Complement component 1s (original) (raw)

From Wikipedia, the free encyclopedia

Protein found in humans

C1S
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ELV, 1NZI, 4J1Y, 4LMF, 4LOR, 4LOS, 4LOT
Identifiers
Aliases C1S, EDSPD2, complement C1s
External IDs OMIM: 120580; MGI: 3644269; HomoloGene: 1314; GeneCards: C1S; OMA:C1S - orthologs
EC number 3.4.21.42
Gene location (Human)Chromosome 12 (human)Chr.Chromosome 12 (human)[1]Chromosome 12 (human)Genomic location for C1SGenomic location for C1SBand12p13.31Start6,988,259 bp[1]End7,071,032 bp[1]
Gene location (Mouse)Chromosome 6 (mouse)Chr.Chromosome 6 (mouse)[2]Chromosome 6 (mouse)Genomic location for C1SGenomic location for C1SBand6|6 F2Start124,601,584 bp[2]End124,613,044 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inpericardiumright lobe of liverparietal pleuraright ovarygallbladderleft ovarygastric mucosatibial nerveleft uterine tubesynovial jointTop expressed inmuscle of thighmorulaembryowhite adipose tissuebone marrowadrenal glandurinary bladderovarylensislet of LangerhansMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function calcium ion binding peptidase activity serine-type peptidase activity protein binding hydrolase activity metal ion binding identical protein binding serine-type endopeptidase activity Cellular component blood microparticle extracellular exosome extracellular region extracellular space Biological process proteolysis complement activation, classical pathway immune system process innate immune response complement activation, lectin pathway complement activation regulation of complement activation Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez716317677EnsemblENSG00000182326ENSMUSG00000079343UniProtP09871Q8CFG8RefSeq (mRNA)NM_001734NM_201442NM_001346850NM_173864RefSeq (protein)NP_001333779NP_001725NP_958850NP_776289Location (UCSC)Chr 12: 6.99 – 7.07 MbChr 6: 124.6 – 124.61 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system. C1s is part of the C1 complex.[5][6][7][8] In humans, it is encoded by the C1S gene.[9]

C1s cleaves C4 and C2, which eventually leads to the production of the classical pathway C3-convertase.

Classical pathway. (Some labels are in Polish.)

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182326Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079343Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sim RB (1981). "The human complement system serine proteases and their proenzymes". Proteolytic Enzymes, Part C. Methods in Enzymology. Vol. 80 Pt C. pp. 26–42. doi:10.1016/s0076-6879(81)80006-7. ISBN 9780121819804. PMID 6281620.
  6. ^ Mackinnon CM, Carter PE, Smyth SJ, Dunbar B, Fothergill JE (December 1987). "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence". European Journal of Biochemistry. 169 (3): 547–53. doi:10.1111/j.1432-1033.1987.tb13644.x. PMID 3500856.
  7. ^ Müller-Eberhard HJ (1988). "Molecular organization and function of the complement system". Annual Review of Biochemistry. 57: 321–47. doi:10.1146/annurev.bi.57.070188.001541. PMID 3052276.
  8. ^ Skoog MT, Mehdi S, Wiseman JS, Bey P (June 1989). "The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 996 (1–2): 89–94. doi:10.1016/0167-4838(89)90099-x. PMID 2500154.
  9. ^ "Entrez Gene: C1S Complement component 1, s subcomponent".