Nuclear receptors are involved in the enhanced IL-6 production by melatonin in U937 cells - PubMed (original) (raw)
. 2000 May-Aug;9(3-4):197-202.
doi: 10.1159/000014639.
Affiliations
- PMID: 10899704
- DOI: 10.1159/000014639
Nuclear receptors are involved in the enhanced IL-6 production by melatonin in U937 cells
J M Guerrero et al. Biol Signals Recept. 2000 May-Aug.
Abstract
This report shows that melatonin enhances IL-6 production by U937 cells via a nuclear receptor-mediated mechanism. Resting U937 cells only express membrane (mt1) melatonin receptors. In these cells, melatonin did not modify basal production of IL-6 or when activated by PMA plus lipopolysaccharide, a treatment that downregulates the expression of mt1 receptor. However, in U937 cells activated with IFN-gamma, which induces the expression of the ROR alpha 1 and ROR alpha 2 nuclear receptors and represses the expression of the mt1 receptor, melatonin can activate IL-6 production. These results show that the expression of nuclear melatonin receptor but not membrane receptors is sufficient for melatonin to activate cytokine production in human lymphocytic and monocytic cell lines.
Copyright 2000 S. Karger AG, Basel
Similar articles
- Correlation between nuclear melatonin receptor expression and enhanced cytokine production in human lymphocytic and monocytic cell lines.
García-Mauriño S, Pozo D, Calvo JR, Guerrero JM. García-Mauriño S, et al. J Pineal Res. 2000 Oct;29(3):129-37. doi: 10.1034/j.1600-079x.2000.290301.x. J Pineal Res. 2000. PMID: 11034109 - The orphan receptor family RZR/ROR, melatonin and 5-lipoxygenase: an unexpected relationship.
Carlberg C, Wiesenberg I. Carlberg C, et al. J Pineal Res. 1995 May;18(4):171-8. doi: 10.1111/j.1600-079x.1995.tb00157.x. J Pineal Res. 1995. PMID: 8531047 Review. - Melatonin counteracts the inhibitory effect of PGE2 on IL-2 production in human lymphocytes via its mt1 membrane receptor.
Carrillo-Vico A, García-Mauriño S, Calvo JR, Guerrero JM. Carrillo-Vico A, et al. FASEB J. 2003 Apr;17(6):755-7. doi: 10.1096/fj.02-0501fje. Epub 2003 Feb 19. FASEB J. 2003. PMID: 12594180 - Involvement of nuclear receptors in the enhanced IL-2 production by melatonin in Jurkat cells.
Guerrero JM, Pozo D, García-Mauriño S, Osuna C, Molinero P, Calvo JR. Guerrero JM, et al. Ann N Y Acad Sci. 2000;917:397-403. doi: 10.1111/j.1749-6632.2000.tb05404.x. Ann N Y Acad Sci. 2000. PMID: 11268366 - Molecular pharmacology, regulation and function of mammalian melatonin receptors.
Dubocovich ML, Rivera-Bermudez MA, Gerdin MJ, Masana MI. Dubocovich ML, et al. Front Biosci. 2003 Sep 1;8:d1093-108. doi: 10.2741/1089. Front Biosci. 2003. PMID: 12957828 Review.
Cited by
- Melatonin membrane receptors in peripheral tissues: distribution and functions.
Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, Ostrom RS, Slominski AT. Slominski RM, et al. Mol Cell Endocrinol. 2012 Apr 4;351(2):152-66. doi: 10.1016/j.mce.2012.01.004. Epub 2012 Jan 8. Mol Cell Endocrinol. 2012. PMID: 22245784 Free PMC article. Review. - Melatonin: buffering the immune system.
Carrillo-Vico A, Lardone PJ, Alvarez-Sánchez N, Rodríguez-Rodríguez A, Guerrero JM. Carrillo-Vico A, et al. Int J Mol Sci. 2013 Apr 22;14(4):8638-83. doi: 10.3390/ijms14048638. Int J Mol Sci. 2013. PMID: 23609496 Free PMC article. Review. - Melatonin and Hippo Pathway: Is There Existing Cross-Talk?
Lo Sardo F, Muti P, Blandino G, Strano S. Lo Sardo F, et al. Int J Mol Sci. 2017 Sep 6;18(9):1913. doi: 10.3390/ijms18091913. Int J Mol Sci. 2017. PMID: 28878191 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Miscellaneous