Plasmacytoid T cells. Immunohistochemical evidence for their monocyte/macrophage origin. (original) (raw)
- Journal List
- Am J Pathol
- v.133(1); 1988 Oct
- PMC1880653
Am J Pathol. 1988 Oct; 133(1): 15–21.
Department of Pathology, Catholic University of Leuven, Belgium.
Abstract
To elucidate the lineage of plasmacytoid T cells, their immunophenotype was studied in reactive lymph nodes with a broad panel of monoclonal antibodies. Plasmacytoid T cells expressed several myelomonocytic markers, and almost all markers highly selective for macrophages. They lacked granulocyte-associated and B or T lymphocyte-associated antigens. These results provide strong evidence that plasmacytoid T cells are of monocyte lineage.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.8M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
Images in this article
Click on the image to see a larger version.
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- LENNERT K, REMMELE W. Karyometrische Untersuchungen an Lymphknotenzellen des Menschen. I. Germinoblasten, Lymphoblasten und Lymphozyten. Acta Haematol. 1958 Feb;19(2):99–113. [PubMed] [Google Scholar]
- Vollenweider R, Lennert K. Plasmacytoid T-cell clusters in non-specific lymphadenitis. Virchows Arch B Cell Pathol Incl Mol Pathol. 1983;44(1):1–14. [PubMed] [Google Scholar]
- Müller-Hermelink HK, Stein H, Steinmann G, Lennert K. Malignant lymphoma of plasmacytoid T-cells. Morphologic and immunologic studies characterizing a special type of T-cell. Am J Surg Pathol. 1983 Dec;7(8):849–862. [PubMed] [Google Scholar]
- Feller AC, Lennert K, Stein H, Bruhn HD, Wuthe HH. Immunohistology and aetiology of histiocytic necrotizing lymphadenitis. Report of three instructive cases. Histopathology. 1983 Nov;7(6):825–839. [PubMed] [Google Scholar]
- Prasthofer EF, Prchal JT, Grizzle WE, Grossi CE. Plasmacytoid T-cell lymphoma associated with chronic myeloproliferative disorder. Am J Surg Pathol. 1985 May;9(5):380–387. [PubMed] [Google Scholar]
- Horny HP, Feller AC, Horst HA, Lennert K. Immunocytology of plasmacytoid T cells: marker analysis indicates a unique phenotype of this enigmatic cell. Hum Pathol. 1987 Jan;18(1):28–32. [PubMed] [Google Scholar]
- Beiske K, Langholm R, Godal T, Marton PF. T-zone lymphoma with predominance of 'plasmacytoid T-cells' associated with myelomonocytic leukaemia--a distinct clinicopathological entity. J Pathol. 1986 Dec;150(4):247–255. [PubMed] [Google Scholar]
- Harris NL, Bhan AK. "Plasmacytoid T cells" in Castleman's disease. Immunohistologic phenotype. Am J Surg Pathol. 1987 Feb;11(2):109–113. [PubMed] [Google Scholar]
- Müller-Hermelink HK, Kaiserling E, Lennert K. Pseudofollikuläre Nester von Plasmazellen (eines besonderen Typs?) in der paracorticalen Pulpa menschlicher Lymphknoten. Virchows Arch B Cell Pathol. 1973;14(1):47–56. [PubMed] [Google Scholar]
- Beiske K, Munthe-Kaas A, Davies CD, Marton PF, Godal T. Single cell studies on the immunological marker profile of plasmacytoid T-zone cells. Lab Invest. 1987 Apr;56(4):381–393. [PubMed] [Google Scholar]
- Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981 Apr;29(4):577–580. [PubMed] [Google Scholar]
- Franklin WA, Mason DY, Pulford K, Falini B, Bliss E, Gatter KC, Stein H, Clarke LC, McGee JO. Immunohistological analysis of human mononuclear phagocytes and dendritic cells by using monoclonal antibodies. Lab Invest. 1986 Mar;54(3):322–335. [PubMed] [Google Scholar]
- Davey FR, Cordell JL, Erber WN, Pulford KA, Gatter KC, Mason DY. Monoclonal antibody (Y1/82A) with specificity towards peripheral blood monocytes and tissue macrophages. J Clin Pathol. 1988 Jul;41(7):753–758. [PMC free article] [PubMed] [Google Scholar]
- Parwaresch MR, Radzun HJ, Kreipe H, Hansmann ML, Barth J. Monocyte/macrophage-reactive monoclonal antibody Ki-M6 recognizes an intracytoplasmic antigen. Am J Pathol. 1986 Oct;125(1):141–151. [PMC free article] [PubMed] [Google Scholar]
- Kreipe H, Radzun HJ, Parwaresch MR, Haislip A, Hansmann ML. Ki-M7 monoclonal antibody specific for myelomonocytic cell lineage and macrophages in human. J Histochem Cytochem. 1987 Oct;35(10):1117–1126. [PubMed] [Google Scholar]
- Radzun HJ, Kreipe H, Bödewadt S, Hansmann ML, Barth J, Parwaresch MR. Ki-M8 monoclonal antibody reactive with an intracytoplasmic antigen of monocyte/macrophage lineage. Blood. 1987 May;69(5):1320–1327. [PubMed] [Google Scholar]
- Hsu SM, Ho YS, Li PJ, Monheit J, Ree HJ, Sheibani K, Winberg CD. L&H variants of Reed-Sternberg cells express sialylated Leu M1 antigen. Am J Pathol. 1986 Feb;122(2):199–203. [PMC free article] [PubMed] [Google Scholar]
- Flavell DJ, Jones DB, Wright DH. Identification of tissue histiocytes on paraffin sections by a new monoclonal antibody. J Histochem Cytochem. 1987 Nov;35(11):1217–1226. [PubMed] [Google Scholar]
- Adams TE, Bodmer JG, Bodmer WF. Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human ia alloantigens. Immunology. 1983 Dec;50(4):613–624. [PMC free article] [PubMed] [Google Scholar]
- Quaranta V, Majdic O, Stingl G, Liszka K, Honigsmann H, Knapp W. A human Ia cytoplasmic determinant located on multiple forms of invariant chain (gamma, gamma 2, gamma 3). J Immunol. 1984 Apr;132(4):1900–1905. [PubMed] [Google Scholar]
- Epstein AL, Marder RJ, Winter JN, Fox RI. Two new monoclonal antibodies (LN-1, LN-2) reactive in B5 formalin-fixed, paraffin-embedded tissues with follicular center and mantle zone human B lymphocytes and derived tumors. J Immunol. 1984 Aug;133(2):1028–1036. [PubMed] [Google Scholar]
- Okon E, Felder B, Epstein A, Lukes RJ, Taylor CR. Monoclonal antibodies reactive with B-lymphocytes and histiocytes in paraffin sections. Cancer. 1985 Jul 1;56(1):95–104. [PubMed] [Google Scholar]
- Poppema S, Hollema H, Visser L, Vos H. Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin-embedded tissue sections. Am J Pathol. 1987 Jun;127(3):418–429. [PMC free article] [PubMed] [Google Scholar]
- Rivano MT, Falini B, Stein H, Canino S, Ciani C, Gerdes J, Ribacchi R, Gobbi M, Pileri S. Histiocytic necrotizing lymphadenitis without granulocytic infiltration (Kikuchi's lymphadenitis). Morphological and immunohistochemical study of eight cases. Histopathology. 1987 Oct;11(10):1013–1027. [PubMed] [Google Scholar]
- Wood GS, Warner NL, Warnke RA. Anti-Leu-3/T4 antibodies react with cells of monocyte/macrophage and Langerhans lineage. J Immunol. 1983 Jul;131(1):212–216. [PubMed] [Google Scholar]
- Wood GS, Turner RR, Shiurba RA, Eng L, Warnke RA. Human dendritic cells and macrophages. In situ immunophenotypic definition of subsets that exhibit specific morphologic and microenvironmental characteristics. Am J Pathol. 1985 Apr;119(1):73–82. [PMC free article] [PubMed] [Google Scholar]
- Hsu SM, Yang K, Jaffe ES. Phenotypic expression of Hodgkin's and Reed-Sternberg cells in Hodgkin's disease. Am J Pathol. 1985 Feb;118(2):209–217. [PMC free article] [PubMed] [Google Scholar]
- Pileri S, Gerdes J, Rivano M, Tazzari PL, Magnani M, Gobbi M, Stein H. Immunohistochemical determination of growth fractions in human permanent cell lines and lymphoid tumours: a critical comparison of the monoclonal antibodies OKT9 and Ki-67. Br J Haematol. 1987 Mar;65(3):271–276. [PubMed] [Google Scholar]
- Thiele DL, Lipsky PE. Mononuclear phagocytes: phenotype and function. Surv Immunol Res. 1984;3(2-3):142–149. [PubMed] [Google Scholar]
- Cresswell P, Blum JS, Kelner DN, Marks MS. Biosynthesis and processing of class II histocompatibility antigens. Crit Rev Immunol. 1987;7(1):31–53. [PubMed] [Google Scholar]
- Shen HH, Talle MA, Goldstein G, Chess L. Functional subsets of human monocytes defined by monoclonal antibodies: a distinct subset of monocytes contains the cells capable of inducing the autologous mixed lymphocyte culture. J Immunol. 1983 Feb;130(2):698–705. [PubMed] [Google Scholar]
- Smolen JS, Chused TM, Novotny EA, Steinberg AD. The human autologous mixed lymphocyte reaction. III. Immune circuits. J Immunol. 1982 Sep;129(3):1050–1053. [PubMed] [Google Scholar]
Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology