Protein kinase, AMP-activated, alpha 1 (original) (raw)

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Protein-coding gene in the species Homo sapiens

PRKAA1
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4RED, 4RER, 4REW, 5EZV
Identifiers
Aliases PRKAA1, AMPK, AMPKa1, Protein kinase, AMP-activated, alpha 1, protein kinase AMP-activated catalytic subunit alpha 1
External IDs OMIM: 602739; MGI: 2145955; HomoloGene: 49590; GeneCards: PRKAA1; OMA:PRKAA1 - orthologs
EC number 2.7.11.26
Gene location (Human)Chromosome 5 (human)Chr.Chromosome 5 (human)[1]Chromosome 5 (human)Genomic location for PRKAA1Genomic location for PRKAA1Bandn/aStart40,759,379 bp[1]End40,798,374 bp[1]
Gene location (Mouse)Chromosome 15 (mouse)Chr.Chromosome 15 (mouse)[2]Chromosome 15 (mouse)Genomic location for PRKAA1Genomic location for PRKAA1Band15|15 A1Start5,173,343 bp[2]End5,211,380 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inAchilles tendonspermrectumgallbladdergastric mucosastromal cell of endometriumepithelium of colontibial arteriesbody of pancreasDescending thoracic aortaTop expressed ingranulocyteislet of Langerhansepithelium of small intestinemammillary bodywhite adipose tissuehandventromedial nucleusmedial vestibular nucleuslateral hypothalamusventral tegmental areaMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function transferase activity nucleotide binding protein kinase activity cAMP-dependent protein kinase activity [acetyl-CoA carboxylase kinase activity] AMP-activated protein kinase activity histone serine kinase activity chromatin binding metal ion binding kinase activity protein serine/threonine kinase activity tau-protein kinase activity protein C-terminus binding protein binding [hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity] ATP binding tau protein binding Cellular component nucleotide-activated protein kinase complex apical plasma membrane nucleoplasm nucleus cytoplasm cytosol nuclear speck intracellular anatomical structure axon dendrite protein-containing complex soma Biological process cellular response to organonitrogen compound steroid metabolic process cellular response to glucose starvation sterol biosynthetic process lipid biosynthetic process regulation of transcription, DNA-templated response to hypoxia cellular response to ethanol glucose homeostasis positive regulation of skeletal muscle tissue development protein heterooligomerization rhythmic process phosphorylation lipid metabolism regulation of vesicle-mediated transport negative regulation of apoptotic process cholesterol metabolic process Wnt signaling pathway response to activity fatty acid metabolic process transcription, DNA-templated cellular response to prostaglandin E stimulus autophagy protein phosphorylation negative regulation of TOR signaling cold acclimation positive regulation of gene expression response to camptothecin fatty acid biosynthetic process fatty acid homeostasis regulation of circadian rhythm fatty acid oxidation regulation of peptidyl-serine phosphorylation cellular response to nutrient levels positive regulation of cell population proliferation negative regulation of glucosylceramide biosynthetic process glucose metabolic process positive regulation of cholesterol biosynthetic process response to caffeine cholesterol biosynthetic process negative regulation of lipid catabolic process response to gamma radiation macroautophagy response to UV positive regulation of glycolytic process response to hydrogen peroxide cellular response to hypoxia signal transduction cellular response to hydrogen peroxide steroid biosynthetic process regulation of signal transduction by p53 class mediator positive regulation of autophagy CAMKK-AMPK signaling cascade regulation of macroautophagy chromatin organization positive regulation of mitochondrial transcription positive regulation of protein targeting to mitochondrion negative regulation of gene expression cellular response to oxidative stress intracellular signal transduction negative regulation of insulin receptor signaling pathway motor behavior regulation of stress granule assembly neuron cellular homeostasis regulation of microtubule cytoskeleton organization cellular response to calcium ion cellular response to glucose stimulus energy homeostasis positive regulation of protein localization negative regulation of tubulin deacetylation positive regulation of peptidyl-lysine acetylation Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez5562105787EnsemblENSG00000132356ENSMUSG00000050697UniProtQ13131Q5EG47RefSeq (mRNA)NM_006251NM_206907NM_001013367NM_001355640RefSeq (protein)NP_006242NP_996790NP_001341957NP_001341958NP_001341963NP_001341964NP_001341965NP_001341966NP_001013385NP_001342569Location (UCSC)Chr 5: 40.76 – 40.8 MbChr 15: 5.17 – 5.21 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.[5][6]

The protein encoded by this gene belongs to the serine/threonine protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[6] A recent study proposes a role in the metastatic cascade and phenotype determination of pancreatic cancer.[7]

Protein kinase, AMP-activated, alpha 1 has been shown to interact with TSC2.[8][9]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132356 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050697 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (Feb 1996). "Mammalian AMP-activated protein kinase subfamily". J Biol Chem. 271 (2): 611–4. doi:10.1074/jbc.271.2.611. PMID 8557660.
  6. ^ a b "Entrez Gene: PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit".
  7. ^ Schneider, Carolin; Hilbert, Jorina; Genevaux, Franziska; Höfer, Stefanie; Krauß, Lukas; Schicktanz, Felix; Contreras, Constanza Tapia; Jansari, Shaishavi; Papargyriou, Aristeidis; Richter, Thorsten; Alfayomy, Abdallah M.; Falcomatà, Chiara; Schneeweis, Christian; Orben, Felix; Öllinger, Ruppert (2024-06-17). "A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction". Advanced Science. doi:10.1002/advs.202307695. ISSN 2198-3844. PMC 11336956.
  8. ^ Inoki, Ken; Zhu Tianqing; Guan Kun-Liang (Nov 2003). "TSC2 mediates cellular energy response to control cell growth and survival". Cell. 115 (5). United States: 577–90. doi:10.1016/S0092-8674(03)00929-2. ISSN 0092-8674. PMID 14651849. S2CID 18173817.
  9. ^ Shaw, Reuben J; Bardeesy Nabeel; Manning Brendan D; Lopez Lyle; Kosmatka Monica; DePinho Ronald A; Cantley Lewis C (Jul 2004). "The LKB1 tumor suppressor negatively regulates mTOR signaling". Cancer Cell. 6 (1). United States: 91–9. doi:10.1016/j.ccr.2004.06.007. ISSN 1535-6108. PMID 15261145.