Diversity in G + C content at the third position of codons in vertebrate genes and its cause. (original) (raw)

• Journal List
• Nucleic Acids Res
• v.14(16); 1986 Aug 26
• PMC311650

Nucleic Acids Res. 1986 Aug 26; 14(16): 6345–6355.

Abstract

Correlation was positive between the G + C content at the codon third position in genes of vertebrates and the G + C content of the genome portion surrounding each gene. Exons of genes with a high G + C% at the codon 3rd position are surrounded by G + C-rich introns and G + C-rich flanking sequences, and those with a low G + C% at the position by A + T-rich introns and flanking sequences. Analysis of G + C content distribution along DNA sequences using a DNA Sequence Data Bank supported the view that the vertebrate genome is a mosaic of regions with clear differences in their G + C content. The biological significance of the variation in G + C content throughout the vertebrate genome is discussed in connection with chromosomal banding.

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