CLDN7 (original) (raw)

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Protein-coding gene in humans

CLDN7
Identifiers
Aliases	CLDN7, CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1, claudin 7
External IDs	OMIM: 609131; MGI: 1859285; HomoloGene: 9649; GeneCards: CLDN7; OMA:CLDN7 - orthologs
Gene location (Human)Chr.Chromosome 17 (human)[1]Band17p13.1Start7,259,903 bp[1]End7,263,983 bp[1]
Gene location (Mouse)Chr.Chromosome 11 (mouse)[2]Band11|11 B3Start69,855,605 bp[2]End69,858,711 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inmucosa of transverse colonduodenumrectumright uterine tubeolfactory zone of nasal mucosaminor salivary glandsbody of pancreasleft lobe of thyroid glandislet of Langerhansright lobe of thyroid glandTop expressed incrypt of lieberkuhn of small intestineleft colonmigratory enteric neural crest cellileumduodenumyolk sacmedullary collecting ductjejunummucosa of urinary bladdertransitional epithelium of urinary bladderMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function structural molecule activity identical protein binding protein binding cell adhesion molecule binding Cellular component bicellular tight junction cell junction basolateral plasma membrane membrane lateral plasma membrane integral component of membrane apicolateral plasma membrane plasma membrane Biological process negative regulation of protein homooligomerization negative regulation of cell adhesion positive regulation of cell motility negative regulation of apoptotic process positive regulation of cell population proliferation calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules response to ethanol Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez136653624EnsemblENSG00000181885ENSG00000288292ENSMUSG00000018569UniProtO95471Q9Z261RefSeq (mRNA)NM_001307NM_001185022NM_001185023NM_001193619NM_016887RefSeq (protein)NP_001171951NP_001171952NP_001298NP_001180548NP_058583Location (UCSC)Chr 17: 7.26 – 7.26 MbChr 11: 69.86 – 69.86 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Claudin-7 is a protein that in humans is encoded by the CLDN7 gene.[5][6] It belongs to the group of claudins.

Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells (Zheng et al., 2003).[supplied by OMIM][6]

1. ^ a b c ENSG00000288292 GRCh38: Ensembl release 89: ENSG00000181885, ENSG00000288292 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018569 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.
6. ^ a b "Entrez Gene: CLDN7 claudin 7".

• Human CLDN7 genome location and CLDN7 gene details page in the UCSC Genome Browser.

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMC 11537529. PMID 10690502. S2CID 26473781.

• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.

• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.

• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.

• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

• Peacock RE, Keen TJ, Inglehearn CF (1998). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748.

• Itoh M, Furuse M, Morita K, et al. (2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

• Kominsky SL, Argani P, Korz D, et al. (2003). "Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast". Oncogene. 22 (13): 2021–33. doi:10.1038/sj.onc.1206199. PMID 12673207. S2CID 20318884.

• Ban Y, Dota A, Cooper LJ, et al. (2003). "Tight junction-related protein expression and distribution in human corneal epithelium". Exp. Eye Res. 76 (6): 663–9. doi:10.1016/S0014-4835(03)00054-X. PMID 12742348.

• Zheng JY, Yu D, Foroohar M, et al. (2004). "Regulation of the expression of the prostate-specific antigen by claudin-7". J. Membr. Biol. 194 (3): 187–97. doi:10.1007/s00232-003-2038-4. PMID 14502431. S2CID 8482475.

• Resnick MB, Konkin T, Routhier J, et al. (2005). "Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study". Mod. Pathol. 18 (4): 511–8. doi:10.1038/modpathol.3800301. PMID 15475928. S2CID 28512983.

• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.