Marwa Mehesen | Cairo University (original) (raw)

Papers by Marwa Mehesen

Research paper thumbnail of Comparing MitoQ10 and heat therapy: Evaluating mechanisms and therapeutic potential for polycystic ovary syndrome induced by circadian rhythm disruption

Chronobiology International

Research paper thumbnail of Possible renoprotective effect of valsartan/sacubitril versus valsartan and Metformin in rat model of diabetic nephropathy

Journal of Advanced Pharmacy Education and Research

Research paper thumbnail of Combined Systemic Intake of K-ATP Opener (Nicorandil) and Mesenchymal Stem Cells Preconditioned With Nicorandil Alleviates Pancreatic Insufficiency in a Model of Bilateral Renal Ischemia/Reperfusion Injury

Frontiers in Physiology

We used nicorandil, a K-ATP channel opener, to study the role of these channels in the ameliorati... more We used nicorandil, a K-ATP channel opener, to study the role of these channels in the amelioration of renal ischemia/reperfusion (I/R)-induced pancreatic injury, and the possible involvement of PI3K/Akt/mTOR signaling pathway. Forty-two male Wistar rats were included in this study, six were sacrificed for extraction of bone marrow mesenchymal stem cells (BM-MSCs) and conducting the in-vitro work, the others were included in vivo study and equally divided into six groups. Group 1 (sham control), but groups 2–6 were subjected to bilateral renal I/R: Group 2 (I/R); Group 3 (I/R-NC), treated with nicorandil; Group 4 (I/R-MSCs), treated with BM-MSCs; Group 5 (I/R-MSCC), treated with nicorandil-preconditioned BM-MSCs; Group 6 (I/R-NC-MSCC), treated with both systemic nicorandil and preconditioned BM-MSCC. Renal injury and subsequent pancreatic damage were detected in the I/R group by a significant increase in serum urea, creatinine, fasting glucose, and pancreatic enzymes. The pancreatic...

Research paper thumbnail of Combined Systemic Intake of K-ATP Opener (Nicorandil) and Mesenchymal Stem Cells Preconditioned With Nicorandil Alleviates Pancreatic Insufficiency in a Model of Bilateral Renal Ischemia/Reperfusion Injury

Frontiers in Physiology

We used nicorandil, a K-ATP channel opener, to study the role of these channels in the ameliorati... more We used nicorandil, a K-ATP channel opener, to study the role of these channels in the amelioration of renal ischemia/reperfusion (I/R)-induced pancreatic injury, and the possible involvement of PI3K/Akt/mTOR signaling pathway. Forty-two male Wistar rats were included in this study, six were sacrificed for extraction of bone marrow mesenchymal stem cells (BM-MSCs) and conducting the in-vitro work, the others were included in vivo study and equally divided into six groups. Group 1 (sham control), but groups 2–6 were subjected to bilateral renal I/R: Group 2 (I/R); Group 3 (I/R-NC), treated with nicorandil; Group 4 (I/R-MSCs), treated with BM-MSCs; Group 5 (I/R-MSCC), treated with nicorandil-preconditioned BM-MSCs; Group 6 (I/R-NC-MSCC), treated with both systemic nicorandil and preconditioned BM-MSCC. Renal injury and subsequent pancreatic damage were detected in the I/R group by a significant increase in serum urea, creatinine, fasting glucose, and pancreatic enzymes. The pancreatic...

Research paper thumbnail of Vitamin D Supplementation Improves Uterine Receptivity in a Rat Model of Vitamin D Deficiency: A Possible Role of HOXA-10/FKBP52 Axis

Frontiers in Physiology, 2021

Synchronized uterine receptivity with the time of implantation is crucial for pregnancy continuit... more Synchronized uterine receptivity with the time of implantation is crucial for pregnancy continuity. Vitamin D (VD) deficiency has been linked to the failure of implantation. Therefore, we tested the link between the Homeobox transcription factor-10/immunophilin FK506-binding protein 52 (HOXA-10/FKBP52) axis and the uterine receptivity in VD-deficient rats. The effect of VD supplementation at different doses was also investigated. Forty-eight pregnant rats were divided into six groups (eight/group); normal control rats fed with standard chow (control), control rats supplemented with VD (equivalent dose of 400 IU/day) (control-D400). VD-deficient group (DEF) and the three VD deficiency groups with VD supplementation were equivalent to 400, 4,000, and 10,000 IU/day (DEF-D400, DEF-D4000, and DEF-D10000, respectively). The expression levels of HOXA-10/FKBP52, progesterone level, and histological evaluation of decidualization using osteopontin (OSN) and progesterone receptor (PGR) were es...

Research paper thumbnail of Contribution of angiotensin II in hepatic ischemia /reperfusion induced lung injury: Acute versus chronic usage of captopril

Background: Acute lung injury is one of the most popular consequences of hepatic ischemia/reperfu... more Background: Acute lung injury is one of the most popular consequences of hepatic ischemia/reperfusion (I/R) injury. Recently it was documented that renin-angiotensin system plays a key role in tissue inflammation, generation of reactive oxygen species (ROS) and tumor necrosis factor-alpha (TNF-α) (the principal liver injury mediators) during I/R. Material and methods: We investigated the effect of acute versus chronic usage of angiotensin converting enzyme inhibitor (captopril) on liver inflammation and lung injury caused by hepatic ischemia for 1h followed by 24h reperfusion. Forty adult Wistar male rats were divided into sham, I/R, I/R-acute captopril (100 mg/kg, 24 and 1.5 h before surgery) and I/R-chronic captopril (10 mg/kg/day for 28 days before surgery) groups. Results: We found captopril pretreatment significantly decreased liver damage indices, adhesion molecules, and TNF-α level in hepatic and tracheal tissues. Histologically, acute captopril pretreatment significantly decreased hepatic Kupffer cells number and lung α-smooth muscle actin expression more than chronic pretreatment. Increased tracheal tone, in response to acetylcholine, was suppressed by acute and chronic captopril pretreatment. Conclusion: Angiotensin II plays a key role in tissue inflammation and airway hyperresponsiveness (AHR) via enhancing production of TNF-α. With more protection observed in lung, acute captopril could attenuate liverinduced lung injury via lowering TNF-α; a suggested possible mediator of airway hyperreactivity.

Research paper thumbnail of Prenatal intake of omega‐3 promotes Wnt/β‐catenin signaling pathway, and preserves integrity of the blood–brain barrier in preeclamptic rats

Physiological Reports

Preeclampsia is a systemic, multi‐organ endotheliopathy, associated with oxidative injury to the ... more Preeclampsia is a systemic, multi‐organ endotheliopathy, associated with oxidative injury to the blood–brain barrier (BBB). Preeclampsia initiates a cascade of events that include neuroinflammation. Recently, it was documented that Wnt/β‐catenin signaling pathway exerts neuroprotective effects and maintain BBB integrity. We investigate the protective effect of omega‐3 against neurovascular complication of preeclampsia and its relation to Wnt/β‐catenin signaling pathway.

Research paper thumbnail of Contribution of angiotensin II in hepatic ischemia /reperfusion induced lung injury: Acute versus chronic usage of captopril

Pulmonary Pharmacology & Therapeutics

Research paper thumbnail of 2015(35B-28)

The aim of the present study is to compare between the anti-inflammatory effect of simvastatin, r... more The aim of the present study is to compare between the anti-inflammatory effect of simvastatin, rosuvastatin alone and in combination with prednisolone on Acetic acid (10%concentration) induced inflammatory bowel disease model in rats. Material and method, Ninety six adult females albino rats weighting 160-210g were used. Induction of colitis was done in 6 th day of experiment. In prophylactic groups drugs were administrated 5 days before and 7days after induction of colitis. In therapeutic groups drugs were administrated7days after induction of colitis. the lesion in distal colone scored macroscopically and microscopically.Disease activity index (DAI), colon weight and colonic myeloperoxidase (MPO),and tumor necrosis factor alpha (TNFα) levels were assissed. Results,The present study showed that intra-colonic administration of 1 ml of acetic acid (10% conc.) using polyethylene tube (8F) resulted in significant increase in mean DAI, mean colon weight, mean colonic MPO,and TNFα levels. Also there was significant increase in mean macroscopic and microscopic pathological score of colon. Prophylactic and therapeutic administration of either simvastatin or rosuvastatin showed significantly decrease in inflammatory parameter. however, rosuvastatin and prednisolonewere more significant than simvastatin. moreover there was no significant difference between rosuvastatin and prednisolone.Conclusion,both simvastatin and rosuvastatin are significantly improving inflammatory parameters in prophylactic and therapeutic groups on IBD model, but effect of rosuvastatin is more significant than that of simvastatin. Moreover, rosuvastatin almost has same effects as prednisolone.

Research paper thumbnail of Comparing MitoQ10 and heat therapy: Evaluating mechanisms and therapeutic potential for polycystic ovary syndrome induced by circadian rhythm disruption

Chronobiology International

Research paper thumbnail of Possible renoprotective effect of valsartan/sacubitril versus valsartan and Metformin in rat model of diabetic nephropathy

Journal of Advanced Pharmacy Education and Research

Research paper thumbnail of Combined Systemic Intake of K-ATP Opener (Nicorandil) and Mesenchymal Stem Cells Preconditioned With Nicorandil Alleviates Pancreatic Insufficiency in a Model of Bilateral Renal Ischemia/Reperfusion Injury

Frontiers in Physiology

We used nicorandil, a K-ATP channel opener, to study the role of these channels in the ameliorati... more We used nicorandil, a K-ATP channel opener, to study the role of these channels in the amelioration of renal ischemia/reperfusion (I/R)-induced pancreatic injury, and the possible involvement of PI3K/Akt/mTOR signaling pathway. Forty-two male Wistar rats were included in this study, six were sacrificed for extraction of bone marrow mesenchymal stem cells (BM-MSCs) and conducting the in-vitro work, the others were included in vivo study and equally divided into six groups. Group 1 (sham control), but groups 2–6 were subjected to bilateral renal I/R: Group 2 (I/R); Group 3 (I/R-NC), treated with nicorandil; Group 4 (I/R-MSCs), treated with BM-MSCs; Group 5 (I/R-MSCC), treated with nicorandil-preconditioned BM-MSCs; Group 6 (I/R-NC-MSCC), treated with both systemic nicorandil and preconditioned BM-MSCC. Renal injury and subsequent pancreatic damage were detected in the I/R group by a significant increase in serum urea, creatinine, fasting glucose, and pancreatic enzymes. The pancreatic...

Research paper thumbnail of Combined Systemic Intake of K-ATP Opener (Nicorandil) and Mesenchymal Stem Cells Preconditioned With Nicorandil Alleviates Pancreatic Insufficiency in a Model of Bilateral Renal Ischemia/Reperfusion Injury

Frontiers in Physiology

We used nicorandil, a K-ATP channel opener, to study the role of these channels in the ameliorati... more We used nicorandil, a K-ATP channel opener, to study the role of these channels in the amelioration of renal ischemia/reperfusion (I/R)-induced pancreatic injury, and the possible involvement of PI3K/Akt/mTOR signaling pathway. Forty-two male Wistar rats were included in this study, six were sacrificed for extraction of bone marrow mesenchymal stem cells (BM-MSCs) and conducting the in-vitro work, the others were included in vivo study and equally divided into six groups. Group 1 (sham control), but groups 2–6 were subjected to bilateral renal I/R: Group 2 (I/R); Group 3 (I/R-NC), treated with nicorandil; Group 4 (I/R-MSCs), treated with BM-MSCs; Group 5 (I/R-MSCC), treated with nicorandil-preconditioned BM-MSCs; Group 6 (I/R-NC-MSCC), treated with both systemic nicorandil and preconditioned BM-MSCC. Renal injury and subsequent pancreatic damage were detected in the I/R group by a significant increase in serum urea, creatinine, fasting glucose, and pancreatic enzymes. The pancreatic...

Research paper thumbnail of Vitamin D Supplementation Improves Uterine Receptivity in a Rat Model of Vitamin D Deficiency: A Possible Role of HOXA-10/FKBP52 Axis

Frontiers in Physiology, 2021

Synchronized uterine receptivity with the time of implantation is crucial for pregnancy continuit... more Synchronized uterine receptivity with the time of implantation is crucial for pregnancy continuity. Vitamin D (VD) deficiency has been linked to the failure of implantation. Therefore, we tested the link between the Homeobox transcription factor-10/immunophilin FK506-binding protein 52 (HOXA-10/FKBP52) axis and the uterine receptivity in VD-deficient rats. The effect of VD supplementation at different doses was also investigated. Forty-eight pregnant rats were divided into six groups (eight/group); normal control rats fed with standard chow (control), control rats supplemented with VD (equivalent dose of 400 IU/day) (control-D400). VD-deficient group (DEF) and the three VD deficiency groups with VD supplementation were equivalent to 400, 4,000, and 10,000 IU/day (DEF-D400, DEF-D4000, and DEF-D10000, respectively). The expression levels of HOXA-10/FKBP52, progesterone level, and histological evaluation of decidualization using osteopontin (OSN) and progesterone receptor (PGR) were es...

Research paper thumbnail of Contribution of angiotensin II in hepatic ischemia /reperfusion induced lung injury: Acute versus chronic usage of captopril

Background: Acute lung injury is one of the most popular consequences of hepatic ischemia/reperfu... more Background: Acute lung injury is one of the most popular consequences of hepatic ischemia/reperfusion (I/R) injury. Recently it was documented that renin-angiotensin system plays a key role in tissue inflammation, generation of reactive oxygen species (ROS) and tumor necrosis factor-alpha (TNF-α) (the principal liver injury mediators) during I/R. Material and methods: We investigated the effect of acute versus chronic usage of angiotensin converting enzyme inhibitor (captopril) on liver inflammation and lung injury caused by hepatic ischemia for 1h followed by 24h reperfusion. Forty adult Wistar male rats were divided into sham, I/R, I/R-acute captopril (100 mg/kg, 24 and 1.5 h before surgery) and I/R-chronic captopril (10 mg/kg/day for 28 days before surgery) groups. Results: We found captopril pretreatment significantly decreased liver damage indices, adhesion molecules, and TNF-α level in hepatic and tracheal tissues. Histologically, acute captopril pretreatment significantly decreased hepatic Kupffer cells number and lung α-smooth muscle actin expression more than chronic pretreatment. Increased tracheal tone, in response to acetylcholine, was suppressed by acute and chronic captopril pretreatment. Conclusion: Angiotensin II plays a key role in tissue inflammation and airway hyperresponsiveness (AHR) via enhancing production of TNF-α. With more protection observed in lung, acute captopril could attenuate liverinduced lung injury via lowering TNF-α; a suggested possible mediator of airway hyperreactivity.

Research paper thumbnail of Prenatal intake of omega‐3 promotes Wnt/β‐catenin signaling pathway, and preserves integrity of the blood–brain barrier in preeclamptic rats

Physiological Reports

Preeclampsia is a systemic, multi‐organ endotheliopathy, associated with oxidative injury to the ... more Preeclampsia is a systemic, multi‐organ endotheliopathy, associated with oxidative injury to the blood–brain barrier (BBB). Preeclampsia initiates a cascade of events that include neuroinflammation. Recently, it was documented that Wnt/β‐catenin signaling pathway exerts neuroprotective effects and maintain BBB integrity. We investigate the protective effect of omega‐3 against neurovascular complication of preeclampsia and its relation to Wnt/β‐catenin signaling pathway.

Research paper thumbnail of Contribution of angiotensin II in hepatic ischemia /reperfusion induced lung injury: Acute versus chronic usage of captopril

Pulmonary Pharmacology & Therapeutics

Research paper thumbnail of 2015(35B-28)

The aim of the present study is to compare between the anti-inflammatory effect of simvastatin, r... more The aim of the present study is to compare between the anti-inflammatory effect of simvastatin, rosuvastatin alone and in combination with prednisolone on Acetic acid (10%concentration) induced inflammatory bowel disease model in rats. Material and method, Ninety six adult females albino rats weighting 160-210g were used. Induction of colitis was done in 6 th day of experiment. In prophylactic groups drugs were administrated 5 days before and 7days after induction of colitis. In therapeutic groups drugs were administrated7days after induction of colitis. the lesion in distal colone scored macroscopically and microscopically.Disease activity index (DAI), colon weight and colonic myeloperoxidase (MPO),and tumor necrosis factor alpha (TNFα) levels were assissed. Results,The present study showed that intra-colonic administration of 1 ml of acetic acid (10% conc.) using polyethylene tube (8F) resulted in significant increase in mean DAI, mean colon weight, mean colonic MPO,and TNFα levels. Also there was significant increase in mean macroscopic and microscopic pathological score of colon. Prophylactic and therapeutic administration of either simvastatin or rosuvastatin showed significantly decrease in inflammatory parameter. however, rosuvastatin and prednisolonewere more significant than simvastatin. moreover there was no significant difference between rosuvastatin and prednisolone.Conclusion,both simvastatin and rosuvastatin are significantly improving inflammatory parameters in prophylactic and therapeutic groups on IBD model, but effect of rosuvastatin is more significant than that of simvastatin. Moreover, rosuvastatin almost has same effects as prednisolone.