Abbas Afkhami | Bu-Ali Sina University (original) (raw)

Papers by Abbas Afkhami

Journal of Hazardous Materials, Jul 30, 2009

This work presents a simple, rapid, and novel method for simultaneous determination of binary mix... more This work presents a simple, rapid, and novel method for simultaneous determination of binary mixtures of some surfactants using continuous wavelet transformation. The method is based on the difference in the effect of surfactants Cetyltrimethylammoniumbromide (CTAB), dodecyl trimethylammonium bromide (DTAB), cetylpyridinium bromide (CPB) and TritonX-100 (TX-100) on the absorption spectra of complex of Beryllium with Chrome Azurol S (CAS) at

International Journal of Molecular Sciences

The iontophoresis delivery of insulin (INS) remains a serious challenge due to the low permeabili... more The iontophoresis delivery of insulin (INS) remains a serious challenge due to the low permeability of the drug through the skin. This work aims to investigate the potential of water-soluble polypyrrole nanoparticles (WS-PPyNPs) as a drug donor matrix for controlled transdermal iontophoresis of INS. WS-PPyNPs have been prepared via a simple chemical polymerization in the presence of sodium dodecyl sulfate (SDS) as both dopant and the stabilizing agent. The synthesis of the soluble polymer was characterized using field emission scanning electron microscopy (FESEM), dynamic light scattering (DLS), fluorescence spectroscopy, and Fourier transform infrared (FT–IR) spectroscopy. The loading mechanism of INS onto the WS-PPyNPs is based on the fact that the drug molecules can be replaced with doped dodecyl sulfate. A two-compartment Franz-type diffusion cell was employed to study the effect of current density, formulation pH, INS concentration, and sodium chloride concentration on anodal i...

Scientific Reports

Phosphorylation of PI3Kγ as a member of lipid kinases-enzymes, plays a crucial role in regulating... more Phosphorylation of PI3Kγ as a member of lipid kinases-enzymes, plays a crucial role in regulating immune cells through the generation of intracellular signals. Deregulation of this pathway is involved in several tumors. In this research, diverse sets of potent and selective isoform-specific PI3Kγ inhibitors whose drug-likeness was confirmed based on Lipinski’s rule of five were used in the modeling process. Genetic algorithm (GA)-based multivariate analysis was employed on the half-maximal inhibitory concentration (IC50) of them. In this way, multiple linear regression (MLR) and artificial neural network (ANN) algorithm, were used to QSAR models construction on 245 compounds with a wide range of pIC50 (5.23–9.32). The stability and robustness of the models have been evaluated by external and internal validation methods (R2 0.623–0.642, RMSE 0.464–0.473, F 40.114, Q2LOO 0.600, and R2y-random 0.011). External verification using a wide variety of structures out of the training and test...

Electrochimica Acta, 2021

Abstract The development of preconcentration methods in the design of electrochemical sensors is ... more Abstract The development of preconcentration methods in the design of electrochemical sensors is attractive due to the lack of efficient strategy for the preconcentration of organic analytes. Herein, we described the employment of electropolymerization as a novel preconcentration approach in the electrochemical determination of melamine (Mel). In this effort, the preconcentration of Mel occurred at a glassy carbon electrode modified with overoxidized Poly-(para–aminophenol) film (GCE/Ox-PPAP) using the potentiodynamic technique. In fact, non-electroactive Mel was electrochemically converted into electroactive poly-(melamine) (PMel) during the electrochemical preconcentration step. The preconcentrated Mel was quantified using the square wave voltammetry (SWV), as the electro-analytical signal. The electrochemical preconcentration step was studied using cyclic voltammetry (CV), computer simulation, electrochemical impedance spectroscopy (EIS), and field emission scanning electron microscope (FESEM) techniques. GCE/Ox-PPAP revealed a good calibration sensitivity of 4.718 μA L μmol −1 in the linear range of 2.0 to 60 μmol L−1, and a limit of detection (LOD) of 0.34 µmol L−1 (S/N = 3). The obtained LOD is lower than the safety limit of Mel in milk and dairy products. Moreover, in this work, the electropolymerization process as the electrochemical preconcentration approach leads to the selective determination of Mel in the presence of possible interferences. Finally, the developed method was successfully used for the Mel detection in real milk samples. The obtained results will also open up opportunities for the design of novel electroanalytical method using a simple strategy.

A method based on the ultrasound-assisted solidification of floating drop microextraction techniq... more A method based on the ultrasound-assisted solidification of floating drop microextraction technique was developed for the spectrophotometric and spectrofluorimetric determination of curcumin in turmeric powder. In this work a small volume of an organic solvent was floated on the surface of an aqueous solution. After sonication the organic solvent is solidified and separated. The effect of extraction parameters such as type and the volume of organic solvent, temperature, salt addition and exposure time, on the extraction recovery was investigated and optimized. Finally, the method droplet was used for the determination of analyte. Under the optimum extraction conditions, a linear range of 0.006–30 μg mL-1 and a relative standard deviation (RSD) of 2.72% for curcumin wasachieved. Limits of detection of 7 and 2 ng mL-1 curcumin was obtained for the spectrophotometric and spectrofluometric methods, respectively. The obtained results show that the application of this method can be succes...

In the present study, a new chemically modified carbon paste electrode (CPE) is constructed for r... more In the present study, a new chemically modified carbon paste electrode (CPE) is constructed for rapid, accurate, simple, highly sensitive, and selective determination of Mo (VI) using differential pulse voltammetry. The electrode was prepared using magnetic nickel zinc ferrite nanocomposite (Ni0.5Zn0.5Fe2O4), as the modifier in CPE (Ni0.5Zn0.5Fe2O4/CPE). Mo (VI) was determined after preconcentration at the surface of the modified electrode at -0.7 V vs. Ag/AgCl. Under the optimal conditions, the linear dynamic range and limit of detection were 0.005-1.00 and 0.003 µgmL-1, respectively. Ten successive measurements of 0.06 and 0.70 µg mL-1 of Mo (VI) ions showed the relative standard deviation of 3.20 and 1.98 %, respectively. The reproducibility and stability of the electrode response were also studied. Investigation of the effects of different cations and anions on the determination of Mo (VI) indicated that the electrode is highly selective. Furthermore, the present method was appl...

Journal of the Iranian Chemical Society, 2021

In an overview, the relationships between activity, property, and chemical structure of the anthr... more In an overview, the relationships between activity, property, and chemical structure of the anthracycline derivatives, as topoisomerase II enzyme inhibitors, were studied in pairs. These analogs were investigated in three categories with known half-maximal inhibitory concentration (IC50), known octanol/water partition coefficient (logP), and both IC50 and logP unknown values. The QSAR and QSPR models were developed on analogs of the first and second groups, respectively. LogP was related to calculated pIC50 ((pIC50)calc) surprisingly (R2 = 0.929, Q2LOO = 0.910, RMSE = 0.235, F = 157.511). External verification was performed through comparing calculated logP (logPcalc) with three programs using 77 analogs out of the training and test sets. In application domain of the model, the suggested model had the highest correlation with ClogP method (R = 0.744) and this was better than the correlation between milogP–ClogP (R = 0.724), AlogP–ClogP (R = 0.662), and AlogP–milogP (R = 0.691). Furthermore, in the case of analogs possessing a long carbon chain substitution (nc ≥ 3), estimation methods had a significant error in calculation logP, while our suggested model provides more accurate results. The proposed algorithm can be useful in primary screening among anthracycline derivatives to select potent drug candidates.

Talanta, 2021

Cras metus lectus, pellentesque ullamcorper bibendum a, interdum non ligula. In ultrices sodales ... more Cras metus lectus, pellentesque ullamcorper bibendum a, interdum non ligula. In ultrices sodales iaculis. Ut ipsum felis, eleifend non nunc ut, pharetra molestie ex. In volutpat ante ex. Suspendisse bibendum tortor a lectus consectetur scelerisque. Ut ut lacus dui. Ut non molestie velit. Sed efficitur enim in venenatis tristique. Mauris pulvinar libero quis faucibus consectetur. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum. Morbi ac scelerisque magna. Integer imperdiet ligula sit amet est vestibulum dapibus. Sed facilisis et tellus sed dictum. Quisque non maximus augue. Etiam euismod semper diam, interdum ultrices velit. Vivamus nulla enim, convallis vel leo sit amet, efficitur maximus est. Nullam eu lacinia metus, a hendrerit mauris. Sed eu pulvinar lorem. Sed augue leo, facilisis at eros quis, convallis sagittis ex. Donec ut tempor lectus, eu cursus est. Vivamus Etiam dapibus tincidunt pulvinar. Cras lorem felis, mattis sodales congue sed, semper eu lorem. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Proin faucibus est dictum, pulvinar dui vitae, elementum leo. Maecenas elementum consequat nisl ut feugiat. Morbi dignissim ex vitae malesuada imperdiet. In blandit, arcu at finibus egestas, neque nisi egestas diam, et fringilla orci est ut ligula. Pellentesque habitant morbi tristique senectus et Morbi ac scelerisque magna. Integer imperdiet ligula sit amet est vestibulum dapibus. Sed facilisis et tellus sed dictum. Quisque non maximus augue. Etiam euismod semper diam, interdum ultrices velit. Vivamus nulla enim, convallis vel leo sit amet, efficitur maximus est. Nullam eu lacinia metus, a hendrerit mauris. Sed eu pulvinar lorem. Sed augue leo, facilisis at eros quis, convallis sagittis ex. Donec ut tempor lectus, eu cursus est. Vivamus

ACS Applied Materials & Interfaces, 2020

An in situ preparation of metal-organic framework (HKUST-1) on the surface of an organic polymer ... more An in situ preparation of metal-organic framework (HKUST-1) on the surface of an organic polymer is reported. The hybrid material was evaluated as sorbent for solid-phase extraction (SPE) of oxygenated and nitrated polycyclic aromatic hydrocarbons (PAHs). The growth of HKUST-1 on MAA-based polymer was accomplished using a layer-by-layer assembly strategy. The HKUST-1-polymer was characterized using powder X-ray diffraction and scanning electron microscopy to demonstrate the incorporation of MOF crystals onto the polymer surface. The MOF (nano)crystals were characterized using high-resolution transmission electron microscopy and high-angle annular-dark-field scanning transmission electron microscopy. The waterstable MOF-polymer was evaluated as SPE sorbent, and several variables that can influence the extraction recoveries of PAH derivatives were investigated. Under the selected conditions, the detection limits varied between 4 and 21 ng•L −1 , and the precision (relative standard deviation) was below 12%. The recovery values for spiked solutions ranged from 95 to 104%, and the enrichment factor achieved was close to 1000-fold using a high sample volume (100 mL) and very low desorption volume (100 μL). The SPE enrichment combined with HPLC and DAD detector was successfully applied to the extraction and determination of polycyclic hydrocarbons in environmental water samples.

Biotechnology Advances, 2019

Microchimica Acta, 2019

The fluorescence of ZnS quantum dots in colloidal water solution changes very slightly on additio... more The fluorescence of ZnS quantum dots in colloidal water solution changes very slightly on addition of glutathione (GSH) but is strongly enhanced in the presence of Zn(II) even in concentrations as low as 10 μM. The resulting Zn(II)-enhanced fluorescence is found to be quenched by GSH. In contrast to GSH, cysteine does not cause an effect. Response surface methodology was applied to optimize the experimental parameters. The best data can be obtained at 305/427 nm as excitation/emission wavelengths. These findings were used to design an indirect method for the fluorometric determination of GSH that has a 0.9 μM detection limit and a response that is linear in the 2.0-104.0 μM GSH concentration range. The relative standard deviation at a level of 65 μM of GSH (for n = 5) is 1.9%.

Journal of Electroanalytical Chemistry, 2018

@carbon nanotubes nanocomposite as a modifier in glassy carbon electrode for sensitive determinat... more @carbon nanotubes nanocomposite as a modifier in glassy carbon electrode for sensitive determination of ciprofloxacin in biological samples. Jeac (2018),

Analytica Chimica Acta, 2018

Carbon dots were successfully synthesized from natural source of date kernel. The prepared carbon... more Carbon dots were successfully synthesized from natural source of date kernel. The prepared carbon dots were used to the determination of Zoledronic acid. This is the first reported fluorescence sensor for sensitive assay of ZA. Cellular imaging and cell labeling of the N-CDs was achieved successfully.

New Journal of Chemistry, 2017

The preparation of nitrogen-doped graphene quantum dots (N-GQDs), by a simple and inexpensive syn... more The preparation of nitrogen-doped graphene quantum dots (N-GQDs), by a simple and inexpensive synthetic procedure, is reported with blue emission and a high quantum yield of 78%.

Journal of Applied Spectroscopy, 2015

The interaction between nitrite ion and bovine hemoglobin was investigated by a spectrofl uoromet... more The interaction between nitrite ion and bovine hemoglobin was investigated by a spectrofl uorometric technique. The experimental results indicated that the interaction causes a static quenching of the fl uorescence of bovine hemoglobin, that the binding reaction is spontaneous, and that H-bonding interactions play a major role in binding of this ion to bovine hemoglobin. The formation constant for this interaction was calculated. Based on Förster's theory of nonradiative energy transfer, the binding distance between this ion and bovine hemoglobin was determined. Furthermore, the interaction of nitrite ion with tyrosine and tryptophan was investigated with synchronous fl uorescence. There was no signifi cant shift of the maximum emission wavelength with interactions of the mentioned ion with bovine hemoglobin, which implies that interaction of nitrite ion with bovine hemoglobin does not affect the microenvironment around the tryptophan and tyrosine residues. Furthermore, the effect of nitrite ion on amino acid residues of bovine hemoglobin was studied by a molecular docking technique.

Sensors and Actuators B: Chemical, 2017

Amino-functionalized carbon quantum dots were used as effective fluorescence probes.  The fluore... more Amino-functionalized carbon quantum dots were used as effective fluorescence probes.  The fluorescence of N-CQDs was quenched in the presence of isotretinoin.  The quenching of N-CQDs induced by isotretinoin is static quenching.  Isotretinoin was measured at 0.03 μmol L − 1 with good sensitivity and selectivity.  The probe has been successfully applied in serum and pharmaceutical samples.

Journal of the Iranian Chemical Society, 2017

quantum yields, superb photostability and long fluorescence lifetimes. Additionally, modification... more quantum yields, superb photostability and long fluorescence lifetimes. Additionally, modification of the QDs with suitable functional groups or ligands has a profound effect on the photoluminescence response of desired target [1, 2]. Accordingly, owing to the novel and incomparable properties than most organic fluorescent dyes, utilization of these nanomaterials is very interesting for photoluminescence investigation of the interactions and development of the optical sensors in relation to the inorganic ions, drugs, toxicant, organic dyes, explosive compounds and biomolecular [1, 3]. Consequently, it has been widespread interest in numerous studies, published in recent years. The optical, physical and chemical properties of QDs, including the luminescence yield, activity, solubility in diverse solvents, photochemical stability and interaction with different targets are influenced by their surface chemistry. Numerous capping or stabilizing agents such as thiols, amines, carboxylic acids and phosphonates used for adaptation of surface chemistry and result in passivation of QDs surface traps from the perspective of the electronic and chemical features and could induce the enhancement of QDs photoluminescence intensity [4, 5]. This passivation of surface traps was generated either directly during synthesis or by post-synthetic modification [4, 6]. Toxic heavy-metal elements such as Cd, Hg and Pb are presenting as an inseparable part of most QDs. ZnS QD, one of the first commonly used semiconductors and a free heavy-metal system that is non-toxic in a wide range of concentrations, shows photoluminescence in the blue range and excellent chemical, optical and photocatalytic properties. Accordingly, this biocompatible QD with wide band gap energy offered notable features for manifold applications such as using for the removal of dyes and hazardous materials and designing the laser, photodetector and sensor [7-11].

Sensors and Actuators B: Chemical, 2017

Abstract A sensitive fluorescence probe based on 3-mercaptopropionic acid (MPA) capped cadmium-su... more Abstract A sensitive fluorescence probe based on 3-mercaptopropionic acid (MPA) capped cadmium-sulfide quantum dots (CdS QDs) was prepared for determination of ciprofloxacin (CIP) in real samples. The synthesized MPA capped CdS QDs was characterized using fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and transmission electron microscopy (TEM) measurements. Based on the results, the fluorescence of MPA capped CdS QDs was quenched in presence of Cu 2+ that it could have occurred because of the nonradiative electron–hole recombination annihilation through an electron transfer process. Subsequently, the fluorescence of MPA capped CdS QDs mixed with the Cu 2+ could be recovered after the addition of CIP due to its strong affinities for Cu 2+ . The recovered fluorescence intensity of capped CdS QDs was proportional to the concentration of CIP in the ranges of 0.13–150.0 μmol L −1 and the detection limit was 0.04 μmol L −1 . The established method showed a good selectivity for CIP among several kinds of ions and biomolecules. The fluorescent probe was successfully applied to determine CIP in pharmaceutical preparation and human serum samples.

New Journal of Chemistry, 2016

From a medical or clinical point of view, to assess toxicity, adverse effects, interactions and t... more From a medical or clinical point of view, to assess toxicity, adverse effects, interactions and therapeutic efficiency, monitoring drug levels in body fluids, such as urine and plasma, has become increasingly necessary.

Journal of Hazardous Materials, Jul 30, 2009

This work presents a simple, rapid, and novel method for simultaneous determination of binary mix... more This work presents a simple, rapid, and novel method for simultaneous determination of binary mixtures of some surfactants using continuous wavelet transformation. The method is based on the difference in the effect of surfactants Cetyltrimethylammoniumbromide (CTAB), dodecyl trimethylammonium bromide (DTAB), cetylpyridinium bromide (CPB) and TritonX-100 (TX-100) on the absorption spectra of complex of Beryllium with Chrome Azurol S (CAS) at

International Journal of Molecular Sciences

The iontophoresis delivery of insulin (INS) remains a serious challenge due to the low permeabili... more The iontophoresis delivery of insulin (INS) remains a serious challenge due to the low permeability of the drug through the skin. This work aims to investigate the potential of water-soluble polypyrrole nanoparticles (WS-PPyNPs) as a drug donor matrix for controlled transdermal iontophoresis of INS. WS-PPyNPs have been prepared via a simple chemical polymerization in the presence of sodium dodecyl sulfate (SDS) as both dopant and the stabilizing agent. The synthesis of the soluble polymer was characterized using field emission scanning electron microscopy (FESEM), dynamic light scattering (DLS), fluorescence spectroscopy, and Fourier transform infrared (FT–IR) spectroscopy. The loading mechanism of INS onto the WS-PPyNPs is based on the fact that the drug molecules can be replaced with doped dodecyl sulfate. A two-compartment Franz-type diffusion cell was employed to study the effect of current density, formulation pH, INS concentration, and sodium chloride concentration on anodal i...

Scientific Reports

Phosphorylation of PI3Kγ as a member of lipid kinases-enzymes, plays a crucial role in regulating... more Phosphorylation of PI3Kγ as a member of lipid kinases-enzymes, plays a crucial role in regulating immune cells through the generation of intracellular signals. Deregulation of this pathway is involved in several tumors. In this research, diverse sets of potent and selective isoform-specific PI3Kγ inhibitors whose drug-likeness was confirmed based on Lipinski’s rule of five were used in the modeling process. Genetic algorithm (GA)-based multivariate analysis was employed on the half-maximal inhibitory concentration (IC50) of them. In this way, multiple linear regression (MLR) and artificial neural network (ANN) algorithm, were used to QSAR models construction on 245 compounds with a wide range of pIC50 (5.23–9.32). The stability and robustness of the models have been evaluated by external and internal validation methods (R2 0.623–0.642, RMSE 0.464–0.473, F 40.114, Q2LOO 0.600, and R2y-random 0.011). External verification using a wide variety of structures out of the training and test...

Electrochimica Acta, 2021

Abstract The development of preconcentration methods in the design of electrochemical sensors is ... more Abstract The development of preconcentration methods in the design of electrochemical sensors is attractive due to the lack of efficient strategy for the preconcentration of organic analytes. Herein, we described the employment of electropolymerization as a novel preconcentration approach in the electrochemical determination of melamine (Mel). In this effort, the preconcentration of Mel occurred at a glassy carbon electrode modified with overoxidized Poly-(para–aminophenol) film (GCE/Ox-PPAP) using the potentiodynamic technique. In fact, non-electroactive Mel was electrochemically converted into electroactive poly-(melamine) (PMel) during the electrochemical preconcentration step. The preconcentrated Mel was quantified using the square wave voltammetry (SWV), as the electro-analytical signal. The electrochemical preconcentration step was studied using cyclic voltammetry (CV), computer simulation, electrochemical impedance spectroscopy (EIS), and field emission scanning electron microscope (FESEM) techniques. GCE/Ox-PPAP revealed a good calibration sensitivity of 4.718 μA L μmol −1 in the linear range of 2.0 to 60 μmol L−1, and a limit of detection (LOD) of 0.34 µmol L−1 (S/N = 3). The obtained LOD is lower than the safety limit of Mel in milk and dairy products. Moreover, in this work, the electropolymerization process as the electrochemical preconcentration approach leads to the selective determination of Mel in the presence of possible interferences. Finally, the developed method was successfully used for the Mel detection in real milk samples. The obtained results will also open up opportunities for the design of novel electroanalytical method using a simple strategy.

A method based on the ultrasound-assisted solidification of floating drop microextraction techniq... more A method based on the ultrasound-assisted solidification of floating drop microextraction technique was developed for the spectrophotometric and spectrofluorimetric determination of curcumin in turmeric powder. In this work a small volume of an organic solvent was floated on the surface of an aqueous solution. After sonication the organic solvent is solidified and separated. The effect of extraction parameters such as type and the volume of organic solvent, temperature, salt addition and exposure time, on the extraction recovery was investigated and optimized. Finally, the method droplet was used for the determination of analyte. Under the optimum extraction conditions, a linear range of 0.006–30 μg mL-1 and a relative standard deviation (RSD) of 2.72% for curcumin wasachieved. Limits of detection of 7 and 2 ng mL-1 curcumin was obtained for the spectrophotometric and spectrofluometric methods, respectively. The obtained results show that the application of this method can be succes...

In the present study, a new chemically modified carbon paste electrode (CPE) is constructed for r... more In the present study, a new chemically modified carbon paste electrode (CPE) is constructed for rapid, accurate, simple, highly sensitive, and selective determination of Mo (VI) using differential pulse voltammetry. The electrode was prepared using magnetic nickel zinc ferrite nanocomposite (Ni0.5Zn0.5Fe2O4), as the modifier in CPE (Ni0.5Zn0.5Fe2O4/CPE). Mo (VI) was determined after preconcentration at the surface of the modified electrode at -0.7 V vs. Ag/AgCl. Under the optimal conditions, the linear dynamic range and limit of detection were 0.005-1.00 and 0.003 µgmL-1, respectively. Ten successive measurements of 0.06 and 0.70 µg mL-1 of Mo (VI) ions showed the relative standard deviation of 3.20 and 1.98 %, respectively. The reproducibility and stability of the electrode response were also studied. Investigation of the effects of different cations and anions on the determination of Mo (VI) indicated that the electrode is highly selective. Furthermore, the present method was appl...

Journal of the Iranian Chemical Society, 2021

In an overview, the relationships between activity, property, and chemical structure of the anthr... more In an overview, the relationships between activity, property, and chemical structure of the anthracycline derivatives, as topoisomerase II enzyme inhibitors, were studied in pairs. These analogs were investigated in three categories with known half-maximal inhibitory concentration (IC50), known octanol/water partition coefficient (logP), and both IC50 and logP unknown values. The QSAR and QSPR models were developed on analogs of the first and second groups, respectively. LogP was related to calculated pIC50 ((pIC50)calc) surprisingly (R2 = 0.929, Q2LOO = 0.910, RMSE = 0.235, F = 157.511). External verification was performed through comparing calculated logP (logPcalc) with three programs using 77 analogs out of the training and test sets. In application domain of the model, the suggested model had the highest correlation with ClogP method (R = 0.744) and this was better than the correlation between milogP–ClogP (R = 0.724), AlogP–ClogP (R = 0.662), and AlogP–milogP (R = 0.691). Furthermore, in the case of analogs possessing a long carbon chain substitution (nc ≥ 3), estimation methods had a significant error in calculation logP, while our suggested model provides more accurate results. The proposed algorithm can be useful in primary screening among anthracycline derivatives to select potent drug candidates.

Talanta, 2021

Cras metus lectus, pellentesque ullamcorper bibendum a, interdum non ligula. In ultrices sodales ... more Cras metus lectus, pellentesque ullamcorper bibendum a, interdum non ligula. In ultrices sodales iaculis. Ut ipsum felis, eleifend non nunc ut, pharetra molestie ex. In volutpat ante ex. Suspendisse bibendum tortor a lectus consectetur scelerisque. Ut ut lacus dui. Ut non molestie velit. Sed efficitur enim in venenatis tristique. Mauris pulvinar libero quis faucibus consectetur. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum. Morbi ac scelerisque magna. Integer imperdiet ligula sit amet est vestibulum dapibus. Sed facilisis et tellus sed dictum. Quisque non maximus augue. Etiam euismod semper diam, interdum ultrices velit. Vivamus nulla enim, convallis vel leo sit amet, efficitur maximus est. Nullam eu lacinia metus, a hendrerit mauris. Sed eu pulvinar lorem. Sed augue leo, facilisis at eros quis, convallis sagittis ex. Donec ut tempor lectus, eu cursus est. Vivamus Etiam dapibus tincidunt pulvinar. Cras lorem felis, mattis sodales congue sed, semper eu lorem. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Proin faucibus est dictum, pulvinar dui vitae, elementum leo. Maecenas elementum consequat nisl ut feugiat. Morbi dignissim ex vitae malesuada imperdiet. In blandit, arcu at finibus egestas, neque nisi egestas diam, et fringilla orci est ut ligula. Pellentesque habitant morbi tristique senectus et Morbi ac scelerisque magna. Integer imperdiet ligula sit amet est vestibulum dapibus. Sed facilisis et tellus sed dictum. Quisque non maximus augue. Etiam euismod semper diam, interdum ultrices velit. Vivamus nulla enim, convallis vel leo sit amet, efficitur maximus est. Nullam eu lacinia metus, a hendrerit mauris. Sed eu pulvinar lorem. Sed augue leo, facilisis at eros quis, convallis sagittis ex. Donec ut tempor lectus, eu cursus est. Vivamus

ACS Applied Materials & Interfaces, 2020

An in situ preparation of metal-organic framework (HKUST-1) on the surface of an organic polymer ... more An in situ preparation of metal-organic framework (HKUST-1) on the surface of an organic polymer is reported. The hybrid material was evaluated as sorbent for solid-phase extraction (SPE) of oxygenated and nitrated polycyclic aromatic hydrocarbons (PAHs). The growth of HKUST-1 on MAA-based polymer was accomplished using a layer-by-layer assembly strategy. The HKUST-1-polymer was characterized using powder X-ray diffraction and scanning electron microscopy to demonstrate the incorporation of MOF crystals onto the polymer surface. The MOF (nano)crystals were characterized using high-resolution transmission electron microscopy and high-angle annular-dark-field scanning transmission electron microscopy. The waterstable MOF-polymer was evaluated as SPE sorbent, and several variables that can influence the extraction recoveries of PAH derivatives were investigated. Under the selected conditions, the detection limits varied between 4 and 21 ng•L −1 , and the precision (relative standard deviation) was below 12%. The recovery values for spiked solutions ranged from 95 to 104%, and the enrichment factor achieved was close to 1000-fold using a high sample volume (100 mL) and very low desorption volume (100 μL). The SPE enrichment combined with HPLC and DAD detector was successfully applied to the extraction and determination of polycyclic hydrocarbons in environmental water samples.

Biotechnology Advances, 2019

Microchimica Acta, 2019

The fluorescence of ZnS quantum dots in colloidal water solution changes very slightly on additio... more The fluorescence of ZnS quantum dots in colloidal water solution changes very slightly on addition of glutathione (GSH) but is strongly enhanced in the presence of Zn(II) even in concentrations as low as 10 μM. The resulting Zn(II)-enhanced fluorescence is found to be quenched by GSH. In contrast to GSH, cysteine does not cause an effect. Response surface methodology was applied to optimize the experimental parameters. The best data can be obtained at 305/427 nm as excitation/emission wavelengths. These findings were used to design an indirect method for the fluorometric determination of GSH that has a 0.9 μM detection limit and a response that is linear in the 2.0-104.0 μM GSH concentration range. The relative standard deviation at a level of 65 μM of GSH (for n = 5) is 1.9%.

Journal of Electroanalytical Chemistry, 2018

@carbon nanotubes nanocomposite as a modifier in glassy carbon electrode for sensitive determinat... more @carbon nanotubes nanocomposite as a modifier in glassy carbon electrode for sensitive determination of ciprofloxacin in biological samples. Jeac (2018),

Analytica Chimica Acta, 2018

Carbon dots were successfully synthesized from natural source of date kernel. The prepared carbon... more Carbon dots were successfully synthesized from natural source of date kernel. The prepared carbon dots were used to the determination of Zoledronic acid. This is the first reported fluorescence sensor for sensitive assay of ZA. Cellular imaging and cell labeling of the N-CDs was achieved successfully.

New Journal of Chemistry, 2017

The preparation of nitrogen-doped graphene quantum dots (N-GQDs), by a simple and inexpensive syn... more The preparation of nitrogen-doped graphene quantum dots (N-GQDs), by a simple and inexpensive synthetic procedure, is reported with blue emission and a high quantum yield of 78%.

Journal of Applied Spectroscopy, 2015

The interaction between nitrite ion and bovine hemoglobin was investigated by a spectrofl uoromet... more The interaction between nitrite ion and bovine hemoglobin was investigated by a spectrofl uorometric technique. The experimental results indicated that the interaction causes a static quenching of the fl uorescence of bovine hemoglobin, that the binding reaction is spontaneous, and that H-bonding interactions play a major role in binding of this ion to bovine hemoglobin. The formation constant for this interaction was calculated. Based on Förster's theory of nonradiative energy transfer, the binding distance between this ion and bovine hemoglobin was determined. Furthermore, the interaction of nitrite ion with tyrosine and tryptophan was investigated with synchronous fl uorescence. There was no signifi cant shift of the maximum emission wavelength with interactions of the mentioned ion with bovine hemoglobin, which implies that interaction of nitrite ion with bovine hemoglobin does not affect the microenvironment around the tryptophan and tyrosine residues. Furthermore, the effect of nitrite ion on amino acid residues of bovine hemoglobin was studied by a molecular docking technique.

Sensors and Actuators B: Chemical, 2017

Amino-functionalized carbon quantum dots were used as effective fluorescence probes.  The fluore... more Amino-functionalized carbon quantum dots were used as effective fluorescence probes.  The fluorescence of N-CQDs was quenched in the presence of isotretinoin.  The quenching of N-CQDs induced by isotretinoin is static quenching.  Isotretinoin was measured at 0.03 μmol L − 1 with good sensitivity and selectivity.  The probe has been successfully applied in serum and pharmaceutical samples.

Journal of the Iranian Chemical Society, 2017

quantum yields, superb photostability and long fluorescence lifetimes. Additionally, modification... more quantum yields, superb photostability and long fluorescence lifetimes. Additionally, modification of the QDs with suitable functional groups or ligands has a profound effect on the photoluminescence response of desired target [1, 2]. Accordingly, owing to the novel and incomparable properties than most organic fluorescent dyes, utilization of these nanomaterials is very interesting for photoluminescence investigation of the interactions and development of the optical sensors in relation to the inorganic ions, drugs, toxicant, organic dyes, explosive compounds and biomolecular [1, 3]. Consequently, it has been widespread interest in numerous studies, published in recent years. The optical, physical and chemical properties of QDs, including the luminescence yield, activity, solubility in diverse solvents, photochemical stability and interaction with different targets are influenced by their surface chemistry. Numerous capping or stabilizing agents such as thiols, amines, carboxylic acids and phosphonates used for adaptation of surface chemistry and result in passivation of QDs surface traps from the perspective of the electronic and chemical features and could induce the enhancement of QDs photoluminescence intensity [4, 5]. This passivation of surface traps was generated either directly during synthesis or by post-synthetic modification [4, 6]. Toxic heavy-metal elements such as Cd, Hg and Pb are presenting as an inseparable part of most QDs. ZnS QD, one of the first commonly used semiconductors and a free heavy-metal system that is non-toxic in a wide range of concentrations, shows photoluminescence in the blue range and excellent chemical, optical and photocatalytic properties. Accordingly, this biocompatible QD with wide band gap energy offered notable features for manifold applications such as using for the removal of dyes and hazardous materials and designing the laser, photodetector and sensor [7-11].

Sensors and Actuators B: Chemical, 2017

Abstract A sensitive fluorescence probe based on 3-mercaptopropionic acid (MPA) capped cadmium-su... more Abstract A sensitive fluorescence probe based on 3-mercaptopropionic acid (MPA) capped cadmium-sulfide quantum dots (CdS QDs) was prepared for determination of ciprofloxacin (CIP) in real samples. The synthesized MPA capped CdS QDs was characterized using fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and transmission electron microscopy (TEM) measurements. Based on the results, the fluorescence of MPA capped CdS QDs was quenched in presence of Cu 2+ that it could have occurred because of the nonradiative electron–hole recombination annihilation through an electron transfer process. Subsequently, the fluorescence of MPA capped CdS QDs mixed with the Cu 2+ could be recovered after the addition of CIP due to its strong affinities for Cu 2+ . The recovered fluorescence intensity of capped CdS QDs was proportional to the concentration of CIP in the ranges of 0.13–150.0 μmol L −1 and the detection limit was 0.04 μmol L −1 . The established method showed a good selectivity for CIP among several kinds of ions and biomolecules. The fluorescent probe was successfully applied to determine CIP in pharmaceutical preparation and human serum samples.

New Journal of Chemistry, 2016

From a medical or clinical point of view, to assess toxicity, adverse effects, interactions and t... more From a medical or clinical point of view, to assess toxicity, adverse effects, interactions and therapeutic efficiency, monitoring drug levels in body fluids, such as urine and plasma, has become increasingly necessary.