Interleukin-6 and the acute phase response (original) (raw)

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  1. Aarden L. A., De Groot E. R., Schaap O. L., Lansdorp P. M. Production of hybridoma growth factor by human monocytes. Eur J Immunol. 1987 Oct;17(10):1411–1416. doi: 10.1002/eji.1830171004. [DOI] [PubMed] [Google Scholar]
  2. Amrani D. L., Mauzy-Melitz D., Mosesson M. W. Effect of hepatocyte-stimulating factor and glucocorticoids on plasma fibronectin levels. Biochem J. 1986 Sep 1;238(2):365–371. doi: 10.1042/bj2380365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Andersson U., Matsuda T. Human interleukin 6 and tumor necrosis factor alpha production studied at a single-cell level. Eur J Immunol. 1989 Jun;19(6):1157–1160. doi: 10.1002/eji.1830190629. [DOI] [PubMed] [Google Scholar]
  4. Andus T., Geiger T., Hirano T., Kishimoto T., Heinrich P. C. Action of recombinant human interleukin 6, interleukin 1 beta and tumor necrosis factor alpha on the mRNA induction of acute-phase proteins. Eur J Immunol. 1988 May;18(5):739–746. doi: 10.1002/eji.1830180513. [DOI] [PubMed] [Google Scholar]
  5. Andus T., Geiger T., Hirano T., Kishimoto T., Tran-Thi T. A., Decker K., Heinrich P. C. Regulation of synthesis and secretion of major rat acute-phase proteins by recombinant human interleukin-6 (BSF-2/IL-6) in hepatocyte primary cultures. Eur J Biochem. 1988 Apr 15;173(2):287–293. doi: 10.1111/j.1432-1033.1988.tb13997.x. [DOI] [PubMed] [Google Scholar]
  6. Andus T., Geiger T., Hirano T., Northoff H., Ganter U., Bauer J., Kishimoto T., Heinrich P. C. Recombinant human B cell stimulatory factor 2 (BSF-2/IFN-beta 2) regulates beta-fibrinogen and albumin mRNA levels in Fao-9 cells. FEBS Lett. 1987 Aug 31;221(1):18–22. doi: 10.1016/0014-5793(87)80344-7. [DOI] [PubMed] [Google Scholar]
  7. Arcone R., Gualandi G., Ciliberto G. Identification of sequences responsible for acute-phase induction of human C-reactive protein. Nucleic Acids Res. 1988 Apr 25;16(8):3195–3207. doi: 10.1093/nar/16.8.3195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bauer J., Birmelin M., Northoff G. H., Northemann W., Tran-Thi T. A., Ueberberg H., Decker K., Heinrich P. C. Induction of rat alpha 2-macroglobulin in vivo and in hepatocyte primary cultures: synergistic action of glucocorticoids and a Kupffer cell-derived factor. FEBS Lett. 1984 Nov 5;177(1):89–94. doi: 10.1016/0014-5793(84)80987-4. [DOI] [PubMed] [Google Scholar]
  9. Bauer J., Ganter U., Geiger T., Jacobshagen U., Hirano T., Matsuda T., Kishimoto T., Andus T., Acs G., Gerok W. Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages. Blood. 1988 Oct;72(4):1134–1140. [PubMed] [Google Scholar]
  10. Bauer J., Lengyel G., Bauer T. M., Acs G., Gerok W. Regulation of interleukin-6 receptor expression in human monocytes and hepatocytes. FEBS Lett. 1989 May 22;249(1):27–30. doi: 10.1016/0014-5793(89)80008-0. [DOI] [PubMed] [Google Scholar]
  11. Bauer J., Tran-Thi T. A., Northoff H., Hirsch F., Schlayer H. J., Gerok W., Heinrich P. C. The acute-phase induction of alpha 2-macroglobulin in rat hepatocyte primary cultures: action of a hepatocyte-stimulating factor, triiodothyronine and dexamethasone. Eur J Cell Biol. 1986 Mar;40(1):86–93. [PubMed] [Google Scholar]
  12. Baumann H., Isseroff H., Latimer J. J., Jahreis G. P. Phorbol ester modulates interleukin 6- and interleukin 1-regulated expression of acute phase plasma proteins in hepatoma cells. J Biol Chem. 1988 Nov 25;263(33):17390–17396. [PMC free article] [PubMed] [Google Scholar]
  13. Baumann H., Jahreis G. P., Sauder D. N., Koj A. Human keratinocytes and monocytes release factors which regulate the synthesis of major acute phase plasma proteins in hepatic cells from man, rat, and mouse. J Biol Chem. 1984 Jun 10;259(11):7331–7342. [PubMed] [Google Scholar]
  14. Baumann H., Muller-Eberhard U. Synthesis of hemopexin and cysteine protease inhibitor is coordinately regulated by HSF-II and interferon-beta 2 in rat hepatoma cells. Biochem Biophys Res Commun. 1987 Aug 14;146(3):1218–1228. doi: 10.1016/0006-291x(87)90778-9. [DOI] [PubMed] [Google Scholar]
  15. Baumann H., Onorato V., Gauldie J., Jahreis G. P. Distinct sets of acute phase plasma proteins are stimulated by separate human hepatocyte-stimulating factors and monokines in rat hepatoma cells. J Biol Chem. 1987 Jul 15;262(20):9756–9768. [PubMed] [Google Scholar]
  16. Baumann H., Richards C., Gauldie J. Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells. J Immunol. 1987 Dec 15;139(12):4122–4128. [PubMed] [Google Scholar]
  17. Baumann H., Won K. A., Jahreis G. P. Human hepatocyte-stimulating factor-III and interleukin-6 are structurally and immunologically distinct but regulate the production of the same acute phase plasma proteins. J Biol Chem. 1989 May 15;264(14):8046–8051. [PubMed] [Google Scholar]
  18. Baumann H., Wong G. G. Hepatocyte-stimulating factor III shares structural and functional identity with leukemia-inhibitory factor. J Immunol. 1989 Aug 15;143(4):1163–1167. [PubMed] [Google Scholar]
  19. Bergui L., Schena M., Gaidano G., Riva M., Caligaris-Cappio F. Interleukin 3 and interleukin 6 synergistically promote the proliferation and differentiation of malignant plasma cell precursors in multiple myeloma. J Exp Med. 1989 Aug 1;170(2):613–618. doi: 10.1084/jem.170.2.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Billiau A. BSF-2 is not just a differentiation factor. Nature. 1986 Dec 4;324(6096):415–415. doi: 10.1038/324415a0. [DOI] [PubMed] [Google Scholar]
  21. Biondi A., Rossi V., Bassan R., Barbui T., Bettoni S., Sironi M., Mantovani A., Rambaldi A. Constitutive expression of the interleukin-6 gene in chronic lymphocytic leukemia. Blood. 1989 Apr;73(5):1279–1284. [PubMed] [Google Scholar]
  22. Bot F. J., van Eijk L., Broeders L., Aarden L. A., Löwenberg B. Interleukin-6 synergizes with M-CSF in the formation of macrophage colonies from purified human marrow progenitor cells. Blood. 1989 Feb;73(2):435–437. [PubMed] [Google Scholar]
  23. Brakenhoff J. P., de Groot E. R., Evers R. F., Pannekoek H., Aarden L. A. Molecular cloning and expression of hybridoma growth factor in Escherichia coli. J Immunol. 1987 Dec 15;139(12):4116–4121. [PubMed] [Google Scholar]
  24. Brouckaert P., Spriggs D. R., Demetri G., Kufe D. W., Fiers W. Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon gamma. J Exp Med. 1989 Jun 1;169(6):2257–2262. doi: 10.1084/jem.169.6.2257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Caracciolo D., Clark S. C., Rovera G. Human interleukin-6 supports granulocytic differentiation of hematopoietic progenitor cells and acts synergistically with GM-CSF. Blood. 1989 Feb 15;73(3):666–670. [PubMed] [Google Scholar]
  26. Castell J. V., Geiger T., Gross V., Andus T., Walter E., Hirano T., Kishimoto T., Heinrich P. C. Plasma clearance, organ distribution and target cells of interleukin-6/hepatocyte-stimulating factor in the rat. Eur J Biochem. 1988 Nov 1;177(2):357–361. doi: 10.1111/j.1432-1033.1988.tb14384.x. [DOI] [PubMed] [Google Scholar]
  27. Castell J. V., Gómez-Lechón M. J., David M., Andus T., Geiger T., Trullenque R., Fabra R., Heinrich P. C. Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS Lett. 1989 Jan 2;242(2):237–239. doi: 10.1016/0014-5793(89)80476-4. [DOI] [PubMed] [Google Scholar]
  28. Castell J. V., Gómez-Lechón M. J., David M., Hirano T., Kishimoto T., Heinrich P. C. Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes. FEBS Lett. 1988 May 23;232(2):347–350. doi: 10.1016/0014-5793(88)80766-x. [DOI] [PubMed] [Google Scholar]
  29. Ceuppens J. L., Baroja M. L., Lorre K., Van Damme J., Billiau A. Human T cell activation with phytohemagglutinin. The function of IL-6 as an accessory signal. J Immunol. 1988 Dec 1;141(11):3868–3874. [PubMed] [Google Scholar]
  30. Chen L., Mory Y., Zilberstein A., Revel M. Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-beta 2. Proc Natl Acad Sci U S A. 1988 Nov;85(21):8037–8041. doi: 10.1073/pnas.85.21.8037. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Chen L., Novick D., Rubinstein M., Revel M. Recombinant interferon-beta 2 (interleukin-6) induces myeloid differentiation. FEBS Lett. 1988 Nov 7;239(2):299–304. doi: 10.1016/0014-5793(88)80939-6. [DOI] [PubMed] [Google Scholar]
  32. Chiu C. P., Lee F. IL-6 is a differentiation factor for M1 and WEHI-3B myeloid leukemic cells. J Immunol. 1989 Mar 15;142(6):1909–1915. [PubMed] [Google Scholar]
  33. Chiu C. P., Moulds C., Coffman R. L., Rennick D., Lee F. Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7099–7103. doi: 10.1073/pnas.85.19.7099. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Ciliberto G., Dente L., Cortese R. Cell-specific expression of a transfected human alpha 1-antitrypsin gene. Cell. 1985 Jun;41(2):531–540. doi: 10.1016/s0092-8674(85)80026-x. [DOI] [PubMed] [Google Scholar]
  35. Content J., De Wit L., Pierard D., Derynck R., De Clercq E., Fiers W. Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta. Proc Natl Acad Sci U S A. 1982 May;79(9):2768–2772. doi: 10.1073/pnas.79.9.2768. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Content J., De Wit L., Poupart P., Opdenakker G., Van Damme J., Billiau A. Induction of a 26-kDa-protein mRNA in human cells treated with an interleukin-1-related, leukocyte-derived factor. Eur J Biochem. 1985 Oct 15;152(2):253–257. doi: 10.1111/j.1432-1033.1985.tb09191.x. [DOI] [PubMed] [Google Scholar]
  37. Coulie P. G., Cayphas S., Vink A., Uyttenhove C., Van Snick J. Interleukin-HP1-related hybridoma and plasmacytoma growth factors induced by lipopolysaccharide in vivo. Eur J Immunol. 1987 Aug;17(8):1217–1220. doi: 10.1002/eji.1830170821. [DOI] [PubMed] [Google Scholar]
  38. Coulie P. G., Vanhecke A., Van Damme J., Cayphas S., Poupart P., De Wit L., Content J. High-affinity binding sites for human 26-kDa protein (interleukin 6, B cell stimulatory factor-2, human hybridoma plasmacytoma growth factor, interferon-beta 2), different from those of type I interferon (alpha, beta), on lymphoblastoid cells. Eur J Immunol. 1987 Oct;17(10):1435–1440. doi: 10.1002/eji.1830171008. [DOI] [PubMed] [Google Scholar]
  39. Darlington G. J., Wilson D. R., Lachman L. B. Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro. J Cell Biol. 1986 Sep;103(3):787–793. doi: 10.1083/jcb.103.3.787. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Daveau M., Christian-Davrinche, Julen N., Hiron M., Arnaud P., Lebreton J. P. The synthesis of human alpha-2-HS glycoprotein is down-regulated by cytokines in hepatoma HepG2 cells. FEBS Lett. 1988 Dec 5;241(1-2):191–194. doi: 10.1016/0014-5793(88)81059-7. [DOI] [PubMed] [Google Scholar]
  41. Defilippi P., Poupart P., Tavernier J., Fiers W., Content J. Induction and regulation of mRNA encoding 26-kDa protein in human cell lines treated with recombinant human tumor necrosis factor. Proc Natl Acad Sci U S A. 1987 Jul;84(13):4557–4561. doi: 10.1073/pnas.84.13.4557. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Dinarello C. A. Interleukin-1 and the pathogenesis of the acute-phase response. N Engl J Med. 1984 Nov 29;311(22):1413–1418. doi: 10.1056/NEJM198411293112205. [DOI] [PubMed] [Google Scholar]
  43. Elias J. A., Trinchieri G., Beck J. M., Simon P. L., Sehgal P. B., May L. T., Kern J. A. A synergistic interaction of IL-6 and IL-1 mediates the thymocyte-stimulating activity produced by recombinant IL-1-stimulated fibroblasts. J Immunol. 1989 Jan 15;142(2):509–514. [PubMed] [Google Scholar]
  44. Evans E., Courtois G. M., Kilian P. L., Fuller G. M., Crabtree G. R. Induction of fibrinogen and a subset of acute phase response genes involves a novel monokine which is mimicked by phorbol esters. J Biol Chem. 1987 Aug 5;262(22):10850–10854. [PubMed] [Google Scholar]
  45. Ferguson-Smith A. C., Chen Y. F., Newman M. S., May L. T., Sehgal P. B., Ruddle F. H. Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21. Genomics. 1988 Apr;2(3):203–208. doi: 10.1016/0888-7543(88)90003-1. [DOI] [PubMed] [Google Scholar]
  46. Fey G. H., Fuller G. M. Regulation of acute phase gene expression by inflammatory mediators. Mol Biol Med. 1987 Dec;4(6):323–338. [PubMed] [Google Scholar]
  47. Fong Y., Moldawer L. L., Marano M., Wei H., Tatter S. B., Clarick R. H., Santhanam U., Sherris D., May L. T., Sehgal P. B. Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man. J Immunol. 1989 Apr 1;142(7):2321–2324. [PubMed] [Google Scholar]
  48. Fowlkes D. M., Mullis N. T., Comeau C. M., Crabtree G. R. Potential basis for regulation of the coordinately expressed fibrinogen genes: homology in the 5' flanking regions. Proc Natl Acad Sci U S A. 1984 Apr;81(8):2313–2316. doi: 10.1073/pnas.81.8.2313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Freeman G. J., Freedman A. S., Rabinowe S. N., Segil J. M., Horowitz J., Rosen K., Whitman J. F., Nadler L. M. Interleukin 6 gene expression in normal and neoplastic B cells. J Clin Invest. 1989 May;83(5):1512–1518. doi: 10.1172/JCI114046. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Frei K., Malipiero U. V., Leist T. P., Zinkernagel R. M., Schwab M. E., Fontana A. On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases. Eur J Immunol. 1989 Apr;19(4):689–694. doi: 10.1002/eji.1830190418. [DOI] [PubMed] [Google Scholar]
  51. Fukui H., Koishihara Y., Nagamuta M., Mizutani Y., Uchida A. Production of interleukin 6 by human spleen cells stimulated with streptococcal preparation OK-432. Immunol Lett. 1989 May;21(2):127–130. doi: 10.1016/0165-2478(89)90048-5. [DOI] [PubMed] [Google Scholar]
  52. Fuller G. M., Bunzel R. J., Woloski B. M., Nham S. U. Isolation of hepatocyte stimulating factor from human monocytes. Biochem Biophys Res Commun. 1987 Apr 29;144(2):1003–1009. doi: 10.1016/s0006-291x(87)80063-3. [DOI] [PubMed] [Google Scholar]
  53. Fuller G. M., Otto J. M., Woloski B. M., McGary C. T., Adams M. A. The effects of hepatocyte stimulating factor on fibrinogen biosynthesis in hepatocyte monolayers. J Cell Biol. 1985 Oct;101(4):1481–1486. doi: 10.1083/jcb.101.4.1481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Fung W. P., Schreiber G. Structure and expression of the genes for major acute phase alpha 1-protein (thiostatin) and kininogen in the rat. J Biol Chem. 1987 Jul 5;262(19):9298–9308. [PubMed] [Google Scholar]
  55. Fung W. P., Thomas T., Dickson P. W., Aldred A. R., Milland J., Dziadek M., Power B., Hudson P., Schreiber G. Structure and expression of the rat transthyretin (prealbumin) gene. J Biol Chem. 1988 Jan 5;263(1):480–488. [PubMed] [Google Scholar]
  56. Ganapathi M. K., May L. T., Schultz D., Brabenec A., Weinstein J., Sehgal P. B., Kushner I. Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell lines. Biochem Biophys Res Commun. 1988 Nov 30;157(1):271–277. doi: 10.1016/s0006-291x(88)80043-3. [DOI] [PubMed] [Google Scholar]
  57. Garman R. D., Jacobs K. A., Clark S. C., Raulet D. H. B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7629–7633. doi: 10.1073/pnas.84.21.7629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Gauldie J., Richards C., Harnish D., Lansdorp P., Baumann H. Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc Natl Acad Sci U S A. 1987 Oct;84(20):7251–7255. doi: 10.1073/pnas.84.20.7251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Geiger T., Andus T., Klapproth J., Hirano T., Kishimoto T., Heinrich P. C. Induction of rat acute-phase proteins by interleukin 6 in vivo. Eur J Immunol. 1988 May;18(5):717–721. doi: 10.1002/eji.1830180510. [DOI] [PubMed] [Google Scholar]
  60. Geiger T., Andus T., Klapproth J., Northoff H., Heinrich P. C. Induction of alpha 1-acid glycoprotein by recombinant human interleukin-1 in rat hepatoma cells. J Biol Chem. 1988 May 25;263(15):7141–7146. [PubMed] [Google Scholar]
  61. Goldman N. D., Liu T. Y. Biosynthesis of human C-reactive protein in cultured hepatoma cells is induced by a monocyte factor(s) other than interleukin-1. J Biol Chem. 1987 Feb 15;262(5):2363–2368. [PubMed] [Google Scholar]
  62. Gross V., Andus T., Castell J., Vom Berg D., Heinrich P. C., Gerok W. O- and N-glycosylation lead to different molecular mass forms of human monocyte interleukin-6. FEBS Lett. 1989 Apr 24;247(2):323–326. doi: 10.1016/0014-5793(89)81361-4. [DOI] [PubMed] [Google Scholar]
  63. Guerne P. A., Zuraw B. L., Vaughan J. H., Carson D. A., Lotz M. Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. J Clin Invest. 1989 Feb;83(2):585–592. doi: 10.1172/JCI113921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Habetswallner D., Pelosi E., Bulgarini D., Camagna A., Samoggia P., Montesoro E., Giannella G., Lazzaro D., Isacchi G., Testa U. Activation and proliferation of normal resting human T lymphocytes in serum-free culture: role of IL-4 and IL-6. Immunology. 1988 Nov;65(3):357–364. [PMC free article] [PubMed] [Google Scholar]
  65. Haegeman G., Content J., Volckaert G., Derynck R., Tavernier J., Fiers W. Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts. Eur J Biochem. 1986 Sep 15;159(3):625–632. doi: 10.1111/j.1432-1033.1986.tb09931.x. [DOI] [PubMed] [Google Scholar]
  66. Harigai M., Hara M., Norioka K., Kitani A., Hirose T., Suzuki K., Kawakami M., Masuda K., Shinmei M., Kawagoe M. Stimulation of interleukin 6-like B-cell differentiation factor production in human adherent synovial cells by recombinant interleukin 1. Scand J Immunol. 1989 Mar;29(3):289–297. doi: 10.1111/j.1365-3083.1989.tb01127.x. [DOI] [PubMed] [Google Scholar]
  67. Helfgott D. C., May L. T., Sthoeger Z., Tamm I., Sehgal P. B. Bacterial lipopolysaccharide (endotoxin) enhances expression and secretion of beta 2 interferon by human fibroblasts. J Exp Med. 1987 Nov 1;166(5):1300–1309. doi: 10.1084/jem.166.5.1300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Helfgott D. C., Tatter S. B., Santhanam U., Clarick R. H., Bhardwaj N., May L. T., Sehgal P. B. Multiple forms of IFN-beta 2/IL-6 in serum and body fluids during acute bacterial infection. J Immunol. 1989 Feb 1;142(3):948–953. [PubMed] [Google Scholar]
  69. Helle M., Brakenhoff J. P., De Groot E. R., Aarden L. A. Interleukin 6 is involved in interleukin 1-induced activities. Eur J Immunol. 1988 Jun;18(6):957–959. doi: 10.1002/eji.1830180619. [DOI] [PubMed] [Google Scholar]
  70. Hirano T., Matsuda T., Hosoi K., Okano A., Matsui H., Kishimoto T. Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2). Immunol Lett. 1988 Jan;17(1):41–45. doi: 10.1016/0165-2478(88)90099-5. [DOI] [PubMed] [Google Scholar]
  71. Hirano T., Matsuda T., Turner M., Miyasaka N., Buchan G., Tang B., Sato K., Shimizu M., Maini R., Feldmann M. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol. 1988 Nov;18(11):1797–1801. doi: 10.1002/eji.1830181122. [DOI] [PubMed] [Google Scholar]
  72. Hirano T., Taga T., Nakano N., Yasukawa K., Kashiwamura S., Shimizu K., Nakajima K., Pyun K. H., Kishimoto T. Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci U S A. 1985 Aug;82(16):5490–5494. doi: 10.1073/pnas.82.16.5490. [DOI] [PMC free article] [PubMed] [Google Scholar]
  73. Hirano T., Taga T., Yasukawa K., Nakajima K., Nakano N., Takatsuki F., Shimizu M., Murashima A., Tsunasawa S., Sakiyama F. Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production. Proc Natl Acad Sci U S A. 1987 Jan;84(1):228–231. doi: 10.1073/pnas.84.1.228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Hirano T., Yasukawa K., Harada H., Taga T., Watanabe Y., Matsuda T., Kashiwamura S., Nakajima K., Koyama K., Iwamatsu A. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature. 1986 Nov 6;324(6092):73–76. doi: 10.1038/324073a0. [DOI] [PubMed] [Google Scholar]
  75. Hirata Y., Ishibashi H., Kimura H., Hayashida K., Nagano M., Okubo H. Alpha 2-macroglobulin secretion enhanced in rat hepatocytes by partially characterized factor from Kupffer cells. Inflammation. 1985 Jun;9(2):201–209. doi: 10.1007/BF00917592. [DOI] [PubMed] [Google Scholar]
  76. Hoang T., Haman A., Goncalves O., Wong G. G., Clark S. C. Interleukin-6 enhances growth factor-dependent proliferation of the blast cells of acute myeloblastic leukemia. Blood. 1988 Aug;72(2):823–826. [PubMed] [Google Scholar]
  77. Horii Y., Muraguchi A., Suematsu S., Matsuda T., Yoshizaki K., Hirano T., Kishimoto T. Regulation of BSF-2/IL-6 production by human mononuclear cells. Macrophage-dependent synthesis of BSF-2/IL-6 by T cells. J Immunol. 1988 Sep 1;141(5):1529–1535. [PubMed] [Google Scholar]
  78. Houssiau F. A., Bukasa K., Sindic C. J., Van Damme J., Van Snick J. Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system. Clin Exp Immunol. 1988 Feb;71(2):320–323. [PMC free article] [PubMed] [Google Scholar]
  79. Houssiau F. A., Coulie P. G., Olive D., Van Snick J. Synergistic activation of human T cells by interleukin 1 and interleukin 6. Eur J Immunol. 1988 Apr;18(4):653–656. doi: 10.1002/eji.1830180427. [DOI] [PubMed] [Google Scholar]
  80. Houssiau F. A., Devogelaer J. P., Van Damme J., de Deuxchaisnes C. N., Van Snick J. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 1988 Jun;31(6):784–788. doi: 10.1002/art.1780310614. [DOI] [PubMed] [Google Scholar]
  81. Ikebuchi K., Ihle J. N., Hirai Y., Wong G. G., Clark S. C., Ogawa M. Synergistic factors for stem cell proliferation: further studies of the target stem cells and the mechanism of stimulation by interleukin-1, interleukin-6, and granulocyte colony-stimulating factor. Blood. 1988 Dec;72(6):2007–2014. [PubMed] [Google Scholar]
  82. Ikebuchi K., Wong G. G., Clark S. C., Ihle J. N., Hirai Y., Ogawa M. Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9035–9039. doi: 10.1073/pnas.84.24.9035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  83. Ishibashi T., Kimura H., Uchida T., Kariyone S., Friese P., Burstein S. A. Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5953–5957. doi: 10.1073/pnas.86.15.5953. [DOI] [PMC free article] [PubMed] [Google Scholar]
  84. Itoh N., Matsuda T., Ohtani R., Okamoto H. Angiotensinogen production by rat hepatoma cells is stimulated by B cell stimulatory factor 2/interleukin-6. FEBS Lett. 1989 Feb 13;244(1):6–10. doi: 10.1016/0014-5793(89)81150-0. [DOI] [PubMed] [Google Scholar]
  85. Jablons D. M., Mulé J. J., McIntosh J. K., Sehgal P. B., May L. T., Huang C. M., Rosenberg S. A., Lotze M. T. IL-6/IFN-beta-2 as a circulating hormone. Induction by cytokine administration in humans. J Immunol. 1989 Mar 1;142(5):1542–1547. [PubMed] [Google Scholar]
  86. Jambou R. C., Snouwaert J. N., Bishop G. A., Stebbins J. R., Frelinger J. A., Fowlkes D. M. High-level expression of a bioengineered, cysteine-free hepatocyte-stimulating factor (interleukin 6)-like protein. Proc Natl Acad Sci U S A. 1988 Dec;85(24):9426–9430. doi: 10.1073/pnas.85.24.9426. [DOI] [PMC free article] [PubMed] [Google Scholar]
  87. Jirik F. R., Podor T. J., Hirano T., Kishimoto T., Loskutoff D. J., Carson D. A., Lotz M. Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J Immunol. 1989 Jan 1;142(1):144–147. [PubMed] [Google Scholar]
  88. Kampschmidt R. F., Upchurch H. F., Eddington C. L., Pulliam L. A. Multiple biological activities of a partially purified leukocytic endogenous mediator. Am J Physiol. 1973 Mar;224(3):530–533. doi: 10.1152/ajplegacy.1973.224.3.530. [DOI] [PubMed] [Google Scholar]
  89. Karin M., Imbra R. J., Heguy A., Wong G. Interleukin 1 regulates human metallothionein gene expression. Mol Cell Biol. 1985 Oct;5(10):2866–2869. doi: 10.1128/mcb.5.10.2866. [DOI] [PMC free article] [PubMed] [Google Scholar]
  90. Katz Y., Revel M., Strunk R. C. Interleukin 6 stimulates synthesis of complement proteins factor B and C3 in human skin fibroblasts. Eur J Immunol. 1989 Jun;19(6):983–988. doi: 10.1002/eji.1830190605. [DOI] [PubMed] [Google Scholar]
  91. Kawano M., Hirano T., Matsuda T., Taga T., Horii Y., Iwato K., Asaoku H., Tang B., Tanabe O., Tanaka H. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature. 1988 Mar 3;332(6159):83–85. doi: 10.1038/332083a0. [DOI] [PubMed] [Google Scholar]
  92. Kharazmi A., Nielsen H., Rechnitzer C., Bendtzen K. Interleukin 6 primes human neutrophil and monocyte oxidative burst response. Immunol Lett. 1989 May;21(2):177–184. doi: 10.1016/0165-2478(89)90056-4. [DOI] [PubMed] [Google Scholar]
  93. Kirnbauer R., Köck A., Schwarz T., Urbanski A., Krutmann J., Borth W., Damm D., Shipley G., Ansel J. C., Luger T. A. IFN-beta 2, B cell differentiation factor 2, or hybridoma growth factor (IL-6) is expressed and released by human epidermal cells and epidermoid carcinoma cell lines. J Immunol. 1989 Mar 15;142(6):1922–1928. [PubMed] [Google Scholar]
  94. Kishimoto T. B-cell stimulatory factors (BSFs): molecular structure, biological function, and regulation of expression. J Clin Immunol. 1987 Sep;7(5):343–355. doi: 10.1007/BF00917012. [DOI] [PubMed] [Google Scholar]
  95. Kishimoto T., Hirano T. A new interleukin with pleiotropic activities. Bioessays. 1988 Jul;9(1):11–15. doi: 10.1002/bies.950090104. [DOI] [PubMed] [Google Scholar]
  96. Kishimoto T., Hirano T. Molecular regulation of B lymphocyte response. Annu Rev Immunol. 1988;6:485–512. doi: 10.1146/annurev.iy.06.040188.002413. [DOI] [PubMed] [Google Scholar]
  97. Klapproth J., Castell J., Geiger T., Andus T., Heinrich P. C. Fate and biological action of human recombinant interleukin 1 beta in the rat in vivo. Eur J Immunol. 1989 Aug;19(8):1485–1490. doi: 10.1002/eji.1830190821. [DOI] [PubMed] [Google Scholar]
  98. Kohase M., Henriksen-DeStefano D., May L. T., Vilcek J., Sehgal P. B. Induction of beta 2-interferon by tumor necrosis factor: a homeostatic mechanism in the control of cell proliferation. Cell. 1986 Jun 6;45(5):659–666. doi: 10.1016/0092-8674(86)90780-4. [DOI] [PubMed] [Google Scholar]
  99. Kohase M., May L. T., Tamm I., Vilcek J., Sehgal P. B. A cytokine network in human diploid fibroblasts: interactions of beta-interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1. Mol Cell Biol. 1987 Jan;7(1):273–280. doi: 10.1128/mcb.7.1.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  100. Koike K., Nakahata T., Takagi M., Kobayashi T., Ishiguro A., Tsuji K., Naganuma K., Okano A., Akiyama Y., Akabane T. Synergism of BSF-2/interleukin 6 and interleukin 3 on development of multipotential hemopoietic progenitors in serum-free culture. J Exp Med. 1988 Sep 1;168(3):879–890. doi: 10.1084/jem.168.3.879. [DOI] [PMC free article] [PubMed] [Google Scholar]
  101. Koj A., Gauldie J., Regoeczi E., Sauder D. N., Sweeney G. D. The acute-phase response of cultured rat hepatocytes. System characterization and the effect of human cytokines. Biochem J. 1984 Dec 1;224(2):505–514. doi: 10.1042/bj2240505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  102. Koj A., Gordon A. H., Gauldie J. An alternative regulatory pathway of the acute phase response: the role of fibroblast-derived interferon-beta 2. Experientia. 1988 Jan 15;44(1):9–10. doi: 10.1007/BF01960222. [DOI] [PubMed] [Google Scholar]
  103. Koj A., Kurdowska A., Magielska-Zero D., Rokita H., Sipe J. D., Dayer J. M., Demczuk S., Gauldie J. Limited effects of recombinant human and murine interleukin 1 and tumour necrosis factor on production of acute phase proteins by cultured rat hepatocytes. Biochem Int. 1987 Mar;14(3):553–560. [PubMed] [Google Scholar]
  104. Kunz D., Zimmermann R., Heisig M., Heinrich P. C. Identification of the promoter sequences involved in the interleukin-6 dependent expression of the rat alpha 2-macroglobulin gene. Nucleic Acids Res. 1989 Feb 11;17(3):1121–1138. doi: 10.1093/nar/17.3.1121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  105. Kurokawa S., Ishibashi H., Hayashida K., Tsuchiya Y., Hirata Y., Sakaki Y., Okubo H., Niho Y. Kupffer cell stimulation of alpha 2-macroglobulin synthesis in rat hepatocytes and the role of glucocorticoid. Cell Struct Funct. 1987 Feb;12(1):35–42. doi: 10.1247/csf.12.35. [DOI] [PubMed] [Google Scholar]
  106. Kushner I., Mackiewicz A. Acute phase proteins as disease markers. Dis Markers. 1987 Mar;5(1):1–11. [PubMed] [Google Scholar]
  107. Kushner I. The acute phase response: an overview. Methods Enzymol. 1988;163:373–383. doi: 10.1016/0076-6879(88)63037-0. [DOI] [PubMed] [Google Scholar]
  108. Kushner I. The phenomenon of the acute phase response. Ann N Y Acad Sci. 1982;389:39–48. doi: 10.1111/j.1749-6632.1982.tb22124.x. [DOI] [PubMed] [Google Scholar]
  109. Le J. M., Fredrickson G., Reis L. F., Diamantstein T., Hirano T., Kishimoto T., Vilcek J. Interleukin 2-dependent and interleukin 2-independent pathways of regulation of thymocyte function by interleukin 6. Proc Natl Acad Sci U S A. 1988 Nov;85(22):8643–8647. doi: 10.1073/pnas.85.22.8643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  110. Leary A. G., Ikebuchi K., Hirai Y., Wong G. G., Yang Y. C., Clark S. C., Ogawa M. Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: comparison with interleukin-1 alpha. Blood. 1988 Jun;71(6):1759–1763. [PubMed] [Google Scholar]
  111. Lotz M., Jirik F., Kabouridis P., Tsoukas C., Hirano T., Kishimoto T., Carson D. A. B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes. J Exp Med. 1988 Mar 1;167(3):1253–1258. doi: 10.1084/jem.167.3.1253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  112. Lotz M., Vaughan J. H., Carson D. A. Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science. 1988 Sep 2;241(4870):1218–1221. doi: 10.1126/science.2457950. [DOI] [PubMed] [Google Scholar]
  113. Lowell C. A., Potter D. A., Stearman R. S., Morrow J. F. Structure of the murine serum amyloid A gene family. Gene conversion. J Biol Chem. 1986 Jun 25;261(18):8442–8452. [PubMed] [Google Scholar]
  114. MILLER L. L., BLY C. G., WATSON M. L., BALE W. F. The dominant role of the liver in plasma protein synthesis; a direct study of the isolated perfused rat liver with the aid of lysine-epsilon-C14. J Exp Med. 1951 Nov;94(5):431–453. doi: 10.1084/jem.94.5.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  115. Mackiewicz A., Kushner I. Interferon beta 2/B-cell stimulating factor 2/interleukin 6 affects glycosylation of acute phase proteins in human hepatoma cell lines. Scand J Immunol. 1989 Mar;29(3):265–271. doi: 10.1111/j.1365-3083.1989.tb01124.x. [DOI] [PubMed] [Google Scholar]
  116. Marinkovic S., Jahreis G. P., Wong G. G., Baumann H. IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo. J Immunol. 1989 Feb 1;142(3):808–812. [PubMed] [Google Scholar]
  117. Matsuda T., Hirano T., Kishimoto T. Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2-dependent cell line and preparation of anti-IL 6 monoclonal antibodies. Eur J Immunol. 1988 Jun;18(6):951–956. doi: 10.1002/eji.1830180618. [DOI] [PubMed] [Google Scholar]
  118. Matsuda T., Hirano T., Nagasawa S., Kishimoto T. Identification of alpha 2-macroglobulin as a carrier protein for IL-6. J Immunol. 1989 Jan 1;142(1):148–152. [PubMed] [Google Scholar]
  119. May L. T., Ghrayeb J., Santhanam U., Tatter S. B., Sthoeger Z., Helfgott D. C., Chiorazzi N., Grieninger G., Sehgal P. B. Synthesis and secretion of multiple forms of beta 2-interferon/B-cell differentiation factor 2/hepatocyte-stimulating factor by human fibroblasts and monocytes. J Biol Chem. 1988 Jun 5;263(16):7760–7766. [PubMed] [Google Scholar]
  120. May L. T., Helfgott D. C., Sehgal P. B. Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved. Proc Natl Acad Sci U S A. 1986 Dec;83(23):8957–8961. doi: 10.1073/pnas.83.23.8957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  121. May L. T., Santhanam U., Tatter S. B., Bhardwaj N., Ghrayeb J., Sehgal P. B. Phosphorylation of secreted forms of human beta 2-interferon/hepatocyte stimulating factor/interleukin-6. Biochem Biophys Res Commun. 1988 May 16;152(3):1144–1150. doi: 10.1016/s0006-291x(88)80404-2. [DOI] [PubMed] [Google Scholar]
  122. May L. T., Torcia G., Cozzolino F., Ray A., Tatter S. B., Santhanam U., Sehgal P. B., Stern D. Interleukin-6 gene expression in human endothelial cells: RNA start sites, multiple IL-6 proteins and inhibition of proliferation. Biochem Biophys Res Commun. 1989 Mar 31;159(3):991–998. doi: 10.1016/0006-291x(89)92206-7. [DOI] [PubMed] [Google Scholar]
  123. Miyaura C., Onozaki K., Akiyama Y., Taniyama T., Hirano T., Kishimoto T., Suda T. Recombinant human interleukin 6 (B-cell stimulatory factor 2) is a potent inducer of differentiation of mouse myeloid leukemia cells (M1). FEBS Lett. 1988 Jul 4;234(1):17–21. doi: 10.1016/0014-5793(88)81293-6. [DOI] [PubMed] [Google Scholar]
  124. Miyaura C., Onozaki K., Akiyama Y., Taniyama T., Hirano T., Kishimoto T., Suda T. Recombinant human interleukin 6 (B-cell stimulatory factor 2) is a potent inducer of differentiation of mouse myeloid leukemia cells (M1). FEBS Lett. 1988 Jul 4;234(1):17–21. doi: 10.1016/0014-5793(88)81293-6. [DOI] [PubMed] [Google Scholar]
  125. Mizutani H., May L. T., Sehgal P. B., Kupper T. S. Synergistic interactions of IL-1 and IL-6 in T cell activation. Mitogen but not antigen receptor-induced proliferation of a cloned T helper cell line is enhanced by exogenous IL-6. J Immunol. 1989 Aug 1;143(3):896–901. [PubMed] [Google Scholar]
  126. Mock B. A., Nordan R. P., Justice M. J., Kozak C., Jenkins N. A., Copeland N. G., Clark S. C., Wong G. G., Rudikoff S. The murine Il-6 gene maps to the proximal region of chromosome 5. J Immunol. 1989 Feb 15;142(4):1372–1376. [PubMed] [Google Scholar]
  127. Morrone G., Ciliberto G., Oliviero S., Arcone R., Dente L., Content J., Cortese R. Recombinant interleukin 6 regulates the transcriptional activation of a set of human acute phase genes. J Biol Chem. 1988 Sep 5;263(25):12554–12558. [PubMed] [Google Scholar]
  128. Moshage H. J., Roelofs H. M., van Pelt J. F., Hazenberg B. P., van Leeuwen M. A., Limburg P. C., Aarden L. A., Yap S. H. The effect of interleukin-1, interleukin-6 and its interrelationship on the synthesis of serum amyloid A and C-reactive protein in primary cultures of adult human hepatocytes. Biochem Biophys Res Commun. 1988 Aug 30;155(1):112–117. doi: 10.1016/s0006-291x(88)81056-8. [DOI] [PubMed] [Google Scholar]
  129. Muraguchi A., Hirano T., Tang B., Matsuda T., Horii Y., Nakajima K., Kishimoto T. The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J Exp Med. 1988 Feb 1;167(2):332–344. doi: 10.1084/jem.167.2.332. [DOI] [PMC free article] [PubMed] [Google Scholar]
  130. Naitoh Y., Fukata J., Tominaga T., Nakai Y., Tamai S., Mori K., Imura H. Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats. Biochem Biophys Res Commun. 1988 Sep 30;155(3):1459–1463. doi: 10.1016/s0006-291x(88)81305-6. [DOI] [PubMed] [Google Scholar]
  131. Nakajima K., Martínez-Maza O., Hirano T., Breen E. C., Nishanian P. G., Salazar-Gonzalez J. F., Fahey J. L., Kishimoto T. Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV. J Immunol. 1989 Jan 15;142(2):531–536. [PubMed] [Google Scholar]
  132. Navarro S., Debili N., Bernaudin J. F., Vainchenker W., Doly J. Regulation of the expression of IL-6 in human monocytes. J Immunol. 1989 Jun 15;142(12):4339–4345. [PubMed] [Google Scholar]
  133. Neta R., Vogel S. N., Sipe J. D., Wong G. G., Nordan R. P. Comparison of in vivo effects of human recombinant IL 1 and human recombinant IL 6 in mice. Lymphokine Res. 1988 Winter;7(4):403–412. [PubMed] [Google Scholar]
  134. Nishida T., Nakai S., Kawakami T., Aihara K., Nishino N., Hirai Y. Dexamethasone regulation of the expression of cytokine mRNAs induced by interleukin-1 in the astrocytoma cell line U373MG. FEBS Lett. 1989 Jan 16;243(1):25–29. doi: 10.1016/0014-5793(89)81210-4. [DOI] [PubMed] [Google Scholar]
  135. Northoff H., Andus T., Tran-Thi T. A., Bauer J., Decker K., Kubanek B., Heinrich P. C. The inflammation mediators interleukin 1 and hepatocyte-stimulating factor are differently regulated in human monocytes. Eur J Immunol. 1987 May;17(5):707–711. doi: 10.1002/eji.1830170520. [DOI] [PubMed] [Google Scholar]
  136. Okada M., Kitahara M., Kishimoto S., Matsuda T., Hirano T., Kishimoto T. IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells. J Immunol. 1988 Sep 1;141(5):1543–1549. [PubMed] [Google Scholar]
  137. Oliviero S., Morrone G., Cortese R. The human haptoglobin gene: transcriptional regulation during development and acute phase induction. EMBO J. 1987 Jul;6(7):1905–1912. doi: 10.1002/j.1460-2075.1987.tb02450.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  138. Oster W., Cicco N. A., Klein H., Hirano T., Kishimoto T., Lindemann A., Mertelsmann R. H., Herrmann F. Participation of the cytokines interleukin 6, tumor necrosis factor-alpha, and interleukin 1-beta secreted by acute myelogenous leukemia blasts in autocrine and paracrine leukemia growth control. J Clin Invest. 1989 Aug;84(2):451–457. doi: 10.1172/JCI114186. [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]
  139. Pepys M. B., Baltz M. L. Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein. Adv Immunol. 1983;34:141–212. doi: 10.1016/s0065-2776(08)60379-x. [DOI] [PubMed] [Google Scholar]
  140. Perlmutter D. H., Colten H. R., Adams S. P., May L. T., Sehgal P. B., Fallon R. J. A cytokine-selective defect in interleukin-1 beta-mediated acute phase gene expression in a subclone of the human hepatoma cell line (HEPG2). J Biol Chem. 1989 May 5;264(13):7669–7674. [PubMed] [Google Scholar]
  141. Perlmutter D. H., Dinarello C. A., Punsal P. I., Colten H. R. Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression. J Clin Invest. 1986 Nov;78(5):1349–1354. doi: 10.1172/JCI112721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  142. Poupart P., De Wit L., Content J. Induction and regulation of the 26-kDa protein in the absence of synthesis of beta-interferon mRNA in human cells. Eur J Biochem. 1984 Aug 15;143(1):15–21. doi: 10.1111/j.1432-1033.1984.tb08332.x. [DOI] [PubMed] [Google Scholar]
  143. Poupart P., De Wit L., Content J. Induction and regulation of the 26-kDa protein in the absence of synthesis of beta-interferon mRNA in human cells. Eur J Biochem. 1984 Aug 15;143(1):15–21. doi: 10.1111/j.1432-1033.1984.tb08332.x. [DOI] [PubMed] [Google Scholar]
  144. Poupart P., Vandenabeele P., Cayphas S., Van Snick J., Haegeman G., Kruys V., Fiers W., Content J. B cell growth modulating and differentiating activity of recombinant human 26-kd protein (BSF-2, HuIFN-beta 2, HPGF). EMBO J. 1987 May;6(5):1219–1224. doi: 10.1002/j.1460-2075.1987.tb02357.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  145. Powanda M. C., Cockerell G. L., Pekarek R. S. Amino acid and zinc movement in relation to protein synthesis early in inflammation. Am J Physiol. 1973 Aug;225(2):399–401. doi: 10.1152/ajplegacy.1973.225.2.399. [DOI] [PubMed] [Google Scholar]
  146. Prowse K. R., Baumann H. Hepatocyte-stimulating factor, beta 2 interferon, and interleukin-1 enhance expression of the rat alpha 1-acid glycoprotein gene via a distal upstream regulatory region. Mol Cell Biol. 1988 Jan;8(1):42–51. doi: 10.1128/mcb.8.1.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  147. Ramadori G., Sipe J. D., Dinarello C. A., Mizel S. B., Colten H. R. Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1. J Exp Med. 1985 Sep 1;162(3):930–942. doi: 10.1084/jem.162.3.930. [DOI] [PMC free article] [PubMed] [Google Scholar]
  148. Ramadori G., Van Damme J., Rieder H., Meyer zum Büschenfelde K. H. Interleukin 6, the third mediator of acute-phase reaction, modulates hepatic protein synthesis in human and mouse. Comparison with interleukin 1 beta and tumor necrosis factor-alpha. Eur J Immunol. 1988 Aug;18(8):1259–1264. doi: 10.1002/eji.1830180817. [DOI] [PubMed] [Google Scholar]
  149. Ray A., Tatter S. B., May L. T., Sehgal P. B. Activation of the human "beta 2-interferon/hepatocyte-stimulating factor/interleukin 6" promoter by cytokines, viruses, and second messenger agonists. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6701–6705. doi: 10.1073/pnas.85.18.6701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  150. Reis L. F., Le J. M., Hirano T., Kishimoto T., Vilcek J. Antiviral action of tumor necrosis factor in human fibroblasts is not mediated by B cell stimulatory factor 2/IFN-beta 2, and is inhibited by specific antibodies to IFN-beta. J Immunol. 1988 Mar 1;140(5):1566–1570. [PubMed] [Google Scholar]
  151. Rennick D., Jackson J., Yang G., Wideman J., Lee F., Hudak S. Interleukin-6 interacts with interleukin-4 and other hematopoietic growth factors to selectively enhance the growth of megakaryocytic, erythroid, myeloid, and multipotential progenitor cells. Blood. 1989 May 15;73(7):1828–1835. [PubMed] [Google Scholar]
  152. Revel M., Zilberstein A. Interferon-beta 2 living up to its name. Nature. 1987 Feb 12;325(6105):581–582. doi: 10.1038/325581b0. [DOI] [PubMed] [Google Scholar]
  153. Ritchie D. G., Fuller G. M. Hepatocyte-stimulating factor: a monocyte-derived acute-phase regulatory protein. Ann N Y Acad Sci. 1983 Jun 27;408:490–502. doi: 10.1111/j.1749-6632.1983.tb23268.x. [DOI] [PubMed] [Google Scholar]
  154. Satoh T., Nakamura S., Taga T., Matsuda T., Hirano T., Kishimoto T., Kaziro Y. Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6. Mol Cell Biol. 1988 Aug;8(8):3546–3549. doi: 10.1128/mcb.8.8.3546. [DOI] [PMC free article] [PubMed] [Google Scholar]
  155. Sehgal P. B., Helfgott D. C., Santhanam U., Tatter S. B., Clarick R. H., Ghrayeb J., May L. T. Regulation of the acute phase and immune responses in viral disease. Enhanced expression of the beta 2-interferon/hepatocyte-stimulating factor/interleukin 6 gene in virus-infected human fibroblasts. J Exp Med. 1988 Jun 1;167(6):1951–1956. doi: 10.1084/jem.167.6.1951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  156. Sehgal P. B., May L. T., Tamm I., Vilcek J. Human beta 2 interferon and B-cell differentiation factor BSF-2 are identical. Science. 1987 Feb 13;235(4790):731–732. doi: 10.1126/science.3492764. [DOI] [PubMed] [Google Scholar]
  157. Sehgal P. B., Sagar A. D. Heterogeneity of poly(I) x poly(C)-induced human fibroblast interferon mRNA species. Nature. 1980 Nov 6;288(5786):95–97. doi: 10.1038/288095a0. [DOI] [PubMed] [Google Scholar]
  158. Sehgal P. B., Walther Z., Tamm I. Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187. Proc Natl Acad Sci U S A. 1987 Jun;84(11):3663–3667. doi: 10.1073/pnas.84.11.3663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  159. Sehgal P. B., Zilberstein A., Ruggieri R. M., May L. T., Ferguson-Smith A., Slate D. L., Revel M., Ruddle F. H. Human chromosome 7 carries the beta 2 interferon gene. Proc Natl Acad Sci U S A. 1986 Jul;83(14):5219–5222. doi: 10.1073/pnas.83.14.5219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  160. Shabo Y., Lotem J., Rubinstein M., Revel M., Clark S. C., Wolf S. F., Kamen R., Sachs L. The myeloid blood cell differentiation-inducing protein MGI-2A is interleukin-6. Blood. 1988 Dec;72(6):2070–2073. [PubMed] [Google Scholar]
  161. Shaw G., Kamen R. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell. 1986 Aug 29;46(5):659–667. doi: 10.1016/0092-8674(86)90341-7. [DOI] [PubMed] [Google Scholar]
  162. Shimizu S., Hirano T., Yoshioka R., Sugai S., Matsuda T., Taga T., Kishimoto T., Konda S. Interleukin-6 (B-cell stimulatory factor 2)-dependent growth of a Lennert's lymphoma-derived T-cell line (KT-3). Blood. 1988 Nov;72(5):1826–1828. [PubMed] [Google Scholar]
  163. Shimizu S., Yoshioka R., Hirose Y., Sugai S., Tachibana J., Konda S. Establishment of two interleukin 6 (B cell stimulatory factor 2/interferon beta 2)-dependent human bone marrow-derived myeloma cell lines. J Exp Med. 1989 Jan 1;169(1):339–344. doi: 10.1084/jem.169.1.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  164. Simpson R. J., Moritz R. L., Rubira M. R., Van Snick J. Murine hybridoma/plasmacytoma growth factor. Complete amino-acid sequence and relation to human interleukin-6. Eur J Biochem. 1988 Sep 1;176(1):187–197. doi: 10.1111/j.1432-1033.1988.tb14267.x. [DOI] [PubMed] [Google Scholar]
  165. Simpson R. J., Moritz R. L., Van Roost, Van Snick J. Characterization of a recombinant murine interleukin-6: assignment of disulfide bonds. Biochem Biophys Res Commun. 1988 Nov 30;157(1):364–372. doi: 10.1016/s0006-291x(88)80056-1. [DOI] [PubMed] [Google Scholar]
  166. Sipe J. D., Vogel S. N., Ryan J. L., McAdam K. P., Rosenstreich D. L. Detection of a mediator derived from endotoxin-stimulated macrohpages that induces the acute phase serum amyloid A response in mice. J Exp Med. 1979 Sep 19;150(3):597–606. doi: 10.1084/jem.150.3.597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  167. Sironi M., Breviario F., Proserpio P., Biondi A., Vecchi A., Van Damme J., Dejana E., Mantovani A. IL-1 stimulates IL-6 production in endothelial cells. J Immunol. 1989 Jan 15;142(2):549–553. [PubMed] [Google Scholar]
  168. Sox H. C., Jr, Liang M. H. The erythrocyte sedimentation rate. Guidelines for rational use. Ann Intern Med. 1986 Apr;104(4):515–523. doi: 10.7326/0003-4819-104-4-515. [DOI] [PubMed] [Google Scholar]
  169. Suda T., Hodgkin P., Lee F., Zlotnik A. Biological activity of recombinant murine interleukin-6 in interleukin-1 T cell assays. J Immunol Methods. 1989 Jun 21;120(2):173–178. doi: 10.1016/0022-1759(89)90239-1. [DOI] [PubMed] [Google Scholar]
  170. Sutherland G. R., Baker E., Callen D. F., Hyland V. J., Wong G., Clark S., Jones S. S., Eglinton L. K., Shannon M. F., Lopez A. F. Interleukin 4 is at 5q31 and interleukin 6 is at 7p15. Hum Genet. 1988 Aug;79(4):335–337. doi: 10.1007/BF00282171. [DOI] [PubMed] [Google Scholar]
  171. Suzuki C., Okano A., Takatsuki F., Miyasaka Y., Hirano T., Kishimoto T., Ejima D., Akiyama Y. Continuous perfusion with interleukin 6 (IL-6) enhances production of hematopoietic stem cells (CFU-S). Biochem Biophys Res Commun. 1989 Mar 31;159(3):933–938. doi: 10.1016/0006-291x(89)92198-0. [DOI] [PubMed] [Google Scholar]
  172. Tabibzadeh S. S., Santhanam U., Sehgal P. B., May L. T. Cytokine-induced production of IFN-beta 2/IL-6 by freshly explanted human endometrial stromal cells. Modulation by estradiol-17 beta. J Immunol. 1989 May 1;142(9):3134–3139. [PubMed] [Google Scholar]
  173. Taga T., Kawanishi Y., Hardy R. R., Hirano T., Kishimoto T. Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression. J Exp Med. 1987 Oct 1;166(4):967–981. doi: 10.1084/jem.166.4.967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  174. Taga T., Kawanishi Y., Hardy R. R., Hirano T., Kishimoto T. Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression. J Exp Med. 1987 Oct 1;166(4):967–981. doi: 10.1084/jem.166.4.967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  175. Takai Y., Wong G. G., Clark S. C., Burakoff S. J., Herrmann S. H. B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes. J Immunol. 1988 Jan 15;140(2):508–512. [PubMed] [Google Scholar]
  176. Takatsuki F., Okano A., Suzuki C., Chieda R., Takahara Y., Hirano T., Kishimoto T., Hamuro J., Akiyama Y. Human recombinant IL-6/B cell stimulatory factor 2 augments murine antigen-specific antibody responses in vitro and in vivo. J Immunol. 1988 Nov 1;141(9):3072–3077. [PubMed] [Google Scholar]
  177. Tanabe O., Akira S., Kamiya T., Wong G. G., Hirano T., Kishimoto T. Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human. J Immunol. 1988 Dec 1;141(11):3875–3881. [PubMed] [Google Scholar]
  178. Tosato G., Gerrard T. L., Goldman N. G., Pike S. E. Stimulation of EBV-activated human B cells by monocytes and monocyte products. Role of IFN-beta 2/B cell stimulatory factor 2/IL-6. J Immunol. 1988 Jun 15;140(12):4329–4336. [PubMed] [Google Scholar]
  179. Tosato G., Pike S. E. Interferon-beta 2/interleukin 6 is a co-stimulant for human T lymphocytes. J Immunol. 1988 Sep 1;141(5):1556–1562. [PubMed] [Google Scholar]
  180. Tsuchiya Y., Hattori M., Hayashida K., Ishibashi H., Okubo H., Sakaki Y. Sequence analysis of the putative regulatory region of rat alpha 2-macroglobulin gene. Gene. 1987;57(1):73–80. doi: 10.1016/0378-1119(87)90178-8. [DOI] [PubMed] [Google Scholar]
  181. Ulich T. R., del Castillo J., Guo K. Z. In vivo hematologic effects of recombinant interleukin-6 on hematopoiesis and circulating numbers of RBCs and WBCs. Blood. 1989 Jan;73(1):108–110. [PubMed] [Google Scholar]
  182. Uyttenhove C., Coulie P. G., Van Snick J. T cell growth and differentiation induced by interleukin-HP1/IL-6, the murine hybridoma/plasmacytoma growth factor. J Exp Med. 1988 Apr 1;167(4):1417–1427. doi: 10.1084/jem.167.4.1417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  183. Van Damme J., Cayphas S., Opdenakker G., Billiau A., Van Snick J. Interleukin 1 and poly(rI).poly(rC) induce production of a hybridoma growth factor by human fibroblasts. Eur J Immunol. 1987 Jan;17(1):1–7. doi: 10.1002/eji.1830170102. [DOI] [PubMed] [Google Scholar]
  184. Van Damme J., Cayphas S., Van Snick J., Conings R., Put W., Lenaerts J. P., Simpson R. J., Billiau A. Purification and characterization of human fibroblast-derived hybridoma growth factor identical to T-cell-derived B-cell stimulatory factor-2 (interleukin-6). Eur J Biochem. 1987 Nov 2;168(3):543–550. doi: 10.1111/j.1432-1033.1987.tb13452.x. [DOI] [PubMed] [Google Scholar]
  185. Van Damme J., Opdenakker G., Simpson R. J., Rubira M. R., Cayphas S., Vink A., Billiau A., Van Snick J. Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor. J Exp Med. 1987 Mar 1;165(3):914–919. doi: 10.1084/jem.165.3.914. [DOI] [PMC free article] [PubMed] [Google Scholar]
  186. Van Damme J., Schaafsma M. R., Fibbe W. E., Falkenburg J. H., Opdenakker G., Billiau A. Simultaneous production of interleukin 6, interferon-beta and colony-stimulating activity by fibroblasts after viral and bacterial infection. Eur J Immunol. 1989 Jan;19(1):163–168. doi: 10.1002/eji.1830190126. [DOI] [PubMed] [Google Scholar]
  187. Van Damme J., Van Beeumen J., Decock B., Van Snick J., De Ley M., Billiau A. Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1 beta and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6. J Immunol. 1988 Mar 1;140(5):1534–1541. [PubMed] [Google Scholar]
  188. Van Snick J., Cayphas S., Szikora J. P., Renauld J. C., Van Roost E., Boon T., Simpson R. J. cDNA cloning of murine interleukin-HP1: homology with human interleukin 6. Eur J Immunol. 1988 Feb;18(2):193–197. doi: 10.1002/eji.1830180202. [DOI] [PubMed] [Google Scholar]
  189. Van Snick J., Cayphas S., Vink A., Uyttenhove C., Coulie P. G., Rubira M. R., Simpson R. J. Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas. Proc Natl Acad Sci U S A. 1986 Dec;83(24):9679–9683. doi: 10.1073/pnas.83.24.9679. [DOI] [PMC free article] [PubMed] [Google Scholar]
  190. Van Snick J., Vink A., Cayphas S., Uyttenhove C. Interleukin-HP1, a T cell-derived hybridoma growth factor that supports the in vitro growth of murine plasmacytomas. J Exp Med. 1987 Mar 1;165(3):641–649. doi: 10.1084/jem.165.3.641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  191. Waage A., Brandtzaeg P., Halstensen A., Kierulf P., Espevik T. The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome. J Exp Med. 1989 Jan 1;169(1):333–338. doi: 10.1084/jem.169.1.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  192. Waage A., Kaufmann C., Espevik T., Husby G. Interleukin-6 in synovial fluid from patients with arthritis. Clin Immunol Immunopathol. 1989 Mar;50(3):394–398. doi: 10.1016/0090-1229(89)90146-3. [DOI] [PubMed] [Google Scholar]
  193. Walther Z., May L. T., Sehgal P. B. Transcriptional regulation of the interferon-beta 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines. J Immunol. 1988 Feb 1;140(3):974–977. [PubMed] [Google Scholar]
  194. Wannemacher R. W., Jr, Pekarek R. S., Thompson W. L., Curnow R. T., Beall F. A., Zenser T. V., DeRubertis F. R., Beisel W. R. A protein from polymorphonuclear leukocytes (LEM) which affects the rate of hepatic amino acid transport and synthesis of acute-phase globulins. Endocrinology. 1975 Mar;96(3):651–661. doi: 10.1210/endo-96-3-651. [DOI] [PubMed] [Google Scholar]
  195. Woloski B. M., Fuller G. M. Identification and partial characterization of hepatocyte-stimulating factor from leukemia cell lines: comparison with interleukin 1. Proc Natl Acad Sci U S A. 1985 Mar;82(5):1443–1447. doi: 10.1073/pnas.82.5.1443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  196. Woloski B. M., Smith E. M., Meyer W. J., 3rd, Fuller G. M., Blalock J. E. Corticotropin-releasing activity of monokines. Science. 1985 Nov 29;230(4729):1035–1037. doi: 10.1126/science.2997929. [DOI] [PubMed] [Google Scholar]
  197. Woloski B. M., Smith E. M., Meyer W. J., 3rd, Fuller G. M., Blalock J. E. Corticotropin-releasing activity of monokines. Science. 1985 Nov 29;230(4729):1035–1037. doi: 10.1126/science.2997929. [DOI] [PubMed] [Google Scholar]
  198. Wong G. G., Clark S. C. Multiple actions of interleukin 6 within a cytokine network. Immunol Today. 1988 May;9(5):137–139. doi: 10.1016/0167-5699(88)91200-5. [DOI] [PubMed] [Google Scholar]
  199. Yamasaki K., Taga T., Hirata Y., Yawata H., Kawanishi Y., Seed B., Taniguchi T., Hirano T., Kishimoto T. Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science. 1988 Aug 12;241(4867):825–828. doi: 10.1126/science.3136546. [DOI] [PubMed] [Google Scholar]
  200. Yasukawa K., Hirano T., Watanabe Y., Muratani K., Matsuda T., Nakai S., Kishimoto T. Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J. 1987 Oct;6(10):2939–2945. doi: 10.1002/j.1460-2075.1987.tb02598.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  201. Yasukawa K., Hirano T., Watanabe Y., Muratani K., Matsuda T., Nakai S., Kishimoto T. Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J. 1987 Oct;6(10):2939–2945. doi: 10.1002/j.1460-2075.1987.tb02598.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  202. Zhang X. G., Klein B., Bataille R. Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma. Blood. 1989 Jul;74(1):11–13. [PubMed] [Google Scholar]
  203. Zhang Y. H., Lin J. X., Yip Y. K., Vilcek J. Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6802–6805. doi: 10.1073/pnas.85.18.6802. [DOI] [PMC free article] [PubMed] [Google Scholar]
  204. Zhang Y., Lin J. X., Vilcek J. Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP. J Biol Chem. 1988 May 5;263(13):6177–6182. [PubMed] [Google Scholar]
  205. Zilberstein A., Ruggieri R., Korn J. H., Revel M. Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines. EMBO J. 1986 Oct;5(10):2529–2537. doi: 10.1002/j.1460-2075.1986.tb04531.x. [DOI] [PMC free article] [PubMed] [Google Scholar]