MRGPRX2 (original) (raw)

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Protein-coding gene in the species Homo sapiens

MRGPRX2
Identifiers
Aliases	MRGPRX2, MGRG3, MRGX2, MAS related GPR family member X2
External IDs	OMIM: 607228; MGI: 3588270; HomoloGene: 24986; GeneCards: MRGPRX2; OMA:MRGPRX2 - orthologs
Gene location (Human)Chr.Chromosome 11 (human)[1]Band11p15.1Start19,054,455 bp[1]End19,060,717 bp[1]
Gene location (Mouse)Chr.Chromosome 7 (mouse)[2]Band7|7 B4Start48,128,367 bp[2]End48,149,069 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed intesticleskin of abdomenskin of legsubcutaneous adipose tissuerectumurinary bladderfundusvaginagastric mucosasmooth muscle tissueTop expressed inmuscle of thighzone of skinquadriceps femoris musclelipesophagusMore reference expression dataBioGPSn/a
Gene ontologyMolecular function neuropeptide binding signal transducer activity mast cell secretagogue receptor activity G protein-coupled receptor activity Cellular component plasma membrane membrane integral component of membrane mast cell granule integral component of plasma membrane Biological process sleep positive regulation of cytokinesis mast cell activation G protein-coupled receptor signaling pathway signal transduction sensory perception of pain mast cell degranulation Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez117194243978EnsemblENSG00000183695ENSMUSG00000074109UniProtQ96LB1Q3UG50RefSeq (mRNA)NM_001303615NM_054030NM_001034868RefSeq (protein)NP_001290544NP_473371NP_001030040Location (UCSC)Chr 11: 19.05 – 19.06 MbChr 7: 48.13 – 48.15 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene.[5][6] It is most abundant on cutaneous mast cells, sensory neurons, and keratinocytes.[7]

Activation of MRGPRX2 on mast cells leads to IgE-independent type 1 hypersensitivity-like symptoms, also known as pseudoallergic reactions, although more rapid and brief. Medications identified to cause MRGPRX2 activation including neuromuscular blocking agents (NMBA) (except for succinylcholine), antibiotics like DNA gyrase inhibitor fluoroquinolones or cell wall synthesis inhibitor vancomycin (which caused Red Man syndrome), icatibant, leuprolide, and morphine.[7]

• MAS1 oncogene
• Pseudoallergy

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183695 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074109 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (September 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–632. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509.
6. ^ "Entrez Gene: MRGPRX2 MAS-related GPR, member X2".
7. ^ a b Akin C, Elhosni M, Khokar DS (2023). "Mast Cells and Mast Cell disorders". In Rich RR, Fleisher TA, Schroeder HW, Weyand CM, Corry DB, Puck J (eds.). Clinical immunology: principles and practice. Elsevier. p. 563. ISBN 978-0-7020-8165-1.

• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. Bibcode:2002FEBSL.520...97T. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
• Robas N, Mead E, Fidock M (November 2003). "MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion". The Journal of Biological Chemistry. 278 (45): 44400–44404. doi:10.1074/jbc.M302456200. PMID 12915402.
• Yang S, Liu Y, Lin AA, Cavalli-Sforza LL, Zhao Z, Su B (June 2005). "Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception". Gene. 352: 30–35. doi:10.1016/j.gene.2005.03.001. PMID 15862286.