Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas (original) (raw)

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| logo citeas | Martinez-A, C., & van Wely, K. H. M. (2011, April 8). Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas. Carcinogenesis. Oxford University Press (OUP). http://doi.org/10.1093/carcin/bgr069 | | | -------------------------------------------------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | |

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Título:
Autor: ; Van Wely, Karel H. M. CSIC ORCID
Palabras clave: CancerChromosomal instabilityMitosisSpindle defectBreakage-fusion-bridge
Fecha de publicación: 2011
Editor: Oxford University Press
Citación: Carcinogenesis 32(6): 796-803 (2011)
Resumen: The majority of sporadic carcinomas suffer from a kind of genetic instability in which chromosome number changes occur together with segmental defects. This means that changes involving intact chromosomes accompany breakage-induced alterations. Whereas the causes of aneuploidy are described in detail, the origins of chromosome breakage in sporadic carcinomas remain disputed. The three main pathways of chromosomal instability proposed until now (random breakage, telomere fusion, and centromere fission) are largely based on animal models and in vitro experiments, and recent studies revealed several discrepancies between animal models and human cancer. Here, we discuss how the experimental systems translate to human carcinomas and compare the theoretical breakage products to data from patient material and cancer cell lines. The majority of chromosomal defects in human carcinomas comprise pericentromeric breaks that are captured by healthy telomeres, and only a minor proportion of chromosome fusions can be attributed to telomere erosion or random breakage. Centromere fission, not telomere erosion, is therefore the most likely trigger of chromosomal instability and early carcinogenesis. Similar centromere-telomere fusions might drive a subset of congenital defects and evolutionary chromosome changes.
Descripción: 8 páginas, 6 figuras.-- El PDF del artículo esta en pre-print.
Versión del editor: http://dx.doi.org/10.1093/carcin/bgr069
URI: http://hdl.handle.net/10261/34691
DOI: 10.1093/carcin/bgr069
ISSN: 0143-3334
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