Dragan Marinkovic | University of Belgrade (original) (raw)

Papers by Dragan Marinkovic

Molecular Neurobiology, May 5, 2021

MYC is well known as a potent oncogene involved in regulating cell cycle and metabolism. Augmente... more MYC is well known as a potent oncogene involved in regulating cell cycle and metabolism. Augmented MYC expression leads to cell cycle dysregulation, intense cell proliferation, and carcinogenesis. Surprisingly, its increased expression in neurons does not induce their proliferation, but leads to neuronal cell death and consequent development of a neurodegenerative phenotype. Interestingly, while cancer and neurodegenerative diseases such as Alzheimer's disease are placed at the opposite sides of cell division spectrum, both start with cell cycle dysregulation and stimulation of proliferation. It seems that MYC action directed toward neuron cell proliferation and neural tissue repair collides with evolutional loss of regenerative capacity of CNS neurons in order to strengthen synaptic structure, to protect our cognitive abilities and therefore character. Accordingly, there are abundant mechanisms that block its expression and action specifically in the brain. Moreover, while MYC expression in brain neurons during neurodegenerative processes is related to their death, there are obvious evidences that MYC action after physical injury is beneficial in case of peripheral nerve recovery. MYC might be a useful tool to repair brain cells upon development of neurodegenerative disease or CNS trauma, including stroke and traumatic brain and spinal cord injury, as even imperfect axonal growth and regeneration strategies will likely be of profound benefit. Understanding complex control of MYC action in the brain might have important therapeutic significance, but also it may contribute to the comprehension of development of neurodegenerative diseases.

Journal of Experimental Medicine, May 5, 2003

Mice deficient for the transcriptional coactivator BOB.1/OBF.1 show several defects in B cell dif... more Mice deficient for the transcriptional coactivator BOB.1/OBF.1 show several defects in B cell differentiation. Numbers of immature transitional B cells in the bone marrow are reduced and fewer B cells reach the periphery. Furthermore, germinal center B cells are absent and marginal zone (MZ) B lymphocytes are markedly reduced. Increased levels of B cell apoptosis in these mice prompted us to analyze expression and function of antiapoptotic proteins. Bcl2 expression is strongly reduced in BOB.1/OBF.1-deficient pre-B cells. When BOB.1/OBF.1-deficient mice were crossed with Bcl2-transgenic mice, B cell development in the bone marrow and numbers of B cells in peripheral lymphoid organs were normalized. However, neither germinal center B cells nor MZ B cells were rescued. Additionally, Bcl2 did not rescue the defects in signaling and affinity maturation found in BOB.1/OBF.1-deficient mice. Interestingly, Bcl2transgenic mice by themselves show an MZ B cell defect. Virtually no functional MZ B cells were detected in these mice. In contrast, mice deficient for Bcl2 show a relative increase in MZ B cell numbers, indicating a previously undetected function of Bcl2 for this B cell compartment.

European Journal of Immunology, Feb 1, 2002

CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid. CD22... more CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid. CD22 inhibits B cell receptor signaling. Mice deficient for CD22 show a largely normal B cell development. Here, we have performed a detailed analysis of the splenic B cell population and found that the subset of marginal zone (MZ) B cells was selectively reduced in CD22deficient mice. CD22-deficient mice showed a lack of TNP-ficoll capturing cells in the MZ and a reduced response to TNP-ficoll, particularly when the antigen was applied intravenously. CD22-deficient B cells showed both enhanced motility as well as enhanced chemotaxis to certain chemokines. The altered chemokine responsiveness or the higher signaling capacity of CD22-deficient B cells may lead to the compromised MZ B cell compartment, as both processes have previously been shown to affect MZ composition.

International Journal of Cancer, Jan 8, 2007

Deregulation of the proto‐oncogene c‐myc is a key event in the pathogenesis of many tumors. A par... more Deregulation of the proto‐oncogene c‐myc is a key event in the pathogenesis of many tumors. A paradigm is the activation of the c‐myc gene by chromosomal translocations in Burkitt lymphoma (BL). Despite expression of a restricted set of Epstein–Barr viral (EBV) antigens, BL cells are not recognized by antigen‐specific cytotoxic T cells (CTLs) because of their inability to process and present HLA class I‐restricted antigens. In contrast, cells of EBV‐driven posttransplant lymphoproliferative disease (PTLD) are recognized and rejected by EBV‐specific CTLs. It is not known whether the poor immunogenicity of BL cells is due to nonexpression of viral antigens, overexpression of c‐myc, or both. To understand the basis for immune recognition and escape, we have compared the mRNA expression profiles of BL and EBV‐immortalized cells (as PTLD model). Among the genes expressed at low level in BL cells, we have identified many genes involved in the NF‐κB and interferon response that play a pivotal role in antigen presentation and immune recognition. Using a cell line in which EBNA2 and c‐myc can be regulated at will, we show that c‐MYC negatively regulates STAT1, the central player linking the Type‐I and Type‐II interferon response. Switching off c‐myc expression leads to STAT1 induction through a direct and indirect mechanism involving induction of Type‐I interferons. c‐MYC thus masks an interferon‐inducing activity in these cells. Our findings imply that immune escape of tumor cells is not only a matter of in vivo selection but may be additionally promoted by activation of a cellular oncogene. © 2007 Wiley‐Liss, Inc.

Materia medica, 2018

As a consequence of significant development of neurosciences several different scientific fields ... more As a consequence of significant development of neurosciences several different scientific fields as neuroeducation, neuroesthetics, nerotheology, neuromarketing etc. had been established. Neuroeconomics is interdisciplinary scientific field that has aim to explain neurological mechanisms of decision making process, mental ability of consideration of several possible alternatives, and ability to follow certain direction of action. Neuroeconomics is based on research methods, techniques and models that are overtaken from neurosciences, but also from cognitive and social psychology, as well as from experimental and behavioral economics. In practical sense, neuroeconomics is mainly involved in situations in which humans are not behaving according to rational model, but rather according to innate and adapted schemes of behavior and due to their strong emotional reaction. In this way, knowledge from the scientific fields of neurology and neurosciences that are obtained mainly by usage of neuroimaging, are used in example to investigate market or to determine functioning of employees in critical situations. This kind of practical approach opens several ethical and legal dilemmas..

Scandinavian Journal of Immunology, Jul 14, 2020

marginal zone B cells (MZB cells), thymus independent (TI), thymus dependent (TD), Accepted Artic... more marginal zone B cells (MZB cells), thymus independent (TI), thymus dependent (TD), Accepted Article This article is protected by copyright. All rights reserved mucosa associated lymphoid tissue lymphoma (MALT lymphoma), marginal zone (MZ), mucosal addressin cell adhesion molecule 1 (MadCAM-1), periarteriolar lymphatic sheath (PALS), metallophylic MOMA1 + macrophages (MMM), MZ macrophages (MZM), B cell receptor (BCR), natural killer (NK) cells, class-switch recombination (CSR), Toll-like receptors (TLR), somatic hypermutation (SHM), Bruton's tyrosine kynasis (Btk), gut-associated lymphoid tissues (GALT), natural killer T (NKT) cells, invariant NKT (iNKT), marginal zone macrophages (MZM), specific intracellular adhesion molecule-grabbing nonintegrin receptor 1 (SIGN-R1), systemic lupus erythematosus (SLE), splenic marginal zone lymphoma (SMZL), nodal marginal zone lymphoma (NMZL), human immunodeficiency virus (HIV), Epstein-Barr virus (EBV), hepatitis C virus (HCV), hepatitis B virus (HBV), paediatric nodal marginal zone lymphoma (pNMZL), Helicobacter pylori (HP)

Materia medica, 2010

... analize (LIFA) za detekciju Lyme borelioze na teritoriji Srbije. Samardžić Svetomir a , Marin... more ... analize (LIFA) za detekciju Lyme borelioze na teritoriji Srbije. Samardžić Svetomir a , Marinković Tatjana b , Milić Aleksandra a ... a Univerzitet u Prištini (Kosovska Mitrovica), Medicinski fakultet b Visoka zdravstveno sanitarna škola 'Visan' Beograd-Zemun c Dom zdravlja, Tutin d ...

Materia medica, 2009

... DI, Zitzelsberger, H., Hutzler, P., Lehmann, L., Braselmann, H., Chimenti, S., Höfler, H. (19... more ... DI, Zitzelsberger, H., Hutzler, P., Lehmann, L., Braselmann, H., Chimenti, S., Höfler, H. (1997) Numerical aberrations of chromosome 7 detected in 15 microns paraffin ... Richter, J., Wagner, U., Kononen, J., Fijan, A., Bruderer, J., Schmid, U., Ackermann, D., Maurer, R., i dr. ...

Journal of Cellular Physiology, Oct 23, 2020

As an oncogene, myelocytomatosis oncogene (MYC) is implicated in the concept of "oncogene addicti... more As an oncogene, myelocytomatosis oncogene (MYC) is implicated in the concept of "oncogene addiction," where switching off the oncogene leads to the cell cycle arrest and cell differentiation. However, recent data suggest that MYC also controls the establishment of the tumour microenvironment and that "oncogene addiction" actually has a strong immune background. Evaluation of the MYC role in the immunoediting process led to the speculation that cancer just uses and distorts the physiological mechanism by which MYC normally prevents rapidly proliferating cells from the elicitation of an autoimmune response. Concordantly, elevated levels of MYC and induction of immunosuppressive molecules are observed during the processes of growth and development, tissue repair, placenta development, and so forth, implying that MYC may be involved in saving regular physiologically proliferating cells from the immune system attack. Even more, a growing body of evidence suggests MYC involvement in the shaping of the adaptive immune response, immunological memory development, and establishment of immunotolerance. This paper offers an overview of MYC actions in the context of modulation of the immune response in pathological and physiological conditions. The determination of such a new role for a well-known oncogene opens new perspectives in biomedicine, and consequently, in the treatment of various pathological conditions.

Materia Medica, 2015

Hair loss in children hospitalized for malignant diseases treatment is most visible manifestation... more Hair loss in children hospitalized for malignant diseases treatment is most visible manifestation that dramatically influences their later selfconfidence. Further, this could strongly affect possible development of psychic crisis. Scientific researches on motivational aspects of involvement for provision of non-formal categories of support to patients with malignant diseases are infrequent. Therefore, this topic should be more investigated in future. Humanitarian initiative "Kilometer of hair", as unique philanthropic activity at territory of Serbia in year 2015, had as an aim to collect hair for preparation of wigs for children treated for malignant diseases. The main question in our study was definition of key motives for hair donation. We classified three main groups of motives. Altruism was detected as motivation in almost one-half of all interviewed subjects. Second group included almost one third of all subjects and their main motivation for hair donation was empathy. The smallest percentage of hair donors was motivated with some kind of public approval and welcome from society. We believe that further research in this area could give some directives for program planning of further improvement of social awareness for psychosocial support to children with malignant diseases.

Materia …, 2007

... Infekcije Ehrlichi-om chaffeensis u različitim regionima Srbije. Samardžić Svetomir a , Marin... more ... Infekcije Ehrlichi-om chaffeensis u različitim regionima Srbije. Samardžić Svetomir a , Marinković Dragan b , Marinković Tatjana b , Simović ... Srpska, Bosna i Hercegovina c Institut za javno zdravlje, Kruševac d Centar za imunološka istraživanja 'Branislav Janković', Beograd ...

International Reviews of Immunology, Jul 7, 2020

Ectopic lymphoid structures (ELS) or tertiary lymphoid organs are structures with the organizatio... more Ectopic lymphoid structures (ELS) or tertiary lymphoid organs are structures with the organization similar to the one of secondary lymphoid organs, formed in non-lymphoid tissues. They are considered to be an important site for the lymphocytic physiological and pathological role in conditions such are chronic infections, autoimmune diseases, cancer, and allograft rejection. Although similar to the secondary lymphoid tissues, the initiation of ELS formation is not preprogramed and requires chronic inflammation, expression of homeostatic chemokines, and lymphotoxin beta receptor activation. Importantly, while ELS formation may be considered beneficiary in antimicrobial and antitumor immunity, the persistence of these active lymphoid structures within the tissue increase the chance for development of autoimmunity and lymphoma. This paper is providing an overview of biological mechanisms involved in ELS formation, as well as the overview of the pathophysiological role of these structures. In addition, the paper discusses the possibility to therapeutically target ELS formation, bearing in mind their bivalent nature and role in different pathophysiological conditions.

10th International Scientific Conference Science and High Education in Function of Sustainable De... more 10th International Scientific Conference Science and High Education in Function of Sustainable Developmen

Molecular Neurobiology, 2021

MYC is well known as a potent oncogene involved in regulating cell cycle and metabolism. Augmente... more MYC is well known as a potent oncogene involved in regulating cell cycle and metabolism. Augmented MYC expression leads to cell cycle dysregulation, intense cell proliferation, and carcinogenesis. Surprisingly, its increased expression in neurons does not induce their proliferation, but leads to neuronal cell death and consequent development of a neurodegenerative phenotype. Interestingly, while cancer and neurodegenerative diseases such as Alzheimer's disease are placed at the opposite sides of cell division spectrum, both start with cell cycle dysregulation and stimulation of proliferation. It seems that MYC action directed toward neuron cell proliferation and neural tissue repair collides with evolutional loss of regenerative capacity of CNS neurons in order to strengthen synaptic structure, to protect our cognitive abilities and therefore character. Accordingly, there are abundant mechanisms that block its expression and action specifically in the brain. Moreover, while MYC expression in brain neurons during neurodegenerative processes is related to their death, there are obvious evidences that MYC action after physical injury is beneficial in case of peripheral nerve recovery. MYC might be a useful tool to repair brain cells upon development of neurodegenerative disease or CNS trauma, including stroke and traumatic brain and spinal cord injury, as even imperfect axonal growth and regeneration strategies will likely be of profound benefit. Understanding complex control of MYC action in the brain might have important therapeutic significance, but also it may contribute to the comprehension of development of neurodegenerative diseases.

Scandinavian Journal of Immunology, 2020

Journal of Cellular Physiology, 2020

As an oncogene, myelocytomatosis oncogene (MYC) is implicated in the concept of “oncogene addicti... more As an oncogene, myelocytomatosis oncogene (MYC) is implicated in the concept of “oncogene addiction,” where switching off the oncogene leads to the cell cycle arrest and cell differentiation. However, recent data suggest that MYC also controls the establishment of the tumour microenvironment and that “oncogene addiction” actually has a strong immune background. Evaluation of the MYC role in the immunoediting process led to the speculation that cancer just uses and distorts the physiological mechanism by which MYC normally prevents rapidly proliferating cells from the elicitation of an autoimmune response. Concordantly, elevated levels of MYC and induction of immunosuppressive molecules are observed during the processes of growth and development, tissue repair, placenta development, and so forth, implying that MYC may be involved in saving regular physiologically proliferating cells from the immune system attack. Even more, a growing body of evidence suggests MYC involvement in the shaping of the adaptive immune response, immunological memory development, and establishment of immunotolerance. This paper offers an overview of MYC actions in the context of modulation of the immune response in pathological and physiological conditions. The determination of such a new role for a well‐known oncogene opens new perspectives in biomedicine, and consequently, in the treatment of various pathological conditions.

Molecular Neurobiology, May 5, 2021

MYC is well known as a potent oncogene involved in regulating cell cycle and metabolism. Augmente... more MYC is well known as a potent oncogene involved in regulating cell cycle and metabolism. Augmented MYC expression leads to cell cycle dysregulation, intense cell proliferation, and carcinogenesis. Surprisingly, its increased expression in neurons does not induce their proliferation, but leads to neuronal cell death and consequent development of a neurodegenerative phenotype. Interestingly, while cancer and neurodegenerative diseases such as Alzheimer's disease are placed at the opposite sides of cell division spectrum, both start with cell cycle dysregulation and stimulation of proliferation. It seems that MYC action directed toward neuron cell proliferation and neural tissue repair collides with evolutional loss of regenerative capacity of CNS neurons in order to strengthen synaptic structure, to protect our cognitive abilities and therefore character. Accordingly, there are abundant mechanisms that block its expression and action specifically in the brain. Moreover, while MYC expression in brain neurons during neurodegenerative processes is related to their death, there are obvious evidences that MYC action after physical injury is beneficial in case of peripheral nerve recovery. MYC might be a useful tool to repair brain cells upon development of neurodegenerative disease or CNS trauma, including stroke and traumatic brain and spinal cord injury, as even imperfect axonal growth and regeneration strategies will likely be of profound benefit. Understanding complex control of MYC action in the brain might have important therapeutic significance, but also it may contribute to the comprehension of development of neurodegenerative diseases.

Journal of Experimental Medicine, May 5, 2003

Mice deficient for the transcriptional coactivator BOB.1/OBF.1 show several defects in B cell dif... more Mice deficient for the transcriptional coactivator BOB.1/OBF.1 show several defects in B cell differentiation. Numbers of immature transitional B cells in the bone marrow are reduced and fewer B cells reach the periphery. Furthermore, germinal center B cells are absent and marginal zone (MZ) B lymphocytes are markedly reduced. Increased levels of B cell apoptosis in these mice prompted us to analyze expression and function of antiapoptotic proteins. Bcl2 expression is strongly reduced in BOB.1/OBF.1-deficient pre-B cells. When BOB.1/OBF.1-deficient mice were crossed with Bcl2-transgenic mice, B cell development in the bone marrow and numbers of B cells in peripheral lymphoid organs were normalized. However, neither germinal center B cells nor MZ B cells were rescued. Additionally, Bcl2 did not rescue the defects in signaling and affinity maturation found in BOB.1/OBF.1-deficient mice. Interestingly, Bcl2transgenic mice by themselves show an MZ B cell defect. Virtually no functional MZ B cells were detected in these mice. In contrast, mice deficient for Bcl2 show a relative increase in MZ B cell numbers, indicating a previously undetected function of Bcl2 for this B cell compartment.

European Journal of Immunology, Feb 1, 2002

CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid. CD22... more CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid. CD22 inhibits B cell receptor signaling. Mice deficient for CD22 show a largely normal B cell development. Here, we have performed a detailed analysis of the splenic B cell population and found that the subset of marginal zone (MZ) B cells was selectively reduced in CD22deficient mice. CD22-deficient mice showed a lack of TNP-ficoll capturing cells in the MZ and a reduced response to TNP-ficoll, particularly when the antigen was applied intravenously. CD22-deficient B cells showed both enhanced motility as well as enhanced chemotaxis to certain chemokines. The altered chemokine responsiveness or the higher signaling capacity of CD22-deficient B cells may lead to the compromised MZ B cell compartment, as both processes have previously been shown to affect MZ composition.

International Journal of Cancer, Jan 8, 2007

Deregulation of the proto‐oncogene c‐myc is a key event in the pathogenesis of many tumors. A par... more Deregulation of the proto‐oncogene c‐myc is a key event in the pathogenesis of many tumors. A paradigm is the activation of the c‐myc gene by chromosomal translocations in Burkitt lymphoma (BL). Despite expression of a restricted set of Epstein–Barr viral (EBV) antigens, BL cells are not recognized by antigen‐specific cytotoxic T cells (CTLs) because of their inability to process and present HLA class I‐restricted antigens. In contrast, cells of EBV‐driven posttransplant lymphoproliferative disease (PTLD) are recognized and rejected by EBV‐specific CTLs. It is not known whether the poor immunogenicity of BL cells is due to nonexpression of viral antigens, overexpression of c‐myc, or both. To understand the basis for immune recognition and escape, we have compared the mRNA expression profiles of BL and EBV‐immortalized cells (as PTLD model). Among the genes expressed at low level in BL cells, we have identified many genes involved in the NF‐κB and interferon response that play a pivotal role in antigen presentation and immune recognition. Using a cell line in which EBNA2 and c‐myc can be regulated at will, we show that c‐MYC negatively regulates STAT1, the central player linking the Type‐I and Type‐II interferon response. Switching off c‐myc expression leads to STAT1 induction through a direct and indirect mechanism involving induction of Type‐I interferons. c‐MYC thus masks an interferon‐inducing activity in these cells. Our findings imply that immune escape of tumor cells is not only a matter of in vivo selection but may be additionally promoted by activation of a cellular oncogene. © 2007 Wiley‐Liss, Inc.

Materia medica, 2018

As a consequence of significant development of neurosciences several different scientific fields ... more As a consequence of significant development of neurosciences several different scientific fields as neuroeducation, neuroesthetics, nerotheology, neuromarketing etc. had been established. Neuroeconomics is interdisciplinary scientific field that has aim to explain neurological mechanisms of decision making process, mental ability of consideration of several possible alternatives, and ability to follow certain direction of action. Neuroeconomics is based on research methods, techniques and models that are overtaken from neurosciences, but also from cognitive and social psychology, as well as from experimental and behavioral economics. In practical sense, neuroeconomics is mainly involved in situations in which humans are not behaving according to rational model, but rather according to innate and adapted schemes of behavior and due to their strong emotional reaction. In this way, knowledge from the scientific fields of neurology and neurosciences that are obtained mainly by usage of neuroimaging, are used in example to investigate market or to determine functioning of employees in critical situations. This kind of practical approach opens several ethical and legal dilemmas..

Scandinavian Journal of Immunology, Jul 14, 2020

marginal zone B cells (MZB cells), thymus independent (TI), thymus dependent (TD), Accepted Artic... more marginal zone B cells (MZB cells), thymus independent (TI), thymus dependent (TD), Accepted Article This article is protected by copyright. All rights reserved mucosa associated lymphoid tissue lymphoma (MALT lymphoma), marginal zone (MZ), mucosal addressin cell adhesion molecule 1 (MadCAM-1), periarteriolar lymphatic sheath (PALS), metallophylic MOMA1 + macrophages (MMM), MZ macrophages (MZM), B cell receptor (BCR), natural killer (NK) cells, class-switch recombination (CSR), Toll-like receptors (TLR), somatic hypermutation (SHM), Bruton's tyrosine kynasis (Btk), gut-associated lymphoid tissues (GALT), natural killer T (NKT) cells, invariant NKT (iNKT), marginal zone macrophages (MZM), specific intracellular adhesion molecule-grabbing nonintegrin receptor 1 (SIGN-R1), systemic lupus erythematosus (SLE), splenic marginal zone lymphoma (SMZL), nodal marginal zone lymphoma (NMZL), human immunodeficiency virus (HIV), Epstein-Barr virus (EBV), hepatitis C virus (HCV), hepatitis B virus (HBV), paediatric nodal marginal zone lymphoma (pNMZL), Helicobacter pylori (HP)

Materia medica, 2010

... analize (LIFA) za detekciju Lyme borelioze na teritoriji Srbije. Samardžić Svetomir a , Marin... more ... analize (LIFA) za detekciju Lyme borelioze na teritoriji Srbije. Samardžić Svetomir a , Marinković Tatjana b , Milić Aleksandra a ... a Univerzitet u Prištini (Kosovska Mitrovica), Medicinski fakultet b Visoka zdravstveno sanitarna škola 'Visan' Beograd-Zemun c Dom zdravlja, Tutin d ...

Materia medica, 2009

... DI, Zitzelsberger, H., Hutzler, P., Lehmann, L., Braselmann, H., Chimenti, S., Höfler, H. (19... more ... DI, Zitzelsberger, H., Hutzler, P., Lehmann, L., Braselmann, H., Chimenti, S., Höfler, H. (1997) Numerical aberrations of chromosome 7 detected in 15 microns paraffin ... Richter, J., Wagner, U., Kononen, J., Fijan, A., Bruderer, J., Schmid, U., Ackermann, D., Maurer, R., i dr. ...

Journal of Cellular Physiology, Oct 23, 2020

As an oncogene, myelocytomatosis oncogene (MYC) is implicated in the concept of "oncogene addicti... more As an oncogene, myelocytomatosis oncogene (MYC) is implicated in the concept of "oncogene addiction," where switching off the oncogene leads to the cell cycle arrest and cell differentiation. However, recent data suggest that MYC also controls the establishment of the tumour microenvironment and that "oncogene addiction" actually has a strong immune background. Evaluation of the MYC role in the immunoediting process led to the speculation that cancer just uses and distorts the physiological mechanism by which MYC normally prevents rapidly proliferating cells from the elicitation of an autoimmune response. Concordantly, elevated levels of MYC and induction of immunosuppressive molecules are observed during the processes of growth and development, tissue repair, placenta development, and so forth, implying that MYC may be involved in saving regular physiologically proliferating cells from the immune system attack. Even more, a growing body of evidence suggests MYC involvement in the shaping of the adaptive immune response, immunological memory development, and establishment of immunotolerance. This paper offers an overview of MYC actions in the context of modulation of the immune response in pathological and physiological conditions. The determination of such a new role for a well-known oncogene opens new perspectives in biomedicine, and consequently, in the treatment of various pathological conditions.

Materia Medica, 2015

Hair loss in children hospitalized for malignant diseases treatment is most visible manifestation... more Hair loss in children hospitalized for malignant diseases treatment is most visible manifestation that dramatically influences their later selfconfidence. Further, this could strongly affect possible development of psychic crisis. Scientific researches on motivational aspects of involvement for provision of non-formal categories of support to patients with malignant diseases are infrequent. Therefore, this topic should be more investigated in future. Humanitarian initiative "Kilometer of hair", as unique philanthropic activity at territory of Serbia in year 2015, had as an aim to collect hair for preparation of wigs for children treated for malignant diseases. The main question in our study was definition of key motives for hair donation. We classified three main groups of motives. Altruism was detected as motivation in almost one-half of all interviewed subjects. Second group included almost one third of all subjects and their main motivation for hair donation was empathy. The smallest percentage of hair donors was motivated with some kind of public approval and welcome from society. We believe that further research in this area could give some directives for program planning of further improvement of social awareness for psychosocial support to children with malignant diseases.

Materia …, 2007

... Infekcije Ehrlichi-om chaffeensis u različitim regionima Srbije. Samardžić Svetomir a , Marin... more ... Infekcije Ehrlichi-om chaffeensis u različitim regionima Srbije. Samardžić Svetomir a , Marinković Dragan b , Marinković Tatjana b , Simović ... Srpska, Bosna i Hercegovina c Institut za javno zdravlje, Kruševac d Centar za imunološka istraživanja 'Branislav Janković', Beograd ...

International Reviews of Immunology, Jul 7, 2020

Ectopic lymphoid structures (ELS) or tertiary lymphoid organs are structures with the organizatio... more Ectopic lymphoid structures (ELS) or tertiary lymphoid organs are structures with the organization similar to the one of secondary lymphoid organs, formed in non-lymphoid tissues. They are considered to be an important site for the lymphocytic physiological and pathological role in conditions such are chronic infections, autoimmune diseases, cancer, and allograft rejection. Although similar to the secondary lymphoid tissues, the initiation of ELS formation is not preprogramed and requires chronic inflammation, expression of homeostatic chemokines, and lymphotoxin beta receptor activation. Importantly, while ELS formation may be considered beneficiary in antimicrobial and antitumor immunity, the persistence of these active lymphoid structures within the tissue increase the chance for development of autoimmunity and lymphoma. This paper is providing an overview of biological mechanisms involved in ELS formation, as well as the overview of the pathophysiological role of these structures. In addition, the paper discusses the possibility to therapeutically target ELS formation, bearing in mind their bivalent nature and role in different pathophysiological conditions.

10th International Scientific Conference Science and High Education in Function of Sustainable De... more 10th International Scientific Conference Science and High Education in Function of Sustainable Developmen

Molecular Neurobiology, 2021

MYC is well known as a potent oncogene involved in regulating cell cycle and metabolism. Augmente... more MYC is well known as a potent oncogene involved in regulating cell cycle and metabolism. Augmented MYC expression leads to cell cycle dysregulation, intense cell proliferation, and carcinogenesis. Surprisingly, its increased expression in neurons does not induce their proliferation, but leads to neuronal cell death and consequent development of a neurodegenerative phenotype. Interestingly, while cancer and neurodegenerative diseases such as Alzheimer's disease are placed at the opposite sides of cell division spectrum, both start with cell cycle dysregulation and stimulation of proliferation. It seems that MYC action directed toward neuron cell proliferation and neural tissue repair collides with evolutional loss of regenerative capacity of CNS neurons in order to strengthen synaptic structure, to protect our cognitive abilities and therefore character. Accordingly, there are abundant mechanisms that block its expression and action specifically in the brain. Moreover, while MYC expression in brain neurons during neurodegenerative processes is related to their death, there are obvious evidences that MYC action after physical injury is beneficial in case of peripheral nerve recovery. MYC might be a useful tool to repair brain cells upon development of neurodegenerative disease or CNS trauma, including stroke and traumatic brain and spinal cord injury, as even imperfect axonal growth and regeneration strategies will likely be of profound benefit. Understanding complex control of MYC action in the brain might have important therapeutic significance, but also it may contribute to the comprehension of development of neurodegenerative diseases.

Scandinavian Journal of Immunology, 2020

Journal of Cellular Physiology, 2020

As an oncogene, myelocytomatosis oncogene (MYC) is implicated in the concept of “oncogene addicti... more As an oncogene, myelocytomatosis oncogene (MYC) is implicated in the concept of “oncogene addiction,” where switching off the oncogene leads to the cell cycle arrest and cell differentiation. However, recent data suggest that MYC also controls the establishment of the tumour microenvironment and that “oncogene addiction” actually has a strong immune background. Evaluation of the MYC role in the immunoediting process led to the speculation that cancer just uses and distorts the physiological mechanism by which MYC normally prevents rapidly proliferating cells from the elicitation of an autoimmune response. Concordantly, elevated levels of MYC and induction of immunosuppressive molecules are observed during the processes of growth and development, tissue repair, placenta development, and so forth, implying that MYC may be involved in saving regular physiologically proliferating cells from the immune system attack. Even more, a growing body of evidence suggests MYC involvement in the shaping of the adaptive immune response, immunological memory development, and establishment of immunotolerance. This paper offers an overview of MYC actions in the context of modulation of the immune response in pathological and physiological conditions. The determination of such a new role for a well‐known oncogene opens new perspectives in biomedicine, and consequently, in the treatment of various pathological conditions.