ELP2 (original) (raw)

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Protein-coding gene in the species Homo sapiens

ELP2
Identifiers
Aliases	ELP2, SHINC-2, STATIP1, StIP, elongator acetyltransferase complex subunit 2, MRT58
External IDs	OMIM: 616054; MGI: 1889642; HomoloGene: 6019; GeneCards: ELP2; OMA:ELP2 - orthologs
Gene location (Human)Chr.Chromosome 18 (human)[1]Band18q12.2Start36,129,444 bp[1]End36,180,557 bp[1]
Gene location (Mouse)Chr.Chromosome 18 (mouse)[2]Band18|18 A2Start24,735,923 bp[2]End24,772,564 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inleft ovaryAchilles tendonright ovaryskin of abdomenganglionic eminenceskin of legepithelium of colonright uterine tubebody of pancreascanal of the cervixTop expressed insacculeotic placodemotor neuronfacial motor nucleusinternal carotid arterycondyleexternal carotid arteryprimitive streakutriclefossaMore reference expression dataBioGPSn/a
Gene ontologyMolecular function RNA polymerase II complex binding protein kinase binding Cellular component histone acetyltransferase complex transcription elongation factor complex nucleus cytoplasm cytosol elongator holoenzyme complex Biological process regulation of transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription, DNA-templated regulation of receptor signaling pathway via JAK-STAT tRNA wobble uridine modification Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez5525058523EnsemblENSG00000134759ENSMUSG00000024271UniProtQ6IA86Q91WG4RefSeq (mRNA)NM_001242875NM_001242876NM_001242877NM_001242878NM_001242879NM_018255NM_001324465NM_001324466NM_001324467NM_001324468NM_001324469NM_021448NM_001360909RefSeq (protein)NP_001229804NP_001229805NP_001229806NP_001229807NP_001229808NP_001311394NP_001311395NP_001311396NP_001311397NP_060725NP_067423NP_001347838Location (UCSC)Chr 18: 36.13 – 36.18 MbChr 18: 24.74 – 24.77 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Elongator complex protein 2 is a protein that in humans is encoded by the ELP2 gene.[5][6][7]

ELP2 has been shown to interact with STAT3[6] and Janus kinase 1.[6]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134759 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024271 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem. 277 (4): 3047–52. doi:10.1074/jbc.M110445200. PMID 11714725.
6. ^ a b c Collum RG, Brutsaert S, Lee G, Schindler C (Oct 2000). "A Stat3-interacting protein (StIP1) regulates cytokine signal transduction". Proc Natl Acad Sci U S A. 97 (18): 10120–5. Bibcode:2000PNAS...9710120C. doi:10.1073/pnas.170192197. PMC 27739. PMID 10954736.
7. ^ "Entrez Gene: STATIP1 signal transducer and activator of transcription 3 interacting protein 1".

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim JH, Lane WS, Reinberg D (2002). "Human Elongator facilitates RNA polymerase II transcription through chromatin". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1241–6. Bibcode:2002PNAS...99.1241K. doi:10.1073/pnas.251672198. PMC 122174. PMID 11818576.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.