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Inflammasome protein scaffolds the DNA damage complex during tumor development
Shen et al. identify a noncanonical role for the inflammasome protein NLR family CARD domain-containing protein 4 (NLRC4) to attenuate tumor development. NLRC4 forms a scaffold to assemble the ataxia telangiectasia and Rad3-related DNA repair complex and the repair kinase checkpoint kinase-1 to promote repair of DNA breaks.
Article14 Oct 2024
- Review Article08 Oct 2024
- Review Article04 Oct 2024
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- ArticleOpen Access18 Oct 2024
Inflammasome protein scaffolds the DNA damage complex during tumor development
Shen et al. identify a noncanonical role for the inflammasome protein NLR family CARD domain-containing protein 4 (NLRC4) to attenuate tumor development. NLRC4 forms a scaffold to assemble the ataxia telangiectasia and Rad3-related DNA repair complex and the repair kinase checkpoint kinase-1 to promote repair of DNA breaks.
- Cheng Shen
- Abhimanu Pandey
- Si Ming Man
Article14 Oct 2024 
Matters Arising08 Oct 2024
Matters Arising08 Oct 2024
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