Dr. maya kushwaha | Barkatullah University, Bhopal, India (original) (raw)

Papers by Dr. maya kushwaha

Cancer is the second leading cause of death globally. Cassia fistula (CF), a member of Leguminosa... more Cancer is the second leading cause of death globally. Cassia fistula (CF), a member of Leguminosae family, is Native to India, Amazon and Sri Lanka, is widely used for its medicinal properties in Indian system of medicine for various ailment from the ancient time. The present investigation was undertaken to investigate the anticarcinogenic action of Cassia fistula L. extract on 2-stage skin carcinogenesis model in Swiss albino mice. The papilloma were produced on mice skin by DMBA and promoted by croton oil and one weeks later, promoted by repeated application of croton oil (1% in acetone/twice in a week) till the end of the experiment (16 weeks). After 16 weeks at the time of termination of the experiment estimation of GSH from the liver and blood tissue of the animals were also done by the method of Beutler et. al. (1963). the outcomes of the papilloma study and GSH estimation was correlated and it was found to be preventive for the formation as well as persistence of papilloma. 21 no. of papilloma were found in CF treated mice as compared to (35) untreated control mice. Our results suggest that Cassia fistula can be a cost effective future herbal alternative medicine for cancer treatment.

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The present study is an attempt to understand the effect of low temperature and presoaking with c... more The present study is an attempt to understand the effect of low temperature and presoaking with cyanobacterial extract on the seed germination of three important crop plants. Exposure of the seeds to low temperature treatment of 10 o C for 5 days under laboratory conditions before potting the plants greatly stimulated the growth rates measured in terms of parameters like shoot and root length, number of leaves, Chlorophyll a and b content of leaves. These values`were greater than plants which were exposed to 25 o C before potting. Addition of cyanobacterial culture to germinating seeds instead of water further enhanced the germination rate obtained with low temperature and this stimulatory effect was maintained in the potted plants. These results point to stratification/vernalization being involved in germination process. Stimulation of the germination with addition of cyanobacterial cultures emphasizes their hormonal role, as these organisms are known to liberate bioactive compounds into their growth medium which are very similar to plant growth hormones. Pretreatment with low temperature and cyanobacterial addition may be key to shortening the life cycle of these important crops and prove to be a very efficient way of managing crops to produce better and faster and therefore of great agricultural importance. Introduction Agriculture in India has a long history dating back to ten thousand years. High yields from crops and good quality products can be achieved only when the seeds are selected and sown wisely. Also soil plays a vital role in the efficiency of crop production and fertility is a big factor to be considered. For this it is necessary to test soil to find out what needs to be added to optimize them. Seeds are a vital component of the world's diet (Bewley, 1997). Seed germination depends on both internal physiological and metabolic conditions and external environmental conditions (Rangaswamy 1996).The external environment mainly the soil can be manipulated in several ways to make it a more productive for growth of plants. Among the most promising ways of doing this is the addition of nitrogenous and phosphatic fertilizers but it has its own disadvantages because they are environmentally damaging. Also the widespread application of single element fertilizers (especially N in Asian countries) in the cultivation of major crops has led to accelerated exhaustion of other major and minor nutrients leading to nutrient imbalances and poor soil fertility. On the other hand, cyanobacteria which are a group of prokaryotic photosynthetic and nitrogen fixing microorganisms are the most promising alternate biofertilizers being considered in replacement of the chemical ones worldwide today. De (1939) attributed the natural fertility of flooded rice field soil and its maintenance to the process of biological nitrogen fixation by cyanobacteria. This was the first report which recognized the agronomic potential of cyanobacteria in India. In addition to providing nitrogen, cyanobacteria also have phosphatase enzymes which break up the organic phosphorus in the soils to available inorganic forms. Thus they are considered as the most potent duel biofertilizers for crops today providing both nitrogen and phosphorus.

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Natural Products, especially plants, have been used for the treatment of various diseases for tho... more Natural Products, especially plants, have been used for the treatment of various diseases for thousands of years. Traditionally, practitioners of Indian medicine have used plant products in various forms like powder, syrup or lotion, although there quantity and dose regulation are not known, unlike their allopathic counterparts. Vegetative and reproductive parts of the Cassia fistula Linn is used extensively in various parts of the world against number of disorders, The primary and secondary metabolites of its vegetative and reproductive parts being most probably responsible for the plant's beneficial effects. It is known as a rich source of tannins, flavanoids and glycosides. The innumerable medicinal properties and therapeutic uses of Cassia fistula as well as its phytochemical investigations prove its importance as a valuable medicinal plant. The present review explores the enormous prospective of the demons trated effect of cassia fistula plants on experimental animal.

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Traditional Systems of medicines play an important role in global health care needs. More than 30... more Traditional Systems of medicines play an important role in global health care needs. More than 30% of the entire plant species are used for medicinal purposes. Purpose: The present investigation was undertaken to investigate the Anticlastogenic effect and antioxidant property of Cassia fistula (CF) extract against Cyclophosphamide (CP) induced micronucleus formation in the mouse bone marrow cells. Methods: The bone marrow micronucleus assay was undertaken for anticlastogenic activity However the fenton reaction method was used to study the antioxidant activity. Results: The single IP administration of CF seed extract at the dose of 500, 1000 and 1500 mg/kg body weight, 24 hours prior the administration of CP (at the dose of 50 mg/kg) have significantly prevented the micronucleus formations in dose dependent manner in bone marrow cells of mice as compared to CP group. In another experiment an in vitro antioxidant assay which is based on the oxidative damage to 2-deoxy-D-ribose induced by hydroxyl radicals (• OH) generated by the reaction between ascorbic acid and (Fe III)-EDTA has been examined. Conclusion : Our results suggest that Cassia fistula have a preventive potential against CP-induced micronucleus formation in Swiss mouse bone marrow cells probably due to its antioxidant properties.

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In the present study, the antibacterial activity of methanolic extract of Cassia fistula was test... more In the present study, the antibacterial activity of methanolic extract of Cassia fistula was tested, which is a deciduous and an ornamental tree native to India and Sri Lanka, (Family – Caesalpinaceae) (Tamil – Sarakondrai). The methanol extract of Cassia fistula seeds was investigated for potential antimicrobial activity against different medically important bacterial strains. Disk diffusion technique was used to determined antimicrobial activity. The extract was effective on tested microorganism. Hence, this plant can be used to discover bioactive natural products that may leads in the development of new pharmaceuticals that address not fulfilled therapeutic needs.

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Cassia fistula Linn is used extensively around the world against various ailments. Its metabolite... more Cassia fistula Linn is used extensively around the world against various ailments. Its metabolite products being most probably responsible for its beneficial effects. This paper reviews the Investigation of primary and secondary metabolite composition and antioxidant activities of 50% methanolic extract of seeds of Cassia fistula which makes this plant remarkable for researchers. Antioxidant properties of hydromethanolic extracts of seeds of Cassia fistula. Reactive oxygen species (ROS) such as superoxide anions, hydrogen peroxide, hydroxyl, and nitric oxide radicals play an important role in oxidative stress. Antioxidant potential of Cassia fistula extracts significantly correlated with the phenolic content of the hydromethanolic extracts and was determined by the hydrogen peroxide scavenging assay.

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ABSTRACT Cassia fistula Linn is used extensively around the world against various ailments. Its m... more ABSTRACT Cassia fistula Linn is used extensively around the world against various ailments. Its metabolite products being most probably responsible for its beneficial effects. This paper reviews the Investigation of primary and secondary metabolite composition and antioxidant activities of 50% methanolic extract of seeds of Cassia fistula which makes this plant remarkable for researchers. Antioxidant properties of hydromethanolic extracts of seeds of Cassia fistula. Reactive oxygen species (ROS) such as superoxide anions, hydrogen peroxide, hydroxyl, and nitric oxide radicals play an important role in oxidative stress. Antioxidant potential of Cassia fistula extracts significantly correlated with the phenolic content of the hydromethanolic extracts and was determined by the hydrogen peroxide scavenging assay. Key Words: Cassia fistula, Hydromethanolic, Reactive oxygen species (ROS), Metabolite, Antioxidant.

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