Expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in acute and chronic inflammation (original) (raw)
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Department of Molecular and Cellular Physiology, Louisiana State University Medical Center
, Shreveport
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Department of Molecular and Cellular Physiology, Louisiana State University Medical Center
, Shreveport
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Department of Molecular and Cellular Physiology, Louisiana State University Medical Center
, Shreveport
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Department of Molecular and Cellular Physiology, Louisiana State University Medical Center
, Shreveport
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Department of Molecular and Cellular Physiology, Louisiana State University Medical Center
, Shreveport
Correspondence: Matthew B. Grisham, Ph.D., Department of Molecular and Cellular Physiology, LSU Medical Center, 1501 Kings Highway, Shreveport, LA 71130-3932. E. M. C. and M. J. E. contributed equally to this manuscript.
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Revision received:
09 November 1998
Accepted:
14 November 1998
Cite
Elaine M Connor, Michael J Eppihimer, Zenichi Morise, D Neil Granger, Matthew B Grisham, Expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in acute and chronic inflammation, Journal of Leukocyte Biology, Volume 65, Issue 3, March 1999, Pages 349–355, https://doi.org/10.1002/jlb.65.3.349
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Abstract
The objective of this study was to quantify, in vivo, constitutive and tumor necrosis factor α (TNF-α)-enhanced expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in different tissues from healthy wild-type mice (C57BL/6) as well as interleukin-10 (IL-10)-deficient mice with and without active colitis. Using the dual radiolabel monoclonal antibody technique, we found substantial constitutive expression of MAdCAM-1 in the intestine, colon, and mesenteric lymph nodes. MAdCAM-1 expression in these tissues was significantly enhanced, in a time-dependent manner, by systemic administration of TNF-α. Maximum surface expression was observed at 18 h after TNF-α administration and remained significantly elevated at 48 h post-TNF-α injection. No significant constitutive nor TNF-α-induced expression of MAdCAM-1 was detected in skeletal muscle, brain, or heart. In IL-10-deficient (IL-10 k/o) mice with no clinical or histological evidence of colitis, constitutive and TNF-α-induced expression of MAdCAM-1 in the intestine, cecum, and colon was not different from those values obtained with healthy wild-type controls. IL-10-deficient mice with active colitis exhibited a four- to fivefold greater expression of MAdCAM-1 in the cecum and colon compared with their healthy controls or to IL-10 k/o mice with no evidence of colitis. Taken together, these data demonstrate that TNF-α enhances surface expression of MAdCAM-1 in intestinal and colonic tissues to the same extent in both wild-type and IL-10 k/o mice with no colonic inflammation, whereas IL-10 k/o mice with active colitis exhibited a profound up-regulation of MAd-CAM-1 in the colon. J. Leukoc. Biol. 65: 349–355; 1999.
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© 1999 Society for Leukocyte Biology
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