Yue Dong | China Foreign Affairs University (original) (raw)

Papers by Yue Dong

Proceedings of Spie the International Society For Optical Engineering, Aug 28, 2008

A BFU is an organ's smallest assembly of diverse cells that functions like the organ, such as the... more A BFU is an organ's smallest assembly of diverse cells that functions like the organ, such as the liver's hepatic lobules. There are approximately 107 BFUs in a human organ. These 100-200 μm structures are perfused by capillaries fed by a terminal arteriole (15μm diameter). BFU sizes, function and number per organ vary with disease, either by loss of BFUs and/or their decrease in function. The BFU is the upper limit of a spherical assembly of cells, immersed in a suitably nutrient medium, which can survive without its own blood supply. However, each BFU has its own blood supply to support the extra energy and/or solutes needed for providing its physiological function (e.g., contraction or secretion). A BFU function is best evaluated by its micro-perfusion, which can be readily evaluated with whole-body CT. Resolution of individual BFUs within in-situ organs, using clinical imaging devices, would require high radiation doses and/or the intolerably long scan-durations needed for suitable signal-to-noise image-data. However, it is possible to obtain a statistical description of the BFU number, size and function from wholebody CT by way of a model. In this study we demonstrate this capability by using the distribution of myocardial terminal arteriolar perfusion territories by way of a nested, multiple, regions-of-interest analysis of the heart wall imaged during transient opacification of its blood supply.

Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging, 2010

ABSTRACT Analysis of 3D images of vascular trees presents a major logistic and multi-scale imagin... more ABSTRACT Analysis of 3D images of vascular trees presents a major logistic and multi-scale imaging challenge. One approach that greatly reduces the image analysis difficulty is to apply an 'erode/dilate' approach to a binarized, segmented, image so as to progressively eliminate branches of increasing diameter. Although this provides useful data for detecting some changes in branching geometry, it eliminates information about the hierarchical structure of the vascular tree. To quantify the impact of this loss of branching hierarchy information we analyzed 3D micro-CT images (4mum and 20mum isotropic voxels) of porcine myocardial "biopsies" obtained in control animals and in animals after 100mum diameter microspheres were injected into the coronary artery perfusing the site of subsequent biopsy. After the in vivo embolization, the vascular tree was injected with radiopaque Microfil and "biopsies" of the myocardium harvested. The analysis of the micro-CT images of the biopsies involved erode/dilate analysis of the opacified vessels in the entire biopsy and also of isolated vascular trees (isolated via a 'connect' function) within the biopsy. The isolated trees were also analyzed by dimensional measurement of the individual interbranch segment lengths and volumes, results that were then put into the same form as those produced by the erode/dilate method. In the embolized specimens the volume-loss of vessels below 60mum diameter closely matched for (i) erode/dilate of entire biopsy, (ii) erode/dilate of isolated tree, and (iii) direct measurement of isolated tree. The erode/dilate method quantifies the effects of a microsphere embolization, indicating what diameter interbranch segments trap a microsphere of a given size.

Journal of Intensive Care, 2015

Contemporary critical care research necessitates involvement of multiple centers, preferably from... more Contemporary critical care research necessitates involvement of multiple centers, preferably from many countries. Adult and pediatric research networks have produced outstanding data; however, their involvement is restricted to a small percentage of the industrialized nations. Implementation of their findings in low- and middle-income countries (LMICs) is fraught with challenges. We conducted an online international survey to assess and compare disease burden and resources to participate in multicenter research studies through a listserv of the World Federation of Pediatric Intensive and Critical Care Societies. Respondents were grouped into high-income countries and LMICs on the basis of World Bank classification. Survey was completed by 73 centers in 34 countries (34 from high-income countries and 39 from LMICs). Compared with high-income countries, the pediatric intensive care units in LMICs were characterized by a lower number of critical care specialists, more difficult access to hemodialysis, and a lower number of elective postoperative patients, but a similar overall disease burden. Training and resources for research were comparable in the two cohorts. Although differences exist in access to both trained providers and equipment, the survey results were more striking in their similarity. It is essential that centers from LMICs be included in multinational studies, to generate results applicable to all children worldwide.

Mayo Clinic proceedings, 2015

To assess the epidemiology of nonoptimal hyponatremia correction and to identify associated morbi... more To assess the epidemiology of nonoptimal hyponatremia correction and to identify associated morbidity and in-hospital mortality. An electronic medical record search identified all patients admitted with profound hyponatremia (sodium <120 mmol/L) from January 1, 2008, through December 31, 2012. Patients were classified as having optimally or nonoptimally corrected hyponatremia at 24 hours after admission. Optimal correction was defined as sodium correction in 24 hours of 6 through 10 mmol/L. We investigated the association between sodium correction and demographic and outcome variables, including occurrence of osmotic demyelination syndrome (ODS). Baseline characteristics by correction outcome categories were compared using the Kruskal-Wallis test for continuous variables and the χ(2) test for categorical variables. Odds ratios for in-hospital mortality between groups were assessed using logistic regression. Adjusted differences in hospital length of stay (LOS) and intensive care ...

JSLS: Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons

We evaluated the efficacy of Microporous Polysaccharide Hemospheres (MPH) for parenchymal hemosta... more We evaluated the efficacy of Microporous Polysaccharide Hemospheres (MPH) for parenchymal hemostasis during laparoscopic partial nephrectomy (LPN) in the porcine model. Six female farm pigs underwent a transperitoneal right lower-pole LPN during occlusion of the renal hilum. Renal parenchyma was excised using cold Endoshears. MPH was applied to the defect and the hilar clamp released. Animals were kept alive for one week. Before sacrifice, left LPN was similarly performed using MPH. Study variables included blood loss, number of MPH applications, hilar clamp time, hemostasis time, perioperative complications, and abnormalities noted at sacrifice. Hemostasis was achieved in all kidneys solely by using MPH. The average excised specimen represented 5.6% (range, 3.6 to 8.5) of renal weight. Mean hilar clamp and hemostatic times were 12.8 minutes (range, 6 to 18) and 2 minutes (range, 1 to 3), respectively. Hemostasis occurred after one MPH application in 8 kidneys (67%). In 3 kidneys, a...

Developments in X-Ray Tomography VI, 2008

A BFU, is an organ's smallest assembly of diverse cells that functions like the organ, such as th... more A BFU, is an organ's smallest assembly of diverse cells that functions like the organ, such as the liver's hepatic lobules. There are approximately 10 7 BFUs in a human organ. These 100-200µm structures are perfused by capillaries fed by a terminal arteriole (<15µm diameter). BFU sizes, function and number per organ vary with disease, either by loss of BFUs and/or their decrease in function. The BFU is the upper limit of a spherical assembly of cells, immersed in a suitably nutrient medium, which can survive without its own blood supply. However, each BFU has its own blood supply to support the extra energy and/or solutes needed for providing its physiological function (e.g., contraction or secretion).

Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 2008

... Yue Donga, Patricia E. Beighleya, Diane R. Eakera, Mair Zamirb, Erik L. Ritmana aDept. ... 5.... more ... Yue Donga, Patricia E. Beighleya, Diane R. Eakera, Mair Zamirb, Erik L. Ritmana aDept. ... 5. EL Ritman, SM Jorgensen, PE Lund, PJ Thomas, JH Dunsmuir, JC Romero, RT Turner, ME Bolander, "Synchrotron-based micro-CT of in situ biological basic functional units and their ...

Medical Imaging 2005: Physiology, Function, and Structure from Medical Images, 2005

ABSTRACT Myocardial microcirculation disturbances often precede angiographically visible of narro... more ABSTRACT Myocardial microcirculation disturbances often precede angiographically visible of narrowing large epicardial coronary arteries and associated symptoms. Clinical tomographic imaging cannot resolve the microcirculation, hence an indirect method of quantitating microvascular disturbances in those images must be developed. We propose that such an indirect method can be based on the characterization of the spatial heterogeneity of myocardial intravascular blood volume. We evaluated the relationship of multi-resolution, nested multi Region-of-Interest (ROI) analysis of EBCT images to the actual intravascular volume of microvascular branches as measured directly with micro-CT images in the same myocardial regions. We selectively altered the intravascular volume of vessels by injecting 30, 100, 200 or 300mum diameter microspheres into anesthetized pigs" LAD coronary arteries prior to EBCT scanning during contrast injection. The heart was then harvested and the LAD coronary artery was infused with Microfil polymer. An approximately 2cm3 transmural "biopsy" of the same ROI within the myocardium analyzed in the EBCT images was scanned by micro-CT resulting in a 3D image of 20mum cubic voxels. Myocardial opacification was measured in both the EBCT and micro-CT images. The EBCT and micro-CT images were analyzed with the nested multi ROI method which provides an index of spatial heterogeneity of intramyocardial blood volume in terms of the linear relationship between the logarithms of the coefficient of variation within the data obtained at any one size of the ROI, and the logarithm of the volume of that selected ROI. The minimum ROI volume in the EBCT analysis was 8.96 mm3 and for the micro-CT it was 0.07 mm3. There is linear correlation when EBCT and micro-CT image CT gray-scale numbers are plotted as Log (standard deviation/mean) against Log (Volume of ROI). The results show that the slopes and offsets of the EBCT-based and micro-CT-based regression lines were indistinguishable. Moreover, when a fraction of microvessels of selected diameter was embolized, the change in the resulting regression line was characteristic for that diameter. In summary, the EBCT-based analysis spatial heterogeneity of myocardial blood volume can be extrapolated to describe the spatial distribution of the microcirculatory branching geometry in terms of intra segmental lumen volume.

D102. QUALITY IMPROVEMENT IN CRITICAL CARE MEDICINE, 2012

Clinical Biochemistry, 2015

We compared two different methods of whole blood sodium measurement to plasma sodium measurement ... more We compared two different methods of whole blood sodium measurement to plasma sodium measurement using samples in the profoundly hyponatremic range (Na &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;120 mmol/L). Whole blood pools with a range of low sodium values were generated using combinations and dilutions of pooled electrolyte-balanced lithium heparin samples submitted for arterial blood gas analysis. Each pool was analyzed five times on a Radiometer 827 blood gas analyzer and iSTAT analyzer. Pools were centrifuged to produce plasma, which was analyzed five times on a Roche Cobas c501 chemistry analyzer. An additional 40 fresh (analyzed on day of collection) excess lithium heparin arterial blood gas samples from 36 patients were analyzed on the Radiometer 827, iSTAT, and Cobas c501 as described above. The setting was a tertiary referral center. Blood samples were collected from a combination of patients in the intensive care unit, operating theaters and emergency room. All methods demonstrated excellent precision, even in the profoundly hyponatremic measurement range (Na &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;120mmol/L using a plasma reference method). However, agreement between the methods varied with the degree of hyponatremia. In the profoundly hyponatremic range, Radiometer whole blood sodium values were nearly identical to plasma reference sodium, while iSTAT whole blood sodium showed a consistent positive bias relative to plasmasodium in this range. If whole blood, direct sodium measurements are compared to plasma sodium in profoundly hyponatremic patients, consideration should be given to using Radiometer blood gas analyzers over iSTAT, since the latter shows a positive bias relative to a plasma comparative method.

PURPOSE Partial (180°+fan angle) scan reconstructions improve temporal resolution but cause large... more PURPOSE Partial (180°+fan angle) scan reconstructions improve temporal resolution but cause large CT number variations. This work sought to determine the magnitude of partial scan artifacts and develop methods to reduce or eliminate the resultant CT number variations. METHOD AND MATERIALS An anthropomorphic cardiac phantom was scanned on a dual-source CT (DSCT) scanner (Siemens Definition). Both cardiac perfusion (zero table feed) and cardiac spiral modes were used, with either one or both x-ray tubes. Additional data were acquired using a novel approach where the ECG-signal was synchronized with the x-ray tube angular position. The central portion of the phantom was replaced with a water tank containing a syringe with different iodine solutions. Images were reconstructed at four temporal resolutions (330, 248, 165, and 83 ms) corresponding to four levels of data symmetry (full, 3/4, half, and 1/4 gantry rotation, respectively). Four circular ROIs were placed symmetrically outside t...

World journal of critical care medicine, Jan 4, 2015

Processes to ensure world-wide best-practice for critical care delivery are likely to minimize pr... more Processes to ensure world-wide best-practice for critical care delivery are likely to minimize preventable death, disability and costly complications for any healthcare system's sickest patients, but no large-scale efforts have so far been undertaken towards these goals. The advances in medical informatics and human factors engineering have provided possibility for novel and user-friendly clinical decision support tools that can be applied in a complex and busy hospital setting. To facilitate timely and accurate best-practice delivery in critically ill patients international group of intensive care unit (ICU) physicians and researchers developed a simple decision support tool: Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN). The tool has been refined and tested in high fidelity simulated clinical environment and has been shown to improve performance of clinical providers faced with simulated emergencies. The aim of this international educational interven...