FBRS (original) (raw)

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Protein-coding gene in the species Homo sapiens

FBRS
Identifiers
Aliases	FBRS, FBS, FBS1, fibrosin
External IDs	OMIM: 608601; MGI: 104648; HomoloGene: 79554; GeneCards: FBRS; OMA:FBRS - orthologs
Gene location (Human)Chr.Chromosome 16 (human)[1]Band16p11.2Start30,658,431 bp[1]End30,670,810 bp[1]
Gene location (Mouse)Chr.Chromosome 7 (mouse)[2]Band7|7 F3Start127,078,371 bp[2]End127,090,883 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inleft testisright testisright uterine tubeanterior pituitarygranulocyteright lobe of thyroid glandskin of legcerebellar vermisleft lobe of thyroid glandgastric mucosaTop expressed ingranulocytezygotesecondary oocytethymusspleenprimary oocytelipadrenal glandesophagusbone marrowMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function growth factor activity Cellular component extracellular space Biological process positive regulation of fibroblast proliferation regulation of signaling receptor activity Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez6431914123EnsemblENSG00000156860ENSMUSG00000042423UniProtQ9HAH7Q8R089RefSeq (mRNA)NM_001105079NM_022452NM_010183RefSeq (protein)NP_001098549NP_034313Location (UCSC)Chr 16: 30.66 – 30.67 MbChr 7: 127.08 – 127.09 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable fibrosin-1 long transcript protein is a protein that in humans is encoded by the FBRS gene.[5][6][7]

Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998).[7]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156860 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042423 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Prakash S, Robbins PW, Wyler DJ (Apr 1995). "Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin". Proc Natl Acad Sci U S A. 92 (6): 2154–8. Bibcode:1995PNAS...92.2154P. doi:10.1073/pnas.92.6.2154. PMC 42442. PMID 7892239.
6. ^ Prakash S, Robbins PW (Nov 1998). "Cloning and analysis of the cDNA for human fibrosin, a novel fibrogenic lymphokine". DNA Cell Biol. 17 (10): 879–84. doi:10.1089/dna.1998.17.879. PMID 9809749.
7. ^ a b "Entrez Gene: FBS1 fibrosin 1".

• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Prakash S, Nanji AA, Robbins PW (1999). "Fibrosin: A novel lymphokine in alcohol-induced fibrosis". Exp. Mol. Pathol. 67 (1): 40–9. doi:10.1006/exmp.1999.2274. PMID 10493891.
• Prakash S, Robbins PW (2002). "Fibrosin: a novel lymphokine in wound healing". Exp. Mol. Pathol. 71 (3): 247–55. doi:10.1006/exmp.2001.2402. PMID 11733950.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Prakash S, Paul WE, Robbins PW (2007). "Fibrosin, a novel fibrogenic cytokine, modulates expression of myofibroblasts". Exp. Mol. Pathol. 82 (1): 42–8. doi:10.1016/j.yexmp.2006.06.008. PMID 17083929.