The embryonic preoptic area is a novel source of cortical GABAergic interneurons (original) (raw)

  1. DIGITAL.CSIC
  2. Biología y Biomedicina
  3. Instituto de Neurociencias (IN)
  4. (IN) Artículos

Por favor, use este identificador para citar o enlazar a este item:http://hdl.handle.net/10261/36795

COMPARTIR / EXPORTAR:

| logo citeas | (n.d.). Error: DOI Not Found. Retrieved from http://doi.org/10.1523/​JNEUROSCI.0604-09.2009 | | | -------------------------------------------------------------- | --------------------------------------------------------------------------------------------- | |

Invitar a revisión por pares abierta

Título:
Autor: CSIC; Martini, Francisco J. CSIC ORCID; Nóbrega-Pereira, Sandrina CSIC ORCID; Pierani, Alessandra; Kessaris, Nicoletta; Marín Parra, Óscar CSIC ORCID
Fecha de publicación: 2009
Editor: Society for Neuroscience
Citación: Journal of Neuroscience 29: 9380 -9389 (2009)
Resumen: GABA-containing (GABAergic) interneurons play an important role in the function of the cerebral cortex. Through mostly inhibitory mechanisms, interneurons control hyperexcitability and synchronize and shape the spatiotemporal dynamics of cortical activity underlying various brain functions. Studies over the past 10 years have demonstrated that, in most mammals, interneurons originate during development from the subcortical telencephalon—the subpallium—and reach the cerebral cortex through tangential migration. Until now, interneurons have been demonstrated to derive exclusively from two subpallial regions, the medial ganglionic eminence and the caudal ganglionic eminence. Here, we show that another subpallial structure, the preoptic area, is a novel source of cortical GABAergic interneurons in the mouse. In utero labeling and genetic lineage-tracing experiments demonstrate that neurons born in this region migrate to the neocortex and hippocampus, where they differentiate into a distinct population of GABAergic interneurons with relatively uniform neurochemical, morphological, and electrophysiological properties.
Versión del editor: http://dx.doi.org/10.1523/​JNEUROSCI.0604-09.2009
URI: http://hdl.handle.net/10261/36795
DOI: 10.1523/​JNEUROSCI.0604-09.2009
ISSN: 0270-6474
Aparece en las colecciones: (IN) Artículos
Ficheros en este ítem:

Mostrar el registro completo

Altmetric

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.