FOXN3 (original) (raw)

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Protein-coding gene in the species Homo sapiens

FOXN3
Identifiers
Aliases	FOXN3, C14orf116, CHES1, PRO1635, forkhead box N3
External IDs	OMIM: 602628; MGI: 1918625; HomoloGene: 3809; GeneCards: FOXN3; OMA:FOXN3 - orthologs
Gene location (Human)Chr.Chromosome 14 (human)[1]Band14q31.3-q32.11Start89,124,871 bp [1]End89,619,149 bp [1]
Gene location (Mouse)Chr.Chromosome 12 (mouse)[2]Band12\|12 EStart99,156,337 bp [2]End99,529,841 bp [2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inparaflocculus of cerebellumtendon of biceps brachiinipplesaphenous veinskin of hipskin of armmucosa of paranasal sinusskin of thighsynovial jointSkeletal muscle tissue of rectus abdominisTop expressed inzygotesecondary oocytehandascending aortasoleus muscleRostral migratory streamtibialis anterior musclefootgastrocnemius muscleaortic valveMore reference expression data BioGPS More reference expression data
Gene ontologyMolecular function DNA binding protein C-terminus binding protein binding DNA-binding transcription factor activity sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process cell cycle mitotic G2 DNA damage checkpoint signaling negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated craniofacial suture morphogenesis cell differentiation positive regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez 1112 71375 Ensembl ENSG00000053254 ENSMUSG00000033713 UniProt O00409 Q499D0RefSeq (mRNA)NM_005197 NM_001085471 NM_183186RefSeq (protein)NP_001078940 NP_005188 NP_899009Location (UCSC)Chr 14: 89.12 – 89.62 Mb Chr 12: 99.16 – 99.53 Mb PubMed search[3][4]
Wikidata
View/Edit Human View/Edit Mouse

Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene.[5][6]

This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.[6]

FOX proteins

^ a b c GRCh38: Ensembl release 89: ENSG00000053254 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033713 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pati D, Keller C, Groudine M, Plon SE (Jun 1997). "Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA". Mol Cell Biol. 17 (6): 3037–46. doi:10.1128/MCB.17.6.3037. PMC 232156. PMID 9154802.
^ a b "Entrez Gene: CHES1 checkpoint suppressor 1".

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Field LL, Tobias R, Thomson G, Plon S (1996). "Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31". Genomics. 33 (1): 1–8. doi:10.1006/geno.1996.0153. PMID 8617492.
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Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Scott KL, Plon SE (2005). "CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor". Gene. 359: 119–26. doi:10.1016/j.gene.2005.06.014. PMID 16102918.
Busygina V, Kottemann MC, Scott KL, et al. (2007). "Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response". Cancer Res. 66 (17): 8397–403. doi:10.1158/0008-5472.CAN-06-0061. PMID 16951149.
Katoh H, Ojima H, Kokubu A, et al. (2007). "Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets". Gastroenterology. 133 (5): 1475–86. doi:10.1053/j.gastro.2007.08.038. PMID 17983802.
CHES1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)