(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells - PubMed (original) (raw)
. 2006 Nov 27;580(27):6302-10.
doi: 10.1016/j.febslet.2006.10.038. Epub 2006 Oct 27.
Affiliations
- PMID: 17083937
- DOI: 10.1016/j.febslet.2006.10.038
Free article
(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells
Fernando J Reyes et al. FEBS Lett. 2006.
Free article
Abstract
Triterpenoids are known to induce apoptosis and to be anti-tumoural. Maslinic acid, a pentacyclic triterpene, is present in high concentrations in olive pomace. This study examines the response of HT29 and Caco-2 colon-cancer cell lines to maslinic-acid treatment. At concentrations inhibiting cell growth by 50-80% (IC50HT29=61+/-1 microM, IC80HT29=76+/-1 microM and IC50Caco-2=85+/-5 microM, IC80Caco-2=116+/-5 microM), maslinic acid induced strong G0/G1 cell-cycle arrest and DNA fragmentation, and increased caspase-3 activity. However, maslinic acid did not alter the cell cycle or induce apoptosis in the non-tumoural intestine cell lines IEC-6 and IEC-18. Moreover, maslinic acid induced cell differentiation in colon adenocarcinoma cells. These findings support a role for maslinic acid as a tumour suppressant and as a possible new therapeutic tool for aberrant cell proliferation in the colon. In this report, we demonstrate for the first time that, in tumoural cancer cells, maslinic acid exerts a significant anti-proliferation effect by inducing an apoptotic process characterized by caspase-3 activation by a p53-independent mechanism, which occurs via mitochondrial disturbances and cytochrome c release.
Similar articles
- Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway.
Reyes-Zurita FJ, Rufino-Palomares EE, Lupiáñez JA, Cascante M. Reyes-Zurita FJ, et al. Cancer Lett. 2009 Jan 8;273(1):44-54. doi: 10.1016/j.canlet.2008.07.033. Epub 2008 Sep 14. Cancer Lett. 2009. PMID: 18790561 - Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells.
Juan ME, Planas JM, Ruiz-Gutierrez V, Daniel H, Wenzel U. Juan ME, et al. Br J Nutr. 2008 Jul;100(1):36-43. doi: 10.1017/S0007114508882979. Epub 2008 Feb 26. Br J Nutr. 2008. PMID: 18298868 - Novel triterpenoid 25-hydroxy-3-oxoolean-12-en-28-oic acid induces growth arrest and apoptosis in breast cancer cells.
Rabi T, Wang L, Banerjee S. Rabi T, et al. Breast Cancer Res Treat. 2007 Jan;101(1):27-36. doi: 10.1007/s10549-006-9275-z. Breast Cancer Res Treat. 2007. PMID: 17028990 - Maslinic acid as an effective anticancer agent.
Lin X, Ozbey U, Sabitaliyevich UY, Attar R, Ozcelik B, Zhang Y, Guo M, Liu M, Alhewairini SS, Farooqi AA. Lin X, et al. Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):87-91. Cell Mol Biol (Noisy-le-grand). 2018. PMID: 30084808 Review. - Maslinic acid, a natural phytoalexin-type triterpene from olives--a promising nutraceutical?
Lozano-Mena G, Sánchez-González M, Juan ME, Planas JM. Lozano-Mena G, et al. Molecules. 2014 Aug 4;19(8):11538-59. doi: 10.3390/molecules190811538. Molecules. 2014. PMID: 25093990 Free PMC article. Review.
Cited by
- Synthesis of Tricyclic Pterolobirin H Analogue: Evaluation of Anticancer and Anti-Inflammatory Activities and Molecular Docking Investigations.
Zentar H, Jannus F, Medina-O'Donnell M, El Mansouri AE, Fernández A, Justicia J, Alvarez-Manzaneda E, Reyes-Zurita FJ, Chahboun R. Zentar H, et al. Molecules. 2023 Aug 23;28(17):6208. doi: 10.3390/molecules28176208. Molecules. 2023. PMID: 37687037 Free PMC article. - Maslinic Acid: A New Compound for the Treatment of Multiple Organ Diseases.
He Y, Wang Y, Yang K, Jiao J, Zhan H, Yang Y, Lv D, Li W, Ding W. He Y, et al. Molecules. 2022 Dec 9;27(24):8732. doi: 10.3390/molecules27248732. Molecules. 2022. PMID: 36557864 Free PMC article. Review. - Semisynthesis and Evaluation of Anti-Inflammatory Activity of the Cassane-Type Diterpenoid Taepeenin F and of Some Synthetic Intermediates.
Zentar H, Jannus F, Gutierrez P, Medina-O'Donnell M, Lupiáñez JA, Reyes-Zurita FJ, Alvarez-Manzaneda E, Chahboun R. Zentar H, et al. J Nat Prod. 2022 Oct 28;85(10):2372-2384. doi: 10.1021/acs.jnatprod.2c00578. Epub 2022 Oct 10. J Nat Prod. 2022. PMID: 36215157 Free PMC article. Review. - Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity.
Parra-Perez AM, Pérez-Jiménez A, Gris-Cárdenas I, Bonel-Pérez GC, Carrasco-Díaz LM, Mokhtari K, García-Salguero L, Lupiáñez JA, Rufino-Palomares EE. Parra-Perez AM, et al. Int J Mol Sci. 2022 Jun 24;23(13):7053. doi: 10.3390/ijms23137053. Int J Mol Sci. 2022. PMID: 35806065 Free PMC article. - Biological Effects of Maslinic Acid on Human Epithelial Cells Used in Tissue Engineering.
Ortiz-Arrabal O, Chato-Astrain J, Crespo PV, Garzón I, Mesa-García MD, Alaminos M, Gómez-Llorente C. Ortiz-Arrabal O, et al. Front Bioeng Biotechnol. 2022 Apr 27;10:876734. doi: 10.3389/fbioe.2022.876734. eCollection 2022. Front Bioeng Biotechnol. 2022. PMID: 35662841 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous