RBRC00165 (original) (raw)
Strain Data Sheet
update : 2024-10-18
| Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC00165 |
| Type | [Targeted Mutation](../animal%5Fkey/list?strainType=Targeted Mutation&%5F%5Flang%5F%5F=en) |
| Species | Mus musculus |
| Strain name | B6.129S4-Zic2/JaruRbrc |
| Former Common name | C57BL/6N-Kd(Zic2), Zic2 Knockdown mouse |
| H-2 Haplotype | |
| ES Cell line | J1 [129S4/SvJae] |
| Background strain | C57BL/6N |
| Appearance | black |
| Strain development | |
| Strain description | |
| Colony maintenance | |
| References | Zic2 controls cerebellar development in cooperation with Zic1.Aruga J, Inoue T, Hoshino J, Mikoshiba KJ. Neurosci., 22, 218-225 (2002). 11756505Zic2 regulates the kinetics of neurulation.Nagai T, Aruga J, Minowa O, Sugimoto T, Ohno Y, Noda T, Mikoshiba KProc. Natl. Acad. Sci. USA, 97, 1618-1623 (2000). 10677508 |
| Health Report |
|---|
| Examination Date / Room / Rack |
| Gene | |||||||
|---|---|---|---|---|---|---|---|
| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Zic2 | zinc finger protein of the cerebellum 2 | 14 | Zic2 | targeted mutation 1, Jun Aruga | holoprosencephaly 5(DisGeNET, MedGEN) | ||
| neo | neomycin resistance gene (E. coli) | 14 | mouse phosphoglycerate kinase promoter (PGK promoter) | holoprosencephaly 5(DisGeNET, MedGEN) |
| Phenotype | |
|---|---|
| Annotation by Mammalian phenotyhpe ontology | abnormal amygdala morphology(MP:0000818)abnormal autopod morphology(MP:0000572)abnormal brain development(MP:0000913)abnormal cerebral cortex morphology(MP:0000788)abnormal cerebral hemisphere morphology(MP:0008540)more 40 phenotypesabnormal dorsal root ganglion morphology(MP:0000961)abnormal forebrain development(MP:0003232)abnormal limb bone morphology(MP:0002115)abnormal nervous system development(MP:0003861)abnormal neural fold formation(MP:0004837)abnormal neural plate morphology(MP:0005657)abnormal neural tube morphology(MP:0002151)abnormal olfactory bulb morphology(MP:0000819)abnormal roof plate morphology(MP:0000923)abnormal spatial learning(MP:0001463)abnormal spatial working memory(MP:0008428)abnormal spinal cord dorsal horn morphology(MP:0006282)abnormal telencephalon development(MP:0000934)abnormal vertebral arch morphology(MP:0004599)anencephaly(MP:0001890)behavior/neurological phenotype(MP:0005386)curly tail(MP:0003051)decreased aggression towards mice(MP:0003863)decreased brain size(MP:0000774)decreased corpus callosum size(MP:0000781)decreased locomotor activity(MP:0001402)decreased neuron number(MP:0008948)decreased prepulse inhibition(MP:0009142)enlarged lateral ventricles(MP:0008535)exencephaly(MP:0000914)fused carpal bones(MP:0008915)fused metacarpal bones(MP:0004639)fused metatarsal bones(MP:0004642)fused tarsal bones(MP:0008919)fusion of vertebral arches(MP:0004613)hindlimb paralysis(MP:0000755)holoprosencephaly(MP:0005157)hyperactivity(MP:0001399)impaired contextual conditioning behavior(MP:0009454)impaired cued conditioning behavior(MP:0009456)increased startle reflex(MP:0001488)microcephaly(MP:0000433)postnatal lethality, complete penetrance(MP:0011085)spina bifida(MP:0003054)thin cerebral cortex(MP:0006254) |
| Detailed phenotype data |
| Ordering Information | |
|---|---|
| Donor DNA | mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Zic2 (Zic finger protein of the cerebellum 2) genomic DNA |
| Research application | [Neurobiology Research](../animal%5Fkey/list?%5F%5Flang%5F%5F=en&researchApplication=Neurobiology Research) |
| Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 97, 1618-1623 (2000). |
| Depositor | Jun Aruga (RIKEN) |
| Strain Status |  Frozen embryos Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months)Cryopreserved sperm (within 1 month)Cryopreserved embryos (within 1 month) |
| Additional Info. | Necessary documents for ordering:Approval form (Japanese / English)Order form (Japanese / English)Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)Acceptance of responsibility for living modified organism (Japanese / English)Lab HP |
| BRC mice in Publications |
|---|
| García-Frigola C, Carreres MI, Vegar C, Mason C, Herrera E.Zic2 promotes axonal divergence at the optic chiasm midline by EphB1-dependent and -independent mechanisms.Development 135(10) 1833-41(2008) 18417618 |
| García-Frigola C, Herrera E.Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets.EMBO J 29(18) 3170-83(2010) 20676059 |
| Sánchez-Arrones L, Nieto-Lopez F, Sánchez-Camacho C, Carreres MI, Herrera E, Okada A, Bovolenta P.Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina.J Neurosci 33(20) 8596-607(2013) 23678105 |