Mousa Numan Ahmad | The University Of Jordan (original) (raw)

Papers by Mousa Numan Ahmad

Research paper thumbnail of Test of insulin resistance in nondiabetic and streptozotocin-induced diabetic rats using glycosylated hemoglobin test and other interventions

Research paper thumbnail of Effects of dietary saturated, monounsaturated and polyunsaturated fats on plasma lipids and lipoproteins in diabetic rats*

Ecology of Food and Nutrition, Aug 1, 1990

... MOUSA NUMAN AHMAD1 and FAISAL A. KHATIB2 ... Abhimanyu, G., Bonanome, A., Grundy, SM, Zhang, ... more ... MOUSA NUMAN AHMAD1 and FAISAL A. KHATIB2 ... Abhimanyu, G., Bonanome, A., Grundy, SM, Zhang, Z. and Unger, RH (1988) Comparison of a high-carbohydrate diet with a high-monounsaturated diet in patients with non-insulin-dependent diabetes mellitus. N. Engl. ...

Research paper thumbnail of Production and Quality Evaluation of Arabic Bread from Different Gluten-Free Flours

Jordan Journal of Agricultural Sciences, Dec 1, 2022

This study aims to produce gluten-free flatbread for Celiac Disease (CD) patients from different ... more This study aims to produce gluten-free flatbread for Celiac Disease (CD) patients from different gluten-free flour sources, at household or commercial level, and compare its quality with that produced from wheat flour. Arabic flat bread was prepared, using the straight dough method, from the whole grains, gluten-free, flours of corn, millet, buckwheat, quinoa, rice, potatoes, and tapioca. Straight grade wheat flour was used for comparison. The specific volume, pocket formation, upper to lower layer ratio and water activity of the obtained breads, as well as their tenderness immediately and 4 hours after baking, and taste were evaluated. Proximate composition of the flours indicated that wheat flour had the highest protein content on wet basis (13.7%) seconded by, and significantly (P≤ 0.05) higher than, those of corn, millet, buckwheat, and quinoa (12.6 %-12.0%). The flours of rice, and potatoes had medium levels (7.90 and 7.85%) but significantly (P≤0.05) higher than the protein content of tapioca flours (0.22%) which was the lowest. Sensory and physical evaluation of the bread types showed that most flour types gave bread loaves with good specific volumes compared to wheat flour. Most bread types were tender when freshly baked, but only wheat and potato breads maintained their tenderness 4 hours after baking. The taste of potato and tapioca breads were the most acceptable and similar (P≤0.05) to that of wheat bread followed by corn and rice breads. It can be concluded that flatbread with good and acceptable sensory and functional properties can be produced at household, and bakery levels without additives, with the simplest of tools and home appliances from most flours especially if consumed fresh after baking.

Research paper thumbnail of Oak (Quercus aegilops L.) Root Bark Tannins Astringency, Antioxidant Potential, and Use as Functional Tea

Jordan Journal of Agricultural Sciences, Jun 1, 2020

Tannins from the root bark of Quercus aegilops L. were extracted in two successive seasons and th... more Tannins from the root bark of Quercus aegilops L. were extracted in two successive seasons and their astringency score and antioxidant potential were evaluated using bovine serum albumin (BSA) radial diffusion and 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) assay methods respectively. The results revealed that the root bark of this oak species contained on average 11.39 %(w/w) tannins as gallic acid, of which about 79% are hydrolyzable (HT) and 21% condensed (CT) tannins with the former composed mainly of ellagitannins and much fewer gallotannins and free gallic acid. The results also revealed that the crude root bark powder and its purified tannins have astringency scores of 15.8 and 138.98 mg BSA/g respectively. The antioxidant potential was evaluated by DPPH assay and expressed as inhibition capacity (IC50) was 149.7 ppm and 19.24 ppm for the crude bark powder and its purified tannins respectively indicating the superior antioxidant potential of these tannins to that of ascorbic acid. The highly-antioxidant functional tea prepared from these tannins was clear and acceptable to tasters.

Research paper thumbnail of Evaluation of the influence of treatment exposure on neuropeptide leptin hormone and obesity risk among Jordanian breast cancer women

Acta Facultatis Medicae Naissensis, 2019

Breast cancer (BC) is the most prevalent and life-threatening malignant tumor in adult females. L... more Breast cancer (BC) is the most prevalent and life-threatening malignant tumor in adult females. Little is known about the association between neuropeptide leptin hormone and development of BC. The aim of the paper was to evaluate the interactive role of neuropeptide leptin hormone among BC Jordanian women with regard to treatment exposure and menopausal status. A total of 396 BC women (25-65 years) attending BC clinics were evaluated by observational study. The experimental design permitted the inclusion of 134 newly diagnosed BC patients who were not exposed to any type of interventions and 262 recently diagnosed BC patients during their first three months of treatment exposure. Manual enzyme-linked immunosorbent assay (ELISA) was used for the quantitative determination of leptin levels. The prevalence of hyperleptinaemia, leptin level higher than 11.1 ng/ml, was almost 27 %, and the mean value of serum leptin (ng/ml) in the whole sample was 8.5 ± 0.03 and it was insignificantly lower in non-chemo (7.1 ± 0.05) than chemo (8.6 ± 0.5) and newly diagnosed (9.2 ± 0.6) BC patients. Leptin was positively correlated with all obesity indices including BMI, WC, WHpR and WHtR. In newly diagnosed BC patients, leptin had the highest correlation with BMI (r = 0.38, p ˂ 0.05), whereas in the recently diagnosed, it was highly correlated with WC (r = 0.38, p < 0.05). The leptin hormone was positively correlated with obesity indices in BC patients and it was higher in postmenopausal BC women. The leptin hormone was decreased after treatment exposure and may be considered as a biomarker for BC prognosis and response to treatment. The leptin hormone may need a closer attention by health care providers in order to improve outcomes after making the diagnosis and treatment exposure.

Research paper thumbnail of HPLC/MS-MS Identification of Oak Quercus aegilops Root Tannins

Journal of Chemistry, Mar 2, 2021

Tannins are natural polyphenolic compounds widely distributed in the plant kingdom in the leaves,... more Tannins are natural polyphenolic compounds widely distributed in the plant kingdom in the leaves, bark, fruits, and other parts. ey have various biological functions in humans and animals and are used mainly in the pharmaceutical and cosmetic industries. e aim of this work was to isolate, extract, purify, and identify the tannins from the root bark of a common oak tree (Quercus aegilops L.) in Jordan and around the Mediterranean. e results showed that at least one form of ellagitannin (ellagic acid ester), quercitrin, afzelechin, valoneic acid, trigalloyl glucose, and catechin was identified in addition to two unidentified compounds. Results of this work can help in developing an ESI MS/MS search library for the constituents of the tannins of oak (Quercus aegilops L.) root bark.

Research paper thumbnail of Impact of Chemotherapy Treatments on Dietary Intakes of Macro and Micronutrients among Jordanian Women with Breast Cancer

Journal of pharmacy and nutrition sciences, Jun 25, 2018

Background: Breast cancer (BC) is the leading cause of cancer related deaths among women worldwid... more Background: Breast cancer (BC) is the leading cause of cancer related deaths among women worldwide. Nutritional factors may account for the large variation in BC incidence around the world. Most studies have shown no link between dietary intakes and increased risk of BC. Objective: To evaluate the dietary intake of macro and some micronutrients among BC patients with respect to chemotherapy treatment. Methods: A total of 168 BC patients aged 20-70 years attending BC clinics at the Jordanian Royal Medical Services, Jordan were evaluated for dietary intake. The study design permitted to include 60 newly-diagnosed BC patients who were not exposed to any type of interventions and 108 recently-diagnosed BC patients (up to three months). Recently group member were subdivided in two subgroups to control exposure to chemotherapy. The Chemo group (have exposed to chemotherapy) and the non-chemo group (have exposed to other types of treatments interventions). Calculations were based on the computerized nutrient analysis program (the food processor nutrition and fitness analysis software (ESHA), version 10.6/.3, Salem, USA). Results: Energy, macronutrients and micronutrients intakes were not significantly different considering exposure to chemotherapy. However, they were less than recommended in all BC patients. Conclusion: The possible risk of dietary undernutrition among BC patients that need a careful monitoring, evaluation and managements care plan.

Research paper thumbnail of Original / Síndrome metabólico Evaluation of several anthropometric indices of obesity as predictors of metabolic syndrome in Jordanian adults

Introduction: anthropometric indices have all been tested for their relation to metabolic syndrom... more Introduction: anthropometric indices have all been tested for their relation to metabolic syndrome (MetS), but with no consistent cutoff points are yet established among different population group. Objective: this study aims to evaluate the predictive power of several anthropometric indices of central obesity as predictors of MetS in a group of Jordanian adults. Methods: in this cross sectional study, 630 adult subjects (308 men and 322 women) aged between 20-70 years were recruited at the King Hussein Medical Center in Amman (Jordan). The diagnosis of MetS was defined by the International Diabetes Federation criteria. Anthropometric measurements (waist circumference [WC]; waist to hip ratio [WHpR]; waist to height ratio [WHtR]; body mass index [BMI]) were performed and recorded following standard procedures. Receiver operating characteristic (ROC) curves were used to determine the efficacy of anthropometric measurements as predictors of MetS. Results: the results indicated that, in men for identifying subjects with MetS risk, area under curve (AUC) from the ROC curves for WC was 0.851, AUC for WHpR was 0.842, AUC for WHtR was 0.85, and AUC for BMI was 0.83. In women, AUC for WC, WHpR, WHtR, and BMI were 0.866, 0.871, 0.872, and 0.831, respectively. Conclusion: it could be concluded that among anthropometric indices, both WHtR and WC had the strongest predictive power for identifying subjects with MetS in men and women. WHtR appears to be the best indicator of central obesity in women and individuals of short stature.

Research paper thumbnail of Original / Síndrome metabólico Suitability of visceral adiposity index as a marker for cardiometabolic risks in Jordanian adults

Introduction: visceral adiposity index (VAI) has recently been proposed as a predictor of cardiom... more Introduction: visceral adiposity index (VAI) has recently been proposed as a predictor of cardiometabolic risk, but its usefulness has not been confirmed. Objectives: to evaluate the association between VAI and conventional adiposity and cardiometabolic risk indices and examine VAI risk predictive ability and compare it with other adiposity indices. Methods: a total of 1 622 Jordanian adults, 686 men and 936 women, aged 20-80 years were included this study. VAI, body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), waist-height ratio (WHtR) were examined and high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), fasting serum glucose (FSG), systolic (SBP), and diastolic (DBP) blood pressure were determined. Associations and age-and genderspecific distribution and differences were evaluated. Receiver operating characteristic (ROC) curve and area under curve (AUC) were used for risk predictive ability comparison. Results: VAI of women (6.82±6.43) was higher than of men (4.15±4.62). VAI severity increased with age in a dose-response trend (p<0.001) in both genders. Women had higher prevalence than men of high risks of VAI and all adiposity and cardiometabolic indices. VAI markedly associated with TG, HDL-C, FSG, SBP and DBP or WHR, WC, WHtR and BMI in respective order of correlation potency for cardiometabolic or adiposity risk indices. In men and women respectively, the largest AUC was for VAI (0.79 vs. 0.77), followed by WHR (0.73 vs. 0.75), WC (0.69 vs. 0.74), WHtR (0.65 vs. 0.71) and BMI (0.53 vs. 0.51). IDONEIDAD DEL ÍNDICE DE ADIPOSIDAD VISCERAL COMO MARCADOR DE RIESGO CARDIOMETABÓLICO EN ADULTOS JORDANOS Resumen Introducción: el índice de adiposidad visceral (VAI) ha sido propuesto recientemente como predictor de riesgo cardiometabólico, pero su utilidad no ha sido confirmada. Objetivos: evaluar la asociación entre VAI y los índices de adiposidad y riesgo cardiometabólico convencionales y examinar la capacidad predictiva del riesgo VAI en comparación con otros índices de adiposidad. Métodos: en este estudio se incluyeron un total de 1.622 adultos de Jordania, 686 hombres y 936 mujeres, de edad entre 20 y 80 años. Fueron examinados el VAI, el índice de masa corporal (BMI), la circunferencia de la cintura (WC), la relación cintura-cadera (WHR) y la relación cintura-estatura (WHtR) y se determinaron el colesterol de lipoproteínas de alta densidad (HDL-C), los triglicéridos (TG), la glucosa sérica en ayunas (FSG), y la presión arterial sistólica (SBP) y diastólica (DBP). Se evaluaron las asociaciones, la distribución por edad y género y las diferencias. El receptor de funcionamiento característico (ROC) y el área bajo la curva (AUC) se utilizaron para comparar la capacidad de predicción del riesgo. Resultados: el VAI de las mujeres (6,82 ± 6,43) fue mayor que el de los hombres (4,15 ± 4,62). El VAI severidad aumenta con la edad en una tendencia dosis-respuesta (p < 0,001) en ambos sexos. Las mujeres tuvieron mayor prevalencia que los hombres de alto riesgo de VAI y todos los índices de adiposidad y cardiometabólicos. VAI marcadamente asociado con TG, HDL-C, FSG, SBP y DBP o WHR, WC, WHtR y el BMI en orden respectivo de la potencia de correlación para los índices de riesgo cardiometabólico o adiposidad. En hombres y mujeres, respectivamente, el AUC era más grande para VAI (0,79 vs. 0,77), seguido por WHR (0,73 vs. 0,75), aseo (0,69 vs. 0,74), WHtR (0,65 vs. 0,71) y el BMI (0,53 vs. 0,51).

Research paper thumbnail of Ameliorative Effect of Selenium Yeast in combination with Pioglitazone on Diabetes outcomes in Streptozotocin-Induced Diabetes in Sprague-Dawley Rats

Journal of Population Therapeutics and Clinical Pharmacology

Anti-diabetic therapies possess many side effects; thus, searching for alternative strategies wit... more Anti-diabetic therapies possess many side effects; thus, searching for alternative strategies with low cost, minimal side effects, and high therapeutic value is very important. The present study aimed to explore the combined use of selenium yeast (SY) and standard anti-diabetic drug pioglitazone (PGZ) for diabetes Ameliorative effect of selenium yeast e203

Research paper thumbnail of Effect of Birhi Vaiety of Date Palm Fruits, (Phoenix dactylifera L.) at the Tamr Stage on Serum Glucose Levels in Streptozotocin-Induced Diabetic Rats

Journal of Agricultural Science, 2015

This study was carried out to investigate the effect of a dietary preparation of Birhi tamr (Phoe... more This study was carried out to investigate the effect of a dietary preparation of Birhi tamr (Phoenix dactylifera L.) on serum glucose levels and body weight in normal, diabetic insulin-treated and diabetic insulin-untreated rats. Diabetes was partially induced by intraperitoneal injection of streptozotocin (32.25 mg/kg). Thirty six male Sprague-Dawley rats (239 ± 8.4 g) were divided into two normal, two diabetic insulin-treated and two diabetic insulin-untreated groups. Each group was fed a diet containing either 0% or 10% tamr for six weeks. Fasting serum glucose levels were determined by enzymatic-calorimetric method using a standard kit procedure.Feeding 10% tamr did not show significant differences (P > 0.05) in serum glucose levels in any of the normal and insulin-treated diabetic rats. Insulin-untreated diabetic rats fed 0% tamr or 10% tamr exhibited significantly (P < 0.05) higher serum glucose levels (496 ± 81.6, 315 ± 61.1 mg/dl respectively) compared to normal (147 ± 5.3, 156 ± 7.6 mg/dl respectively) and insulin-treated diabetic rats (227 ± 17.6, 268± 18.9 mg/dl respectively). Feeding 10% tamr to insulin-untreated rats induced significant (P < 0.05) reduction in this variable. The findings of the present study may provide support for the favourable effect of date palm fruits as tamr, on blood glucose in streptozotocin-diabetic rats. This effect cannot be simply explained on the basis of the macro-nutrient composition of tamr. However, due to the apparent effects of tamr on blood glucose in normal and insulin-treated and insulin-untreated diabetic rats, the possible presence of insulin-like substance in tamr may not be excluded. The mechanism of action of the blood glucose-lowering effect of tamr awaits further investigation.

Research paper thumbnail of Current Prospects of Rome Criteria for the Diagnosis of Irritable Bowel Syndrome

Jordan Journal of Agricultural Sciences

Irritable bowel syndrome (IBS) is a worldwide health problem. It is often diagnosed by periodical... more Irritable bowel syndrome (IBS) is a worldwide health problem. It is often diagnosed by periodically- updated Rome symptom-based criteria, but the effects of recent updates on IBS diagnosis are not well clarified. This article overviews Rome III and IV IBS criteria, highlighting changes and updates that may impact IBS diagnosis. PubMed, Medline, Science Direct, Clinical trials.gov, and WHO databases were searched through to July 2021. Rome IV criteria are more restrictive, specific, and precise in patients′ diagnosis, selection, prognosis, and follow-up than Rome III criteria, in turn, IBS prevalence and number of patients with IBS-unspecified and IBS-mixed subtypes decrease, but overall symptom severity and patients′ homogeneity increase. In essence, the slight difference between Rome III and IV criteria reflects a considerable influence on IBS diagnosis, subtyping, and prevalence. Rome IV IBS patients form a homogeneous subset of Rome III IBS patients with more severe symptoms. Thu...

Research paper thumbnail of Human Nutrition and Dietetics: Understanding the Profession and Development Actions in Jordan

Jordan Journal of Agricultural Sciences

In Jordan, human nutrition and dietetics are among the most developed allied health professions, ... more In Jordan, human nutrition and dietetics are among the most developed allied health professions, but documented information regarding its current status is generally not available. The purpose of this article is to clarify the status of this profession in the country and to trace the developmental activities that have taken place over the past five decades. Currently, there have been remarkable transitions in health attributes among Jordanians as related to nutritional status since fifty years ago. This is manifested in rapid dietary, socio-economic, epidemiologic, and demographic shifts. Accelerated changes have occurred in general health and nutritional status trends, including a decline in the incidence of infectious diseases, increased life expectancy, a surge in all levels of education, rise in urbanization, mechanization and market globalization, decreased physical activity, diets have become denser in energy and richer in carbohydrates, fat, and animal foods. Concordant troub...

Research paper thumbnail of Introduction to the Jjas Special Issue “Celebrating the Country's Centenary”: The Development of Sciences and Technology of Agriculture, Food, and Nutrition in Jordan

Jordan Journal of Agricultural Sciences

This JJAS special issue on “The Development of Sciences and Technology of Agriculture, Food, and ... more This JJAS special issue on “The Development of Sciences and Technology of Agriculture, Food, and Nutrition in Jordan” has been announced soon after the declaration of the official day of the centenary of the founding of the Jordanian state on the 11th of April 2021 (Ahmad, 2021). The issue comprises 13 invited review articles that describe the advancement in basic and applied scientific research in the fields of agriculture, food, and nutrition in a hundred years of the country’s establishment. The development in science and technology of these fields has emerged as a powerful paradigm for Jordan’s next generation of economics, food security, and human health (JIC, 2018).

Research paper thumbnail of MOUSA NUMAN AHMAD: CURRICULUM VITAE December 2021

Research paper thumbnail of Graphical Abstract and Highlights- Fatty Acids Recommendations- Controversies and Updates

Research paper thumbnail of Interactive role of breast cancer on dyslipidemia and hypertension metabolic risk according to treatment exposure and menopausal status

Forum of Clinical Oncology, 2021

Background Breast cancer (BC) is the principal cause of cancer related deaths among women worldwi... more Background Breast cancer (BC) is the principal cause of cancer related deaths among women worldwide. The available evidence suggests that cardio-metabolic risk factors such as dyslipidemia and hypertension may contribute differently to breast cancer severity and pathogenesis. The aim of this study is to evaluate the interactive role of BC on dyslipidemia and HTN risk according to the type of treatment exposure and menopausal status. Patients and methods Observational experimental design implemented; permit to include 134 newly-diagnosed patients who were naïve to any type of treatment interventions and 262 recently-diagnosed patients during their first three months of treatments’ exposure including chemotherapy treatments. Patients with breast cancer were evaluated for dyslipidemia and hypertension biomarkers. Results About 5.0% of breast cancer patients had dyslipidemia. The prevalence of increased triglycerides and total cholesterol were more frequent (p < 0.05) in recently-dia...

Research paper thumbnail of The impact of treatment exposure on diabetes biomarkers among Jordanian breast cancer women: a connection through FBG, C-peptide and HOMA-IR

Current Gynecologic Oncology, 2017

Background: Breast cancer is the most frequently occurring and life-threatening malignant tumor i... more Background: Breast cancer is the most frequently occurring and life-threatening malignant tumor in women. The evidence that associates diabetes' biomarkers with breast cancer is highly controversial. Aims: To evaluate diabetes' biomarkers in breast cancer patients according to type of treatment exposure, breast cancer severity and menopausal status. Material and methods: A total of 396 breast cancer patients aged between 25 and 65 years attending breast cancer clinics were evaluated. The experimental design permitted to include 134 newly-diagnosed breast cancer patients who were not exposed to any type of interventions and 262 recently diagnosed breast cancer patients (up to three months). Recently, group members were subdivided in two subgroups to control exposure to therapy specially chemotherapy. The patients were further divided according to breast cancer stages and postmenopausal status. Diabetes biomarkers consisted of fasting blood glucose (FBG), C-peptide and HOMA-IR. Results: The high FBG was more prevalent in advance (24.1%) than early (10.6%) stage breast cancer. Compared with premenopausal breast cancer patients, postmenopausal breast cancer patients had higher prevalence of abnormal FBG (21.0% vs. 11.1%). The differences were also significant in the mean of FBG (103.0 ± 1.5 vs. 89.0 ± 0.0 mg/dL). In postmenopausal breast cancer patients, FBG was higher in the recently diagnosed whom expose to treatments including chemotherapy (106.5 ± 1.7 mg/dL vs. 126.2 ± 1.2 mm Hg) compared to the newly-diagnosed group whom not yet expose to any kind of treatment interventions. Conclusion: Diabetes was prevalent among breast cancer patients and it was higher in postmenopausal and advanced stage breast cancer women. The burden of diabetes on treatment expose breast cancer women tend to be high and warrants closer attention by health care provider to improved outcomes after diagnosis and treatment exposure.

Research paper thumbnail of Fructose-Induced Insulin Resistance: Prospective Biochemical Mechanisms

Jordan Journal of Agricultural Sciences

Increased intake of dietary fructose is markedly associated with multiple negative health outcome... more Increased intake of dietary fructose is markedly associated with multiple negative health outcomes and burdens. Insulin resistance (IR) and type 2 diabetes mellitus (T2DM) are the most common complications that present with conjugated cellular-biochemical abnormalities. This article explains the involvement of increased dietary fructose intake in the occurrence of IR and T2DM and addresses basic metabolic mechanisms. PubMed, Medline, Science Direct, ADI, and WHO databases were searched through June 2021. Current research predicts that over 350 million people may have diabetes by 2030. IR acts as an influencer promoter of T2DM development. IR can occur as a result of high fructose intake. Fructose metabolism results in de novo lipogenesis, while its decreasing effect of peroxisome proliferator-activated receptor (PPAR) activity elevates the levels of inflammatory cytokines, resulting in down-regulation of insulin receptor substrate-1 phosphorylation. Fructose stimulates oxidative str...

Research paper thumbnail of The Antioxidant and Pro-oxidant Impacts of Varying Levels of Alpha-Lipoic Acid on Biomarkers of Myoglobin Oxidation in Vitro

Jordan Journal of Agricultural Sciences

R-alpha-lipoic acid (R-ALA) has been known to protect protein oxidation and lessen the pathogenes... more R-alpha-lipoic acid (R-ALA) has been known to protect protein oxidation and lessen the pathogenesis of oxidative-related multiple diseases; however, its dosing remains unresolved. This study aimed to examine whether in vitro R-ALA varying levels would have antioxidant or pro-oxidant impacts on biomarkers of myoglobin oxidation in terms of carbonyls and free thiols for myoglobin upon long-term incubation. Myoglobin (1mg/mL) was concentrated with 6 different concentrations of R-ALA: 50 µM, 100 µM, 500 µM, 1mM, 2mM and 4mM for 30 days at pH 6.6 and temperature 37 °C. Myoglobin oxidative modifications as protein carbonyls and its oxidative defense as free thiols were determined by standard procedures. Thirty-day coincubation of native myoglobin with R-ALA at 500 µM, 1mM, 2mM, and 4mM significantly (p<0.05) elevated carbonyls (2.51±0.19; 2.59±0.22; 2.71±0.32 and 2.79±0.39 nmol/ mg protein respectively) compared to their levels in native control myoglobin (1.67±0.43 nmol/ mg protein) a...

Research paper thumbnail of Test of insulin resistance in nondiabetic and streptozotocin-induced diabetic rats using glycosylated hemoglobin test and other interventions

Research paper thumbnail of Effects of dietary saturated, monounsaturated and polyunsaturated fats on plasma lipids and lipoproteins in diabetic rats*

Ecology of Food and Nutrition, Aug 1, 1990

... MOUSA NUMAN AHMAD1 and FAISAL A. KHATIB2 ... Abhimanyu, G., Bonanome, A., Grundy, SM, Zhang, ... more ... MOUSA NUMAN AHMAD1 and FAISAL A. KHATIB2 ... Abhimanyu, G., Bonanome, A., Grundy, SM, Zhang, Z. and Unger, RH (1988) Comparison of a high-carbohydrate diet with a high-monounsaturated diet in patients with non-insulin-dependent diabetes mellitus. N. Engl. ...

Research paper thumbnail of Production and Quality Evaluation of Arabic Bread from Different Gluten-Free Flours

Jordan Journal of Agricultural Sciences, Dec 1, 2022

This study aims to produce gluten-free flatbread for Celiac Disease (CD) patients from different ... more This study aims to produce gluten-free flatbread for Celiac Disease (CD) patients from different gluten-free flour sources, at household or commercial level, and compare its quality with that produced from wheat flour. Arabic flat bread was prepared, using the straight dough method, from the whole grains, gluten-free, flours of corn, millet, buckwheat, quinoa, rice, potatoes, and tapioca. Straight grade wheat flour was used for comparison. The specific volume, pocket formation, upper to lower layer ratio and water activity of the obtained breads, as well as their tenderness immediately and 4 hours after baking, and taste were evaluated. Proximate composition of the flours indicated that wheat flour had the highest protein content on wet basis (13.7%) seconded by, and significantly (P≤ 0.05) higher than, those of corn, millet, buckwheat, and quinoa (12.6 %-12.0%). The flours of rice, and potatoes had medium levels (7.90 and 7.85%) but significantly (P≤0.05) higher than the protein content of tapioca flours (0.22%) which was the lowest. Sensory and physical evaluation of the bread types showed that most flour types gave bread loaves with good specific volumes compared to wheat flour. Most bread types were tender when freshly baked, but only wheat and potato breads maintained their tenderness 4 hours after baking. The taste of potato and tapioca breads were the most acceptable and similar (P≤0.05) to that of wheat bread followed by corn and rice breads. It can be concluded that flatbread with good and acceptable sensory and functional properties can be produced at household, and bakery levels without additives, with the simplest of tools and home appliances from most flours especially if consumed fresh after baking.

Research paper thumbnail of Oak (Quercus aegilops L.) Root Bark Tannins Astringency, Antioxidant Potential, and Use as Functional Tea

Jordan Journal of Agricultural Sciences, Jun 1, 2020

Tannins from the root bark of Quercus aegilops L. were extracted in two successive seasons and th... more Tannins from the root bark of Quercus aegilops L. were extracted in two successive seasons and their astringency score and antioxidant potential were evaluated using bovine serum albumin (BSA) radial diffusion and 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) assay methods respectively. The results revealed that the root bark of this oak species contained on average 11.39 %(w/w) tannins as gallic acid, of which about 79% are hydrolyzable (HT) and 21% condensed (CT) tannins with the former composed mainly of ellagitannins and much fewer gallotannins and free gallic acid. The results also revealed that the crude root bark powder and its purified tannins have astringency scores of 15.8 and 138.98 mg BSA/g respectively. The antioxidant potential was evaluated by DPPH assay and expressed as inhibition capacity (IC50) was 149.7 ppm and 19.24 ppm for the crude bark powder and its purified tannins respectively indicating the superior antioxidant potential of these tannins to that of ascorbic acid. The highly-antioxidant functional tea prepared from these tannins was clear and acceptable to tasters.

Research paper thumbnail of Evaluation of the influence of treatment exposure on neuropeptide leptin hormone and obesity risk among Jordanian breast cancer women

Acta Facultatis Medicae Naissensis, 2019

Breast cancer (BC) is the most prevalent and life-threatening malignant tumor in adult females. L... more Breast cancer (BC) is the most prevalent and life-threatening malignant tumor in adult females. Little is known about the association between neuropeptide leptin hormone and development of BC. The aim of the paper was to evaluate the interactive role of neuropeptide leptin hormone among BC Jordanian women with regard to treatment exposure and menopausal status. A total of 396 BC women (25-65 years) attending BC clinics were evaluated by observational study. The experimental design permitted the inclusion of 134 newly diagnosed BC patients who were not exposed to any type of interventions and 262 recently diagnosed BC patients during their first three months of treatment exposure. Manual enzyme-linked immunosorbent assay (ELISA) was used for the quantitative determination of leptin levels. The prevalence of hyperleptinaemia, leptin level higher than 11.1 ng/ml, was almost 27 %, and the mean value of serum leptin (ng/ml) in the whole sample was 8.5 ± 0.03 and it was insignificantly lower in non-chemo (7.1 ± 0.05) than chemo (8.6 ± 0.5) and newly diagnosed (9.2 ± 0.6) BC patients. Leptin was positively correlated with all obesity indices including BMI, WC, WHpR and WHtR. In newly diagnosed BC patients, leptin had the highest correlation with BMI (r = 0.38, p ˂ 0.05), whereas in the recently diagnosed, it was highly correlated with WC (r = 0.38, p < 0.05). The leptin hormone was positively correlated with obesity indices in BC patients and it was higher in postmenopausal BC women. The leptin hormone was decreased after treatment exposure and may be considered as a biomarker for BC prognosis and response to treatment. The leptin hormone may need a closer attention by health care providers in order to improve outcomes after making the diagnosis and treatment exposure.

Research paper thumbnail of HPLC/MS-MS Identification of Oak Quercus aegilops Root Tannins

Journal of Chemistry, Mar 2, 2021

Tannins are natural polyphenolic compounds widely distributed in the plant kingdom in the leaves,... more Tannins are natural polyphenolic compounds widely distributed in the plant kingdom in the leaves, bark, fruits, and other parts. ey have various biological functions in humans and animals and are used mainly in the pharmaceutical and cosmetic industries. e aim of this work was to isolate, extract, purify, and identify the tannins from the root bark of a common oak tree (Quercus aegilops L.) in Jordan and around the Mediterranean. e results showed that at least one form of ellagitannin (ellagic acid ester), quercitrin, afzelechin, valoneic acid, trigalloyl glucose, and catechin was identified in addition to two unidentified compounds. Results of this work can help in developing an ESI MS/MS search library for the constituents of the tannins of oak (Quercus aegilops L.) root bark.

Research paper thumbnail of Impact of Chemotherapy Treatments on Dietary Intakes of Macro and Micronutrients among Jordanian Women with Breast Cancer

Journal of pharmacy and nutrition sciences, Jun 25, 2018

Background: Breast cancer (BC) is the leading cause of cancer related deaths among women worldwid... more Background: Breast cancer (BC) is the leading cause of cancer related deaths among women worldwide. Nutritional factors may account for the large variation in BC incidence around the world. Most studies have shown no link between dietary intakes and increased risk of BC. Objective: To evaluate the dietary intake of macro and some micronutrients among BC patients with respect to chemotherapy treatment. Methods: A total of 168 BC patients aged 20-70 years attending BC clinics at the Jordanian Royal Medical Services, Jordan were evaluated for dietary intake. The study design permitted to include 60 newly-diagnosed BC patients who were not exposed to any type of interventions and 108 recently-diagnosed BC patients (up to three months). Recently group member were subdivided in two subgroups to control exposure to chemotherapy. The Chemo group (have exposed to chemotherapy) and the non-chemo group (have exposed to other types of treatments interventions). Calculations were based on the computerized nutrient analysis program (the food processor nutrition and fitness analysis software (ESHA), version 10.6/.3, Salem, USA). Results: Energy, macronutrients and micronutrients intakes were not significantly different considering exposure to chemotherapy. However, they were less than recommended in all BC patients. Conclusion: The possible risk of dietary undernutrition among BC patients that need a careful monitoring, evaluation and managements care plan.

Research paper thumbnail of Original / Síndrome metabólico Evaluation of several anthropometric indices of obesity as predictors of metabolic syndrome in Jordanian adults

Introduction: anthropometric indices have all been tested for their relation to metabolic syndrom... more Introduction: anthropometric indices have all been tested for their relation to metabolic syndrome (MetS), but with no consistent cutoff points are yet established among different population group. Objective: this study aims to evaluate the predictive power of several anthropometric indices of central obesity as predictors of MetS in a group of Jordanian adults. Methods: in this cross sectional study, 630 adult subjects (308 men and 322 women) aged between 20-70 years were recruited at the King Hussein Medical Center in Amman (Jordan). The diagnosis of MetS was defined by the International Diabetes Federation criteria. Anthropometric measurements (waist circumference [WC]; waist to hip ratio [WHpR]; waist to height ratio [WHtR]; body mass index [BMI]) were performed and recorded following standard procedures. Receiver operating characteristic (ROC) curves were used to determine the efficacy of anthropometric measurements as predictors of MetS. Results: the results indicated that, in men for identifying subjects with MetS risk, area under curve (AUC) from the ROC curves for WC was 0.851, AUC for WHpR was 0.842, AUC for WHtR was 0.85, and AUC for BMI was 0.83. In women, AUC for WC, WHpR, WHtR, and BMI were 0.866, 0.871, 0.872, and 0.831, respectively. Conclusion: it could be concluded that among anthropometric indices, both WHtR and WC had the strongest predictive power for identifying subjects with MetS in men and women. WHtR appears to be the best indicator of central obesity in women and individuals of short stature.

Research paper thumbnail of Original / Síndrome metabólico Suitability of visceral adiposity index as a marker for cardiometabolic risks in Jordanian adults

Introduction: visceral adiposity index (VAI) has recently been proposed as a predictor of cardiom... more Introduction: visceral adiposity index (VAI) has recently been proposed as a predictor of cardiometabolic risk, but its usefulness has not been confirmed. Objectives: to evaluate the association between VAI and conventional adiposity and cardiometabolic risk indices and examine VAI risk predictive ability and compare it with other adiposity indices. Methods: a total of 1 622 Jordanian adults, 686 men and 936 women, aged 20-80 years were included this study. VAI, body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), waist-height ratio (WHtR) were examined and high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), fasting serum glucose (FSG), systolic (SBP), and diastolic (DBP) blood pressure were determined. Associations and age-and genderspecific distribution and differences were evaluated. Receiver operating characteristic (ROC) curve and area under curve (AUC) were used for risk predictive ability comparison. Results: VAI of women (6.82±6.43) was higher than of men (4.15±4.62). VAI severity increased with age in a dose-response trend (p<0.001) in both genders. Women had higher prevalence than men of high risks of VAI and all adiposity and cardiometabolic indices. VAI markedly associated with TG, HDL-C, FSG, SBP and DBP or WHR, WC, WHtR and BMI in respective order of correlation potency for cardiometabolic or adiposity risk indices. In men and women respectively, the largest AUC was for VAI (0.79 vs. 0.77), followed by WHR (0.73 vs. 0.75), WC (0.69 vs. 0.74), WHtR (0.65 vs. 0.71) and BMI (0.53 vs. 0.51). IDONEIDAD DEL ÍNDICE DE ADIPOSIDAD VISCERAL COMO MARCADOR DE RIESGO CARDIOMETABÓLICO EN ADULTOS JORDANOS Resumen Introducción: el índice de adiposidad visceral (VAI) ha sido propuesto recientemente como predictor de riesgo cardiometabólico, pero su utilidad no ha sido confirmada. Objetivos: evaluar la asociación entre VAI y los índices de adiposidad y riesgo cardiometabólico convencionales y examinar la capacidad predictiva del riesgo VAI en comparación con otros índices de adiposidad. Métodos: en este estudio se incluyeron un total de 1.622 adultos de Jordania, 686 hombres y 936 mujeres, de edad entre 20 y 80 años. Fueron examinados el VAI, el índice de masa corporal (BMI), la circunferencia de la cintura (WC), la relación cintura-cadera (WHR) y la relación cintura-estatura (WHtR) y se determinaron el colesterol de lipoproteínas de alta densidad (HDL-C), los triglicéridos (TG), la glucosa sérica en ayunas (FSG), y la presión arterial sistólica (SBP) y diastólica (DBP). Se evaluaron las asociaciones, la distribución por edad y género y las diferencias. El receptor de funcionamiento característico (ROC) y el área bajo la curva (AUC) se utilizaron para comparar la capacidad de predicción del riesgo. Resultados: el VAI de las mujeres (6,82 ± 6,43) fue mayor que el de los hombres (4,15 ± 4,62). El VAI severidad aumenta con la edad en una tendencia dosis-respuesta (p < 0,001) en ambos sexos. Las mujeres tuvieron mayor prevalencia que los hombres de alto riesgo de VAI y todos los índices de adiposidad y cardiometabólicos. VAI marcadamente asociado con TG, HDL-C, FSG, SBP y DBP o WHR, WC, WHtR y el BMI en orden respectivo de la potencia de correlación para los índices de riesgo cardiometabólico o adiposidad. En hombres y mujeres, respectivamente, el AUC era más grande para VAI (0,79 vs. 0,77), seguido por WHR (0,73 vs. 0,75), aseo (0,69 vs. 0,74), WHtR (0,65 vs. 0,71) y el BMI (0,53 vs. 0,51).

Research paper thumbnail of Ameliorative Effect of Selenium Yeast in combination with Pioglitazone on Diabetes outcomes in Streptozotocin-Induced Diabetes in Sprague-Dawley Rats

Journal of Population Therapeutics and Clinical Pharmacology

Anti-diabetic therapies possess many side effects; thus, searching for alternative strategies wit... more Anti-diabetic therapies possess many side effects; thus, searching for alternative strategies with low cost, minimal side effects, and high therapeutic value is very important. The present study aimed to explore the combined use of selenium yeast (SY) and standard anti-diabetic drug pioglitazone (PGZ) for diabetes Ameliorative effect of selenium yeast e203

Research paper thumbnail of Effect of Birhi Vaiety of Date Palm Fruits, (Phoenix dactylifera L.) at the Tamr Stage on Serum Glucose Levels in Streptozotocin-Induced Diabetic Rats

Journal of Agricultural Science, 2015

This study was carried out to investigate the effect of a dietary preparation of Birhi tamr (Phoe... more This study was carried out to investigate the effect of a dietary preparation of Birhi tamr (Phoenix dactylifera L.) on serum glucose levels and body weight in normal, diabetic insulin-treated and diabetic insulin-untreated rats. Diabetes was partially induced by intraperitoneal injection of streptozotocin (32.25 mg/kg). Thirty six male Sprague-Dawley rats (239 ± 8.4 g) were divided into two normal, two diabetic insulin-treated and two diabetic insulin-untreated groups. Each group was fed a diet containing either 0% or 10% tamr for six weeks. Fasting serum glucose levels were determined by enzymatic-calorimetric method using a standard kit procedure.Feeding 10% tamr did not show significant differences (P > 0.05) in serum glucose levels in any of the normal and insulin-treated diabetic rats. Insulin-untreated diabetic rats fed 0% tamr or 10% tamr exhibited significantly (P < 0.05) higher serum glucose levels (496 ± 81.6, 315 ± 61.1 mg/dl respectively) compared to normal (147 ± 5.3, 156 ± 7.6 mg/dl respectively) and insulin-treated diabetic rats (227 ± 17.6, 268± 18.9 mg/dl respectively). Feeding 10% tamr to insulin-untreated rats induced significant (P < 0.05) reduction in this variable. The findings of the present study may provide support for the favourable effect of date palm fruits as tamr, on blood glucose in streptozotocin-diabetic rats. This effect cannot be simply explained on the basis of the macro-nutrient composition of tamr. However, due to the apparent effects of tamr on blood glucose in normal and insulin-treated and insulin-untreated diabetic rats, the possible presence of insulin-like substance in tamr may not be excluded. The mechanism of action of the blood glucose-lowering effect of tamr awaits further investigation.

Research paper thumbnail of Current Prospects of Rome Criteria for the Diagnosis of Irritable Bowel Syndrome

Jordan Journal of Agricultural Sciences

Irritable bowel syndrome (IBS) is a worldwide health problem. It is often diagnosed by periodical... more Irritable bowel syndrome (IBS) is a worldwide health problem. It is often diagnosed by periodically- updated Rome symptom-based criteria, but the effects of recent updates on IBS diagnosis are not well clarified. This article overviews Rome III and IV IBS criteria, highlighting changes and updates that may impact IBS diagnosis. PubMed, Medline, Science Direct, Clinical trials.gov, and WHO databases were searched through to July 2021. Rome IV criteria are more restrictive, specific, and precise in patients′ diagnosis, selection, prognosis, and follow-up than Rome III criteria, in turn, IBS prevalence and number of patients with IBS-unspecified and IBS-mixed subtypes decrease, but overall symptom severity and patients′ homogeneity increase. In essence, the slight difference between Rome III and IV criteria reflects a considerable influence on IBS diagnosis, subtyping, and prevalence. Rome IV IBS patients form a homogeneous subset of Rome III IBS patients with more severe symptoms. Thu...

Research paper thumbnail of Human Nutrition and Dietetics: Understanding the Profession and Development Actions in Jordan

Jordan Journal of Agricultural Sciences

In Jordan, human nutrition and dietetics are among the most developed allied health professions, ... more In Jordan, human nutrition and dietetics are among the most developed allied health professions, but documented information regarding its current status is generally not available. The purpose of this article is to clarify the status of this profession in the country and to trace the developmental activities that have taken place over the past five decades. Currently, there have been remarkable transitions in health attributes among Jordanians as related to nutritional status since fifty years ago. This is manifested in rapid dietary, socio-economic, epidemiologic, and demographic shifts. Accelerated changes have occurred in general health and nutritional status trends, including a decline in the incidence of infectious diseases, increased life expectancy, a surge in all levels of education, rise in urbanization, mechanization and market globalization, decreased physical activity, diets have become denser in energy and richer in carbohydrates, fat, and animal foods. Concordant troub...

Research paper thumbnail of Introduction to the Jjas Special Issue “Celebrating the Country's Centenary”: The Development of Sciences and Technology of Agriculture, Food, and Nutrition in Jordan

Jordan Journal of Agricultural Sciences

This JJAS special issue on “The Development of Sciences and Technology of Agriculture, Food, and ... more This JJAS special issue on “The Development of Sciences and Technology of Agriculture, Food, and Nutrition in Jordan” has been announced soon after the declaration of the official day of the centenary of the founding of the Jordanian state on the 11th of April 2021 (Ahmad, 2021). The issue comprises 13 invited review articles that describe the advancement in basic and applied scientific research in the fields of agriculture, food, and nutrition in a hundred years of the country’s establishment. The development in science and technology of these fields has emerged as a powerful paradigm for Jordan’s next generation of economics, food security, and human health (JIC, 2018).

Research paper thumbnail of MOUSA NUMAN AHMAD: CURRICULUM VITAE December 2021

Research paper thumbnail of Graphical Abstract and Highlights- Fatty Acids Recommendations- Controversies and Updates

Research paper thumbnail of Interactive role of breast cancer on dyslipidemia and hypertension metabolic risk according to treatment exposure and menopausal status

Forum of Clinical Oncology, 2021

Background Breast cancer (BC) is the principal cause of cancer related deaths among women worldwi... more Background Breast cancer (BC) is the principal cause of cancer related deaths among women worldwide. The available evidence suggests that cardio-metabolic risk factors such as dyslipidemia and hypertension may contribute differently to breast cancer severity and pathogenesis. The aim of this study is to evaluate the interactive role of BC on dyslipidemia and HTN risk according to the type of treatment exposure and menopausal status. Patients and methods Observational experimental design implemented; permit to include 134 newly-diagnosed patients who were naïve to any type of treatment interventions and 262 recently-diagnosed patients during their first three months of treatments’ exposure including chemotherapy treatments. Patients with breast cancer were evaluated for dyslipidemia and hypertension biomarkers. Results About 5.0% of breast cancer patients had dyslipidemia. The prevalence of increased triglycerides and total cholesterol were more frequent (p < 0.05) in recently-dia...

Research paper thumbnail of The impact of treatment exposure on diabetes biomarkers among Jordanian breast cancer women: a connection through FBG, C-peptide and HOMA-IR

Current Gynecologic Oncology, 2017

Background: Breast cancer is the most frequently occurring and life-threatening malignant tumor i... more Background: Breast cancer is the most frequently occurring and life-threatening malignant tumor in women. The evidence that associates diabetes' biomarkers with breast cancer is highly controversial. Aims: To evaluate diabetes' biomarkers in breast cancer patients according to type of treatment exposure, breast cancer severity and menopausal status. Material and methods: A total of 396 breast cancer patients aged between 25 and 65 years attending breast cancer clinics were evaluated. The experimental design permitted to include 134 newly-diagnosed breast cancer patients who were not exposed to any type of interventions and 262 recently diagnosed breast cancer patients (up to three months). Recently, group members were subdivided in two subgroups to control exposure to therapy specially chemotherapy. The patients were further divided according to breast cancer stages and postmenopausal status. Diabetes biomarkers consisted of fasting blood glucose (FBG), C-peptide and HOMA-IR. Results: The high FBG was more prevalent in advance (24.1%) than early (10.6%) stage breast cancer. Compared with premenopausal breast cancer patients, postmenopausal breast cancer patients had higher prevalence of abnormal FBG (21.0% vs. 11.1%). The differences were also significant in the mean of FBG (103.0 ± 1.5 vs. 89.0 ± 0.0 mg/dL). In postmenopausal breast cancer patients, FBG was higher in the recently diagnosed whom expose to treatments including chemotherapy (106.5 ± 1.7 mg/dL vs. 126.2 ± 1.2 mm Hg) compared to the newly-diagnosed group whom not yet expose to any kind of treatment interventions. Conclusion: Diabetes was prevalent among breast cancer patients and it was higher in postmenopausal and advanced stage breast cancer women. The burden of diabetes on treatment expose breast cancer women tend to be high and warrants closer attention by health care provider to improved outcomes after diagnosis and treatment exposure.

Research paper thumbnail of Fructose-Induced Insulin Resistance: Prospective Biochemical Mechanisms

Jordan Journal of Agricultural Sciences

Increased intake of dietary fructose is markedly associated with multiple negative health outcome... more Increased intake of dietary fructose is markedly associated with multiple negative health outcomes and burdens. Insulin resistance (IR) and type 2 diabetes mellitus (T2DM) are the most common complications that present with conjugated cellular-biochemical abnormalities. This article explains the involvement of increased dietary fructose intake in the occurrence of IR and T2DM and addresses basic metabolic mechanisms. PubMed, Medline, Science Direct, ADI, and WHO databases were searched through June 2021. Current research predicts that over 350 million people may have diabetes by 2030. IR acts as an influencer promoter of T2DM development. IR can occur as a result of high fructose intake. Fructose metabolism results in de novo lipogenesis, while its decreasing effect of peroxisome proliferator-activated receptor (PPAR) activity elevates the levels of inflammatory cytokines, resulting in down-regulation of insulin receptor substrate-1 phosphorylation. Fructose stimulates oxidative str...

Research paper thumbnail of The Antioxidant and Pro-oxidant Impacts of Varying Levels of Alpha-Lipoic Acid on Biomarkers of Myoglobin Oxidation in Vitro

Jordan Journal of Agricultural Sciences

R-alpha-lipoic acid (R-ALA) has been known to protect protein oxidation and lessen the pathogenes... more R-alpha-lipoic acid (R-ALA) has been known to protect protein oxidation and lessen the pathogenesis of oxidative-related multiple diseases; however, its dosing remains unresolved. This study aimed to examine whether in vitro R-ALA varying levels would have antioxidant or pro-oxidant impacts on biomarkers of myoglobin oxidation in terms of carbonyls and free thiols for myoglobin upon long-term incubation. Myoglobin (1mg/mL) was concentrated with 6 different concentrations of R-ALA: 50 µM, 100 µM, 500 µM, 1mM, 2mM and 4mM for 30 days at pH 6.6 and temperature 37 °C. Myoglobin oxidative modifications as protein carbonyls and its oxidative defense as free thiols were determined by standard procedures. Thirty-day coincubation of native myoglobin with R-ALA at 500 µM, 1mM, 2mM, and 4mM significantly (p<0.05) elevated carbonyls (2.51±0.19; 2.59±0.22; 2.71±0.32 and 2.79±0.39 nmol/ mg protein respectively) compared to their levels in native control myoglobin (1.67±0.43 nmol/ mg protein) a...