MPP1 (original) (raw)

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Protein-coding gene in the species Homo sapiens

MPP1
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EJY, 2EV8, 3NEY
Identifiers
Aliases	MPP1, AAG12, DXS552E, EMP55, MRG1, PEMP, membrane palmitoylated protein 1, MAGUK p55 scaffold protein 1
External IDs	OMIM: 305360; MGI: 105941; HomoloGene: 1826; GeneCards: MPP1; OMA:MPP1 - orthologs
Gene location (Human)Chr.X chromosome (human)[1]BandXq28Start154,778,684 bp[1]End154,821,007 bp[1]
Gene location (Mouse)Chr.X chromosome (mouse)[2]BandX A7.3|X 38.15 cMStart74,153,339 bp[2]End74,174,622 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inmonocytebloodjejunal mucosatrabecular bonebone marrowbone marrow cellsduodenumright lungspleengranulocyteTop expressed infetal liver hematopoietic progenitor celltibiofemoral jointbloodjejunumileumright kidneystroma of bone marrowgranulocyteendothelial cell of lymphatic vesselwhite adipose tissueMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function guanylate kinase activity protein binding Cellular component cortical cytoskeleton cell projection integral component of plasma membrane intracellular anatomical structure membrane stereocilium cytosol plasma membrane nuclear speck Biological process regulation of neutrophil chemotaxis signal transduction GDP metabolic process GMP metabolic process Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez435417524EnsemblENSG00000130830ENSMUSG00000031402UniProtQ00013P70290RefSeq (mRNA)NM_001166460NM_001166461NM_001166462NM_002436NM_008621RefSeq (protein)NP_001159932NP_001159933NP_001159934NP_002427NP_032647Location (UCSC)Chr X: 154.78 – 154.82 MbChr X: 74.15 – 74.17 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

55 kDa erythrocyte membrane protein is a protein that in humans is encoded by the MPP1 gene.[5][6]

Palmitoylated membrane protein 1 is the prototype of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 1 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.[6]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130830 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031402 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Ruff P, Speicher DW, Husain-Chishti A (Sep 1991). "Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif". Proc Natl Acad Sci U S A. 88 (15): 6595–9. Bibcode:1991PNAS...88.6595R. doi:10.1073/pnas.88.15.6595. PMC 52133. PMID 1713685.
6. ^ a b "Entrez Gene: MPP1 membrane protein, palmitoylated 1, 55kDa".

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• Kim AC, Metzenberg AB, Sahr KE, et al. (1997). "Complete genomic organization of the human erythroid p55 gene (MPP1), a membrane-associated guanylate kinase homologue". Genomics. 31 (2): 223–9. doi:10.1006/geno.1996.0035. PMID 8824805.
• Marfatia SM, Morais-Cabral JH, Kim AC, et al. (1997). "The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C. Analysis of the binding interface by in vitro mutagenesis". J. Biol. Chem. 272 (39): 24191–7. doi:10.1074/jbc.272.39.24191. PMID 9305870.
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• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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• Gosens I, van Wijk E, Kersten FF, et al. (2007). "MPP1 links the Usher protein network and the Crumbs protein complex in the retina". Hum. Mol. Genet. 16 (16): 1993–2003. doi:10.1093/hmg/ddm147. PMID 17584769.