Differences in platelet-related parameters among patients with audiographically distinct sudden sensorineural hearing loss: A retrospective study - PubMed (original) (raw)

Yuanyuan Sun et al. Medicine (Baltimore). 2017 Sep.

Abstract

We explored possible relationships between sudden sensorineural hearing loss (SSNHL) in patients differing in terms of audiographic data and the levels of vascular markers in routine blood data.We included 37 patients with low-frequency SSNHL (LF-SSNHL), 28 with high-frequency SSNHL (HF-SSNHL), 32 with all-frequency SSNHL (AF-SSNHL), 32 with total-deafness SSNHL (TD-SSNHL), and 31 age- and sex-matched healthy controls. Peripheral venous blood samples were collected, and routine blood parameters including platelet and lymphocyte count, mean platelet volume (MPV), and platelet-to-lymphocyte ratio (PLR) were measured. Each group was divided into recovery subgroup and unrecovery subgroup in accordance with hearing level after 1 month therapy, then compared the difference of platelet and lymphocyte count, MPV, and PLR between the 2 subgroups.No significant difference was observed between platelet count of all SSNHL patients and control group (all P > .05). MPV of AF-SSNHL and TD-SSNHL, PLR of all SSNHL patients were significantly higher than those of control group (all P < .05), while lymphocyte count of all audiographically distinct SSNHL patients was significantly lower than that of control group (all P < .05). However, the difference of platelet count, lymphocyte count, MPV, and PLR among audiographically distinct SSNHL patients was not significant (all P > .05). In HF-SSNHL patients, lymphocyte count of unrecovery subgroup was significantly lower, while MPV and PLR of the unrecovery subgroup were significantly higher than those of recovery subgroup (all P < .05). In AF-SSNHL patients, MPV of the unrecovery group was significantly higher than that of recovery subgroup (P < .05).Lymphocyte count, MPV, and PLR may be relative to SSSNHL, but they could not be used to distinct SSNHL audiographically. Lower lymphocyte, higher MPV, and PLR may be indicative for the prognosis of HF-SSNHL patients; higher MPV may be related to bad treatment outcome of AF-SSNHL patients.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1

Figure 1

The difference of platelet, lymphocyte, MPV, and PLR between SSNHL groups and control group. AF-SSNHL = all-frequency SSNHL, HF-SSNHL = high-frequency SSNHL, LF-SSNHL = low-frequency SSNHL, MPV = mean platelet volume, PLR = platelet to lymphocyte ratio, SSNHL = sudden sensorineural hearing loss, TD-SSNHL = total deafness SSNHL. ∗Meant significant difference between 2 groups (P < .05). The error bars indicate standard errors.

Similar articles

Cited by

References

    1. Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association. [Guideline of diagnosis and treatment of sudden deafness (2015)]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2015;50:443–7. - PubMed
    1. Nosrati-Zarenoe R, Arlinger S, Hultcrantz E. Idiopathic sudden sensorineural hearing loss: results drawn from the Swedish national database. Acta Otolaryngol 2007;127:1168–75. - PubMed
    1. Karli R, Alacam H, Unal R, et al. Mean platelet volume: is it a predictive parameter in the diagnosis of sudden sensorineural hearing loss? Indian J Otolaryngol Head Neck Surg 2013;65:350–3. - PMC - PubMed
    1. Michel O. Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. [The revised version of the german guidelines “sudden idiopathic sensorineural hearing loss”]. Laryngorhinootologie 2011;90:290–3. - PubMed
    1. Balta S, Demirkol S, Fau-Kucuk U, et al. The platelet lymphocyte ratio may be useful inflammatory indicator in clinical. Hemodial Int 2013;17:668–9. - PubMed

MeSH terms

Substances

LinkOut - more resources