Binucleated and Multinucleated Neurons are Formed by Fusion (original) (raw)

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References

1. Sergeeva SS, Sotnikov OS, Paramonova NV. Method for creating a neurophysiological model of a simple nervous system possessing reverberation. Ross. Fiziol. Zh. 2020;106(9):1163-1169. doi: https://doi.org/10.31857/S0869813920080075. Russian.
   Article Google Scholar
2. Sotnikov OS. Reticular theory of Camillo Golgi and restructuring electrical synapses in syncytial perforations. Biol. Bull. 2019;46(2):128-143.
   Article Google Scholar
3. Yarygin NE, Yarygin VN. Pathological and Adoptive Changes of Neurons. Moscow, 1973. Russian.
4. Ackman JB, Siddiqi F, Walikonis RS, LoTurco JJ. Fusion of microglia with pyramidal neurons after retroviral infection. J. Neurosci. 2006;26(44):11413-11422. doi: https://doi.org/10.1523/JNEUROSCI.3340-06.2006
   Article CAS PubMed PubMed Central Google Scholar
5. Alvarez-Dolado M, Pardal R, Garcia-Verdugo JM, Fike JR, Lee HO, Pfeffer K, Lois C, Morrison SJ, Alvarez-Buylla A. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature. 2003;425:968-973. doi: https://doi.org/10.1038/nature02069
   Article CAS PubMed Google Scholar
6. Anastas SB, Mueller D, Semple-Rowland SL, Breunig JJ, Sarkisian MR. Failed cytokinesis of neural progenitors in citron kinase-deficient rats leads to multinucleated neurons. Cereb. Cortex. 2011;21(2):338-344. doi: https://doi.org/10.1093/cercor/bhq099
   Article PubMed Google Scholar
7. Bae JS, Han HS, Youn DH, Carter JE, Modo M, Schuchman EH, Jin HK. Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration. Stem Cells. 2007;25(5):1307-1316. doi: https://doi.org/10.1634/stemcells.2006-0561
   Article CAS PubMed Google Scholar
8. Blümcke I, Wiestler OD. Gangliogliomas: an antriguing tumor entity associated with focal epilepsies. J. Neuropathol. Exp. Neurol. 2002;61(7):575-584. doi: https://doi.org/10.1093/jnen/61.7.575
   Article PubMed Google Scholar
9. Chen KA, Cruz PE, Lanuto DJ, Flotte TR, Borchelt DR, Srivastava A, Zhang J, Steindler DA, Zheng T. Cellular fusion for gene delivery to SCA1 affected Purkinje neurons. Mol. Cell. Neurosci. 2011;47(1):61-70. doi: https://doi.org/10.1016/j.mcn.2011.03.003
   Article CAS PubMed PubMed Central Google Scholar
10. DiLorenzo DJ, Jankovic J, Simpson RK, Takei H, Powell SZ. Long-term deep brain stimulation for essential tremor: 12-year clinicopathologic follow-up. Mov. Disord. 2010;25(2):232-238. doi: https://doi.org/10.1002/mds.22935
    Article PubMed Google Scholar
11. Espejel S, Romero R, Alvarez-Buylla A. Radiation damage increases Purkinje neuron heterokaryons in neonatal cerebellum. Ann. Neurol. 2009;66(1):100-109. doi: https://doi.org/10.1002/ana.21670
    Article PubMed Google Scholar
12. Fèvre-Montange M, Szathmari A, Champier J, Mokhtari K, Chrétien F, Coulon A, Figarella-Branger D, Polivka M, Varlet P, Uro-Coste E, Fauchon F, Jouvet A. Pineocytoma and pineal parenchymal tumors of intermediate differentiation presenting cytologic pleomorphism: a multicenter study. Brain Pathol. 2008;18(3):354-359. doi: https://doi.org/10.1111/j.1750-3639.2008.00128.x
    Article PubMed PubMed Central Google Scholar
13. Hirohata S. Histopathology of central nervous system lesions in Behcet’s desease. J. Neurol. Sci. 2008;267(1-2):41-47. doi: https://doi.org/10.1016/j.jns.2007.09.041
    Article CAS PubMed Google Scholar
14. Kawataki T, Sato E, Sato T, Kinouchi H. Anaplastic ganglioglioma with malignant features in both neuronal and glial components — case report. Neurol. Med. Chir. (Tokyo). 2010;50(3):228-231. doi: https://doi.org/10.2176/nmc.50.228
    Article Google Scholar
15. Kemp K, Gordon D, Wraith DC, Mallam E, Hartfield E, Uney J, Wilkins A, Scolding N. Fusion between human mesenchymal stem cells and rodent cerebellar Purkinje cells. Neuropathol. Appl. Neurobiol. 2011;37(2):166-178. doi: https://doi.org/10.1111/j.1365-2990.2010.01122.x
    Article CAS PubMed PubMed Central Google Scholar
16. Kemp K, Gray E, Wilkins A, Scolding N. Purkinje cell fusion and binucleate heterokaryon formation in multiple sclerosis cerebellum. Brain. 2012;135(Pt 10):2962-2972. doi: https://doi.org/10.1093/brain/aws226
    Article PubMed Google Scholar
17. Magrassi L, Grimaldi P, Ibatici A, Corselli M, Ciardelli L, Castello S, Podestà M, Frassoni F, Rossi F. Induction and survival of binucleated Purkinje neurons by selective damage and aging. J. Neurosci. 2007;27(37):9885-9892. doi: https://doi.org/10.1523/JNEUROSCI.2539-07.2007
    Article CAS PubMed PubMed Central Google Scholar
18. Martin-Padura I, Marighetti P, Gregato G, Agliano A, Malazzi O, Mancuso P, Pruneri G, Viale A, Bertolini F. Spontaneous cell fusion of acute leukemia cells and macrophages observed in cells with leukemic potential. Neoplasia. 2012;14(11):1057-1066. doi: https://doi.org/10.1593/neo.12736
    Article CAS PubMed PubMed Central Google Scholar
19. Müller T. Light microscopic analysis of cellular networks in the pineal gland of the golden hamster as revealed by methylene blue labeling. Ital. J. Anat. Embryol. 2000;105(3):159-165.
    PubMed Google Scholar
20. Nern C, Wolff I, Macas J, von Randow J, Scharenberg C, Priller J, Momma S. Fusion of hematopoietic cells with Purkinje neurons does not lead to stable heterokaryon formation under noninvasive conditions. J. Neurosci. 2009;29(12):3799-3807. doi: https://doi.org/10.1523/JNEUROSCI.5848-08.2009.
    Article CAS PubMed PubMed Central Google Scholar
21. Paltsyn A, Komissarova S, Dubrovin I, Kubatiev A. Increased cell fusion in cerebral cortex may contribute to poststroke regeneration. Stroke Res. Treat. 2013;2013:869327. doi: https://doi.org/10.1155/2013/869327
    Article PubMed PubMed Central Google Scholar
22. Paltsyn AA, Manukhina EB, Goryacheva AV, Downey HF, Dubrovin IP, Komissarova SV, Kubatiev AA. Intermittent hypoxia stimulates formation of binuclear neurons in brain cortex — a role of cell fusion in neuroprotection? Exp. Biol. Med. (Maywood). 2014;239(5):595-600. doi: https://doi.org/10.1177/1535370214523898
    Article CAS Google Scholar
23. Richard JP, Leikina E, Langen R, Henne WM, Popova M, Balla T, McMahon HT, Kozlov MM, Chernomordik LV. Intracellular curvature-generating proteins in cell-to-cell fusion. Biochem. J. 2011;440(2):185-193. doi: https://doi.org/10.1042/BJ20111243
    Article CAS PubMed Google Scholar
24. Sotnikov OS. Properties Live Axoplasm. New York, 2016.
25. Terashima T, Kojima H, Fujimiya M, Matsumura K, Oi J, Hara M, Kashiwagi A, Kimura H, Yasuda H, Chan L. The fusion of bone-marrow-derived proinsulin-expressing cells with nerve cells underlies diabetic neuropathy. Proc. Natl Acad. Sci. USA. 2005;102(35):12525-12530. doi: https://doi.org/10.1073/pnas.0505717102
    Article CAS PubMed PubMed Central Google Scholar
26. Weimann JM, Charlton CA, Brazelton TR, Hackman RC, Blau HM. Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains. Proc. Natl Acad. Sci. USA. 2003;100(4):2088-2093. doi: https://doi.org/10.1073/pnas.0337659100
    Article CAS PubMed PubMed Central Google Scholar
27. Zhu X, Siedlak SL, Wang Y, Perry G, Castellani RJ, Cohen ML, Smith MA. Neuronal binucleation in Alzheimer disease hippocampus. Neuropathol. Appl. Neurobiol. 2008;34(4):457-465. doi: https://doi.org/10.1111/j.1365-2990.2007.00908.x
    Article CAS PubMed Google Scholar

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