Regulatory mechanisms of viral hepatitis B and C (original) (raw)
Ali N and Siddiqui A 1995 Interaction of polypyrimidine tract-binding protein with the 5′ noncoding region of the hepatitis C virus RNA genome and its functional requirements in internal initiation of translation;J. Virol.69 6367–6375 CASPubMedPubMed Central Google Scholar
Ali N and Siddiqui A 1997 The La antigen binds 5′ noncoding regions of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translation;Proc. Natl. Acad. Sci. USA94 2249–2254 ArticleCASPubMedPubMed Central Google Scholar
Antonucci T K and Rutter W J 1989 Hepatitis B virus (HBV) promoters are regulated by the HBV enhancer in a tissue specific manner;J. Virol.20 579–583 Google Scholar
Baeuerle P A and Baltimore D 1988 IκB: a specific inhibitor of the NF-κB transcription factor;Science242 540–546 ArticleCASPubMed Google Scholar
Bartenschlager R and Lohmann V 2000 Replication of hepatitis C virus;J. Gen. Virol.81 1631–1648 ArticleCASPubMed Google Scholar
Beasley R P, Lin C C, Hwang L Y and Chein C S 1981 Hepatocellular carcinoma and hepatitis B virus;Lancet2 1129–1133 ArticleCASPubMed Google Scholar
Becker S A, Lee T H, Butel J S and Slagle B L 1998 Hepatitis B virus X protein interfere with cellular DNA repair;J. Virol.72 266–272 CASPubMedPubMed Central Google Scholar
Benn J and Schneider R J 1994 Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP Kinase signaling 19 cascade;Proc. Natl. Acad. Sci. USA91 10350–10354 ArticleCASPubMedPubMed Central Google Scholar
Blight K J, Kolykhalov A A and Rice C M 2000 Efficient initiation of HCV RNA replication in cell culture;Science290 1972–1974 ArticleCASPubMed Google Scholar
Bouchard M J, Wang L H and Schneider R J 2001 Calcium signaling by HBx protein in hepatitis B virus DNA replication;Science294 2376–2378 ArticleCASPubMed Google Scholar
Breen A P and Murphy J A 1995 Reaction of oxyl radical with DNA;Free Rad. Biol. Med.18 1033–1077 ArticleCASPubMed Google Scholar
Brown E A, Zhang H, Ping L H and Lemon S M 1992 Secondary structure of the 5′ nontranslated regions of hepatitis C virus and pestivirus genomic RNAs;Nucleic Acids Res.20 5041–5045 ArticleCASPubMedPubMed Central Google Scholar
Broomberg J F, Wrzeszczynska M H, Devgan G, Zhao Y, Pestell R G, Albanese C and Darnell J E Jr 1999 Stat-3 as an oncogene;Cell98 295–303 Article Google Scholar
Carballo M, Conde M, Bekay R E, Martin-Nieto J, Camacho M J, Monteseiris J, Conde J, Bedoya F J and Sobrino F 1999 Oxidative stress triggers STAT-3 tyrosine phosphorylation and nuclear translocation in human lymphocytes;J. Biol. Chem.274 17580–17586 ArticleCASPubMed Google Scholar
Chang L J, Pryciak P, Ganem D and Varmus H E 1989 Biosynthesis of the reverse transcriptase of hepatitis B virus involves de novo translational initiation not ribosomal frameshifting;Nature (London)337 364–368 ArticleCAS Google Scholar
Chen H S, Kaneko R, Girones R W, Anderson W E, Hornbuckle B C, Tennant P J, Cote J L, Gerin R H, Purcell R H and Miller R H 1993 The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks;J. Virol.67 1218–1226 CASPubMedPubMed Central Google Scholar
Cheong J-H, Yi M-K, Lin Y and Murakami S 1995 Human RPB5, a subunit shared by eukaryotic nuclear polymerases, binds human 20 hepatitis B virus X protein and may play a role in X transactivation;EMBO J.14 143–150 ArticleCASPubMedPubMed Central Google Scholar
Dash S, Halim A B, Tsuji H, Hiramatsu N and Gerber M A 1997 Transfection of HepG2 cells with infectious hepatitis C virus genome;Am. J. Pathol.151 363–373 CASPubMedPubMed Central Google Scholar
Doria M, Klein N, Lucito R and Schneider R J 1995 The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors;EMBO J.14 4747–4757 ArticleCASPubMedPubMed Central Google Scholar
Dizdaroglu M 1994 Chemical determination of oxidative DNA damage by gas chromatography-mass spectrometry;Methods Enzymol.234 3–16 ArticleCASPubMed Google Scholar
Du M Q, Carmichael P L and Phillips D H 1994 Induction of activating mutations in the human C-Has-ras-1 proto-oncogene by oxygen free radicals;Mol. Carcinogenesis11 170–175 ArticleCAS Google Scholar
Feray C, Gigou M, Samuel D, Reyes G, Bernuau J, Reynes M, Bismuth H and Brechot C 1993 Hepatitis C virus RNA and hepatitis B virus DNA in serum and liver of patients with fulminant hepatitis;Gastroenterology104 549–555 ArticleCASPubMed Google Scholar
Freeman R B Jr 2002 Diagnosis hepatocellular carcinoma: A virtual reality;Liver Transplantation8 762–764 ArticlePubMed Google Scholar
Gale M Jr, Blakely C M, Kwieciszewski B, Tan S L, Dossett M, Korth M J, Polyak S J, Gretch D R and Katze M G 1998 Control of PKR protein kinase by hepatitis C virus non structural 5A protein: molecular mecahnisms of kinase regulation;Mol. Cell. Biol.18 5208–5218 ArticleCASPubMedPubMed Central Google Scholar
Gale M Jr, Korth M J, Tang N M, Tan S L, Hopkins D A, Dever T E, Polyak S J, Gretch D R and Katze M G 1997 Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein;Virology230 217–227 ArticleCASPubMed Google Scholar
Gale M J Jr, Kwieciszewski B, Tan S L, Dossett M, Nakao H and Katze M G 1999 Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase;J. Virol.103 6505–6515 Google Scholar
Ghosh A K, Steele R, Meyer K, Ray R and Ray R B 1999 Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth;J. Gen. Virol.80 1179–1183 ArticleCASPubMed Google Scholar
Gong G, Waris G, Tanveer R and Siddiqui A 2001 Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kB;Proc. Natl. Acad. Sci. USA98 9599–9604 ArticleCASPubMedPubMed Central Google Scholar
Haviv I, Shamay M, Doitsh G and Shaul Y 1998 Hepatitis B virus pX target TFIIB in transcription coactivator;Mol. Cell. Biol.18 1562–1569 ArticleCASPubMedPubMed Central Google Scholar
Haydon G H, Jarvis L P, Simmonds P, Harrison D J, Garden O J and Hayes P C 1997 Association between chronic hepatitis C infection and hepatocellular carcinoma in Scotish population;Gut40 128–132 ArticleCASPubMedPubMed Central Google Scholar
Haze K, Yoshida H, Yanagi H, Yura T and Mori K 1999 Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress;Mol. Cell. Biol.10 3787–3799 ArticleCAS Google Scholar
Henkler F, Hoare J, Waseem N, Goldin R, McGarvey M, Koshy R and King I 2001 Intracellular localization of the hepatitis B virus HBx protein;J. Gen. Virol.82 871–882 ArticleCASPubMed Google Scholar
Hijikata M, Mizushima H, Tanji Y, Komoda Y, Hirowatari Y, Akagi T, Kato N, Kimura K and Shimotohno K 1993 Proteolytic processing and membrane association of putative non-structural proteins of hepatitis C virus;Proc. Natl. Acad. Sci. USA90 10773–10777 ArticleCASPubMedPubMed Central Google Scholar
Huang J, Kwong J, Sun E C and Liang T J 1996 Proteasome complex as a potential cellular target of hepatitis B virus X protein;J. Virol.70 5582–5591 CASPubMedPubMed Central Google Scholar
Huh K-W and Siddiqui A 2002 Characterization of the mitochondrial association of hepatitis B virus X protein, HBx;Mitochondrion1 349–359 ArticleCASPubMed Google Scholar
Ikeda M, Yi M, Li K and Lemon S M 2002 Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of Hepatitis C virus replicate efficiently in cultured Huh7 cells;J. Virol.76 2997–3006 ArticleCASPubMedPubMed Central Google Scholar
Jameel S and Siddiqui A 1986 The human hepatitis B virus enhancer requires trans-acting cellular factors for activity;Mol. Cell. Biol.6 710–715 ArticleCASPubMedPubMed Central Google Scholar
Kankeo T, Tanji Y, Satoh S, Hijikata M, Asabe S, Kimura K and Shimotohno K 1994 Production of two phosphoproteins from the NS5A region of the hepatitis C virus genome;Biochem. Biophys. Res. Commun.205 320–326 Article Google Scholar
Katze M G 1995 Regulation of the interferon-induced PKR: can viruses cope?;Trends Microbiol.3 75–78 ArticleCASPubMed Google Scholar
Kaufman R J 1999 Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls;Genes Dev.13 1211–1233 ArticleCASPubMed Google Scholar
Kekule A, Lauer U, Weiss L, Luber B and Hofschneider P 1993 Hepatitis B virus transactivator HBx uses a tumour promoter signaling pathway;Nature (London)361 742–745 ArticleCAS Google Scholar
Kew M C, Yu M C, Keda M A, Coppin A, Sarkin A and Hodkinson 1997 The relative roles of hepatitis B and hepatitis C viruses in the etiology of hepatocellular carcinoma in southern African blacks;Gastroenterology112 184–187 ArticleCASPubMed Google Scholar
Klein N P and Schneider R J 1997 Activation of Src family of kinase by HBV HBx protein, and coupled signaling to Ras;Mol. Cell. Biol.17 6427–6436 ArticleCASPubMedPubMed Central Google Scholar
Kolykhalov A A, Agapov E V and Rice C M 1994 Specificity of the hepatitis C virus NS3 serine protease: effects of substitution at the 3/4, 4A/4B, 4B/5A, and 5A/5B cleavage sites on polyprotein processing;J. Virol.68 7525–7533 CASPubMedPubMed Central Google Scholar
Kolykhalov A A, Feinstone S M and Rice C M 1996 Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA;J. Virol.70 3363–3371 CASPubMedPubMed Central Google Scholar
Kosovsky M J, Qadri I and Siddiqui A 1996 The regulation of hepatitis B virus gene expression: an overview of the cis- and trans-acting components; in_Hepatitis B virus: molecular mechanism in disease and novel strategies for therapy_ (eds) R Koshy and W H Caselmann (London: Imperial College Press) pp 21–50 Google Scholar
Liaw Y F 1995 Role of hepatitis C virus in dual and triple hepatitis virus infection;Hepatology22 1101–1108 CASPubMed Google Scholar
Liberman E, Fong Y-L, Selby M J, Choo Q L, Cousens L, Houghton M and Benedict Yen T S 1999 Activation of the grp78 and grp94 promoters by hepatitis C virus E2 envelope protein;J. Virol.73 3718–3722 CASPubMedPubMed Central Google Scholar
Livolsi A, Busuttil V, Imber V, Abraham R T and Peyron J F 2001 Tyrosine phosphorylation-dependent activation of NF-kB: requirement for p56 LCK and ZAP-70 protein tyrosine kinases;Eur. J. Biochem.268 1–9 Article Google Scholar
Lohmann V, Korner F, Koch J-O, Herian U, Theilmann L and Bartenschlager R 1999 Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line;Science285 110–113 ArticleCASPubMed Google Scholar
Lucito R and Schneider R J 1992 Hepatitis B virus X protein activates transcription factor NF-κB without a requirement for protein kinase C;J. Virol.66 983–991 CASPubMedPubMed Central Google Scholar
Maguire H F, Hoeffler J P and Siddiqui A 1991 HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions;Science252 842–844 ArticleCASPubMed Google Scholar
Meurs E, Chong K, Galabru J, Thomas N S, Kerr I M, Williams B R G and Hovanessian A G 1990 Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon;Cell41 379–390 Article Google Scholar
Meyer M, Caselmann W H, Schluter V, Schreck R, Hofschneider P H and Baeuerle P A 1992 Hepatitis B virus transactivator MHBs: activation of NF-κB, selective inhibition by antioxidants and integral membrane localization;EMBO J.11 2991–3001 ArticleCASPubMedPubMed Central Google Scholar
Miller R H and Purcell R H 1990 Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups;Proc. Natl. Acad. Sci. USA87 2057–2061 ArticleCASPubMedPubMed Central Google Scholar
Nolt F S 1997 Laboratory diagnosis of hepatitis C;Immunol. Invest.26 199–207 Article Google Scholar
Ou J H, Bao H, Shih C and Tahara S M 1990 Preferred translation of human hepatitis B virus polymerase from core protein- but not from precore protein-specific transcript;J. Virol.64 4578–4581 CASPubMedPubMed Central Google Scholar
Pahl H L 1999 Signal transduction from the endoplasmic reticulum to the cell Nucleus;Physiol. Rev.70 683–701 Article Google Scholar
Pahl H L and Baeuerle P A 1995 Expression of influenza hemagglutinin activates transcription factor NF-κB;J. Virol.6 1480–1484 Google Scholar
Pahl H L, Sester M, Burgert H G and Baeuerele P A 1996 Activation of transcription factor NF-κB by adeno virus E3/19 K requires its ER retention;J. Cell. Biol.132 511–522 ArticleCASPubMed Google Scholar
Peterhans E 1997 Oxidants and antioxidants in viral diseases: Disease mechanisms and metabolic regulation;J. Nutr.127 962S-965S ArticleCASPubMed Google Scholar
Pietschmann T, Lohmann V, Kaul A, Krieger N, Rinck G, Rutter G, Strand D and Bartenschlager R 2002 Persistent and transient replication of full length hepatitis C virus genome in cell culture;J. Virol.76 4008–4021 ArticleCASPubMedPubMed Central Google Scholar
Qadri I, Conaway J W, Conaway R C, Schaack J and Siddiqui A 1996 Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH;Proc. Natl. Acad. Sci. USA93 10578–10583 ArticleCASPubMedPubMed Central Google Scholar
Qadri I, Maguire H F and Siddiqui A 1995 Hepatitis B virus transactivator protein X in teracts with the TATA binding protein;Proc. Natl. Acad. Sci. USA92 1003–1007 ArticleCASPubMedPubMed Central Google Scholar
Reed K E, Xu J and Rice C M 1997 Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A associated kinase;J. Virol.71 7187–7197 CASPubMedPubMed Central Google Scholar
Rahmani Z, Huh K-W, Lasher R L and Siddiqui A 2000 Hepatitis B virus X protein colocalize to mitochondria with a human voltage-dependent anion channel, hVDAC3 and alters its transmemebrane potential;J. Virol.74 2840–2846 ArticleCASPubMedPubMed Central Google Scholar
Saito I, Miyamura T, Ohbayashi A, Harada H, Katayama T, Kikuchi S, Watanabe S, Koi T Y, Onji M, Ohta Y, Choo Q-L, Houghton M and Kuo G 1990 Hepatitis C virus infection is associated with the development of hepatocellular carcinoma;Proc. Natl. Acad. Sci. USA87 6547–6549 ArticleCASPubMedPubMed Central Google Scholar
Schreck R, Rieber P and Baeurele P A1991 Reactive oxygen intermediates as apparently widely used messengers in the activation of NF-κB transcription factor and HIV;EMBO J.10 2247–2258 ArticleCASPubMedPubMed Central Google Scholar
Schwarz K B 1996 Oxidative stress during viral infection: A review;Free Rad. Biol. Med.21 641–649 ArticleCASPubMed Google Scholar
Schoonbroodt S, Ferreira V, Best-Belpomme M, Boelaert J, Legrand-Poels S, Korner M and Piette L 2000 Crucial role of the amino-terminal tyrosine residue 42 and the carboxy-terminal PEST domain of IκBα in NF-κB activation by an oxidative stress;J. Immunol.164 4292–4300 ArticleCASPubMed Google Scholar
Shirota Y, Luo H, Qin W, Kaneko S, Yamashita T, Kobayashi K and Murakami S 2002 Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent polymerase activity_J. Biol. Chem._ 277 11149–11155 ArticleCASPubMed Google Scholar
Siddiqui A, Gayne R, Srinivasan A, Mapoles J and Farr R W 1989 Trans-activation of viral enhancers inducing the long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein;Virology169 479–484 ArticleCASPubMed Google Scholar
Siddiqui A, Jameel S and Mapoles J 1987 Expression of hepatitis B virus X gene in mammalian cells;Proc. Natl. Acad. Sci. USA84 2513–2517 ArticleCASPubMedPubMed Central Google Scholar
Spangberg K, Wiklund L and Schwartz S 2001 Binding of the La autoantigen to the hepatitis C virus 3′ untranslated region protects the RNA from repid degradation in vitro;J. Gen. Virol.82 113–120 ArticleCASPubMed Google Scholar
Takada S, Shriakat Y, Kaneniwa N and Koike K 1999 Association of HBV X protein with the mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death;Oncogene18 6965–6973 ArticleCASPubMed Google Scholar
Tanji Y, Hijikata M, Hirowatari Y and Shimotohno K 1994 Hepatitis C virus polyprotein processing: kinetics and mutagenic analysis of serine proteinase-dependent cleavage;J. Virol.68 8418–8422 CASPubMedPubMed Central Google Scholar
Tanji Y, Kaneko T, Sahto S and Shimotohno K 1995 Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A;J. Virol.69 3980–3986 CASPubMedPubMed Central Google Scholar
Tardiff K D, Mori K and Siddiqui A 2002 Hepatitis C virus subgenomic replicons induce ER stress activating an intracellular signaling pathway;J. Virol. (in press)
Traenckner E B-M, Pahl H L, Henkel T, Schmidt K N, Wilk S and Baeuerle PA 1995 Phosphorylation of human IκB-α on serine 32 and 36 control IκB-α proteolysis and NF-κB activation in response to diverse stimuli;EMBO J.14 2876–2883 ArticleCASPubMedPubMed Central Google Scholar
Tsukiyama-kohara K, Iizuka N, Kohara M and Nomoto A 1992 Internal ribosome entry site within hepatitis C virus RNA;J. Virol.66 1476–1483 CASPubMedPubMed Central Google Scholar
Tu H, Gao L, Shi T, Taylor D, Yang T, Mircheff A, Wen Y, Gorbalenyz A, Hwang S and Lai M 1999 Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein;Virology263 30–41 ArticleCASPubMed Google Scholar
Twu J-S, Chu K and Robinson W S 1989 Hepatitis B virus X gene can transactivate heterologous viral sequence;Proc. Natl. Acad. Sci. USA86 2046–2050 ArticleCASPubMedPubMed Central Google Scholar
Wang X W, Forrester K, Yeh H, Feitelson M A, Gu J R and Harris C C 1994a Hepatitis B virus X protein inhibits p53 sequence specific DNA binding, transcriptional activity, and association with transcription factor ERCC3;Proc. Natl. Acad. Sci. USA91 2230–2234 ArticleCASPubMedPubMed Central Google Scholar
Wang C, Sarnow P and Siddiqui A 1994b Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism;J. Virol.67 3338–3344 Google Scholar
Waris G, Huh K-W and Siddiqui A 2001 Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-κB via oxidative stress;Mol. Cell. Biol.21 7721–7730 ArticleCASPubMedPubMed Central Google Scholar
Williams J S and Andrisani O M 1995 The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB;Proc. Natl. Acad. Sci. USA92 3819–3823 ArticleCASPubMedPubMed Central Google Scholar
Xu Z, Jensen G and Benedict Yen T S 1997 Activation of Hepatitis B Virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum;J. Virol.71 7387–7392 CASPubMedPubMed Central Google Scholar
Yen T S B 1993 Regulation of hepatitis B virus gene expression;Semin. Virol.4 33–42 ArticleCAS Google Scholar
Yoo B J, Selby M J, Choe J, Suh B S, Choi S H, Joh J S, Nuovo G J, Lee H S, Houghton M and Han J H 1995 Transfection of a differentiated human hepatoma cell line (Huh7) with in vitro-transcribed hepatitis C virus (HCV) RNA and establishment of a long-term culture persistently infected with HCV;J. Virol.69 32–38 CASPubMedPubMed Central Google Scholar
Yoshida H, Haze K, Yangi H, Yura T and Mori K 1998 Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose regulated proteins;J. Biol. Chem.273 33741–33749 ArticleCASPubMed Google Scholar
Zoulim F, Saputelli J and Seeger C 1994 Woodchuck hepatitis B virus X gene is important for viral infection in vivo;J. Virol.68 2026–2030 CASPubMedPubMed Central Google Scholar
Zwacka R, Zhang Y, Zhou W, Halldorson J and Engelhardt J 1998 Ischemia/reperfusion injury in the liver of Balb/c mice activates AP-1 and nuclear factor kappa B independently of IκB degradation;Hepatology28 1022–1030 ArticleCASPubMed Google Scholar