Understanding the contribution of zinc transporters in the function of the early secretory pathway (original) (raw)
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| タイトル: | Understanding the contribution of zinc transporters in the function of the early secretory pathway |
|---|---|
| 著者: | Kambe, Taiho    https://orcid.org/0000-0001-9757-063X (unconfirmed)Matsunaga, MayuTakeda, Taka Aki |
| 著者名の別形: | 神戸, 大朋松永, 麻佑武田, 貴成 |
| キーワード: | ZNT/Solute carrier family 30 member (SLC30A)ZIP/SLC39Aearly secretory pathwayER stressunfolded protein response (UPR)zinc-requiring ectoenzymestissue non-specific alkaline phosphatase (TNAP)metallation |
| 発行日: | 19-Oct-2017 |
| 出版者: | MDPI AG |
| 誌名: | International Journal of Molecular Sciences |
| 巻: | 18 |
| 号: | 10 |
| 論文番号: | 2179 |
| 抄録: | More than one-third of newly synthesized proteins are targeted to the early secretory pathway, which is comprised of the endoplasmic reticulum (ER), Golgi apparatus, and other intermediate compartments. The early secretory pathway plays a key role in controlling the folding, assembly, maturation, modification, trafficking, and degradation of such proteins. A considerable proportion of the secretome requires zinc as an essential factor for its structural and catalytic functions, and recent findings reveal that zinc plays a pivotal role in the function of the early secretory pathway. Hence, a disruption of zinc homeostasis and metabolism involving the early secretory pathway will lead to pathway dysregulation, resulting in various defects, including an exacerbation of homeostatic ER stress. The accumulated evidence indicates that specific members of the family of Zn transporters (ZNTs) and Zrt- and Irt-like proteins (ZIPs), which operate in the early secretory pathway, play indispensable roles in maintaining zinc homeostasis by regulating the influx and efflux of zinc. In this review, the biological functions of these transporters are discussed, focusing on recent aspects of their roles. In particular, we discuss in depth how specific ZNT transporters are employed in the activation of zinc-requiring ectoenzymes. The means by which early secretory pathway functions are controlled by zinc, mediated by specific ZNT and ZIP transporters, are also subjects of this review. |
| 著作権等: | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). |
| URI: | http://hdl.handle.net/2433/233798 |
| DOI(出版社版): | 10.3390/ijms18102179 |
| PubMed ID: | 29048339 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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