MYLK3 (original) (raw)

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Protein-coding gene in the species Homo sapiens

MYLK3
Identifiers
Aliases	MYLK3, MLCK, MLCK2, caMLCK, myosin light chain kinase 3
External IDs	OMIM: 612147; MGI: 2443063; HomoloGene: 35278; GeneCards: MYLK3; OMA:MYLK3 - orthologs
Gene location (Human)Chr.Chromosome 16 (human)[1]Band16q11.2Start46,702,282 bp[1]End46,790,407 bp[1]
Gene location (Mouse)Chr.Chromosome 8 (mouse)[2]Band8|8 C3Start86,050,932 bp[2]End86,112,974 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed incardiac muscle tissue of right atriumright ventriclemyocardium of left ventricleright auricleSkeletal muscle tissue of biceps brachiibody of tongueapex of heartthoracic diaphragmSkeletal muscle tissue of rectus abdoministriceps brachii muscleTop expressed inmyocardium of ventricleatriuminterventricular septumatrioventricular valveepithelium of small intestineesophagusmigratory enteric neural crest cellendocardial cushionleft ventriclebone marrowMore reference expression dataBioGPSn/a
Gene ontologyMolecular function calmodulin-dependent protein kinase activity kinase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity transferase activity ATP binding myosin light chain kinase activity Cellular component cytoplasm actin cytoskeleton cytosol intracellular anatomical structure Biological process protein phosphorylation positive regulation of sarcomere organization regulation of vascular permeability involved in acute inflammatory response sarcomere organization cellular response to interleukin-1 phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction sarcomerogenesis cardiac myofibril assembly Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez91807213435EnsemblENSG00000140795ENSMUSG00000031698UniProtQ32MK0Q3UIZ8RefSeq (mRNA)NM_001308301NM_182493NM_001297612NM_175441RefSeq (protein)NP_001295230NP_872299NP_001284541NP_780650Location (UCSC)Chr 16: 46.7 – 46.79 MbChr 8: 86.05 – 86.11 MbPubMed search[3][4]
Wikidata
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Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.[5][6]

Phosphorylation of cardiac myosin heavy chains (see MYH7B) and light chains (see MYL2) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes.[7]

• Myosin light-chain kinase

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140795 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031698 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: MLCK MLCK protein".
6. ^ Seguchi O, Takashima S, Yamazaki S, Asakura M, Asano Y, Shintani Y, Wakeno M, Minamino T, Kondo H, Furukawa H, Nakamaru K, Naito A, Takahashi T, Ohtsuka T, Kawakami K, Isomura T, Kitamura S, Tomoike H, Mochizuki N, Kitakaze M (October 2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812–24. doi:10.1172/JCI30804. PMC 1978424. PMID 17885681.
7. ^ Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H (March 2008). "Identification of cardiac-specific myosin light chain kinase". Circ. Res. 102 (5): 571–80. doi:10.1161/CIRCRESAHA.107.161687. PMC 2504503. PMID 18202317.

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clayburgh DR, Rosen S, Witkowski ED, et al. (2005). "A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability". J. Biol. Chem. 279 (53): 55506–13. doi:10.1074/jbc.M408822200. PMC 1237105. PMID 15507455.
• Wang F, Graham WV, Wang Y, et al. (2005). "Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression". Am. J. Pathol. 166 (2): 409–19. doi:10.1016/S0002-9440(10)62264-X. PMC 1237049. PMID 15681825.
• Russo JM, Florian P, Shen L, et al. (2005). "Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure". Gastroenterology. 128 (4): 987–1001. doi:10.1053/j.gastro.2005.01.004. PMC 1237051. PMID 15825080.
• Shimizu S, Yoshida T, Wakamori M, et al. (2006). "Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells". J. Physiol. 570 (Pt 2): 219–35. doi:10.1113/jphysiol.2005.097998. PMC 1464317. PMID 16284075.
• Kim MT, Kim BJ, Lee JH, et al. (2006). "Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells". Am. J. Physiol., Cell Physiol. 290 (4): C1031–40. doi:10.1152/ajpcell.00602.2004. PMID 16306123.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Connell LE, Helfman DM (2007). "Myosin light chain kinase plays a role in the regulation of epithelial cell survival". J. Cell Sci. 119 (Pt 11): 2269–81. doi:10.1242/jcs.02926. PMID 16723733.
• Seguchi O, Takashima S, Yamazaki S, et al. (2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812–24. doi:10.1172/JCI30804. PMC 1978424. PMID 17885681.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.