E2F4 (original) (raw)

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Protein-coding gene in the species Homo sapiens

E2F4
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CF7
Identifiers
Aliases E2F4, E2F-4, E2F transcription factor 4
External IDs OMIM: 600659; MGI: 103012; HomoloGene: 1471; GeneCards: E2F4; OMA:E2F4 - orthologs
Gene location (Human)Chromosome 16 (human)Chr.Chromosome 16 (human)[1]Chromosome 16 (human)Genomic location for E2F4Genomic location for E2F4Band16q22.1Start67,192,155 bp[1]End67,198,918 bp[1]
Gene location (Mouse)Chromosome 8 (mouse)Chr.Chromosome 8 (mouse)[2]Chromosome 8 (mouse)Genomic location for E2F4Genomic location for E2F4Band8|8 D3Start106,024,295 bp[2]End106,032,002 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inpancreatic ductal cellgranulocyteleft uterine tubeanterior pituitarytransverse colonmucosa of transverse colonapex of heartbody of stomachright lobe of thyroid glandupper lobe of left lungTop expressed intail of embryozygoteyolk sacgenital tubercleventricular zoneembryoneural layer of retinalipmuscle of thighgranulocyteMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function DNA binding protein domain specific binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding promoter-specific chromatin binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding Cellular component transcription regulator complex nucleoplasm nucleus RNA polymerase II transcription regulator complex Biological process regulation of cell size epithelial cell development cell volume homeostasis regulation of transcription, DNA-templated multi-ciliated epithelial cell differentiation transcription by RNA polymerase II regulation of transcription involved in G1/S transition of mitotic cell cycle blood circulation cell projection organization regulation of cell population proliferation animal organ morphogenesis cell cycle motile cilium assembly centriole assembly transcription, DNA-templated mitotic cell cycle DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest positive regulation of transcription by RNA polymerase II cilium assembly negative regulation of transcription by RNA polymerase II regulation of cell cycle Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez1874104394EnsemblENSG00000205250ENSMUSG00000014859UniProtQ16254Q8R0K9RefSeq (mRNA)NM_001950NM_148952RefSeq (protein)NP_001941NP_683754Location (UCSC)Chr 16: 67.19 – 67.2 MbChr 8: 106.02 – 106.03 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene.[5][6]

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.[7]

The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids (Asp + Glu), and a tumor suppressor protein association domain which is embedded within the transactivation domain.

E2F4 has been shown to interact with Smad3.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000205250 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014859 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM (Dec 1994). "E2F-4, a new member of the E2F transcription factor family, interacts with p107". Genes Dev. 8 (22): 2665–79. doi:10.1101/gad.8.22.2665. PMID 7958924.
  6. ^ Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (Apr 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proc Natl Acad Sci U S A. 92 (6): 2403–7. Bibcode:1995PNAS...92.2403S. doi:10.1073/pnas.92.6.2403. PMC 42492. PMID 7892279.
  7. ^ "Entrez Gene: E2F4 E2F transcription factor 4, p107/p130-binding".
  8. ^ Chen CR, Kang Y, Siegel PM, Massagué J (July 2002). "E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression". Cell. 110 (1): 19–32. doi:10.1016/S0092-8674(02)00801-2. PMID 12150994. S2CID 8945574.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.