Dendritic cells and the pathogenesis of rheumatoid arthritis (original) (raw)
Journal Article
,
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital
,
Australia
Correspondence: Dr. Ranjeny Thomas, Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, 4102, Australia. E-mail: rthomas@medicine.pa.uq.edu.au
Search for other works by this author on:
,
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital
,
Australia
Search for other works by this author on:
,
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital
,
Australia
Search for other works by this author on:
,
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital
,
Australia
Search for other works by this author on:
,
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital
,
Australia
Search for other works by this author on:
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital
,
Australia
Search for other works by this author on:
Received:
10 February 1999
Revision received:
23 April 1999
Published:
01 August 1999
Cite
Ranjeny Thomas, Kelli PA MacDonald, Allison R Pettit, Lois L Cavanagh, Jagdish Padmanabha, Simone Zehntner, Dendritic cells and the pathogenesis of rheumatoid arthritis, Journal of Leukocyte Biology, Volume 66, Issue 2, August 1999, Pages 286–292, https://doi.org/10.1002/jlb.66.2.286
Close
Navbar Search Filter Mobile Enter search term Search
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease in which unknown arthrogenic autoantigen is presented to CD4+ T cells. The strong association of the disease with an epitope within the HLA-DR chain shared between various alleles of HLA-DR4 and DR1 emphasizes the importance of antigen presentation. This immune response predominantly occurs in the synovial tissue and fluid of the joints and autoreactive T cells are readily demonstrable in both the synovial compartment and blood. Circulating dendritic cells (DC) are phenotypically and functionally identical with normal peripheral blood (PB) DC. In the synovial tissue, fully differentiated perivascular DC are found in close association with T cells and with B cell follicles, sometimes containing follicular DC. These perivascular DC migrate across the activated endothelium from blood and receive differentiative signals within the joint from monocyte-derived cytokines and CD40-ligand+ T cells. In the SF, DC manifest an intermediate phenotype, similar to that of monocyte-derived DC in vitro. Like a delayed-type hypersensitivity response, the rheumatoid synovium represents an effector site. DC at many effector sites have a characteristic pattern of infiltration and differentiation. It is important to note that the effector response is not self-limiting in RA autoimmune inflammation. In this article, we argue that the presentation of self-antigen by DC and by autoantibody-producing B cells is critical for the perpetuation of the autoimmune response. Permanently arresting this ongoing immune response with either pharmaceutical agents or immunotherapy is a major challenge for immunology. J. Leukoc. Biol. 66: 286–292; 1999.
This content is only available as a PDF.
© 1999 Society for Leukocyte Biology
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
You do not currently have access to this article.
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
Dendritic cells and the pathogenesis of rheumatoid arthritis - 24 Hours access
EUR €48.00
GBP £41.00
USD $51.00
Rental
This article is also available for rental through DeepDyve.
Citations
Views
Altmetric
Metrics
Total Views 30
0 Pageviews
30 PDF Downloads
Since 2/1/2023
| Month: | Total Views: |
|---|---|
| February 2023 | 1 |
| April 2023 | 2 |
| May 2023 | 2 |
| July 2023 | 2 |
| August 2023 | 1 |
| September 2023 | 1 |
| November 2023 | 1 |
| December 2023 | 2 |
| January 2024 | 4 |
| February 2024 | 1 |
| March 2024 | 1 |
| April 2024 | 3 |
| May 2024 | 2 |
| July 2024 | 3 |
| August 2024 | 3 |
| September 2024 | 1 |
Citations
92 Web of Science
×
Email alerts
Citing articles via
More from Oxford Academic