Cyclin E1 (original) (raw)

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Protein-coding gene in the species Homo sapiens

CCNE1
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1W98
Identifiers
Aliases CCNE1, CCNE, pcyclin E1
External IDs OMIM: 123837; MGI: 88316; HomoloGene: 14452; GeneCards: CCNE1; OMA:CCNE1 - orthologs
Gene location (Human)Chromosome 19 (human)Chr.Chromosome 19 (human)[1]Chromosome 19 (human)Genomic location for CCNE1Genomic location for CCNE1Band19q12Start29,811,991 bp[1]End29,824,312 bp[1]
Gene location (Mouse)Chromosome 7 (mouse)Chr.Chromosome 7 (mouse)[2]Chromosome 7 (mouse)Genomic location for CCNE1Genomic location for CCNE1Band7 B3|7 25.35 cMStart37,797,409 bp[2]End37,806,959 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed insecondary oocyteplacentatesticledeciduabone marrowleft testisright testisamniotic fluidgingival epitheliummucosa of transverse colonTop expressed inembryoepiblastmorulacondylefossainternal carotid arteryfetal liver hematopoietic progenitor cellprimitive streakembryomandibular prominenceMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function transcription coactivator activity kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein binding androgen receptor binding protein kinase binding cyclin-dependent protein serine/threonine kinase activity protein kinase activity Cellular component cytosol cyclin-dependent protein kinase holoenzyme complex nucleoplasm nucleus cyclin E1-CDK2 complex cytoplasm centrosome Biological process androgen receptor signaling pathway Wnt signaling pathway regulation of transcription involved in G1/S transition of mitotic cell cycle regulation of cell cycle cell division positive regulation of transcription, DNA-templated protein phosphorylation DNA replication initiation cell cycle regulation of protein kinase activity negative regulation of transcription by RNA polymerase II telomere maintenance homologous chromosome pairing at meiosis chromosome organization involved in meiotic cell cycle G1/S transition of mitotic cell cycle regulation of cyclin-dependent protein serine/threonine kinase activity mitotic cell cycle regulation of mitotic nuclear division positive regulation of cell population proliferation positive regulation of cell cycle positive regulation of G1/S transition of mitotic cell cycle mitotic cell cycle phase transition Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez89812447EnsemblENSG00000105173ENSMUSG00000002068UniProtP24864Q61457RefSeq (mRNA)NM_001238NM_057182NM_001322259NM_001322261NM_001322262NM_007633RefSeq (protein)NP_001229NP_001309188NP_001309190NP_001309191NP_001309188.1NP_001309190.1NP_031659Location (UCSC)Chr 19: 29.81 – 29.82 MbChr 7: 37.8 – 37.81 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.[5]

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.[6]

Cyclin E1 has been shown to interact with:

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105173 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002068 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lew DJ, Dulić V, Reed SI (October 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. S2CID 12166415.
  6. ^ "Entrez Gene: CCNE1 cyclin E1".
  7. ^ a b c d e f Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. 19 (2): 1460–9. doi:10.1128/mcb.19.2.1460. PMC 116074. PMID 9891079.
  8. ^ Xu X, Burke SP (March 1996). "Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25". J. Biol. Chem. 271 (9): 5118–24. doi:10.1074/jbc.271.9.5118. PMID 8617791.
  9. ^ a b Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM (January 2003). "CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis". Mol. Biol. Cell. 14 (1): 201–13. doi:10.1091/mbc.E02-06-0319. PMC 140238. PMID 12529437.
  10. ^ Singer JD, Gurian-West M, Clurman B, Roberts JM (September 1999). "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells". Genes Dev. 13 (18): 2375–87. doi:10.1101/gad.13.18.2375. PMC 317026. PMID 10500095.
  11. ^ a b Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM (September 1992). "Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle". Science. 257 (5077): 1689–94. Bibcode:1992Sci...257.1689K. doi:10.1126/science.1388288. PMID 1388288.
  12. ^ a b McKenzie PP, Danks MK, Kriwacki RW, Harris LC (July 2003). "P21Waf1/Cip1 dysfunction in neuroblastoma: a novel mechanism of attenuating G0-G1 cell cycle arrest". Cancer Res. 63 (13): 3840–4. PMID 12839982.
  13. ^ Mayer C, Zhao J, Yuan X, Grummt I (February 2004). "mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability". Genes Dev. 18 (4): 423–34. doi:10.1101/gad.285504. PMC 359396. PMID 15004009.
  14. ^ Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M (August 2000). "NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry". J. Biol. Chem. 275 (33): 25411–7. doi:10.1074/jbc.M001676200. PMID 10827081.
  15. ^ Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M (December 1999). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins". Biochem. Biophys. Res. Commun. 266 (1): 115–22. doi:10.1006/bbrc.1999.1777. PMID 10581175.
  16. ^ Li Y, Graham C, Lacy S, Duncan AM, Whyte P (December 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes Dev. 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. PMID 8253383.
  17. ^ Wong AK, Shanahan F, Chen Y, Lian L, Ha P, Hendricks K, Ghaffari S, Iliev D, Penn B, Woodland AM, Smith R, Salada G, Carillo A, Laity K, Gupte J, Swedlund B, Tavtigian SV, Teng DH, Lees E (November 2000). "BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines". Cancer Res. 60 (21): 6171–7. PMID 11085541.