Yavuz Osman Birdane | Afyon Kocatepe University (original) (raw)

Papers by Yavuz Osman Birdane

Kocatepe Veterinary Journal, Dec 19, 2023

World Journal of Gastroenterology, 2007

Kocatepe veteriner dergisi, Dec 22, 2014

Drug and Chemical Toxicology, Dec 21, 2022

Kocatepe Veterinary Journal, 2018

Biopharmaceutics Applications in Drug Development, 2008

For systemically acting drugs, absorption is a prerequisite for therapeutic activity when drugs a... more For systemically acting drugs, absorption is a prerequisite for therapeutic activity when drugs are administered extravascularly. Factors affecting drug absorption have been discussed in previous chapters. This chapter will cover general methods to evaluate bioavailability and bioequivalence. Scientific principles as well as regulatory perspectives related to these two topics will be discussed. Historically, the development of sensitive and precise bioanalytical methods in the 1960s and 1970s allowed for the first time the measurement of very low levels of drug concentrations in biological fluids. As a result, pharmacokinetic profiles of drugs, describing absorption, distribution, and clearance, could be determined. Regulations related to bioavailability and bioequivalence were put into place, considering the latest advances in the science. Currently, bioavailability and bioequivalence play a significant role in the discovery, development, and regulation of new drug products. Additionally, bioequivalence studies are a crucial component of abbreviated new drug applications (ANDAs), leading to market access of safe, effective, and low cost generic drugs.

Veterinarni Medicina, Jun 30, 2015

Journal of Veterinary Pharmacology and Therapeutics, 2010

Florfenicol, a fluorinated derivative of thiamphenicol, is a broadspectrum antibiotic used in vet... more Florfenicol, a fluorinated derivative of thiamphenicol, is a broadspectrum antibiotic used in veterinary medicine belonging to the family of agents that includes chloramphenicol and thiamphenicol (Graham et al., 1988; Cannon et al., 1990). Florfenicol is effective against most fish-pathogenic bacteria including Photobacterium damsela (subsp. Piscicida), Vibrio anguillarum, Aeromonas hydrophila, Aeromonas salmonicida, Edwardsiella ictalur, and Edwardsiella tarda (McGinnis et al., 2003). These common pathogens causing the most economically serious diseases in olive flounder are Edwardsiella tarda, Flexibacter maritimus, Vibrio spp. (V. anguillarum, V. ichthyoenteri), and streptococcus spp. (S. iniae, S. parauberis, Lactococcus garvieae) as similar in other marine fish species (NFRDI, 2006). Florfenicol has been demonstrated to be effective in the treatment of various fish diseases in yellowtail fish (Yasunaga & Yasumoto, 1988), channel catfish (McGinnis et al., 2003), goldfish (Fukui et al., 1987), and Atlantic salmon (Inglis et al., 1991). Because florfenicol has been proven to be clinically effective in controlling fish pathogens in fish, it has been approved for use in Europe, Norway, Canada, Japan, China, and South Korea for a variety of fish species (Gaunt et al., 2003) Its pharmacokinetic profile have also been described for

Beneficial effects of Foeniculum vulgare on ethanol-induced acute gastric mucosal injury in rats

Indian Veterinary Journal, 2009

ABSTRACT Human exposure to aflatoxin B 1 (AFB 1) can arise from direct consumption of contaminate... more ABSTRACT Human exposure to aflatoxin B 1 (AFB 1) can arise from direct consumption of contaminated commodites like milk of farm anmals previously exposed to AFB 1 in their feed. (Concon, 1989). Aflatoxin M, (AFM 1) is relatively stable in raw and processed milk products, and is unaffected by pasteurization or processing into cheese. Thus, if raw milk contains AFM 1 , cheese made from such milk will also contain AFM 1 (Barbieri et al., 1994; Sarimehmetoglu et al,. 2004). Taking this into account, this study was initiated to investigate the presence of AFM 1 in various types of cheese samples consumed in Afyonkarahisar, Turkey. A total of 242 cheese samples (167 Turkish white cheese, 75 kashar cheese) were collected from Afyonkarahisar retail market and analysed for AFM 1 with the competitive ELISA using with specific antibody coated microtiter strips purchased from R-Biopharm GmbH. The samples were analysed between March 2005 and July 2005 in Afyonkarahisar, Turkey. The mean values of the absorbance were obtained for the standards, and the samples were evaluated according to standard Ridawin.exe program prepared by R-Bioparm. Results and Discussion In 36 positive cheese samples (14.9%), the AFM1 levels were higher than the limits of the Turkish Food Codex (250 ng/kg for cheese; Anon, 1997). On the other hand, 145 Turkish white cheese (86.8%) and 66 kashar cheese (88%) contained AFM 1 at variable levels. It was found that 11.97% of Turkish white cheese, 21.3% and of Kashar cheese have higher AFM 1 levels than the acceptable levels (&gt; 250 mg/kg) of the Turkish Food Codex. In many studies, the level of contamination of cheese by AFM 1 seems to vary. Seyrek (2001) reported of 110 cheese samples, 5.51 of the samples had greater levels of AFM 1 than the permissible levels. Oruc and Sonal (2001) determined AFM 1 levels in milk and cheese from Bursa, Turkey and found AFM 1 in 89.5% of cheese samples (0-810 ng/kg). Dagoglu et al., (1995) analysed 75 Turkish white cheese samplse and found a 42% incidence of AFM 1 . In the present study, 88% of kashar cheeses (66 samples) and 86.8% of Turkish white cheeses (145 samples) were AFM 1 Aflatoxin M 1 in Cheese positive, and AFM 1 concentrations exceeded in 21.3% of kashar cheese (16 samples) as well as 11.97% of Turkish white cheeses (20 samples) the Turkish legal limis of 250ng/kg. The number of the samples in which the aflatoxin contamination exceeds the legal limit was similar to the other reports made on this subject around the world (Barbieri et al., 1994; Trucksess and Page, 1986). Such a high contamination probably caused by only a few contaminated milk samples entering the bulk milk supply. In conclusion, it may be stated that more emphasis should be given to the routine AFM 1 inspection of milk and dairy products in Turkey.

Florfenikol; tiamfenikol ve kloramfenikole direncli enterik bakterileri de icine alan genis spekt... more Florfenikol; tiamfenikol ve kloramfenikole direncli enterik bakterileri de icine alan genis spektrumlu ve tiamfenikolun tek florlu yapisal analogudur. Bu arastirmada 30 mg/kg tek doz IV yol ile uygulanan florfenikolun koyunlardaki farmakokinetik parametreleri belirlendi. Florfenikolun plazmadaki konsantrasyonlari, UV detektoru bulunan, dalga boyu 223 nm olan yuksek performansli likit kromatografi (HPLC) de belirlendi. Ilac uygulamasini takiben 5., 10., 15., 20., 30., 45. dakikalar ile 1., 1.5, 2., 3., 4., 6., 8., 10., 12., 14., 18., 24., 30. saatlerde kan ornekleri alindi. IV uygulamadan sonra HPLC tarafindan belirlenen plazmadaki ilac konsantrasyonlarindan elde edilen plazma-zaman konsantrasyon verileri iki kompartmanli modele gore degerlendirildi. IV uygulama yolu ile 30 mg/kg uygulanan florfenikolun farmakokinetik parametreleri ise eliminasyon yarilama omru (t½) 3.34±0.25 saat, ortalama kanda kalis zamani (MRT) 3.68±0.07 saat, denge halindeki dagilim hacmi (Vdss) 0.97±0.07 kg/l,...

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2003

Effects of amikacin, gentamicin, kanamycin, and streptomycin on renal tissue superoxide dismutase... more Effects of amikacin, gentamicin, kanamycin, and streptomycin on renal tissue superoxide dismutase, glutathione peroxidase, glutathione and malondialdehyde, serum creatinine, potassium, sodium, total protein, glucose, uric acid, and total bilirubin levels were investigated. All aminoglycoside antibiotics decreased renal tissue glutathione levels.

Bulletin of The Veterinary Institute in Pulawy, 2006

The present study was aimed to analyse the presence and levels of aflatoxin M1 (AFM1), in 177 yog... more The present study was aimed to analyse the presence and levels of aflatoxin M1 (AFM1), in 177 yogurt samples consisting of 104 samples of ordinary yogurt, 21 of fruit yogurt, and 52 of strained (Torba) yogurt. The competitive ELISA method was used to determine the aflatoxin. The highest AFM1 concentration was 150 ng/kg in strained yogurt, 100 ng/kg in ordinary yogurt as well as in fruit yogurt. The incidence of AFM1 contamination in yogurt samples were 65.38% (68 samples) of all ordinary yogurt samples, 33.33% (7 samples) of all fruit yogurt samples, and 55.77% (29 samples) of all strained yogurt samples. In addition, 11.53% of ordinary yogurt (12 samples), 9.52% of fruit yogurt (2 samples), and 21.15% of strained yogurt (11 samples) had higher AFM1 levels, than the acceptable levels for the Turkish Food Codex (50 ng/kg for yogurt). The results of this study imply that more emphasis should be given to the routine AFM1 inspection of milk and dairy products in the Afyonkarahisar regio...

85 OZET Gunumuzde teknolojik ilerlemelere paralel olarak ilac endustrisinde de gelismeler artarak... more 85 OZET Gunumuzde teknolojik ilerlemelere paralel olarak ilac endustrisinde de gelismeler artarak devam etmektedir. Ilac firmalari piyasada fazla satilan ilac urunlerini, farkli isimler altinda uretip, ruhsatlandirip, satisa sunmaktadir. Boylece piyasada, ayni etkin maddeyi ayni miktarlarda iceren benzer mustahzarlarin sayisi da hizla artmaktadir. Ayni etkin maddeleri ayni oranda iceren benzer mustehzarlarin birbirlerinin muadili olabilmeleri icin farmasotik olarak biyoesdeger olmalari gerekir. Ilac tanimi geregi, etkin, guvenli, uygun ve kabul edilebilir maliyette olmalidir. Ilacla yapilacak sagaltim uygulamalarinda basariyi etkileyen en onemli faktorlerden biri de ilacin biyoyararlanimi yani, uygulama yerinden hedef bolgeye ulasabilen miktaridir. Sistemik etkili ilaclardan beklenen terapotik cevabin elde edilip edilemeyecegi biyoyararlanim calismalari ile saptanir. Dolayisiyla da ilaclara uretim ve satis iznini veren saglik otoriteleri jenerik ilaclarin orijinal ilaclara biyoesdeg...