Effects of progesterone on postovariectomy bone loss in aged rats (original) (raw)
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Department of Medicine, VA West Side Medical Center, and University of Illinois College of Medicine, Chicago, IL 60612
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Department of Medicine, VA West Side Medical Center, and University of Illinois College of Medicine, Chicago, IL 60612
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Department of Pathobiology, College of Veterinary Medicine, Ohio State University, Columbus, OH 43210
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Department of Medicine, VA West Side Medical Center, and University of Illinois College of Medicine, Chicago, IL 60612
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Department of Medicine, VA West Side Medical Center, and University of Illinois College of Medicine, Chicago, IL 60612
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Department of Civil Engineering, Mechanics and Metallurgy, College of Engineering, University of Illinois, Chicago, IL 60680
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Department of Medicine, VA West Side Medical Center, and University of Illinois College of Medicine, Chicago, IL 60612
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Received:
08 January 1990
Revision received:
22 June 1990
Published:
01 November 1990
Cite
E.I. Barengolts, H.F. Gajardo, T.J. Rosol, J.J. D'Anza, M. Pena, J. Botsis, S.C. Kukreja, Effects of progesterone on postovariectomy bone loss in aged rats, Journal of Bone and Mineral Research, Volume 5, Issue 11, 1 November 1990, Pages 1143–1147, https://doi.org/10.1002/jbmr.5650051109
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Abstract
The effects of progesterone on oophorectomy‐induced bone loss in aged rats were evaluated. Female rats aged 12 months were divided into three groups: (1) sham‐operated controls (SHAM); (2) oophorectomized (OVX); (3) OVX rats treated with progesterone (OVX + PROG). After 20 weeks the dry weight, bone ash, and calcium content of femur, tibia, and fourth lumbar vertebra were significantly lower in OVX than in sham rats. These reductions did not occur in OVX rats treated with PROG. There was no difference in the bone composition between the control and progesterone‐treated rats. Vertebral bone histomorphometry showed increased bone resorption as well as increased bone formation parameters in OVX rats. Progesterone treatment inhibited the increased resorption indices, but the bone formation remained elevated. The results indicate that progesterone therapy prevents the postovariectomy bone loss in aged rats. The protective effect of progesterone is mediated by inhibition of bone resorption while maintaining the increased bone formation. These findings suggest that progesterone alone may be a valuable agent for management of postmenopausal osteoporosis.
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