Melatonin signaling in T cells: Functions and applications - PubMed (original) (raw)
Review
doi: 10.1111/jpi.12394. Epub 2017 Mar 1.
Wenkai Ren 1 2 3, Shuai Chen 1, Jie Yin 1, Jing Wang 1, Bie Tan 1, Guoyao Wu 4, Fuller W Bazer 4, Yuanyi Peng 5, Tiejun Li 1 6, Russel J Reiter 7, Yulong Yin 1 2 8
Affiliations
- PMID: 28152213
- DOI: 10.1111/jpi.12394
Review
Melatonin signaling in T cells: Functions and applications
Wenkai Ren et al. J Pineal Res. 2017 Apr.
Abstract
Melatonin affects a variety of physiological processes including circadian rhythms, cellular redox status, and immune function. Importantly, melatonin significantly influences T-cell-mediated immune responses, which are crucial to protect mammals against cancers and infections, but are associated with pathogenesis of many autoimmune diseases. This review focuses on our current understanding of the significance of melatonin in T-cell biology and the beneficial effects of melatonin in T-cell response-based diseases. In addition to expressing both membrane and nuclear receptors for melatonin, T cells have the four enzymes required for the synthesis of melatonin and produce high levels of melatonin. Meanwhile, melatonin is highly effective in modulating T-cell activation and differentiation, especially for Th17 and Treg cells, and also memory T cells. Mechanistically, the influence of melatonin in T-cell biology is associated with membrane and nuclear receptors as well as receptor-independent pathways, for example, via calcineurin. Several cell signaling pathways, including ERK1/2-C/EBPα, are involved in the regulatory roles of melatonin in T-cell biology. Through modulation in T-cell responses, melatonin exerts beneficial effects in various inflammatory diseases, such as type 1 diabetes, systemic lupus erythematosus, and multiple sclerosis. These findings highlight the importance of melatonin signaling in T-cell fate determination, and T cell-based immune pathologies.
Keywords: T cells; Th17 cells; Treg cells; melatonin; multiple sclerosis; systemic lupus erythematosus.
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Similar articles
- Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses.
Farez MF, Mascanfroni ID, Méndez-Huergo SP, Yeste A, Murugaiyan G, Garo LP, Balbuena Aguirre ME, Patel B, Ysrraelit MC, Zhu C, Kuchroo VK, Rabinovich GA, Quintana FJ, Correale J. Farez MF, et al. Cell. 2015 Sep 10;162(6):1338-52. doi: 10.1016/j.cell.2015.08.025. Cell. 2015. PMID: 26359987 Free PMC article. - The roles of Egr-2 in autoimmune diseases.
Zhang M, Wang Y, Wang JS, Liu J, Liu MM, Yang HB. Zhang M, et al. Inflammation. 2015;38(3):972-7. doi: 10.1007/s10753-014-0059-z. Inflammation. 2015. PMID: 25381473 - Regulation of T Cell Activation and Differentiation by Extracellular Vesicles and Their Pathogenic Role in Systemic Lupus Erythematosus and Multiple Sclerosis.
Ulivieri C, Baldari CT. Ulivieri C, et al. Molecules. 2017 Feb 2;22(2):225. doi: 10.3390/molecules22020225. Molecules. 2017. PMID: 28157168 Free PMC article. Review. - Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms.
Jamshidian A, Shaygannejad V, Pourazar A, Zarkesh-Esfahani SH, Gharagozloo M. Jamshidian A, et al. J Neuroimmunol. 2013 Sep 15;262(1-2):106-12. doi: 10.1016/j.jneuroim.2013.06.007. Epub 2013 Jul 9. J Neuroimmunol. 2013. PMID: 23845464 - Recovery of the immune balance between Th17 and regulatory T cells as a treatment for systemic lupus erythematosus.
Yang J, Yang X, Zou H, Chu Y, Li M. Yang J, et al. Rheumatology (Oxford). 2011 Aug;50(8):1366-72. doi: 10.1093/rheumatology/ker116. Epub 2011 Apr 12. Rheumatology (Oxford). 2011. PMID: 21489974 Review.
Cited by
- Melatonin's Impact on Wound Healing.
Sohn EH, Kim SN, Lee SR. Sohn EH, et al. Antioxidants (Basel). 2024 Oct 2;13(10):1197. doi: 10.3390/antiox13101197. Antioxidants (Basel). 2024. PMID: 39456451 Free PMC article. Review. - The Effect of Light Exposure at Night (LAN) on Carcinogenesis via Decreased Nocturnal Melatonin Synthesis.
Giudice A, Crispo A, Grimaldi M, Polo A, Bimonte S, Capunzo M, Amore A, D'Arena G, Cerino P, Budillon A, Botti G, Costantini S, Montella M. Giudice A, et al. Molecules. 2018 May 29;23(6):1308. doi: 10.3390/molecules23061308. Molecules. 2018. PMID: 29844288 Free PMC article. Review. - Amino Acids As Mediators of Metabolic Cross Talk between Host and Pathogen.
Ren W, Rajendran R, Zhao Y, Tan B, Wu G, Bazer FW, Zhu G, Peng Y, Huang X, Deng J, Yin Y. Ren W, et al. Front Immunol. 2018 Feb 27;9:319. doi: 10.3389/fimmu.2018.00319. eCollection 2018. Front Immunol. 2018. PMID: 29535717 Free PMC article. Review. - Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury.
Zhang Y, Lang R, Guo S, Luo X, Li H, Liu C, Dong W, Bao C, Yu Y. Zhang Y, et al. Front Neurosci. 2022 Nov 9;16:981772. doi: 10.3389/fnins.2022.981772. eCollection 2022. Front Neurosci. 2022. PMID: 36440294 Free PMC article. Review. - Bacteriostatic Potential of Melatonin: Therapeutic Standing and Mechanistic Insights.
He F, Wu X, Zhang Q, Li Y, Ye Y, Li P, Chen S, Peng Y, Hardeland R, Xia Y. He F, et al. Front Immunol. 2021 May 31;12:683879. doi: 10.3389/fimmu.2021.683879. eCollection 2021. Front Immunol. 2021. PMID: 34135911 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous