Associations between vitamin D receptor polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis - PubMed (original) (raw)
Meta-Analysis
doi: 10.1002/ibd.22966.
Affiliations
- PMID: 22467262
- DOI: 10.1002/ibd.22966
Meta-Analysis
Associations between vitamin D receptor polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis
Le-Ning Xue et al. Inflamm Bowel Dis. 2013 Jan.
Abstract
Background: Several polymorphisms have been identified in the vitamin D receptor (VDR) gene, while their roles in the incidence of ulcerative colitis (UC) and Crohn's disease (CD) are conflicting. This meta-analysis was designed to clarify the impact of these polymorphisms on UC and CD risk.
Methods: The PubMed, Embase, and Cochrane electronic databases were searched from February 1995 to August 2011 for studies on the four VDR polymorphisms: TaqI, BsmI, FokI, and ApaI. Data were extracted and pooled odd ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.
Results: Nine studies were included. In Asians, the ff genotype of FokI was associated with increased UC risk (OR = 1.65; 95% CI, 1.11- 2.45). The "a" allele carrier status of ApaI appeared to be a protective factor for CD (OR = 0.81; 95% CI, 0.67-0.97). The tt genotype increased the risk of CD in Europeans (OR = 1.23; 95% CI, 1.02-1.49). Moreover, the tt genotype of TaqI in males had a moderate elevated risk of UC (OR = 1.56; 95% CI, 1.02-2.39) and CD (OR = 1.84; 95% CI, 1.19-2.83).
Conclusions: The meta-analysis reveals a significant increase in CD risk for Europeans carrying TaqI tt genotype and a significant decrease in CD risk for all carriers of the Apal "a" allele. For Asians, the VDR FokI polymorphism appears to confer susceptibility to UC. For males, the TaqI tt genotype is associated with susceptibilities to both UC and CD. Our study explored the genetic risk prediction in UC and CD, and may provide valuable insights into IBD therapy.
Similar articles
- Association of vitamin D receptor gene polymorphisms with the susceptibility to ulcerative colitis in patients from Southeast China.
Xia SL, Yu LQ, Chen H, Hu DY, Shao XX, Guo MD, Jiang LJ, Lin XX, Lin XQ, Jiang Y. Xia SL, et al. J Recept Signal Transduct Res. 2015;35(6):530-5. doi: 10.3109/10799893.2014.975248. Epub 2014 Oct 27. J Recept Signal Transduct Res. 2015. PMID: 25347331 - Polymorphisms of the vitamin D receptor gene and the risk of inflammatory bowel disease: a meta-analysis.
Wang L, Wang ZT, Hu JJ, Fan R, Zhou J, Zhong J. Wang L, et al. Genet Mol Res. 2014 Apr 8;13(2):2598-610. doi: 10.4238/2014.April.8.2. Genet Mol Res. 2014. PMID: 24782048 - Association between vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus: a meta-analysis.
Mao S, Huang S. Mao S, et al. Rheumatol Int. 2014 Mar;34(3):381-8. doi: 10.1007/s00296-013-2898-6. Epub 2013 Nov 9. Rheumatol Int. 2014. PMID: 24212677 - Association between vitamin D receptor polymorphisms and hepatitis B virus infection susceptibility: A meta-analysis study.
He Q, Huang Y, Zhang L, Yan Y, Liu J, Song X, Chen W. He Q, et al. Gene. 2018 Mar 1;645:105-112. doi: 10.1016/j.gene.2017.12.027. Epub 2017 Dec 14. Gene. 2018. PMID: 29248582 Review. - Associations between CD24 gene polymorphisms and inflammatory bowel disease: A meta-analysis.
Huang XL, Xu DH, Wang GP, Zhang S, Yu CG. Huang XL, et al. World J Gastroenterol. 2015 May 21;21(19):6052-9. doi: 10.3748/wjg.v21.i19.6052. World J Gastroenterol. 2015. PMID: 26019472 Free PMC article. Review.
Cited by
- The Role of Vitamin D and Vitamin D Receptor Gene Polymorphisms in the Course of Inflammatory Bowel Disease in Children.
Śledzińska K, Kloska A, Jakóbkiewicz-Banecka J, Landowski P, Oppmann A, Wilczynski S, Zagierska A, Kamińska B, Żmijewski MA, Liberek A. Śledzińska K, et al. Nutrients. 2024 Jul 13;16(14):2261. doi: 10.3390/nu16142261. Nutrients. 2024. PMID: 39064704 Free PMC article. - Correlation between Polymorphisms of Vitamin D Metabolism Genes and Perianal Disease in Crohn's Disease.
Cusato J, Cafasso C, Antonucci M, Palermiti A, Manca A, Caviglia GP, Vernero M, Armandi A, Saracco GM, D'Avolio A, Ribaldone DG. Cusato J, et al. Biomedicines. 2024 Jan 30;12(2):320. doi: 10.3390/biomedicines12020320. Biomedicines. 2024. PMID: 38397922 Free PMC article. - The Role of Vitamin D in Patients with Inflammatory Bowel Disease Treated with Vedolizumab.
Abraham BP, Fan C, Thurston T, Moskow J, Malaty HM. Abraham BP, et al. Nutrients. 2023 Nov 20;15(22):4847. doi: 10.3390/nu15224847. Nutrients. 2023. PMID: 38004241 Free PMC article. - Genotype Prevalence of Lactose Deficiency, Vitamin D Deficiency, and the Vitamin D Receptor in a Chilean Inflammatory Bowel Disease Cohort: Insights from an Observational Study.
Pérez-Jeldres T, Bustamante ML, Segovia-Melero R, Aguilar N, Magne F, Ascui G, Uribe D, Azócar L, Hernández-Rocha C, Estela R, Silva V, De La Vega A, Arriagada E, Gonzalez M, Onetto GF, Escobar S, Baez P, Zazueta A, Pavez-Ovalle C, Miquel JF, Álvarez-Lobos M. Pérez-Jeldres T, et al. Int J Mol Sci. 2023 Oct 3;24(19):14866. doi: 10.3390/ijms241914866. Int J Mol Sci. 2023. PMID: 37834314 Free PMC article. - Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity.
Su X, Gao Y, Yang R. Su X, et al. Front Immunol. 2023 May 15;14:1127743. doi: 10.3389/fimmu.2023.1127743. eCollection 2023. Front Immunol. 2023. PMID: 37256134 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical