Importin subunit alpha-3 (original) (raw)

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Protein-coding gene in the species Homo sapiens

KPNA4
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4UAE
Identifiers
Aliases KPNA4, IPOA3, QIP1, SRP3, karyopherin subunit alpha 4
External IDs OMIM: 602970; MGI: 1100848; HomoloGene: 20521; GeneCards: KPNA4; OMA:KPNA4 - orthologs
Gene location (Human)Chromosome 3 (human)Chr.Chromosome 3 (human)[1]Chromosome 3 (human)Genomic location for KPNA4Genomic location for KPNA4Band3q25.33Start160,495,007 bp[1]End160,565,571 bp[1]
Gene location (Mouse)Chromosome 3 (mouse)Chr.Chromosome 3 (mouse)[2]Chromosome 3 (mouse)Genomic location for KPNA4Genomic location for KPNA4Band3|3 E1Start68,974,482 bp[2]End69,034,446 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inbiceps brachiiSkeletal muscle tissue of biceps brachiiSkeletal muscle tissue of rectus abdoministail of epididymisendothelial cellbody of tongueright ventriclecorpus epididymisoral cavitysaphenous veinTop expressed inspermatocyteintercostal muscleexternal carotid arteryinternal carotid arterytriceps brachii muscleleft lung lobespermatidabdominal wallepithelium of lenssternocleidomastoid muscleMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function protein binding nuclear localization sequence binding nuclear import signal receptor activity Cellular component cytoplasm cytosol nuclear pore nucleoplasm nucleus nuclear membrane Biological process protein transport response to hydrogen peroxide protein import into nucleus NLS-bearing protein import into nucleus modulation by virus of host cellular process viral process Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez384016649EnsemblENSG00000186432ENSMUSG00000027782UniProtO00629O35343RefSeq (mRNA)NM_002268NM_008467RefSeq (protein)NP_002259NP_032493Location (UCSC)Chr 3: 160.5 – 160.57 MbChr 3: 68.97 – 69.03 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Importin subunit alpha-3, also known as karyopherin subunit alpha-4, is a protein that in humans is encoded by the KPNA4 gene.[5][6]

The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.[7]

KPNA4 has been shown to interact with RECQL[5] and STAT3.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186432 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027782 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Seki T, Tada S, Katada T, Enomoto T (May 1997). "Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL". Biochemical and Biophysical Research Communications. 234 (1): 48–53. doi:10.1006/bbrc.1997.6535. PMID 9168958.
  6. ^ Köhler M, Ansieau S, Prehn S, Leutz A, Haller H, Hartmann E (Nov 1997). "Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family". FEBS Letters. 417 (1): 104–8. doi:10.1016/S0014-5793(97)01265-9. PMID 9395085. S2CID 84237136.
  7. ^ "Entrez Gene: KPNA4 karyopherin alpha 4 (importin alpha 3)".
  8. ^ Liu L, McBride KM, Reich NC (Jun 2005). "STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3". Proc Natl Acad Sci U S A. 102 (23): 8150–5. Bibcode:2005PNAS..102.8150L. doi:10.1073/pnas.0501643102. PMC 1149424. PMID 15919823.