Induction and Repression of NF-κB-Driven Inflammatory Genes (original) (raw)
Aarnisalo P, Palvimo JJ, Jänne OA (1998) CREB-binding protein in androgen receptor-mediated signaling. Proc Natl Acad Sci USA 95: 2122–2127 ArticlePubMedCAS Google Scholar
Abu-amer Y, Ross FR, McHugh KP, Livolsi A, Peyron JF, Teitelbaum SL (1998) Tumor necrosis factor-alfa activation of nuclear transcription factorkappaB in marrow macrophages is mediated by c-src tyrosine phosphorylation of IkappaBalfa. J Biol Chem 273: 29417–29423 ArticlePubMedCAS Google Scholar
Adcock IM, Nasuhara Y, Stevens DA, Barnes PJ (1999) Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol 127: 1003–1011 ArticlePubMedCAS Google Scholar
Agalioti T, Lomvardas S, Parekh B, Yie J, Maniatis T, Thanos D (2000) Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. Cell 103: 667–78 ArticlePubMedCAS Google Scholar
Agarwal S, Rao A (1998a) Long-range transcriptional regulation of cytokine gene expression. Curr Opin Immunol 10: 345–52 ArticlePubMedCAS Google Scholar
Agarwal S, Rao A (1998b) Modulation of chromatin structure regulates cytok- ine gene expression during T cell differentiation. Immunity 9: 765–775 ArticlePubMedCAS Google Scholar
Ait-si-ali S, Ramirez S, Barre FX, Dkhissi F, Magnaghi-Jaulin L, Girault JA, Robin P, Knibiehler M, Pritchard LL, Ducommun B, Trouche D, Harel-Bellan A (1998) Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein El A. Nature 396: 184–186 ArticlePubMedCAS Google Scholar
Akimaru H, Hou-Dx, Ishii S (1997) Drosophila CBP is required for dorsal dependent twist gene expression. Nat Genet 17: 211–214 ArticlePubMedCAS Google Scholar
Akira S, Taga T, Kishimoto T (1993) Interleukin-6 in biology and medicine. Adv Immunol 54: 1–78 ArticlePubMedCAS Google Scholar
Alberts AS, Geneste O, Treisman R (1998) Activation of SRF-regulated chromosomal templates by rho-family GTPases requires a signal that also induces H4 hyperacetylation. Cell 92: 475–487 ArticlePubMedCAS Google Scholar
Anrather J, Csizmadia V, Soares MP, Winkler H (1999) Regulation of NF-kappaB Re1A phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. J Biol Chem 274: 13594–13603 ArticlePubMedCAS Google Scholar
Ashburner BP, Westerheide SD, Baldwin AS Jr (2001) The p65 (RelA) Subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol Cell Biol 21: 7065–7077 ArticlePubMedCAS Google Scholar
Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M (1995) Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270: 286–290 ArticlePubMedCAS Google Scholar
Baeuerle PA, Baichwal VR (1997) NF-K13 as a frequent target for immunosuppressive and anti-inflammatory molecules. Adv Immunol 65: 111–137 ArticlePubMedCAS Google Scholar
Baldwin AS Jr (2001) Series introduction: the transcription factor NF-kappaB and human disease. J Clin Invest 107: 3–6 ArticlePubMedCAS Google Scholar
Barkett M, Xue D, Horvitz HR, Gilmore TD (1997) Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro. J Biol Chem 272: 29419–29422 ArticlePubMedCAS Google Scholar
Barnes PJ (1999) Novel approaches and targets for treatment of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160: S72 — S79 PubMedCAS Google Scholar
Barnes PJ, Adcock IM (1995) Steroid resistance in asthma. QJM 88: 455–468 PubMedCAS Google Scholar
Beato M, Herrlich P, Schutz G (1995) Steroid hormone receptors: many actors in search of a plot. Cell 83: 851–7 ArticlePubMedCAS Google Scholar
Beg AA, Sha WC, Bronson RT, Baltimore D (1995) Constitutive NF-kappaB activation, enhanced granulopoiesis, and neonatal lethality in IkappaBalfadeficient mice. Genes Dev 9: 2736–2746 ArticlePubMedCAS Google Scholar
Belvisi MG, Brown TJ, Wicks S, Foster ML (2001a) New glucocorticosteroids with an improved therapeutic ratio? Pulm Pharmacol Ther 14: 221–227 ArticlePubMedCAS Google Scholar
Belvisi MG, Wicks SL, Battram CH, Bottoms SE, Redford JE, Woodman P, Brown TJ, Webber SE, Foster ML (2001b) Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity. J Immunol 166: 1975–1982 PubMedCAS Google Scholar
Bender K, Göttlicher M, Whiteside S, Rahmsdorf HJ, Herrlich P (1998) Sequential DNA damage-independent and -dependent activation of NF-kappaB by UV. EMBO J 17: 5170–5181 ArticlePubMedCAS Google Scholar
Bensaude O, Bonnet F, Casse C, Dubois MF, Nguyen VT, Palancade B (1999) Regulated phosphorylation of the RNA polymerase II C-terminal domain ( CTD ). Biochem Cell Biol 77: 249–255 Google Scholar
Beraud C, Henzel WJ, Baeuerle PA (1999) Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation. Proc Natl Acad Sci USA 96: 429–434 ArticlePubMedCAS Google Scholar
Berger SL, Felsenfeld G (2001) Chromatin goes global. Mol Cell 8:263–268 Beyaert R (1999) NF-kappaB as an emerging target in atopy. Emerg Ther Targets 3: 1–16 Google Scholar
Beyaert R, Cuenda A, Vanden Berghe W, Plaisance S, Lee JC, Haegeman G, Cohen P, Fiers W (1996) The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor. EMBO J 15: 1914–1923 PubMedCAS Google Scholar
Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM (1999) Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev 13: 64–75 ArticlePubMedCAS Google Scholar
Bird TA, Schooley K, Dower SK, Hagen H, Virca GD (1997) Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit. J Biol Chem 272: 32606–32612 Article Google Scholar
Blobel GA (2000) CREB-binding protein and p300: molecular integrators of hematopoietic transcription. Blood 95: 745–755 PubMedCAS Google Scholar
Bonnet F, Vigneron M, Bensaude O, Dubois MF (1999) Transcription-independent phosphorylation of the RNA polymerase II C-terminal domain (CTD) involves ERK kinases (MEK1/2). Nucleic Acids Res 27: 4399–43404 ArticlePubMedCAS Google Scholar
Bork PM, Schmitz ML, Kuhnt M, Escher C, Heinrich M (1997) Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB. FEBS Lett 402: 85–90 ArticlePubMedCAS Google Scholar
Bottazzi ME, Zhu X, Bohmer RM, Assoian RK (1999) Regulation of p21(cipl) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase. J Cell Biol 146: 1255–1264 ArticlePubMedCAS Google Scholar
Brooks PM, Day RO (1991) Nonsteroidal anti-inflammatory drugs — differences and similarities. N Engl J Med 324: 1716–1725 ArticlePubMedCAS Google Scholar
Brostjan C, Anrather J, Csizmadia V, Stroka D, Soares M, Bach FH, Winkler H (1996) Glucocorticoid-mediated repression of NFkappaB activity in endothelial cells does not involve induction of IkappaBalpha synthesis. J Biol Chem 271: 19612–19616 ArticlePubMedCAS Google Scholar
Carter AB, Hunninghake GW (2000) A constitutive active MEK —ERK pathway negatively regulates NF-kappa B-dependent gene expression by modulating TATA-binding protein phosphorylation. J Biol Chem 275: 27858–27864 PubMedCAS Google Scholar
Cato AC, Wade E (1996) Molecular mechanisms of anti-inflammatory action of glucocorticoids. Bioessays 18: 371–378 ArticlePubMedCAS Google Scholar
Chan HM, La Thangue NB (2001) p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J Cell Sci 114: 2363–2373 Google Scholar
Chau AS, Shibuya EK (1999) Inactivation of p42 mitogen-activated protein kinase is required for exit from M-phase after cyclin destruction. J Biol Chem 274: 32085–32090 ArticlePubMedCAS Google Scholar
Chawla S, Hardingham GE, Quinn DR, Bading H (1998) CBP: A signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV. Science 281: 1505–1509 Google Scholar
Chen FE, Huang DB, Chen YQ, Ghosh G (1998) Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA. Nature 391: 410–413 ArticlePubMedCAS Google Scholar
Chen F, Castranova V, Shi X, Demers LM (1999) New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem 45: 7–17 PubMedCAS Google Scholar
Chen L, Fischle W, Verdin E, Greene WC (2001) Duration of nuclear NF-kap- paB action regulated by reversible acetylation. Science 293: 1653–1657 ArticleCAS Google Scholar
Christman JW, Lancaster LH, Blackwell TS (1998) Nuclear factor kappa B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy [see comments]. Intensive Care Med 24: 1131–1138 ArticlePubMedCAS Google Scholar
Clayton AL, Rose S, Barratt MJ, Mahadevan LC (2000) Phosphoacetylation of histone H3 on c-fos-and c-jun-associated nucleosomes upon gene activation. EMBO J 19: 3714–3726 ArticlePubMedCAS Google Scholar
Cohen L, Henzel WJ, Baeuerle PA (1998) IKAP is a scaffold protein of the IkappaB kinase complex. Nature 395: 292–296 ArticlePubMedCAS Google Scholar
Cohen LE, Hashimoto Y, Zanger K, Wondisford F, Radovick S (1999) CREBindependent regulation by CBP is a novel mechanism of human growth hormone gene expression. J Clin Invest 104: 1123–1130 ArticlePubMedCAS Google Scholar
Cramer P, Muller CW (1999) A firm hand on NFkappaB: structures of the IkappaBalpha-NFkappaB complex. Structure Fold Des 7: R1 — R6 ArticlePubMedCAS Google Scholar
Cuervo AM, Hu W, Lim B, Dice FJ (1998) IkappaB is a substrate for a selective pathway of lysosomal proteolysis. Mol Biol Cell 9: 1995–2010 PubMedCAS Google Scholar
Davie JR, Samuel SK, Spencer VA, Holth LT, Chadee DN, Peltier CP, Sun JM, Chen HY, Wright JA (1999) Organization of chromatin in cancer cells: role of signalling pathways. Biochem Cell Bio177: 265–275 Google Scholar
De Bosscher K, Schmitz ML, Vanden Berghe W, Plaisance S, Fiers W, Haegeman G (1997) Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation. Proc Natl Acad Sci USA 94: 13504–1359 ArticlePubMedCAS Google Scholar
De Bosscher K, Vanden Berghe W, Haegeman G (2000a) Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors. J Neuroimmunol 109: 16–22 ArticlePubMed Google Scholar
De Bosscher K, Vanden Berghe W, Vermeulen L, Plaisance S, Boone E, Haegeman, G (2000b) Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell. Proc Natl Acad Sci 97: 3919–3924 ArticlePubMed Google Scholar
De Bosscher K, Vanden Berghe W, Haegeman G (2001) Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators. Mol Endocrinol 15: 219–227 ArticlePubMed Google Scholar
De Kloet ER, Vreugdenhil E, Oitzl MS, Joels M (1998) Brain corticosteroid receptor balance in health and disease. Endocr Rev 19: 269–301 ArticlePubMed Google Scholar
De Kloet ER, Meijer OC, Vreugdenhil E, Joels M (2000) The Yin and Yang of nuclear receptors: symposium on nuclear receptors in brain, Oegstgeest, The Netherlands 13–14 April 2000. Trends Endocrinol Metab 11: 245–248 ArticlePubMed Google Scholar
Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A (1999) The Bc1–3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. Oncogene 18: 3316–3323 ArticlePubMedCAS Google Scholar
Delerive P, Gervois P, Fruchart JC, Staels B (2000) Induction of ikappa balpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators. J Biol Chem 275: 36703–36707 ArticlePubMedCAS Google Scholar
Delerive P, Monté D, Dubois G, Trottein F, Fruchart-Najib Mariani J, Fruchart J-C, Staels B (2001) The orphan nuclear receptor RORalfa is a negative regulator of the inflammatory response. EMBO Reports 21: 42–48 Article Google Scholar
Delerive P, De Bosscher K, Vanden Berghe W, Fruchart JC, Haegeman G, Staels B (2002) DNA binding-independent induction of IkappaBalpha gene transcription by PPARalpha. Mol Endocrinol 16: 1029–1039 ArticlePubMedCAS Google Scholar
DeLuca C, Kwon H, Lin R, Wainberg M, Hiscott J (1999) NF-kappaB activation and HIV-1 induced apoptosis. Cytokine Growth Factor Rev 10: 235–253 ArticlePubMedCAS Google Scholar
Denison C, Kodadek T (1998) Small-molecule-based strategies for controlling gene expression. Chem Biol 5: R129 — R145 ArticlePubMedCAS Google Scholar
Desterro J, Rodriguez M, Hay RT (1998) SUMO-1 modification of IkBalfa inhibits NF-kappaB activation. Mol Cell 2: 233–239 ArticlePubMedCAS Google Scholar
DiDonato JA, Saatcioglu F, Karin M (1996) Molecular mechanisms of immunosuppression and anti-inflammatory activities by glucocorticoids. Am J Respir Crit Care Med 154: S11 — S15 PubMedCAS Google Scholar
Diehl JA, Tong W, Sun G, Hannink M (1995) Tumor necrosis factor-alpha-dependent activation of a ReIA homodimer in astrocytes. Increased phosphorylation of ReIA and MAD-3 precede activation of Re1A. J Biol Chem 270: 2703–2707 ArticlePubMedCAS Google Scholar
Doucas V, Tini M, Egan DA, Evans RM (1999) Modulation of CREB binding protein function by the promyelocytic ( PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. Proc Natl Acad Sci USA 96: 2627–2632 Google Scholar
Doucas V, Shi Y, Miyamoto S, West A, Verma I, Evans RM (2000) Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-kappaB and the glucocorticoid receptor. Proc Natl Acad Sci USA 97: 11893–11898 ArticlePubMedCAS Google Scholar
Drier EA, Huang LH, Steward R (1999) Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation. Genes Dev 13: 556–568 ArticlePubMedCAS Google Scholar
Dubnicoff T, Valentine SA, Chen G, Shi T, Lengyel JA, Paroush Z, Courey AJ (1997) Conversion of dorsal from an activator to a repressor by the global corepressor Groucho. Genes Dev 11: 2952–2957 ArticlePubMedCAS Google Scholar
Dumont A, Hehner SP, Schmitz ML, Gustafsson JA, Lidén J, Okret S, van der Saag PT, Wissink S, van der Burg B, Herrlich P, Haegeman G, De Bosscher K, Fiers W (1998) Cross-talk between steroids and NF-kappa B: what language? Trends Biochem Sci 23: 233–235 ArticlePubMedCAS Google Scholar
Egan LJ, Mays DC, Huntoon CJ, Bell MP, Pike MG, Sandborn WJ, Lipsky JJ, McKean DJ (1999) Inhibition of interleukin-1-stimulated NF-kappaB Re1A/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity. J Biol Chem 274: 26448–26453 ArticlePubMedCAS Google Scholar
El Kharroubi A, Piras G, Zensen R, Martin MA (1998) Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. Mol Cell Biol 18: 2535–2544 PubMed Google Scholar
Emery JG, Ohlstein EH, Jaye M (2001) Therapeutic modulation of transcription factor activity. Trends Pharmacol Sci 22: 233–240 ArticlePubMedCAS Google Scholar
Erschler WB, Keller ET (2000) Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med 51: 245–270 Article Google Scholar
Espinos E, Le Van Thai A, Pomies C, Weber MJ (1999) Cooperation between phosphorylation and acetylation processes in transcriptional control. Mol Cell Biol 19: 3474–3484 PubMedCAS Google Scholar
Francastel C, Schubeler D, Martin DIK, Groudine M (2000) Nuclear compartmentalization and gene activity. Nat Rev Mol Cell Biol 1: 137–143 ArticlePubMedCAS Google Scholar
Gerritsen ME, Williams AJ, Neish AS, Moore S, Shi Y (1997) CREB-binding protein/p300 are transcriptional coactivators of p65. Proc Natl Acad Sci USA 94: 2927–2932 ArticlePubMedCAS Google Scholar
Ghosh S, May MJ, Kopp EB (1998) NF-kappaB and rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16: 225–260 ArticlePubMedCAS Google Scholar
Giguere V, Hollenberg SM, Rosenfeld MG, Evans RM (1986) Functional domains of the human glucocorticoid receptor. Cell 46: 645–652 ArticlePubMedCAS Google Scholar
Giles RH, Peters DJM, Breuning MH (1998) Conjunction dysfunction: CBP/p300 in human disease. TIG 14: 178–183 ArticlePubMedCAS Google Scholar
Glass CK, Rosenfeld MG (2000) The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev 14: 121–141 PubMedCAS Google Scholar
Glass CK, Rose DW, Rosenfeld MG (1997) Nuclear receptor coactivators. Curr Opin Cell Biol 9: 222–232 ArticlePubMedCAS Google Scholar
Gribnau J, de Boer E, Trimborn T, Wijgerde M, Milot E, Grosveld F, Fraser P (1998) Chromatin interaction mechanism of transcriptional control in vivo. EMBO J 17: 6020–6027 ArticlePubMedCAS Google Scholar
Hager GL, Lim CS, Elbi C, Baumann CT (2000) Trafficking of nuclear receptors in living cells. J Steroid Biochem Mol Biol 74: 249–254 ArticlePubMedCAS Google Scholar
Handel ML (1997) Transcription factors AP-1 and NF-kappa B: where steroids meet the gold standard of anti-rheumatic drugs. Inflamm Res 46: 282–286 ArticlePubMedCAS Google Scholar
Handel ML, Nguyen LQ, Lehmann TP (2000) Inhibition of transcription factors by anti-inflammatory and anti-rheumatic drugs: can variability in response be overcome? Clin Exp Pharmacol Physiol 27: 139–144 ArticlePubMedCAS Google Scholar
Heck S, Bender K, Kullmann M, Gottlicher M, Herrlich P, Cato AC (1997) I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor. EMBO J 16: 4698–4707 ArticlePubMedCAS Google Scholar
Heissmeyer V, Krappmann D, Wulczyn FG, Scheidereit C (1999) NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3p50 complexes. EMBO J 18: 4766–4778 ArticlePubMedCAS Google Scholar
Herrlich P (2001) Cross-talk between glucocorticoid receptor and AP-1. Oncogene 20: 2465–2475 ArticlePubMedCAS Google Scholar
Hodges M, Tissot C, Freemont PS (1998) Protein regulation: tag wrestling with relatives of ubiquitin. Curr Biol 8: R749 — R752 ArticlePubMedCAS Google Scholar
Hofmann TG, Hehner SP, Bacher S, Droge W, Schmitz ML (1998) Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription. FEBS Lett 441: 441–446 ArticlePubMedCAS Google Scholar
Hollenberg SM, Evans RM (1988) Multiple and cooperative trans-activation domains of the human glucocorticoid receptor. Cell 55: 899–906 ArticlePubMedCAS Google Scholar
Hong SH, Wong CW, Privalsky ML (1998) Signaling by tyrosine kinases negatively regulates the interaction between transcription factors and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor. Mol Endocrinol 12: 1161–1171 ArticlePubMedCAS Google Scholar
Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L (1996) Nuclear receptor coactivators and corepressors. Mol Endocrinol 10: 1167–1177 ArticlePubMedCAS Google Scholar
Hottiger MO, Felzien LK, Nabel GJ (1998) Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300. EMBO J 17: 3124–3134 ArticlePubMedCAS Google Scholar
Hsieh JJD, Zhou S, Chen L, Young DB, Hayward SD (1999) CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci USA 1: 23–28 Article Google Scholar
Hu SC, Chrivia J, Ghosh A (1999) Regulation of CBP-mediated transcription by neuronal calcium signaling. Neuron 22: 799–808 ArticlePubMedCAS Google Scholar
Huxford T, Huang DB, Malek S, Ghosh G (1998) The crystal structure of the IkappaBalfa/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell 95: 759–770 ArticlePubMedCAS Google Scholar
Ikeda K, Steger DJ, Eberharter A, Workman JL (1999) Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexes. Mol Cell Biol 19: 855–863 PubMedCAS Google Scholar
Imbert V, Rupec RA, Livolsi A, Pahl HL, Traenckner EB, Mueller Dieckmann C, Farahifar D, Rossi B, Auberger P, Baeuerle PA, Peyron JF (1996) Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of IkappaB-alpha. Cell 86: 787–798 ArticlePubMedCAS Google Scholar
Israel A (2000) The IKK complex: an integrator of all signals that activate NFkappaB? Trends Cell Biol 10: 129–133 ArticlePubMedCAS Google Scholar
Ito K, Barnes PJ, Adcock IM (2000) Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-lbeta-induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol 20: 6891–6903 ArticlePubMedCAS Google Scholar
Jacobs MD, Harrison SC (1998) Structure of an IkappaBalpha/NF-kappaB complex. Cell 95: 749–758 ArticlePubMedCAS Google Scholar
Jin Y, Wang Y, Walker DL, Dong H, Conley C, Johansen J, Johansen KM (1999) JIL-1: a novel chromosomal tandem kinase implicated in transcriptional regulation in Drosophila. Mol Cell 4: 129–135 ArticlePubMedCAS Google Scholar
Jobin C, Sartor RB (2000) The IkappaB/NF-kappaB system: a key determinant of mucosal inflammation and protection. Am J Physiol Cell Physiol 278: C451 — C462 PubMedCAS Google Scholar
Jonat C, Rahmsdorf HJ, Park KK, Cato AC, Gebel S, Ponta H, Herrlich P (1990) Antitumor promotion and anti-inflammation: down-modulation of AP-1 ( Fos/Jun) activity by glucocorticoid hormone. Cell 62: 1189–1204 Google Scholar
Jue DM, Jeon KI, Jeong JY (1999) Nuclear factor kappaB ( NF-kappaB) pathway as a therapeutic target in rheumatoid arthritis. J Korean Med Sci 14: 231–238 Google Scholar
Kaiser GC, Yan F, Polk DB (1999) Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes. Gastroenterology 116: 602–609 ArticlePubMedCAS Google Scholar
Kamei Y, Xy L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin S-C, Heyman RA, Rose DW, Glass CK, Rosenfeld MG (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85: 403–414 ArticlePubMedCAS Google Scholar
Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, Evans RM, Kadesch T (1998) A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev 12: 2269–2277 ArticlePubMedCAS Google Scholar
Karin M (1998) New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell 93: 487–490 ArticlePubMedCAS Google Scholar
Karin M (1999) How NF-kappa B is activated: the role of the I kappa B kinase (IKK) complex. Oncogene 18: 6867–6874 ArticlePubMedCAS Google Scholar
Karin M, Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 18: 621–663 ArticlePubMedCAS Google Scholar
Karin M, Delhase M (2000) The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin Immunol 12: 85–98 ArticlePubMedCAS Google Scholar
Karin M, Liu-Zg, Zandi E (1997) Ap-1 function and regulation. Curr Opin Cell Biol 9: 240–246 ArticlePubMedCAS Google Scholar
Kawasaki H, Eckner R, Yao TP, Taira K, Chiu R, Livingston DM, Yokoyama KK (1998) Distinct roles of the co-activators p300 and CBP in retinoicacid-induced F9-cell differentiation. Nature 393: 284–289 ArticlePubMedCAS Google Scholar
Kim RH, Flanders KC, Reffey SB, Anderson LA, Duckett CS, Perkins ND, Roberts AB (2001) SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. J Biol Chem 20: 20 Google Scholar
Kopp E, Ghosh S (1994) Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 265: 956–959 ArticlePubMedCAS Google Scholar
Korzus E, Torchia J, Rose DW, Xu L, Kurokawa R, McInerney EM, Mullen TM, Glass CK, Rosenfeld MG (1998) Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science 279: 703–707 ArticlePubMedCAS Google Scholar
Kouzarides T (1999) Histone acetylases and deacetylases in cell proliferation. Curr Opin Genet Dev 9: 40–48 ArticlePubMedCAS Google Scholar
Kouzarides T (2000) Acetylation: a regulatory modification to rival phosphorylation? EMBO J 19: 1176–1179 ArticlePubMedCAS Google Scholar
Kung AL, Rebel VI, Bronson RT, Ch’ng LE, Sieff CA, Livingston DM, Yao TP (2000) Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev 14: 272–277 PubMedCAS Google Scholar
Lamberti C, Lin KM, Yamamoto Y, Verma U, Verma IM, Byers S, Gaynor RB (2001) Regulation of beta-catenin function by the I kappa B kinases. J Biol Chem 29: 29 Google Scholar
Lee SK, Kim HJ, Na SY, Kim TS, Choi HS, Im SY, Lee JW (1998) Steroid Receptor Coactivator-1 coactivates Activating Protein-1 mediated transactivations through interaction with the c-Jun and c-Fos subunits. J Biol Chem 273: 16651–16654 ArticlePubMedCAS Google Scholar
Lemon B, Tjian T (2000) Orchestrated response: a symphony of transcription factors for gene control. Genes Dev 14:2551–2569. Review Google Scholar
Li N, Karin M (1998) Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms. Proc Natl Acad Sci USA 95: 13012–13017 ArticlePubMedCAS Google Scholar
Li CC, Korner M, Ferris DK, Chen E, Dai RM, Longo DL (1994) NF-kappa B/Rel family members are physically associated phosphoproteins. Biochem J 303: 499–506 PubMedCAS Google Scholar
Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M (1999) The IKKbeta subunit of IkappaB kinase ( IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 189: 1839–1845 Google Scholar
Li Q, Estepa G, Memet S, Israel A, Verma I (2000) Complete lack of NF-kappa B activity in IKK1 and IKK2 double-deficient mice: additional defects in neurulation. Genes Dev 14: 1729–1733 PubMedCAS Google Scholar
Li X, Commane M, Nie H, Hua X, Chatterjee-Kishore M, Wald D, Haag M, Stark G (2000) Actl, an NF-kappa B-activating protein. Proc Natl Acad Sci USA 97: 10489–10493 ArticlePubMedCAS Google Scholar
Lidén J, Delaunay F, Rafter I, Gustafsson J, Okret S (1997) A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of Re1A transactivation. J Biol Chem 272: 21467–21472 ArticlePubMed Google Scholar
Lidén J, Rafter I, Truss M, Gustafsson JA, Okret S (2000) Glucocorticoid effects on NF-kappaB binding in the transcription of the ICAM-1 gene. Biochem Biophys Res Commun 273: 1008–1014 ArticlePubMedCAS Google Scholar
Liu L, Kwak YT, Bex F, Garcia-Martinez LF, Li XH, Meek K, Lane WS, Gaynor RB (1998) DNA-dependent protein kinase phosphorylation of IkappaBalfa and IkBbeta regulates NF-kappaB DNA binding properties. Mol Cell Biol 18: 4221–4234 PubMedCAS Google Scholar
Liu YZ, Chrivia JC, Latchman DS (1998) Nerve growth factor up-regulates the transcriptional activity of CBP through activation of the p42/p44(MAPK) cascade. J Biol Chem 273: 32400–32407 ArticlePubMedCAS Google Scholar
Liu YZ, Thomas NS, Latchman DS (1999) CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment. Neuroreport 10: 1239–1243 ArticlePubMedCAS Google Scholar
Lo WS, Duggan L, Tolga NC, Emre Belotserkovskya R, Lane WS, Shiekhattar R, Berger SL (2001) Snfl—a histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription. Science 293: 1142–1146 ArticlePubMedCAS Google Scholar
Lyss G, Knorre A, Schmidt TJ, Pahl HL, Merfort I (1998) The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NFkappaB by directly targeting p65. J Biol Chem 273: 33508–33516 ArticlePubMedCAS Google Scholar
Madrid LV, Wang CY, Guttridge DC, Schottelius AJ, Baldwin AS Jr, Mayo MW (2000) Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol Cell Biol 20: 1626–1638 ArticlePubMedCAS Google Scholar
Magnaghi-Jaulin L, Ait-Si-Ali S, Harel-Bellan A (1999) Histone acetylation in signal transduction by growth regulatory signals. Semin Cell Dev Biol 10: 197–203 ArticlePubMedCAS Google Scholar
Maniatis T (1999) A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways. Genes Dev 13: 505–510 ArticlePubMedCAS Google Scholar
Marmorstein R (2001) Protein modules that manipulate histone tails for chromatin regulation. Nat Rev Mol Cell Biol 2: 422–432 ArticlePubMedCAS Google Scholar
Martinez-Balbas MA, Bannister AJ, Martin K, Haus-Seuffert P, Meisterernst M, Kouzarides T (1998) The acetyltransferase activity of CBP stimulates transcription. EMBO J 17: 2886–2893 ArticlePubMedCAS Google Scholar
Masumi A, Wang IM, Lefebvre B, YANG XJ, Nakatani Y, Ozato K (1999) The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness. Mol Cell Biol 19: 1810–1820 PubMedCAS Google Scholar
Mayr B, Montminy M (2001) Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2: 599–609 ArticlePubMedCAS Google Scholar
Mayr BM, Canettieri G, Montminy MR (2001) Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB. Proc Natl Acad Sci USA 98: 10936–10941 ArticlePubMedCAS Google Scholar
McEwan IJ, Wright PH, Gustafsson JA (1997) Mechanisms of gene expression by the glucocorticoid receptor: role of protein-protein interactions. Bioessays 19: 153–160 ArticlePubMedCAS Google Scholar
Mercurio F, Manning AM (1999) Multiple signals converging on NF-kappa B. Curr Op Cell Biol 11: 226–232 ArticlePubMedCAS Google Scholar
Merienne K, Pannetier S, Harel-Bellan A, Sassone-Corsi P (2001) Mitogenregulated rsk2-cbp interaction controls their kinase and acetylase activities. Mol Cell Biol 21: 7089–7096 ArticlePubMedCAS Google Scholar
Merika M, Williams AJ, Chen G, Collins T, Thanos D (1998) Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription. Mol Cell 1: 277–287 ArticlePubMedCAS Google Scholar
Michael LF, Asahara H, Shulman AI, Kraus WL, Montminy M (2000) The phosphorylation status of a cyclic AMP-responsive activator is modulated via a chromatin-dependent mechanism. Mol Cell Biol 20: 1596–1603 ArticlePubMedCAS Google Scholar
Min W, Ghosh S, Lengyel P (1996) The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities. Mol Cell Biol 16: 359–368 PubMedCAS Google Scholar
Miyamoto S, Seufzer BJ, Shumway SD (1998) Novel IkappaB alpha pro- teolytic pathway in WEHI231 immature B cells. Mol Cell Biol 18: 19–29 PubMedCAS Google Scholar
Munshi N, Merika M, Yie J, Senger K, Chen G, Thanos D (1998) Acetylation of HMG I(Y) by CBP turns off IFNbeta expression by disrupting the enhanceosome. Mol Cell 2: 457–468 ArticlePubMedCAS Google Scholar
Munshi N, Agalioti T, Lomvardas S, Merika M, Chen G, Thanos D (2001) Coordination of a transcriptional switch by HMGI(Y) acetylation. Science 293: 1133–1136 ArticlePubMedCAS Google Scholar
Na S, Lee S, Han S, Choi H, Im S, Lee J (1998) Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kB-mediated transactivations. J Biol Chem 273: 10831–10834 ArticlePubMedCAS Google Scholar
Naar AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R (1999) Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature 398: 828–832 ArticlePubMedCAS Google Scholar
Nakajima T, Fukimizu A, Takahashi J, Gage FH, Fisher T, Blenis J, Montminy MR (1996) The signal-dependent coactivator CBP is a nuclear target for pp90rsk. Cell 86: 465–474 ArticlePubMedCAS Google Scholar
Naumann M, Scheidereit C (1994) Activation of NF-kappa B in vivo is regulated by multiple phosphorylations. EMBO J 13: 4597–4607 PubMedCAS Google Scholar
Neurath MF, Becker C, Barbulescu K (1998) Role of NF-kappaB in immune and inflammatory responses in the gut. Gut 43: 856–860 ArticlePubMedCAS Google Scholar
Nissen R, Yamamoto K (2000) The glucocorticoid receptor inhibits NF-kappa B by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain Genes Dev 14: 2314–2329 CAS Google Scholar
O’Connor MJ, Zimmermann H, Nielsen S, Bernard HU, Kouzarides T (1999) Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300. J Virol 73: 3574–3581 PubMed Google Scholar
Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M (1998) Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Molecular Cell 2: 353–359 ArticlePubMedCAS Google Scholar
Perissi V, Dasen JS, Kurokawa R, Wang ZY, Korzus E, Rose DW, Glass CK, Rosenfeld MG (1999) Factor-specific modulation of CREB-binding protein acetyltransferase activity. Proc. Natl. Acad. Sci. USA 96: 3652–3657 Google Scholar
Perkins ND (1997) Achieving transcriptional specificity with NF-kappaB. Int J Biochem Cell Biol 29: 1433–1448 ArticlePubMedCAS Google Scholar
Perkins ND, Felzien LK, Betts JC, Leung K, Beach DH, Nabel GJ (1997) Regulation of NFkB by cyclin-dependent kinases associated with the p300 coactivator. Science 275: 523–527 ArticlePubMedCAS Google Scholar
Peters RT, Liao SM, Maniatis T (2000) IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex. Mol Cell 5: 513–522 ArticlePubMedCAS Google Scholar
Pierce JW, Read MA, Ding H, Luscinskas FW, Collins T (1996) Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration. J Immunol 156: 3961–3969 PubMedCAS Google Scholar
Plaisance S, Vanden Berghe W, Boone E, Fiers W, Haegeman G (1997) Recombination signal sequence binding protein Jkappa is constitutively bound to the NF-icB site of the interleukin-6 promoter and is a negative regulatory factor. Molecular and Cell Biol 17: 3733–3743 CAS Google Scholar
Pomerantz JL, Baltimore D (1999) NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J 18: 6694–6704 ArticlePubMedCAS Google Scholar
Pumiglia KM, Decker SJ (1997) Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA 94: 448–452 ArticlePubMedCAS Google Scholar
Rachez C, Gamble M, Chang CP, Atkins GB, Lazar MA, Freedman LP (2000) The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. Mol Cell Biol 20: 2718–2726 ArticlePubMedCAS Google Scholar
Radhakrishnan I, Perez-alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE (1998) Solution structure of the MX domain of CBP bound to the transactivation domain of CREB; a model for activator:coactivator interactions. Cell 91: 741–752 Article Google Scholar
Ray A, Prefontaine KE (1994) Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc Natl Acad Sci USA 91: 752–756 ArticlePubMedCAS Google Scholar
Rayet B, Gelinas C (1999) Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18: 6938–6947 ArticlePubMedCAS Google Scholar
Reichardt HM, Tuckermann JP, Gottlicher M, Vujic M, Weih F, Angel P, Herrlich P, Schutz G (2001) Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J 20: 7168–7173 ArticlePubMedCAS Google Scholar
Roberts CJ, Nelson B, Marton MJ, Stoughton R, Meyer MR, Bennett HA, He YD, Dai H, Walker WL, Hughes TR, Tyers M, Boone C, Friend SH (2000) Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science 287: 873–880 ArticlePubMedCAS Google Scholar
Rogler G, Brand K, Vogl D, Page S, Hofmeister R, Andus T, Knuechel R, Baeuerle PA, Scholmerich J, Gross V (1998) Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology 115: 357–369 ArticlePubMedCAS Google Scholar
Saccani S, Pantano S, Natoli G (2001) Two waves of nuclear factor kappaB recruitment to target promoters. J Exp Med 193: 1351–1359 ArticlePubMedCAS Google Scholar
Sakaguchi K, Herrera JE, Saito S, Miki T, Bustin M, Vassilev A, Anderson CW, Appella E (1998) DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev 12: 2831–2841 ArticlePubMedCAS Google Scholar
Sakurai H, Chiba H, Miyoshi H, Sugita T, Toriumi W (1999) IkappaB Kinases Phosphorylate NF-kappa B p65 Subunit on Serine 536 in the Transactivation Domain J Biol Chem 274: 30353–30356 CAS Google Scholar
Sassone-Corsi P, Mizzen CA, Cheung P, Crosio C, Monaco L, Jacquot S, Hanauer A, Allis CD (1999) Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science 285: 886–891 ArticlePubMedCAS Google Scholar
Savory JG, Hsu B, Laquian IR, Giffin W, Reich T, Hache RJ, Lefebvre YA (1999) Discrimination between NLI- and NL2-mediated nuclear localization of the glucocorticoid receptor. Mol Cell Biol 19: 1025–1037 PubMedCAS Google Scholar
Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin AS, Jr (1995) Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol Cell Biol 15: 943–953 PubMedCAS Google Scholar
Schiltz RL, Nakatani Y (2000) The P/CAF acetylase complex as a potential tumor suppressor. Biochim Biophys Acta 1470: M37 — M53 PubMedCAS Google Scholar
Schmitz ML, Stelzer G, Altmann H, Meisterernst M, Baeuerle PA (1995) Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators. J Biol Chem 270: 7219–7226 ArticlePubMedCAS Google Scholar
Schmitz ML, Bacher S, Kracht M (2001) IkB-independent control of NF-kappa B activity by modulatory phosphorylations. Trends Biochem Sci 26: 187–191 Article Google Scholar
Schreiber S, Nikolaus S, Hampe J (1998) Activation of nuclear factor kappa B inflammatory bowel disease. Gut 42: 477–484 ArticlePubMedCAS Google Scholar
See RH, Calvo D, Shi Y, Kawa H, Luke MP, Yuan Z (2001) Stimulation of p300-mediated transcription by the kinase MEKK1. J Biol Chem 276: 16310–16317 ArticlePubMedCAS Google Scholar
Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M (2001) Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293: 1495–1499 Google Scholar
Senger K, Merika M, Agalioti T, Yie J, Escalante CR, Chen G, Aggarwal AK, Thanos D (2000) Gene repression by coactivator repulsion. Mol Cell 6: 931–937 ArticlePubMedCAS Google Scholar
Sha WC (1998) Regulation of immune responses by NF-kappa B/Rel transcription factors. J Exp Med 187: 143–146 ArticlePubMedCAS Google Scholar
Sheppard KA, Phelps KM, Williams AJ, Thanos D, Glass CK, Rosenfeld MG, Gerritsen ME, Collins T (1998) Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1. J Biol Chem 273: 29291–29294 ArticlePubMedCAS Google Scholar
Sheppard KA, Rose DW, Hague ZK, Kurokawa R, McInerney E, Westin S, Thanos D, Rosenfeld MG, Glass CK, Collins T (1999) Transcriptional activation by NF-kappaB requires multiple coactivators. Mol Cell Biol 19: 6367–6378 PubMedCAS Google Scholar
Sheridan PL, Mayall TP, Verdin E, Jones KA (1997) Histone acetyltransferases regulate HIV-1 enhancer activity in vitro. Genes Dev 11: 3327–3340 ArticlePubMedCAS Google Scholar
Shikama N, Lyon J, La Thangue NB (1997) The p300/CBP family: integrating signals with transcription factors and chromatin. Trends Cell Biol 7: 230–236 ArticleCAS Google Scholar
Shumilla JA, Broderick RJ, Wang Y, Barchowsky A (1999) Chromium(VI) inhibits the transcriptional activity of nuclear factor-kappaB by decreasing the interaction of p65 with cAMP-responsive element-binding protein-binding protein. J Biol Chem 274: 36207–36212 ArticlePubMedCAS Google Scholar
Sif S, Stukenberg PT, Kirschner MW, Kingston RE (1998) Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. Genes Dev 12: 2842–2851 ArticlePubMedCAS Google Scholar
Silverman N, Maniatis T (2001) NF-kappaB signaling pathways in mammalian and insect innate immunity. Genes Dev 15: 2321–2342 ArticlePubMedCAS Google Scholar
Sizemore N, Leung S, Stark GR (1999) Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/ReIA subunit. Mol Cell Biol 19: 4798–4805 PubMedCAS Google Scholar
Snowden AW, Perkins ND (1998) Cell cycle regulation of the transcriptional coactivators p300 and CREB binding protein. Biochem Pharmacol 55: 1947–1954 ArticlePubMedCAS Google Scholar
Spencer E, Jiang J, Chen ZJ (1999) Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP. Genes Dev 13: 284–294 ArticlePubMedCAS Google Scholar
Stein B, Yang MX (1995) Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol Cell Biol 15: 4971–4979 PubMedCAS Google Scholar
Stein B, Baldwin AS, Ballard DW, Greene WC, Angel P, Herrlich P (1993) Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J 12: 3879–3891 PubMedCAS Google Scholar
Stenoien DL, Mancini MG, Patel K, Allegretto EA, Smith CL, Mancini MA (2000) Subnuclear trafficking of estrogen receptor-alpha and steroid receptor coactivator-1. Mol Endocrinol 14: 518–534 ArticlePubMedCAS Google Scholar
Stenoien DL, Patel K, Mancini MG, Dutertre M, Smith CL, O’Malley BW, Mancini MA (2001) FRAP reveals that mobility of oestrogen receptor-alpha is ligand-and proteasome-dependent. Nat Cell Biol 3: 15–23 ArticlePubMedCAS Google Scholar
Stewart S, Crabtree GR (2000) Transcription. Regulation of the regulators. Nature 408: 46–47 Google Scholar
Stöcklin E, Wissler M, Gouilleux F, Groner B (1996) Functional interactions between StatS and the glucocorticoid receptor. Nature 383: 726–728 ArticlePubMed Google Scholar
Strahl BD, Allis CD (2000) The language of covalent histone modifications. Nature 403: 41–45 ArticlePubMedCAS Google Scholar
Tai DI, Tsai SL, Chen YM, Chuang YL, Peng CY, Sheen IS, Yeh CT, Chang KS, Huang SN, Kuo GC, Liaw YF (2000) Activation of nuclear factor kappa, in hepatitis C virus infection: implications for pathogenesis and hepatocarcinogenesis [see comments]. Hepatology 31: 656–664 ArticlePubMedCAS Google Scholar
Tak PP, Firestein GS (2001) NF-kappaB: a key role in inflammatory diseases. J Clin Invest 107: 7–11 ArticlePubMedCAS Google Scholar
Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S (1999) Limb and skin abnormalities in mice lacking IKKalpha. Science 284: 313–316 ArticlePubMedCAS Google Scholar
Tetsuka T, Uranishi H, Imai H, Ono T, Sonta S, Takahashi N, Asamitsu K, Okamoto T (2000) Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats. J Biol Chem 275: 4383–4390 ArticlePubMedCAS Google Scholar
Thomson S, Clayton AL, Hazzalin CA, Rose S, Barratt MJ, Mahadevan LC (1999a) The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. EMBO J 18: 4779–4793 ArticlePubMedCAS Google Scholar
Thomson S, Mahadevan LC, Clayton AL (1999b) MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction. Semin Cell Dev Biol 10: 205–214 ArticlePubMedCAS Google Scholar
Tojima Y, Fujimoto A, Delhase M, Chen Y, Hatakeyama S, Nakayama K, Kaneko Y, Nimura Y, Motoyama N, Ikeda K, Karin M, Nakanishi M (2000) NAK is an IkappaB kinase-activating kinase. Nature 404: 778–782 ArticlePubMedCAS Google Scholar
Torchia J, Rose DW, Inostroza J, Kamei Y, Westin S, Glass CK, Rosenfeld MG (1997) The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387: 677–684 ArticlePubMedCAS Google Scholar
Torchia J, Glass C, Rosenfeld MG (1998) Co-activators and co-repressors in the integration of transcriptional responses. Cuff Opin Cell Biol 10: 373–383 ArticleCAS Google Scholar
Unlap MT, Jope RS (1997) Dexamethasone attenuates NF-kappa B DNA binding activity without inducing IkappaB levels in rat brain in vivo. Brain Res Mol Brain Res 45: 83–89 ArticlePubMedCAS Google Scholar
Urnov FD, Wolfe AP (2001) Chromatin remodeling and transcriptional activation: the cast (in order of appearance). Oncogene 20: 2991–3006 ArticlePubMedCAS Google Scholar
Utley RT, Ikeda K, Grant PA, Cote J, Steger DJ, Eberharter A, John S, Workman JL (1998) Transcriptional activators direct histone acetyltransferase complexes to nucleosomes. Nature 394: 498–502 ArticlePubMedCAS Google Scholar
Valentine SA, Chen G, Shandala T, Fernandez J, Mische S, Saint R, Courey AJ (1998) Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencer. Mol Cell Biol 18: 6584–6594 PubMedCAS Google Scholar
Van de Stolpe A, Caldenhoven E, Raaijmakers J, Van der Saag P, Koenderman L (1993) Glucocorticoid-mediated repression of intercellular adhesion molecule-1 expression in human monocytic and bronchial epithelial cell lines. Am J Respir Cell Mol Biol 8: 340–347 PubMed Google Scholar
Van de Stolpe A, Caldenhoven E, Stade BG, Koenderman L, Raaijmakers JA, Johnson JP, van der Saag PT (1994) 12-O-tetradecanoylphorbol-l3-acetateand tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter. J Biol Chem 269: 6185–6192 Google Scholar
Van Lint C, Emiliani S, Ott M, Verdin E (1996) Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J 15: 1112–1120 PubMed Google Scholar
Vanden Berghe W, Plaisance S, Boone E, De Bosscher K, Schmitz ML, Fiers W, Haegeman G (1998) p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor. J Biol Chem 273: 3285–3290 Google Scholar
Vanden Berghe W, De Bosscher K, Boone E, Plaisance S, Haegeman G (1999a) The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter. J Biol Chem 274: 32091–3208 Article Google Scholar
Vanden Berghe W, Francesconi E, De Bosscher K, Rèsche-Rigon M, Haegeman G (1999b) Dissociated glucocorticoids with anti-inflammatory potential repress interleukin-6 gene expression by an NF-kappa-B-dependent Mechanism. Mol Pharmacol 56: 797–806 Google Scholar
Vanden Berghe W, Vermeulen L, De Wilde G, De Bosscher K, Boone E, Haegeman G (2000) Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6. Biochem Pharmacol 60: 1185–1195 Article Google Scholar
Vane JR, Botting RM (1998) Anti-inflammatory drugs and their mechanism of action. Inflamm Res 47: S78 — S87 ArticlePubMedCAS Google Scholar
Vane JR, Botting RM (2000) The future of NSAID therapy: selective COX-2 inhibitors. Int J Clin Pract 54: 7–9 PubMedCAS Google Scholar
Vane JR, Flower RJ, Botting RM (1990) History of aspirin and its mechanism of action. Stroke 21:IV12—IV23 Google Scholar
Vayssière BM, Dupont A, Petit F, Garcia T, Marchandeau C, Gronemeyer H, Resche-Rigon M (1997) Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit anti-inflammatory activity in vivo. Mol Endocrinol 11: 1245–1255 ArticlePubMed Google Scholar
Versaw WK, Blank V, Andrews NM, Bresnick EH (1998) Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region. Proc Natl Acad Sci USA 95: 8756–8760 ArticlePubMedCAS Google Scholar
Vuillard L, Nicholson J, Hay RT (1999) A complex containing betaTrCP recruits Cdc34 to catalyse ubiquitination of IkappaBalpha. FEBS Lett 455: 311–314 ArticlePubMedCAS Google Scholar
Waddick KG, Uckun FM (1999) Innovative treatment programs against cancer: II. Nuclear factor-kappaB ( NF-kappaB) as a molecular target. Biochem Pharmacol 57: 9–17 Google Scholar
Wadgaonkar R, Phelps KM, Hague Z, Williams AJ, Silverman ES, Collins T (1999) CREB-binding protein is a nuclear integrator of nuclear factor-kappaB and p53 signaling. J Biol Chem 274: 1879–1882 ArticlePubMedCAS Google Scholar
Wan Y, Coxe KK, Thackray VG, Housley PR, Nordeen SK (2001) Separable features of the ligand-binding domain determine the differential subcellular localization and ligand-binding specificity of glucocorticoid receptor and progesterone receptor. Mol Endocrinol 15: 17–31 ArticlePubMedCAS Google Scholar
Wang D, Baldwin ASJ (1998) Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alfa is mediated through phosphorylation of Re1A/p65 on serine 529. J Biol Chem 273: 29411–29416 ArticlePubMedCAS Google Scholar
Wang LS, Chow KC, Wu CW (1999) Expression and up-regulation of interleukin-6 in oesophageal carcinoma cells by n-sodium butyrate. Br J Cancer 80: 1617–1622 ArticlePubMedCAS Google Scholar
Wang D, Westerheide S, Hanson J, Baldwin AJ (2000) TNFalpha-induced phosphorylation of RelA/p65 on Ser529 is Controlled by casein kinase II. J Biol Chem 275: 32592–32597 ArticlePubMedCAS Google Scholar
Webster-J Jewell-Cm Bodwell-Je Munck A, Sar M, Cidlowski-J (1997) Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein. J Biol Chem 272: 9287–9293 Article Google Scholar
Weinmann AS, Plevy SE, Smale ST (1999) Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription. Immunity 11: 665–675 ArticlePubMedCAS Google Scholar
Weinmann AS, Mitchell DM, Sanjabi S, Bradley MN, Hoffmann A, Liou HC, Smale ST (2001) Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, rel-independent event. Nat Immunol 2: 51–57 ArticlePubMedCAS Google Scholar
Wells WA (2001) Histones rule! The FASEB conference on chromatin and transcription. 7–12 July 2001. J Cell Biol 154: 906–907 ArticlePubMedCAS Google Scholar
Wen Y, Yan DH, Spohn B, Deng J, Lin SY, Hung MC (2000) Tumor suppression and sensitization to tumor necrosis factor alpha-induced apoptosis by an interferon-inducible protein, p202, in breast cancer cells. Cancer Res 60: 42–46 PubMedCAS Google Scholar
West MJ, Lowe AD, Karn J (2001) Activation of human immunodeficiency virus transcription in T cells revisited: NF-kappaB p65 stimulates transcriptional elongation. J Virol 75: 8524–8537 ArticlePubMedCAS Google Scholar
White DW, Gilmore TD (1998) Bd-2 and CrmA have different effects on transformation, apoptosis and the stability of IkB-a in chicken spleen cells transformed by temperature-sensitive v-rel oncoproteins. Oncogene 13: 891–899 Google Scholar
Wissink S, van Heerde EC, Schmitz ML, Kalkhoven E, van der Burg B, Baeuerle PA, van der Saag PT (1997) Distinct domains of the ReIA NFkappaB subunit are required for negative cross-talk and direct interaction with the glucocorticoid receptor. J Biol Chem 272: 22278–22284 ArticlePubMedCAS Google Scholar
Wissink S, van Heerde EC, vand der Burg B, van der Saag PT (1998) A dual mechanism mediates repression of NF-kappaB activity by glucocorticoids. Mol Endocrinol 12: 355–363 ArticlePubMedCAS Google Scholar
Witt O, Sand K, Pekrun A (2000) Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways. Blood 95: 2391–2396 PubMedCAS Google Scholar
Wolfe AP (2001) Chromatin remodeling: why it is important in cancer. Oncogene 20: 2988–2990 ArticleCAS Google Scholar
Wu WH, Hampsey M (1999) Transcription: common cofactors and cooperative recruitment. Curr Biol 9: R606 — R609 ArticlePubMedCAS Google Scholar
Xu L, Lavinsky RM, Dasen JS, Flynn SE, McInerney EM, Mullen TM, Heinzel T, Szeto D, Korzus E, Kurokawa R, Aggarwal AK, Rose DW, Glass CK, Rosenfeld MG (1998) Signal-specific co-activator domain requirements for Pit-1 activation. Nature 395: 301–306 ArticlePubMedCAS Google Scholar
Yamamoto Y, Gaynor RB (2001) Therapeutic potential of inhibition of the NFkappaB pathway in the treatment of inflammation and cancer. J Clin Invest 107: 135–142 ArticlePubMedCAS Google Scholar
Yamit-Hezi A, Dikstein R (1998) TAF(II)105 mediates activation of anti-apoptotic genes by NF-kappa B. EMBO J 17: 5161–5169 ArticlePubMedCAS Google Scholar
Yan F, Polk DB (1999) Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells. J Biol Chem 274: 36631–36636 ArticlePubMedCAS Google Scholar
Yaron A, Hatzubai A, Davis M, Lawn I, Amit S, Manning-Am Andersen-Js Mann M, Mercurio F, Ben-Neriah Y (1998) Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature 396: 590–594 CAS Google Scholar
Yin MJ, Yamamoto Y, Gaynor RB (1998) The anti-inflammatory agents aspirin and salicylate inhibit the activity of IkappaB kinase-beta. Nature 396: 77–80 ArticlePubMedCAS Google Scholar
Young PR (1998) Pharmacological modulation of cytokine action and produc- tion through signaling pathways. Cytokine Growth Factor Rev 9: 239–257 ArticlePubMedCAS Google Scholar
Yuan LW, Gambee JE (2000) Phosphorylation of p300 at serine 89 by protein kinase C. J Biol Chem 275: 40946–40951 ArticlePubMedCAS Google Scholar
Zanger K, Cohen LE, Hashimoto K, Radovick S, Wondisford FE (1999) A novel mechanism for cyclic adenosine 3’,5’-monophosphate regulation of gene expression by CREB-binding protein. Mol Endocrinol 13: 268–275 ArticlePubMedCAS Google Scholar
Zhang GJ, Adachi I (1999) Serum interleukin-6 levels correlate to tumor progression and prognosis in metastatic breast carcinoma. Anticancer Res 19: 1427–432 PubMedCAS Google Scholar
Zhang Y, Reinberg D (2001) Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev 15: 2343–2360 ArticlePubMedCAS Google Scholar
Zhong H, SuYang H, Erdjument-Bromage H, Tempst P, Ghosh S (1997) The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell 89: 413–424 ArticlePubMedCAS Google Scholar
Zhong H, Voll RE, Ghosh S (1998) Phoshorylation of NF-kappaB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell 1: 661–671 ArticlePubMedCAS Google Scholar
Zhu W, Downey JS, Gu J, Di Padova F, Gram H, Han J (2000) Regulation of TNF expression by multiple mitogen-activated protein kinase pathways. J Immunol 164: 6349–6358 PubMedCAS Google Scholar