ARHGEF26 gene cDNA ORF clone, Homo sapiens(human) (original) (raw)

• Summary

  Gene Symbol	ARHGEF26
  Entrez Gene ID	26084
  Full Name	Rho guanine nucleotide exchange factor 26
  Synonyms	CSGEF,HMFN1864,SGEF
  General protein information	Preferred NamesRho guanine nucleotide exchange factor 26 Namesrho guanine nucleotide exchange factor 26Rho guanine nucleotide exchange factor (GEF) 26SH3 domain-containing guanine exchange factorSrc homology 3 domain-containing guanine nucleotide exchange factortesticular tissue protein Li 171
  Gene Type	protein-coding
  Organism	Homo sapiens(human)
  Genome	Chromosome: 3 Map Location: 3q25.2
  Summary	This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011].
  Disorder MIM:	617552

• mRNA and Protein(s)

  mRNA	Protein	Name
  XM_017006160.1	XP_016861649.1	rho guanine nucleotide exchange factor 26 isoform X2
  NM_001251963.2	NP_001238892.1	rho guanine nucleotide exchange factor 26 isoform 2
  NM_015595.3	NP_056410.3	rho guanine nucleotide exchange factor 26 isoform 1
  NM_001251962.1	NP_001238891.1	rho guanine nucleotide exchange factor 26 isoform 1
  NM_001251963.1	NP_001238892.1	rho guanine nucleotide exchange factor 26 isoform 2
  XM_011512672.1	XP_011510974.1	rho guanine nucleotide exchange factor 26 isoform X1
  NM_015595.4	NP_056410.3	rho guanine nucleotide exchange factor 26 isoform 1

• Pathways from BioSystems
  
• Homologies

  LOC708205	XP_002803053.1
  Gallus gallus (chicken)	ARHGEF26	XP_426718.3
  Bos taurus (cattle)	ARHGEF26	NP_001192918.1
  Mus musculus (house mouse)	Arhgef26	NP_001074764.1
  Xenopus tropicalis (tropical clawed frog)	arhgef26	XP_002933294.2
  Canis lupus familiaris (dog)	ARHGEF26	XP_005634713.1
  Homo sapiens (human)	ARHGEF26	NP_056410.3
  Rattus norvegicus (Norway rat)	Arhgef26	XP_227201.4
  Pan troglodytes (chimpanzee)	ARHGEF26	XP_526354.3

• Gene Ontology
  
• Bibliography

Related articles in PubMed

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Klarin D, Zhu QM, Emdin CA, Chaffin M, Horner S, McMillan BJ, Leed A, Weale ME, Spencer CCA, Aguet F, Segr? AV, Ardlie KG, Khera AV, Kaushik VK, Natarajan P, , Kathiresan S
Nature genetics49(9)1392-1397(2017 Sep)
A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells.
Goicoechea SM, Zinn A, Awadia SS, Snyder K, Garcia-Mata R
Journal of cell science130(6)1064-1077(2017 03)
SGEF Is Regulated via TWEAK/Fn14/NF-?B Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide.
Ensign SP, Roos A, Mathews IT, Dhruv HD, Tuncali S, Sarkaria JN, Symons MH, Loftus JC, Berens ME, Tran NL
Molecular cancer research : MCR14(3)302-12(2016 Mar)
Tyrosine Phosphorylation of SGEF Regulates RhoG Activity and Cell Migration.
Okuyama Y, Umeda K, Negishi M, Katoh H
PloS one11(7)e0159617(2016)
GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ARHGEF26 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARHGEF26 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

• Reference Sequences (Refseq)

161121181241301361421481541601661721781841901961102110811141120112611321138114411501	ATGGAGCTTG CAGTACTGAA AGTTGCCCTG GAAAATGCTG TCCTGTATCA AAACTACAAG GAAAAGGCCC TTGACATTGA TTCTGATGAA GAGTCAGAGC CCAAAGAACA GAAGTCAGAT GAAAAAATTG TGATTCACCA TAAGCCATTG AGATCCACAT GGAGCCAACT CTCTGCGGTG AAAAGAAAGG GATTATCTCA GACAGTAAGC CAGGAGGAAA GAAAGAGACA AGAGGCTATC TTTGAAGTCA TATCCTCTGA ACATTCATAT TTACTCAGCT TGGAGATCTT GATACGAATG TTTAAAAATT CTAAAGAACT GAGTGATACA ATGACTAAAA CCGAGAGGCA CCATCTTTTC TCCAATATTA CAGATGTCTG TGAGGCAAGC AAAAAGTTCT TTATAGAGTT GGAAGCAAGA CATCAGAATA ATATCTTCAT AGATGACATA AGTGACATTG TGGAAAAACA CACAGCATCC ACATTTGACC CATATGTGAA ATACTGCACA AATGAAGTCT ACCAACAACG AACACTACAA AAATTGTTAG CTACCAATCC ATCCTTTAAG GAAGTATTGT CAAGGATTGA GTCCCATGAA GACTGTAGGA ACTTACCCAT GATCTCTTTT CTCATTCTCC CCATGCAGAG GGTGACCCGC CTTCCCCTGC TGATGGATAC TATCTGTCAA AAAACACCTA AGGACTCTCC GAAGTATGAA GTCTGCAAAA GAGCCTTGAA GGAAGTTAGC AAGTTGGTTC GACTATGCAA TGAGGGCGCC CGGAAGATGG AAAGGACTGA GATGATGTAC ACAATTAACT CCCAGCTGGA ATTTAAAATT AAGCCTTTTC CTTTAGTCTC CTCTTCCCGG TGGTTGGTAA AAAGAGGTGA ATTGACAGCC TATGTTGAAG ACACTGTGCT TTTCTCAAGA AGGACATCCA AACAGCAAGT CTACTTCTTT CTCTTTAACG ATGTGCTCAT TATCACCAAG AAGAAGAGTG AAGAAAGTTA CAACGTCAAT GATTATTCCT TAAGAGATCA GCTATTGGTG GAATCTTGTG ACAATGAAGA GCTTAATTCT TCTCCAGGGA AGAACAGCTC CACAATGCTC TATTCAAGAC AGAGCTCTGC CAGTCACCTC TTTACTCTGA CAGTCCTTAG TAACCACGCG AATGAGAAAG TGGAGATGCT ACTAGGAGCT GAGACGCAGA GCGAGCGAGC CCGCTGGATA ACTGCCCTGG GACACAGCAG CGGGAAGCCG CCTGCAGACC GAACCTCACT GACCCAGGTG GAAATCGTTA GGTCATTTAC TGCTAAGCAG CCAGATGAAC TCTCCCTGCA GGTGGCTGAC GTCGTCCTCA TCTATCAACG TGTCAGCGAT GGCTGGTATG AGGGGGAACG ACTACGAGAT GGAGAAAGAG GCTGGTTTCC TATGGAATGT GCCAAGGAGA TAACATGTCA AGCTACAATT GATAAGAATG TGGAGAGAAT GGGACGCTTG CTAGGACTGG AGACCAACGT GTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq	XP_016861649.1
---------------	---------------
CDS	46..1569
Translation
Target ORF information: RefSeq Version XM_017006160.1 Organism Homo sapiens(human) Definition Homo sapiens Rho guanine nucleotide exchange factor 26 (ARHGEF26), transcript variant X2, mRNA. Target ORF information: Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK	XM_017006160.1
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------	--------------------------------------------------------------------

ORF Insert Sequence:

161121181241301361421481541601661721781841901961102110811141120112611321138114411501156116211681174118011861192119812041210121612221228123412401246125212581	ATGGACGGCG AGAGCGAGGT GGATTTTTCT AGCAACAGCA TAACCCCTTT GTGGCGGAGG CGGTCGATTC CTCAGCCCCA CCAGGTTCTG GGCCGGAGCA AGCCGAGGCC CCAGTCCTAC CAGAGCCCCA ACGGGTTACT AATTACGGAT TTCCCGGTGG AGGACGGAGG GACGCTCCTC GCAGCGCAGA TTCCCGCCCA GGTGCCCACC GCCTCGGACA GCAGGACGGT ACATAGGAGC CCCCTGCTTC TGGGCGCCCA GCGGAGAGCG GTGGCCAATG GTGGGACGGC ATCCCCGGAG TACAGGGCTG CCTCTCCTCG ACTTCGACGG CCCAAGTCAC CCAAGCTCCC CAAAGCGGTG CCTGGCGGCT CCCCGAAATC CCCAGCAAAT GGCGCGGTGA CCTTGCCTGC GCCGCCGCCG CCGCCGGTTC TGCGCCCCCC GCGGACTCCT AACGCGCCCG CCCCCTGCAC CCCCGAGGAG GACCTTACTG GGTTGACTGC CAGCCCGGTG CCTTCGCCCA CTGCAAATGG CCTTGCCGCT AATAACGACT CTCCTGGGTC AGGTTCGCAG TCCGGCCGGA AGGCAAAGGA CCCCGAACGG GGGCTCTTTC CTGGGCCCCA GAAAAGTTCT TCGGAACAAA AACTCCCCCT CCAAAGGCTG CCCTCCCAGG AGAACGAGCT CCTCGAGAAT CCTTCCGTGG TTTTGAGTAC AAACAGCCCC GCCGCCCTCA AAGTGGGGAA GCAGCAGATC ATTCCGAAGA GTCTGGCCTC GGAAATTAAA ATAAGTAAAT CCAACAATCA AAATGTGGAG CCCCACAAGA GACTCCTCAA GGTGCGCAGC ATGGTGGAGG GCCTAGGAGG ACCCCTGGGT CACGCAGGGG AGGAGAGTGA GGTCGATAAC GACGTGGATA GCCCAGGGTC TCTGCGGAGA GGCTTGCGGT CCACGTCTTA TCGCAGGGCA GTGGTCAGTG GCTTTGATTT TGACAGTCCT ACCAGCTCGA AGAAGAAGAA CAGAATGTCC CAGCCTGTTC TGAAAGTGGT GATGGAAGAC AAGGAGAAGT TTTCCAGTCT GGGAAGGATA AAGAAAAAAA TGCTGAAAGG ACAAGGAACA TTTGATGGGG AAGAAAATGC TGTCCTGTAT CAAAACTACA AGGAAAAGGC CCTTGACATT GATTCTGATG AAGAGTCAGA GCCCAAAGAA CAGAAGTCAG ATGAAAAAAT TGTGATTCAC CATAAGCCAT TGAGATCCAC ATGGAGCCAA CTCTCTGCGG TGAAAAGAAA GGGATTATCT CAGACAGTAA GCCAGGAGGA AAGAAAGAGA CAAGAGGCTA TCTTTGAAGT CATATCCTCT GAACATTCAT ATTTACTCAG CTTGGAGATC TTGATACGAA TGTTTAAAAA TTCTAAAGAA CTGAGTGATA CAATGACTAA AACCGAGAGG CACCATCTTT TCTCCAATAT TACAGATGTC TGTGAGGCAA GCAAAAAGTT CTTTATAGAG TTGGAAGCAA GACATCAGAA TAATATCTTC ATAGATGACA TAAGTGACAT TGTGGAAAAA CACACAGCAT CCACATTTGA CCCATATGTG AAATACTGCA CAAATGAAGT CTACCAACAA CGAACACTAC AAAAATTGTT AGCTACCAAT CCATCCTTTA AGGAAGTATT GTCAAGGATT GAGTCCCATG AAGACTGTAG GAACTTACCC ATGATCTCTT TTCTCATTCT CCCCATGCAG AGGGTGACCC GCCTTCCCCT GCTGATGGAT ACTATCTGTC AAAAAACACC TAAGGACTCT CCGAAGTATG AAGTCTGCAA AAGAGCCTTG AAGGAAGTTA GCAAGTTGGT TCGACTATGC AATGAGGGCG CCCGGAAGAT GGAAAGGACT GAGATGATGT ACACAATTAA CTCCCAGCTG GAATTTAAAA TTAAGCCTTT TCCTTTAGTC TCCTCTTCCC GGTGGTTGGT AAAAAGAGGT GAATTGACAG CCTATGTTGA AGACACTGTG CTTTTCTCAA GAAGGACATC CAAACAGCAA GTCTACTTCT TTCTCTTTAA CGATGTGCTC ATTATCACCA AGAAGAAGAG TGAAGAAAGT TACAACGTCA ATGATTATTC CTTAAGAGAT CAGCTATTGG TGGAATCTTG TGACAATGAA GAGCTTAATT CTTCTCCAGG GAAGAACAGC TCCACAATGC TCTATTCAAG ACAGAGCTCT GCCAGTCACC TCTTTACTCT GACAGTCCTT AGTAACCACG CGAATGAGAA AGTGGAGATG CTACTAGGAG CTGAGACGCA GAGCGAGCGA GCCCGCTGGA TAACTGCCCT GGGACACAGC AGCGGGAAGC CGCCTGCAGA CCGAACCTCA CTGACCCAGG TGGAAATCGT TAGGTCATTT ACTGCTAAGC AGCCAGATGA ACTCTCCCTG CAGGTGGCTG ACGTCGTCCT CATCTATCAA CGTGTCAGCG ATGGCTGGTA TGAGGGGGAA CGACTACGAG ATGGAGAAAG AGGCTGGTTT CCTATGGAAT GTGCCAAGGA GATAACATGT CAAGCTACAA TTGATAAGAA TGTGGAGAGA ATGGGACGCT TGCTAGGACT GGAGACCAAC GTGTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq	NP_056410.3
---------------	------------
CDS	212..2827
Translation
Target ORF information: RefSeq Version NM_015595.3 Organism Homo sapiens(human) Definition Homo sapiens Rho guanine nucleotide exchange factor 26 (ARHGEF26), transcript variant 2, mRNA. Target ORF information: Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK	NM_015595.3
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------	-----------------------------------------------------------------

ORF Insert Sequence:

161121181241301361421481541601661721781841901961102110811141120112611321138114411501156116211681174118011861192119812041210121612221228123412401246125212581	ATGGACGGCG AGAGCGAGGT GGATTTTTCT AGCAACAGCA TAACCCCTTT GTGGCGGAGG CGGTCGATTC CTCAGCCCCA CCAGGTTCTG GGCCGGAGCA AGCCGAGGCC CCAGTCCTAC CAGAGCCCCA ACGGGTTACT AATTACGGAT TTCCCGGTGG AGGACGGAGG GACGCTCCTC GCAGCGCAGA TTCCCGCCCA GGTGCCCACC GCCTCGGACA GCAGGACGGT ACATAGGAGC CCCCTGCTTC TGGGCGCCCA GCGGAGAGCG GTGGCCAATG GTGGGACGGC ATCCCCGGAG TACAGGGCTG CCTCTCCTCG ACTTCGACGG CCCAAGTCAC CCAAGCTCCC CAAAGCGGTG CCTGGCGGCT CCCCGAAATC CCCAGCAAAT GGCGCGGTGA CCTTGCCTGC GCCGCCGCCG CCGCCGGTTC TGCGCCCCCC GCGGACTCCT AACGCGCCCG CCCCCTGCAC CCCCGAGGAG GACCTTACTG GGTTGACTGC CAGCCCGGTG CCTTCGCCCA CTGCAAATGG CCTTGCCGCT AATAACGACT CTCCTGGGTC AGGTTCGCAG TCCGGCCGGA AGGCAAAGGA CCCCGAACGG GGGCTCTTTC CTGGGCCCCA GAAAAGTTCT TCGGAACAAA AACTCCCCCT CCAAAGGCTG CCCTCCCAGG AGAACGAGCT CCTCGAGAAT CCTTCCGTGG TTTTGAGTAC AAACAGCCCC GCCGCCCTCA AAGTGGGGAA GCAGCAGATC ATTCCGAAGA GTCTGGCCTC GGAAATTAAA ATAAGTAAAT CCAACAATCA AAATGTGGAG CCCCACAAGA GACTCCTCAA GGTGCGCAGC ATGGTGGAGG GCCTAGGAGG ACCCCTGGGT CACGCAGGGG AGGAGAGTGA GGTCGATAAC GACGTGGATA GCCCAGGGTC TCTGCGGAGA GGCTTGCGGT CCACGTCTTA TCGCAGGGCA GTGGTCAGTG GCTTTGATTT TGACAGTCCT ACCAGCTCGA AGAAGAAGAA CAGAATGTCC CAGCCTGTTC TGAAAGTGGT GATGGAAGAC AAGGAGAAGT TTTCCAGTCT GGGAAGGATA AAGAAAAAAA TGCTGAAAGG ACAAGGAACA TTTGATGGGG AAGAAAATGC TGTCCTGTAT CAAAACTACA AGGAAAAGGC CCTTGACATT GATTCTGATG AAGAGTCAGA GCCCAAAGAA CAGAAGTCAG ATGAAAAAAT TGTGATTCAC CATAAGCCAT TGAGATCCAC ATGGAGCCAA CTCTCTGCGG TGAAAAGAAA GGGATTATCT CAGACAGTAA GCCAGGAGGA AAGAAAGAGA CAAGAGGCTA TCTTTGAAGT CATATCCTCT GAACATTCAT ATTTACTCAG CTTGGAGATC TTGATACGAA TGTTTAAAAA TTCTAAAGAA CTGAGTGATA CAATGACTAA AACCGAGAGG CACCATCTTT TCTCCAATAT TACAGATGTC TGTGAGGCAA GCAAAAAGTT CTTTATAGAG TTGGAAGCAA GACATCAGAA TAATATCTTC ATAGATGACA TAAGTGACAT TGTGGAAAAA CACACAGCAT CCACATTTGA CCCATATGTG AAATACTGCA CAAATGAAGT CTACCAACAA CGAACACTAC AAAAATTGTT AGCTACCAAT CCATCCTTTA AGGAAGTATT GTCAAGGATT GAGTCCCATG AAGACTGTAG GAACTTACCC ATGATCTCTT TTCTCATTCT CCCCATGCAG AGGGTGACCC GCCTTCCCCT GCTGATGGAT ACTATCTGTC AAAAAACACC TAAGGACTCT CCGAAGTATG AAGTCTGCAA AAGAGCCTTG AAGGAAGTTA GCAAGTTGGT TCGACTATGC AATGAGGGCG CCCGGAAGAT GGAAAGGACT GAGATGATGT ACACAATTAA CTCCCAGCTG GAATTTAAAA TTAAGCCTTT TCCTTTAGTC TCCTCTTCCC GGTGGTTGGT AAAAAGAGGT GAATTGACAG CCTATGTTGA AGACACTGTG CTTTTCTCAA GAAGGACATC CAAACAGCAA GTCTACTTCT TTCTCTTTAA CGATGTGCTC ATTATCACCA AGAAGAAGAG TGAAGAAAGT TACAACGTCA ATGATTATTC CTTAAGAGAT CAGCTATTGG TGGAATCTTG TGACAATGAA GAGCTTAATT CTTCTCCAGG GAAGAACAGC TCCACAATGC TCTATTCAAG ACAGAGCTCT GCCAGTCACC TCTTTACTCT GACAGTCCTT AGTAACCACG CGAATGAGAA AGTGGAGATG CTACTAGGAG CTGAGACGCA GAGCGAGCGA GCCCGCTGGA TAACTGCCCT GGGACACAGC AGCGGGAAGC CGCCTGCAGA CCGAACCTCA CTGACCCAGG TGGAAATCGT TAGGTCATTT ACTGCTAAGC AGCCAGATGA ACTCTCCCTG CAGGTGGCTG ACGTCGTCCT CATCTATCAA CGTGTCAGCG ATGGCTGGTA TGAGGGGGAA CGACTACGAG ATGGAGAAAG AGGCTGGTTT CCTATGGAAT GTGCCAAGGA GATAACATGT CAAGCTACAA TTGATAAGAA TGTGGAGAGA ATGGGACGCT TGCTAGGACT GGAGACCAAC GTGTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq	NP_001238891.1
---------------	---------------
CDS	285..2900
Translation
Target ORF information: RefSeq Version NM_001251962.1 Organism Homo sapiens(human) Definition Homo sapiens Rho guanine nucleotide exchange factor 26 (ARHGEF26), transcript variant 1, mRNA. Target ORF information: Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK	NM_001251962.1
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------	--------------------------------------------------------------------

ORF Insert Sequence:

161121181241301361421481541601661721781841901961102110811141120112611321138114411501156116211681174118011861192119812041210121612221228123412401246125212581	ATGGACGGCG AGAGCGAGGT GGATTTTTCT AGCAACAGCA TAACCCCTTT GTGGCGGAGG CGGTCGATTC CTCAGCCCCA CCAGGTTCTG GGCCGGAGCA AGCCGAGGCC CCAGTCCTAC CAGAGCCCCA ACGGGTTACT AATTACGGAT TTCCCGGTGG AGGACGGAGG GACGCTCCTC GCAGCGCAGA TTCCCGCCCA GGTGCCCACC GCCTCGGACA GCAGGACGGT ACATAGGAGC CCCCTGCTTC TGGGCGCCCA GCGGAGAGCG GTGGCCAATG GTGGGACGGC ATCCCCGGAG TACAGGGCTG CCTCTCCTCG ACTTCGACGG CCCAAGTCAC CCAAGCTCCC CAAAGCGGTG CCTGGCGGCT CCCCGAAATC CCCAGCAAAT GGCGCGGTGA CCTTGCCTGC GCCGCCGCCG CCGCCGGTTC TGCGCCCCCC GCGGACTCCT AACGCGCCCG CCCCCTGCAC CCCCGAGGAG GACCTTACTG GGTTGACTGC CAGCCCGGTG CCTTCGCCCA CTGCAAATGG CCTTGCCGCT AATAACGACT CTCCTGGGTC AGGTTCGCAG TCCGGCCGGA AGGCAAAGGA CCCCGAACGG GGGCTCTTTC CTGGGCCCCA GAAAAGTTCT TCGGAACAAA AACTCCCCCT CCAAAGGCTG CCCTCCCAGG AGAACGAGCT CCTCGAGAAT CCTTCCGTGG TTTTGAGTAC AAACAGCCCC GCCGCCCTCA AAGTGGGGAA GCAGCAGATC ATTCCGAAGA GTCTGGCCTC GGAAATTAAA ATAAGTAAAT CCAACAATCA AAATGTGGAG CCCCACAAGA GACTCCTCAA GGTGCGCAGC ATGGTGGAGG GCCTAGGAGG ACCCCTGGGT CACGCAGGGG AGGAGAGTGA GGTCGATAAC GACGTGGATA GCCCAGGGTC TCTGCGGAGA GGCTTGCGGT CCACGTCTTA TCGCAGGGCA GTGGTCAGTG GCTTTGATTT TGACAGTCCT ACCAGCTCGA AGAAGAAGAA CAGAATGTCC CAGCCTGTTC TGAAAGTGGT GATGGAAGAC AAGGAGAAGT TTTCCAGTCT GGGAAGGATA AAGAAAAAAA TGCTGAAAGG ACAAGGAACA TTTGATGGGG AAGAAAATGC TGTCCTGTAT CAAAACTACA AGGAAAAGGC CCTTGACATT GATTCTGATG AAGAGTCAGA GCCCAAAGAA CAGAAGTCAG ATGAAAAAAT TGTGATTCAC CATAAGCCAT TGAGATCCAC ATGGAGCCAA CTCTCTGCGG TGAAAAGAAA GGGATTATCT CAGACAGTAA GCCAGGAGGA AAGAAAGAGA CAAGAGGCTA TCTTTGAAGT CATATCCTCT GAACATTCAT ATTTACTCAG CTTGGAGATC TTGATACGAA TGTTTAAAAA TTCTAAAGAA CTGAGTGATA CAATGACTAA AACCGAGAGG CACCATCTTT TCTCCAATAT TACAGATGTC TGTGAGGCAA GCAAAAAGTT CTTTATAGAG TTGGAAGCAA GACATCAGAA TAATATCTTC ATAGATGACA TAAGTGACAT TGTGGAAAAA CACACAGCAT CCACATTTGA CCCATATGTG AAATACTGCA CAAATGAAGT CTACCAACAA CGAACACTAC AAAAATTGTT AGCTACCAAT CCATCCTTTA AGGAAGTATT GTCAAGGATT GAGTCCCATG AAGACTGTAG GAACTTACCC ATGATCTCTT TTCTCATTCT CCCCATGCAG AGGGTGACCC GCCTTCCCCT GCTGATGGAT ACTATCTGTC AAAAAACACC TAAGGACTCT CCGAAGTATG AAGTCTGCAA AAGAGCCTTG AAGGAAGTTA GCAAGTTGGT TCGACTATGC AATGAGGGCG CCCGGAAGAT GGAAAGGACT GAGATGATGT ACACAATTAA CTCCCAGCTG GAATTTAAAA TTAAGCCTTT TCCTTTAGTC TCCTCTTCCC GGTGGTTGGT AAAAAGAGGT GAATTGACAG CCTATGTTGA AGACACTGTG CTTTTCTCAA GAAGGACATC CAAACAGCAA GTCTACTTCT TTCTCTTTAA CGATGTGCTC ATTATCACCA AGAAGAAGAG TGAAGAAAGT TACAACGTCA ATGATTATTC CTTAAGAGAT CAGCTATTGG TGGAATCTTG TGACAATGAA GAGCTTAATT CTTCTCCAGG GAAGAACAGC TCCACAATGC TCTATTCAAG ACAGAGCTCT GCCAGTCACC TCTTTACTCT GACAGTCCTT AGTAACCACG CGAATGAGAA AGTGGAGATG CTACTAGGAG CTGAGACGCA GAGCGAGCGA GCCCGCTGGA TAACTGCCCT GGGACACAGC AGCGGGAAGC CGCCTGCAGA CCGAACCTCA CTGACCCAGG TGGAAATCGT TAGGTCATTT ACTGCTAAGC AGCCAGATGA ACTCTCCCTG CAGGTGGCTG ACGTCGTCCT CATCTATCAA CGTGTCAGCG ATGGCTGGTA TGAGGGGGAA CGACTACGAG ATGGAGAAAG AGGCTGGTTT CCTATGGAAT GTGCCAAGGA GATAACATGT CAAGCTACAA TTGATAAGAA TGTGGAGAGA ATGGGACGCT TGCTAGGACT GGAGACCAAC GTGTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq	NP_056410.3
---------------	------------
CDS	182..2797
Translation
Target ORF information: RefSeq Version NM_015595.4 Organism Homo sapiens(human) Definition Homo sapiens Rho guanine nucleotide exchange factor 26 (ARHGEF26), transcript variant 2, mRNA. Target ORF information: Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK	NM_015595.4
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------	-----------------------------------------------------------------

ORF Insert Sequence:

16112118124130136142148154160166172178184190196110211081114112011261132113811441150115611621168117411801186119211981204121012161222122812341	ATGGACGGCG AGAGCGAGGT GGATTTTTCT AGCAACAGCA TAACCCCTTT GTGGCGGAGG CGGTCGATTC CTCAGCCCCA CCAGGTTCTG GGCCGGAGCA AGCCGAGGCC CCAGTCCTAC CAGAGCCCCA ACGGGTTACT AATTACGGAT TTCCCGGTGG AGGACGGAGG GACGCTCCTC GCAGCGCAGA TTCCCGCCCA GGTGCCCACC GCCTCGGACA GCAGGACGGT ACATAGGAGC CCCCTGCTTC TGGGCGCCCA GCGGAGAGCG GTGGCCAATG GTGGGACGGC ATCCCCGGAG TACAGGGCTG CCTCTCCTCG ACTTCGACGG CCCAAGTCAC CCAAGCTCCC CAAAGCGGTG CCTGGCGGCT CCCCGAAATC CCCAGCAAAT GGCGCGGTGA CCTTGCCTGC GCCGCCGCCG CCGCCGGTTC TGCGCCCCCC GCGGACTCCT AACGCGCCCG CCCCCTGCAC CCCCGAGGAG GACCTTACTG GGTTGACTGC CAGCCCGGTG CCTTCGCCCA CTGCAAATGG CCTTGCCGCT AATAACGACT CTCCTGGGTC AGGTTCGCAG TCCGGCCGGA AGGCAAAGGA CCCCGAACGG GGGCTCTTTC CTGGGCCCCA GAAAAGTTCT TCGGAACAAA AACTCCCCCT CCAAAGGCTG CCCTCCCAGG AGAACGAGCT CCTCGAGAAT CCTTCCGTGG TTTTGAGTAC AAACAGCCCC GCCGCCCTCA AAGTGGGGAA GCAGCAGATC ATTCCGAAGA GTCTGGCCTC GGAAATTAAA ATAAGTAAAT CCAACAATCA AAATGTGGAG CCCCACAAGA GACTCCTCAA GGTGCGCAGC ATGGTGGAGG GCCTAGGAGG ACCCCTGGGT CACGCAGGGG AGGAGAGTGA GGTCGATAAC GACGTGGATA GCCCAGGGTC TCTGCGGAGA GGCTTGCGGT CCACGTCTTA TCGCAGGGCA GTGGTCAGTG GCTTTGATTT TGACAGTCCT ACCAGCTCGA AGAAGAAGAA CAGAATGTCC CAGCCTGTTC TGAAAGTGGT GATGGAAGAC AAGGAGAAGT TTTCCAGTCT GGGAAGGATA AAGAAAAAAA TGCTGAAAGG ACAAGGAACA TTTGATGGGG AAGAAAATGC TGTCCTGTAT CAAAACTACA AGGAAAAGGC CCTTGACATT GATTCTGATG AAGAGTCAGA GCCCAAAGAA CAGAAGTCAG ATGAAAAAAT TGTGATTCAC CATAAGCCAT TGAGATCCAC ATGGAGCCAA CTCTCTGCGG TGAAAAGAAA GGGATTATCT CAGACAGTAA GCCAGGAGGA AAGAAAGAGA CAAGAGGCTA TCTTTGAAGT CATATCCTCT GAACATTCAT ATTTACTCAG CTTGGAGATC TTGATACGAA TGTTTAAAAA TTCTAAAGAA CTGAGTGATA CAATGACTAA AACCGAGAGG CACCATCTTT TCTCCAATAT TACAGATGTC TGTGAGGCAA GCAAAAAGTT CTTTATAGAG TTGGAAGCAA GACATCAGAA TAATATCTTC ATAGATGACA TAAGTGACAT TGTGGAAAAA CACACAGCAT CCACATTTGA CCCATATGTG AAATACTGCA CAAATGAAGT CTACCAACAA CGAACACTAC AAAAATTGTT AGCTACCAAT CCATCCTTTA AGGAAGTATT GTCAAGGATT GAGTCCCATG AAGACTGTAG GAACTTACCC ATGATCTCTT TTCTCATTCT CCCCATGCAG AGGGTGACCC GCCTTCCCCT GCTGATGGAT ACTATCTGTC AAAAAACACC TAAGGACTCT CCGAAGTATG AAGTCTGCAA AAGAGCCTTG AAGGAAGTTA GCAAGTTGGT TCGACTATGC AATGAGGGCG CCCGGAAGAT GGAAAGGACT GAGATGATGT ACACAATTAA CTCCCAGCTG GAATTTAAAA TTAAGCCTTT TCCTTTAGTC TCCTCTTCCC GGTGGTTGGT AAAAAGAGGT GAATTGACAG CCTATGTTGA AGACACTGTG CTTTTCTCAA GAAGGACATC CAAACAGCAA GTCTACTTCT TTCTCTTTAA CGATGTGCTC ATTATCACCA AGAAGAAGAG TGAAGAAAGT TACAACGTCA ATGATTATTC CTTAAGAGAT CAGCTATTGG TGGAATCTTG TGACAATGAA GAGCTTAATT CTTCTCCAGG GAAGAACAGC TCCACAATGC TCTATTCAAG ACAGAGCTCT GCCAGTCACC TCTTTACTCT GACAGTCCTT AGTAACCACG CGAATGAGAA AGTGGAGATG CTACTAGGAG CTGAGACGCA GAGCGAGCGA GCCCGCTGGA TAACTGCCCT GGGACACAGC AGCGGGAAGC CGCCTGCAGA CCGAACCTGT GGCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq	NP_001238892.1
---------------	---------------
CDS	182..2557
Translation
Target ORF information: RefSeq Version NM_001251963.2 Organism Homo sapiens(human) Definition Homo sapiens Rho guanine nucleotide exchange factor 26 (ARHGEF26), transcript variant 3, mRNA. Target ORF information: Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK	NM_001251963.2
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------	--------------------------------------------------------------------

ORF Insert Sequence:

16112118124130136142148154160166172178184190196110211081114112011261132113811441150115611621168117411801186119211981204121012161222122812341	ATGGACGGCG AGAGCGAGGT GGATTTTTCT AGCAACAGCA TAACCCCTTT GTGGCGGAGG CGGTCGATTC CTCAGCCCCA CCAGGTTCTG GGCCGGAGCA AGCCGAGGCC CCAGTCCTAC CAGAGCCCCA ACGGGTTACT AATTACGGAT TTCCCGGTGG AGGACGGAGG GACGCTCCTC GCAGCGCAGA TTCCCGCCCA GGTGCCCACC GCCTCGGACA GCAGGACGGT ACATAGGAGC CCCCTGCTTC TGGGCGCCCA GCGGAGAGCG GTGGCCAATG GTGGGACGGC ATCCCCGGAG TACAGGGCTG CCTCTCCTCG ACTTCGACGG CCCAAGTCAC CCAAGCTCCC CAAAGCGGTG CCTGGCGGCT CCCCGAAATC CCCAGCAAAT GGCGCGGTGA CCTTGCCTGC GCCGCCGCCG CCGCCGGTTC TGCGCCCCCC GCGGACTCCT AACGCGCCCG CCCCCTGCAC CCCCGAGGAG GACCTTACTG GGTTGACTGC CAGCCCGGTG CCTTCGCCCA CTGCAAATGG CCTTGCCGCT AATAACGACT CTCCTGGGTC AGGTTCGCAG TCCGGCCGGA AGGCAAAGGA CCCCGAACGG GGGCTCTTTC CTGGGCCCCA GAAAAGTTCT TCGGAACAAA AACTCCCCCT CCAAAGGCTG CCCTCCCAGG AGAACGAGCT CCTCGAGAAT CCTTCCGTGG TTTTGAGTAC AAACAGCCCC GCCGCCCTCA AAGTGGGGAA GCAGCAGATC ATTCCGAAGA GTCTGGCCTC GGAAATTAAA ATAAGTAAAT CCAACAATCA AAATGTGGAG CCCCACAAGA GACTCCTCAA GGTGCGCAGC ATGGTGGAGG GCCTAGGAGG ACCCCTGGGT CACGCAGGGG AGGAGAGTGA GGTCGATAAC GACGTGGATA GCCCAGGGTC TCTGCGGAGA GGCTTGCGGT CCACGTCTTA TCGCAGGGCA GTGGTCAGTG GCTTTGATTT TGACAGTCCT ACCAGCTCGA AGAAGAAGAA CAGAATGTCC CAGCCTGTTC TGAAAGTGGT GATGGAAGAC AAGGAGAAGT TTTCCAGTCT GGGAAGGATA AAGAAAAAAA TGCTGAAAGG ACAAGGAACA TTTGATGGGG AAGAAAATGC TGTCCTGTAT CAAAACTACA AGGAAAAGGC CCTTGACATT GATTCTGATG AAGAGTCAGA GCCCAAAGAA CAGAAGTCAG ATGAAAAAAT TGTGATTCAC CATAAGCCAT TGAGATCCAC ATGGAGCCAA CTCTCTGCGG TGAAAAGAAA GGGATTATCT CAGACAGTAA GCCAGGAGGA AAGAAAGAGA CAAGAGGCTA TCTTTGAAGT CATATCCTCT GAACATTCAT ATTTACTCAG CTTGGAGATC TTGATACGAA TGTTTAAAAA TTCTAAAGAA CTGAGTGATA CAATGACTAA AACCGAGAGG CACCATCTTT TCTCCAATAT TACAGATGTC TGTGAGGCAA GCAAAAAGTT CTTTATAGAG TTGGAAGCAA GACATCAGAA TAATATCTTC ATAGATGACA TAAGTGACAT TGTGGAAAAA CACACAGCAT CCACATTTGA CCCATATGTG AAATACTGCA CAAATGAAGT CTACCAACAA CGAACACTAC AAAAATTGTT AGCTACCAAT CCATCCTTTA AGGAAGTATT GTCAAGGATT GAGTCCCATG AAGACTGTAG GAACTTACCC ATGATCTCTT TTCTCATTCT CCCCATGCAG AGGGTGACCC GCCTTCCCCT GCTGATGGAT ACTATCTGTC AAAAAACACC TAAGGACTCT CCGAAGTATG AAGTCTGCAA AAGAGCCTTG AAGGAAGTTA GCAAGTTGGT TCGACTATGC AATGAGGGCG CCCGGAAGAT GGAAAGGACT GAGATGATGT ACACAATTAA CTCCCAGCTG GAATTTAAAA TTAAGCCTTT TCCTTTAGTC TCCTCTTCCC GGTGGTTGGT AAAAAGAGGT GAATTGACAG CCTATGTTGA AGACACTGTG CTTTTCTCAA GAAGGACATC CAAACAGCAA GTCTACTTCT TTCTCTTTAA CGATGTGCTC ATTATCACCA AGAAGAAGAG TGAAGAAAGT TACAACGTCA ATGATTATTC CTTAAGAGAT CAGCTATTGG TGGAATCTTG TGACAATGAA GAGCTTAATT CTTCTCCAGG GAAGAACAGC TCCACAATGC TCTATTCAAG ACAGAGCTCT GCCAGTCACC TCTTTACTCT GACAGTCCTT AGTAACCACG CGAATGAGAA AGTGGAGATG CTACTAGGAG CTGAGACGCA GAGCGAGCGA GCCCGCTGGA TAACTGCCCT GGGACACAGC AGCGGGAAGC CGCCTGCAGA CCGAACCTGT GGCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq	NP_001238892.1
---------------	---------------
CDS	212..2587
Translation
Target ORF information: RefSeq Version NM_001251963.1 Organism Homo sapiens(human) Definition Homo sapiens Rho guanine nucleotide exchange factor 26 (ARHGEF26), transcript variant 3, mRNA. Target ORF information: Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK	NM_001251963.1
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------	--------------------------------------------------------------------

ORF Insert Sequence:

16112118124130136142148154160166172178184190196110211081114112011261132113811441150115611621168117411801186119211981204121012161222122812341240124612521	ATGGACGGCG AGAGCGAGGT GGATTTTTCT AGCAACAGCA TAACCCCTTT GTGGCGGAGG CGGTCGATTC CTCAGCCCCA CCAGGTTCTG GGCCGGAGCA AGCCGAGGCC CCAGTCCTAC CAGAGCCCCA ACGGGTTACT AATTACGGAT TTCCCGGTGG AGGACGGAGG GACGCTCCTC GCAGCGCAGA TTCCCGCCCA GGTGCCCACC GCCTCGGACA GCAGGACGGT ACATAGGAGC CCCCTGCTTC TGGGCGCCCA GCGGAGAGCG GTGGCCAATG GTGGGACGGC ATCCCCGGAG TACAGGGCTG CCTCTCCTCG ACTTCGACGG CCCAAGTCAC CCAAGCTCCC CAAAGCGGTG CCTGGCGGCT CCCCGAAATC CCCAGCAAAT GGCGCGGTGA CCTTGCCTGC GCCGCCGCCG CCGCCGGTTC TGCGCCCCCC GCGGACTCCT AACGCGCCCG CCCCCTGCAC CCCCGAGGAG GACCTTACTG GGTTGACTGC CAGCCCGGTG CCTTCGCCCA CTGCAAATGG CCTTGCCGCT AATAACGACT CTCCTGGGTC AGGTTCGCAG TCCGGCCGGA AGGCAAAGGA CCCCGAACGG GGGCTCTTTC CTGGGCCCCA GAAAAGTTCT TCGGAACAAA AACTCCCCCT CCAAAGGCTG CCCTCCCAGG AGAACGAGCT CCTCGAGAAT CCTTCCGTGG TTTTGAGTAC AAACAGCCCC GCCGCCCTCA AAGTGGGGAA GCAGCAGATC ATTCCGAAGA GTCTGGCCTC GGAAATTAAA ATAAGTAAAT CCAACAATCA AAATGTGGAG CCCCACAAGA GACTCCTCAA GGTGCGCAGC ATGGTGGAGG GCCTAGGAGG ACCCCTGGGT CACGCAGGGG AGGAGAGTGA GGTCGATAAC GACGTGGATA GCCCAGGGTC TCTGCGGAGA GGCTTGCGGT CCACGTCTTA TCGCAGGGCA GTGGTCAGTG GCTTTGATTT TGACAGTCCT ACCAGCTCGA AGAAGAAGAA CAGAATGTCC CAGCCTGTTC TGAAAGTGGT GATGGAAGAC AAGGAGAAGT TTTCCAGTCT GGGAAGGATA AAGAAAAAAA TGCTGAAAGG ACAAGGAACA TTTGATGGGG AAGAAAATGC TGTCCTGTAT CAAAACTACA AGGAAAAGGC CCTTGACATT GATTCTGATG AAGAGTCAGA GCCCAAAGAA CAGAAGTCAG ATGAAAAAAT TGTGATTCAC CATAAGCCAT TGAGATCCAC ATGGAGCCAA CTCTCTGCGG TGAAAAGAAA GGGATTATCT CAGACAGTAA GCCAGGAGGA AAGAAAGAGA CAAGAGGCTA TCTTTGAAGT CATATCCTCT GAACATTCAT ATTTACTCAG CTTGGAGATC TTGATACGAA TGTTTAAAAA TTCTAAAGAA CTGAGTGATA CAATGACTAA AACCGAGAGG CACCATCTTT TCTCCAATAT TACAGATGTC TGTGAGGCAA GCAAAAAGTT CTTTATAGAG TTGGAAGCAA GACATCAGAA TAATATCTTC ATAGATGACA TAAGTGACAT TGTGGAAAAA CACACAGCAT CCACATTTGA CCCATATGTG AAATACTGCA CAAATGAAGT CTACCAACAA CGAACACTAC AAAAATTGTT AGCTACCAAT CCATCCTTTA AGGAAGTATT GTCAAGGATT GAGTCCCATG AAGACTGTAG GAACTTACCC ATGATCTCTT TTCTCATTCT CCCCATGCAG AGGGTGACCC GCCTTCCCCT GCTGATGGAT ACTATCTGTC AAAAAACACC TAAGGACTCT CCGAAGTATG AAGTCTGCAA AAGAGCCTTG AAGGAAGTTA GCAAGCCTTT TCCTTTAGTC TCCTCTTCCC GGTGGTTGGT AAAAAGAGGT GAATTGACAG CCTATGTTGA AGACACTGTG CTTTTCTCAA GAAGGACATC CAAACAGCAA GTCTACTTCT TTCTCTTTAA CGATGTGCTC ATTATCACCA AGAAGAAGAG TGAAGAAAGT TACAACGTCA ATGATTATTC CTTAAGAGAT CAGCTATTGG TGGAATCTTG TGACAATGAA GAGCTTAATT CTTCTCCAGG GAAGAACAGC TCCACAATGC TCTATTCAAG ACAGAGCTCT GCCAGTCACC TCTTTACTCT GACAGTCCTT AGTAACCACG CGAATGAGAA AGTGGAGATG CTACTAGGAG CTGAGACGCA GAGCGAGCGA GCCCGCTGGA TAACTGCCCT GGGACACAGC AGCGGGAAGC CGCCTGCAGA CCGAACCTCA CTGACCCAGG TGGAAATCGT TAGGTCATTT ACTGCTAAGC AGCCAGATGA ACTCTCCCTG CAGGTGGCTG ACGTCGTCCT CATCTATCAA CGTGTCAGCG ATGGCTGGTA TGAGGGGGAA CGACTACGAG ATGGAGAAAG AGGCTGGTTT CCTATGGAAT GTGCCAAGGA GATAACATGT CAAGCTACAA TTGATAAGAA TGTGGAGAGA ATGGGACGCT TGCTAGGACT GGAGACCAAC GTGTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq	XP_011510974.1
---------------	---------------
CDS	212..2737
Translation
Target ORF information: RefSeq Version XM_011512672.1 Organism Homo sapiens(human) Definition Homo sapiens Rho guanine nucleotide exchange factor 26 (ARHGEF26), transcript variant X1, mRNA. Target ORF information: Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK	XM_011512672.1
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------	--------------------------------------------------------------------

ORF Insert Sequence:

• PubMed

  Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease. Nature genetics49(9)1392-1397(2017 Sep) Klarin D,Zhu QM,Emdin CA,Chaffin M,Horner S,McMillan BJ,Leed A,Weale ME,Spencer CCA,Aguet F,Segr? AV,Ardlie KG,Khera AV,Kaushik VK,Natarajan P,,Kathiresan S

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