, et al. (2006). "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation". EMBO Rep. 7 (4): 418–24. doi:10.1038/sj.embor.7400639. PMC 1456919. PMID 16462731.

• Zick A, Onn I, Bezalel R, et al. (2005). "Assigning functions to genes: identification of S-phase expressed genes in Leishmania major based on post-transcriptional control elements". Nucleic Acids Res. 33 (13): 4235–42. doi:10.1093/nar/gki742. PMC 1181863. PMID 16052032.

• Pan YR, Lee EY (2009). "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity". Cell Cycle. 8 (4): 655–64. doi:10.4161/cc.8.4.7844. PMID 19197159.

• Takahashi M, Yamagiwa A, Nishimura T, et al. (2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.