Associations Between Vitamin D Receptor Polymorphisms and Susceptibility to Ulcerative Colitis and Crohn's Disease: A Meta-analysis (original) (raw)

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*Department of Gastroenterology

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*Department of Gastroenterology

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*Department of Gastroenterology

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*Department of Gastroenterology

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†Department of Gynecology, Changzhou No. 2 Hospital, Affiliated with Nanjing Medical University, Changzhou City, Jiangsu Province, China.

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*Department of Gastroenterology

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25 February 2012

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Le-Ning Xue, Ke-Qun Xu, Wei Zhang, Qiang Wang, Jia Wu, Xiao-Yong Wang, Associations Between Vitamin D Receptor Polymorphisms and Susceptibility to Ulcerative Colitis and Crohn's Disease: A Meta-analysis, Inflammatory Bowel Diseases, Volume 19, Issue 1, 1 January 2013, Pages 54–60, https://doi.org/10.1002/ibd.22966
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Background

Several polymorphisms have been identified in the vitamin D receptor (VDR) gene, while their roles in the incidence of ulcerative colitis (UC) and Crohn's disease (CD) are conflicting. This meta-analysis was designed to clarify the impact of these polymorphisms on UC and CD risk.

Methods

The PubMed, Embase, and Cochrane electronic databases were searched from February 1995 to August 2011 for studies on the four VDR polymorphisms: TaqI, BsmI, FokI, and ApaI. Data were extracted and pooled odd ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.

Results

Nine studies were included. In Asians, the ff genotype of FokI was associated with increased UC risk (OR = 1.65; 95% CI, 1.11– 2.45). The “a” allele carrier status of ApaI appeared to be a protective factor for CD (OR = 0.81; 95% CI, 0.67–0.97). The tt genotype increased the risk of CD in Europeans (OR = 1.23; 95% CI, 1.02–1.49). Moreover, the tt genotype of TaqI in males had a moderate elevated risk of UC (OR = 1.56; 95% CI, 1.02–2.39) and CD (OR = 1.84; 95% CI, 1.19–2.83).

Conclusions

The meta-analysis reveals a significant increase in CD risk for Europeans carrying TaqI tt genotype and a significant decrease in CD risk for all carriers of the Apal “a” allele. For Asians, the VDR FokI polymorphism appears to confer susceptibility to UC. For males, the TaqI tt genotype is associated with susceptibilities to both UC and CD. Our study explored the genetic risk prediction in UC and CD, and may provide valuable insights into IBD therapy.

Copyright © 2013 Crohn's & Colitis Foundation of America, Inc.

Topic:

• polymorphism
• crohn's disease
• inflammatory bowel disease
• ulcerative colitis
• genotype
• vitamin d3 receptor

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