SUMO3 (original) (raw)

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Protein-coding gene in the species Homo sapiens

SUMO3
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1U4A, 2IO1, 2MP2
Identifiers
Aliases SUMO3, SMT3A, SMT3H1, SUMO-3, Smt3B, small ubiquitin-like modifier 3, small ubiquitin like modifier 3
External IDs OMIM: 602231; MGI: 1336201; HomoloGene: 38251; GeneCards: SUMO3; OMA:SUMO3 - orthologs
Gene location (Human)Chromosome 21 (human)Chr.Chromosome 21 (human)[1]Chromosome 21 (human)Genomic location for SUMO3Genomic location for SUMO3Band21q22.3Start44,805,617 bp[1]End44,818,779 bp[1]
Gene location (Mouse)Chromosome 10 (mouse)Chr.Chromosome 10 (mouse)[2]Chromosome 10 (mouse)Genomic location for SUMO3Genomic location for SUMO3Band10 C1|10 39.72 cMStart77,441,931 bp[2]End77,454,165 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inendothelial celltibiaparietal pleuravisceral pleurapalpebral conjunctivagerminal epitheliummiddle temporal gyrusretinal pigment epitheliumBrodmann area 23hair follicleTop expressed inyolk sacneural layer of retinaolfactory bulbstriatum of neuraxisMesencephalonepiblastdentate gyrus of hippocampal formation granule cellrhombencephalonstomachCerebellumMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function protein binding protein tag enzyme binding ubiquitin-like protein ligase binding Cellular component cytoplasm PML body nucleus kinetochore nucleoplasm Biological process negative regulation of DNA binding protein sumoylation Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez661220610EnsemblENSG00000184900ENSMUSG00000020265UniProtP55854Q9Z172RefSeq (mRNA)NM_006936NM_001286416NM_001301671NM_001301672NM_001301673NM_019929RefSeq (protein)NP_001273345NP_008867NP_001288600NP_001288601NP_001288602NP_064313Location (UCSC)Chr 21: 44.81 – 44.82 MbChr 10: 77.44 – 77.45 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Small ubiquitin-related modifier 3 is a protein that in humans is encoded by the SUMO3 gene.[5][6]

SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002).[supplied by OMIM][6]

SUMO3 has been shown to interact with ARNTL[7] and Thymine-DNA glycosylase.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184900 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020265 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lapenta V, Chiurazzi P, van der Spek P, Pizzuti A, Hanaoka F, Brahe C (March 1997). "SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family". Genomics. 40 (2): 362–6. doi:10.1006/geno.1996.4556. PMID 9119407.
  6. ^ a b "Entrez Gene: SUMO3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)".
  7. ^ Lee J, Lee Y, Lee MJ, Park E, Kang SH, Chung CH, Lee KH, Kim K (October 2008). "Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex". Molecular and Cellular Biology. 28 (19): 6056–65. doi:10.1128/MCB.00583-08. PMC 2546997. PMID 18644859.
  8. ^ Hardeland U, Steinacher R, Jiricny J, Schär P (March 2002). "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover". The EMBO Journal. 21 (6): 1456–64. doi:10.1093/emboj/21.6.1456. PMC 125358. PMID 11889051.