Epstein RJ (1990) Drug-induced DNA damage and tumor chemosensitivity. J Clin Oncol 8:2062–2084 PubMedCAS Google Scholar
Schärer OD (2005) DNA interstrand crosslinks: natural and drug-induced DNA adducts that induce unique cellular responses. Chembiochem 6:27–32 ArticlePubMedCAS Google Scholar
Noll DM, Mason TM, Miller PS (2006) Formation and repair of interstrand cross-links in DNA. Chem Rev 106:277–301 ArticlePubMedCAS Google Scholar
Helleday T, Petermann E, Lundin C, Hodgson B, Sharma RA (2008) DNA repair pathways as targets for cancer therapy. Nat Rev Cancer 8:193–204 ArticlePubMedCAS Google Scholar
Goodman L, Wintrobe M, Dameshek W, Goodman M, Gilman A (1946) Nitrogen mustard therapy—use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. J Am Med Assoc 132:126–132 CAS Google Scholar
Kohn KW (1996) Beyond DNA cross-linking: history and prospects of DNA-targeted cancer treatment—Fifteenth Bruce F. Cain Memorial Award lecture. Cancer Res 56:5533–5546 PubMedCAS Google Scholar
Gilman A, Philips F (1946) The biological actions and therapeutic applications of the B-chloroethyl amines and sulfides. Science 103:409–436 ArticlePubMedCAS Google Scholar
Brookes P, Lawley PD (1961) The reaction of mono- and di-functional alkylating agents with nucleic acids. Biochem J 80:496–503 PubMedCAS Google Scholar
Kohn KW, Spears CL, Doty P (1966) Inter-strand crosslinking of DNA by nitrogen mustard. J Mol Biol 19:266–288 ArticlePubMedCAS Google Scholar
Rajski SR, Williams RM (1998) DNA cross-linking agents as antitumor drugs. Chem Rev 98:2723–2796 ArticlePubMedCAS Google Scholar
Stone MP, Cho Y-J, Huang H, Kim H-Y, Kozekov ID, Kozekova A, Wang H, Minko IG, Lloyd RS, Harris TM, Rizzo CJ (2008) Interstrand DNA cross-links induced by alpha, beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources. Accounts Chem Res 41:793–804 ArticleCAS Google Scholar
Panasci L, Xu Z-Y, Bello V, Aloyz R (2002) The role of DNA repair in nitrogen mustard drug resistance. Anticancer Drugs 13:211–220 ArticlePubMedCAS Google Scholar
McHugh PJ, Spanswick VJ, Hartley JA (2001) Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance. Lancet Oncol 2:483–490 ArticlePubMedCAS Google Scholar
Ojwang JO, Grueneberg DA, Loechler EL (1989) Synthesis of a duplex oligonucleotide containing a nitrogen mustard interstrand DNA–DNA cross-link. Cancer Res 49:6529–6537 PubMedCAS Google Scholar
Rink S, Solomon M, Taylor M, Rajur S, McLaughlin L, Hopkins P (1993) Covalent Structure of a nitrogen mustard-induced DNA interstrand cross-link—an N7-to-N7 linkage of deoxyguanosine residues at the duplex sequence 5′-d(GNC). J Am Chem Soc 115:2551–2557 ArticleCAS Google Scholar
Millard J, Raucher S, Hopkins P (1990) Mechlorethamine cross-links deoxyguanosine residues at 5′-GNC sequences in duplex DNA fragments. J Am Chem Soc 112:2459–2460 ArticleCAS Google Scholar
Rink SM, Hopkins PB (1995) A mechlorethamine-induced DNA interstrand cross-link bends duplex DNA. Biochemistry 34:1439–1445 ArticlePubMedCAS Google Scholar
Guainazzi A, Campbell AJ, Angelov T, Simmerling C, Schärer OD (2010) Synthesis and molecular modeling of a nitrogen mustard DNA interstrand crosslink. Chem Eur J (in press)
Kallama S, Hemminki K (1984) Alkylation of guanosine by phosphoramide mustard, chloromethine hydrochloride and chlorambucil. Acta Pharmacol Toxicol 54:214–220 ArticleCAS Google Scholar
Kallama S, Hemminki K (1986) Stabilities of 7-alkylguanosines and 7-deoxyguanosines formed by phosphoramide mustard and nitrogen mustard. Chem Biol Interact 57:85–96 ArticlePubMedCAS Google Scholar
Fan Y, Gold B (1999) Sequence-specificity for DNA interstrand cross-linking by alpha, ω-alkanediol dimethylsulfonate esters: evidence for DNA distortion by the initial monofunctional lesion. J Am Chem Soc 121:11942–11946 ArticleCAS Google Scholar
Mehta JR, Przybylski M, Ludlum DB (1980) Alkylation of guanosine and deoxyguanosine by phosphoramide mustard. Cancer Res 40:4183–4186 PubMedCAS Google Scholar
Grueneberg D, Ojwang J, Benasutti M, Hartman S, Loechler E (1991) Construction of a human shuttle vector containing a single nitrogen mustard interstrand, DNA–DNA cross-link at a unique plasmid location. Cancer Res 51:2268–2272 PubMedCAS Google Scholar
Berardini M, Mackay W, Loechler E (1997) Evidence for a recombination-independent pathway for the repair of DNA interstrand cross-links based on a site-specific study with nitrogen mustard. Biochemistry 36:3506–3513 ArticlePubMedCAS Google Scholar
Berardini M, Foster P, Loechler E (1999) DNA polymerase II (polB) is involved in a new DNA repair pathway for DNA interstrand cross-links in Escherichia coli. J Bacteriol 181:2878–2882 PubMedCAS Google Scholar
Angelov T, Guainazzi A, Schärer OD (2009) Generation of DNA interstrand cross-links by post-synthetic reductive amination. Org Lett 11:661–664 ArticlePubMedCAS Google Scholar
Rosenberg B, VanCamp L, Trosko JE, Mansour VH (1969) Platinum compounds: a new class of potent antitumour agents. Nature 222:385–386 ArticlePubMedCAS Google Scholar
Rosenberg B, VanCamp L, Krigas T (1965) Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode. Nature 205:698–699 ArticlePubMedCAS Google Scholar
Kelland L (2007) The resurgence of platinum-based cancer chemotherapy. Nat Rev Cancer 7:573–584 ArticlePubMedCAS Google Scholar
Jamieson ER, Lippard SJ (1999) Structure, recognition, and processing of cisplatin-DNA adducts. Chem Rev 99:2467–2498 ArticlePubMedCAS Google Scholar
Huang H, Zhu L, Reid BR, Drobny GP, Hopkins PB (1995) Solution structure of a cisplatin-induced DNA interstrand cross-link. Science 270:1842–1845 ArticlePubMedCAS Google Scholar
Coste F, Malinge JM, Serre L, Shepard W, Roth M, Leng M, Zelwer C (1999) Crystal structure of a double-stranded DNA containing a cisplatin interstrand cross-link at 1.63 Å resolution: hydration at the platinated site. Nucleic Acids Res 27:1837–1846 ArticlePubMedCAS Google Scholar
Hofr C, Brabec V (2001) Thermal and thermodynamic properties of duplex DNA containing site-specific interstrand cross-link of antitumor cisplatin or its clinically ineffective trans isomer. J Biol Chem 276:9655–9661 ArticlePubMedCAS Google Scholar
Räschle M, Knipscheer P, Knipsheer P, Enoiu M, Angelov T, Sun J, Griffith JD, Ellenberger TE, Schärer OD, Walter JC (2008) Mechanism of replication-coupled DNA interstrand crosslink repair. Cell 134:969–980 ArticlePubMedCAS Google Scholar
Johannessen T-CA, Bjerkvig R, Tysnes BB (2008) DNA repair and cancer stem-like cells—potential partners in glioma drug resistance? Cancer Treat Rev 34:558–567 ArticlePubMedCAS Google Scholar
Ludlum DB (1997) The chloroethylnitrosoureas: sensitivity and resistance to cancer chemotherapy at the molecular level. Cancer Invest 15:588–598 ArticlePubMedCAS Google Scholar
Fischhaber PL, Gall AS, Duncan JA, Hopkins PB (1999) Direct demonstration in synthetic oligonucleotides that N, _N_′-bis(2-chloroethyl)-nitrosourea cross links N1 of deoxyguanosine to N3 of deoxycytidine on opposite strands of duplex DNA. Cancer Res 59:4363–4368 PubMedCAS Google Scholar
Alzeer J, Schärer OD (2006) A modified thymine for the synthesis of site-specific thymine–guanine DNA interstrand crosslinks. Nucleic Acids Res 34:4458–4466 ArticlePubMedCAS Google Scholar
Noll DM, Noronha AM, Miller PS (2001) Synthesis and characterization of DNA duplexes containing an N(4)C-ethyl-N(4)C interstrand cross-link. J Am Chem Soc 123:3405–3411 ArticlePubMedCAS Google Scholar
Wilds CJ, Noronha AM, Robidoux S, Miller PS (2004) Mispair-aligned N3T-alkyl-N3T interstrand cross-linked DNA: synthesis and characterization of duplexes with interstrand cross-links of variable lengths. J Am Chem Soc 126:9257–9265 ArticlePubMedCAS Google Scholar
Wilds CJ, Xu F, Noronha AM (2008) Synthesis and characterization of DNA containing an N-1-2′-deoxyinosine-ethyl-N-3-thymidine interstrand cross-link: a structural mimic of the cross-link formed by 1, 3-bis-(2-chloroethyl)-1-nitrosourea. Chem Res Toxicol 21:686–695 ArticlePubMedCAS Google Scholar
Smeaton MB, Hlavin EM, McGregor Mason T, Noronha AM, Wilds CJ, Miller PS (2008) Distortion-dependent unhooking of interstrand cross-links in mammalian cell extracts. Biochemistry 47:9920–9930 ArticlePubMedCAS Google Scholar
Smeaton MB, Hlavin EM, Noronha AM, Murphy SP, Wilds CJ, Miller PS (2009) Effect of cross-link structure on DNA interstrand cross-link repair synthesis. Chem Res Toxicol 22:1285–1297 ArticlePubMedCAS Google Scholar
Hofheinz R-D, Beyer U, Al-Batran S-E, Hartmann JT (2008) Mitomycin C in the treatment of gastrointestinal tumours: recent data and perspectives. Onkologie 31:271–281 ArticlePubMedCAS Google Scholar
Tomasz M, Lipman R, Chowdary D, Pawlak J, Verdine GL, Nakanishi K (1987) Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA. Science 235:1204–1208 ArticlePubMedCAS Google Scholar
Tomasz M, Chowdary D, Lipman R, Shimotakahara S, Veiro D, Walker V, Verdine GL (1986) Reaction of DNA with chemically or enzymatically activated mitomycin C: isolation and structure of the major covalent adduct. Proc Natl Acad Sci USA 83:6702–6706 ArticlePubMedCAS Google Scholar
Rink SM, Lipman R, Alley SC, Hopkins PB, Tomasz M (1996) Bending of DNA by the mitomycin C-induced, GpG intrastrand cross-link. Chem Res Toxicol 9:382–389 ArticlePubMedCAS Google Scholar
Norman D, Live D, Sastry M, Lipman R, Hingerty BE, Tomasz M, Broyde S, Patel DJ (1990) NMR and computational characterization of mitomycin cross-linked to adjacent deoxyguanosines in the minor groove of the d(T-A-C-G-T-A).d(T-A-C-G-T-A) duplex. Biochemistry 29:2861–2875 ArticlePubMedCAS Google Scholar
Warren AJ, Ihnat MA, Ogdon SE, Rowell EE, Hamilton JW (1998) Binding of nuclear proteins associated with mammalian DNA repair to the mitomycin C-DNA interstrand crosslink. Environ Mol Mutagen 31:70–81 ArticlePubMedCAS Google Scholar
Mustra DJ, Warren AJ, Hamilton JW (2001) Preferential binding of human full-length XPA and the minimal DNA binding domain (XPA-MF122) with the mitomycin C-DNA interstrand cross-link. Biochemistry 40:7158–7164 ArticlePubMedCAS Google Scholar
Zheng H, Wang X, Warren A, Legerski R, Nairn R, Hamilton J, Li L (2003) Nucleotide excision repair- and polymerase eta-mediated error-prone removal of mitomycin C interstrand cross-links. Mol Cell Biol 23:754–761 ArticlePubMedCAS Google Scholar
Cimino G, Gamper H, Isaacs S, Hearst J (1985) Psoralens as photoactive probes of nucleic acid structure and function: organic chemistry, photochemistry, and biochemistry. Annu Rev Biochem 54:1151–1193 ArticlePubMedCAS Google Scholar
Stern RS (2007) Psoralen and ultraviolet a light therapy for psoriasis. N Engl J Med 357:682–690 ArticlePubMedCAS Google Scholar
Spielmann HP, Sastry SS, Hearst JE (1992) Methods for the large-scale synthesis of psoralen furan-side monoadducts and diadducts. Proc Natl Acad Sci USA 89:4514–4518 ArticlePubMedCAS Google Scholar
Kobertz W, Essigmann JM (1997) Solid-phase synthesis of oligonucleotides containing a site-specific psoralen derivative. J Am Chem Soc 119:5960–5961 ArticleCAS Google Scholar
Spielmann HP, Dwyer TJ, Hearst JE, Wemmer DE (1995) Solution structures of psoralen monoadducted and cross-linked DNA oligomers by NMR spectroscopy and restrained molecular dynamics. Biochemistry 34:12937–12953 ArticlePubMedCAS Google Scholar
Hwang GS, Kim JK, Choi BS (1996) The solution structure of a psoralen cross-linked DNA duplex by NMR and relaxation matrix refinement. Biochem Biophys Res Commun 219:191–197 ArticlePubMedCAS Google Scholar
Sinden RR, Hagerman PJ (1984) Interstrand psoralen cross-links do not introduce appreciable bends in DNA. Biochemistry 23:6299–6303 ArticlePubMedCAS Google Scholar
Thazhathveetil AK, Liu ST, Indig FE, Seidman MM (2007) Psoralen conjugates for visualization of genomic interstrand cross-links localized by laser photoactivation. Bioconjug Chem 18:431–437 ArticlePubMedCAS Google Scholar
Majumdar A, Muniandy PA, Liu J, Liu JL, Liu ST, Cuenoud B, Seidman MM (2008) Targeted gene knock in and sequence modulation mediated by a psoralen-linked triplex-forming oligonucleotide. J Biol Chem 283:11244–11252 ArticlePubMedCAS Google Scholar
Niedernhofer LJ, Daniels JS, Rouzer CA, Greene RE, Marnett LJ (2003) Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells. J Biol Chem 278:31426–31433 ArticlePubMedCAS Google Scholar
Cheng G, Shi Y, Sturla SJ, Jalas JR, McIntee EJ, Villalta PW, Wang M, Hecht SS (2003) Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formaldehyde cross-links. Chem Res Toxicol 16:145–152 ArticlePubMedCAS Google Scholar
Minko IG, Harbut MB, Kozekov ID, Kozekova A, Jakobs PM, Olson SB, Moses RE, Harris TM, Rizzo CJ, Lloyd RS (2008) Role for DNA polymerase kappa in the processing of N2-N2-guanine interstrand cross-links. J Biol Chem 283:17075–17082 ArticlePubMedCAS Google Scholar
Dooley PA, Tsarouhtsis D, Korbel GA, Nechev LV, Shearer J, Zegar IS, Harris CM, Stone MP, Harris TM (2001) Structural studies of an oligodeoxynucleotide containing a trimethylene interstrand cross-link in a 5′-(CpG) motif: model of a malondialdehyde cross-link. J Am Chem Soc 123:1730–1739 ArticlePubMedCAS Google Scholar
Dooley PA, Zhang M, Korbel GA, Nechev LV, Harris CM, Stone MP, Harris TM (2003) NMR determination of the conformation of a trimethylene interstrand cross-link in an oligodeoxynucleotide duplex containing a 5′-d(GpC) motif. J Am Chem Soc 125:62–72 ArticlePubMedCAS Google Scholar
Shapiro R, Dubelman S, Feinberg AM, Crain PF, McCloskey JA (1977) Isolation and identification of cross-linked nucleosides from nitrous acid treated deoxyribonucleic acid. J Am Chem Soc 99:302–303 ArticlePubMedCAS Google Scholar
Kirchner J, Hopkins P (1991) Nitrous-acid cross-links duplex DNA fragments through deoxyguanosine residues at the sequence 5′-CG. J Am Chem Soc 113:4681–4682 ArticleCAS Google Scholar
Caulfield JL, Wishnok JS, Tannenbaum SR (2003) Nitric oxide-induced interstrand cross-links in DNA. Chem Res Toxicol 16:571–574 ArticlePubMedCAS Google Scholar
Edfeldt NBF, Harwood EA, Sigurdsson ST, Hopkins PB, Reid BR (2004) Solution structure of a nitrous acid induced DNA interstrand cross-link. Nucleic Acids Res 32:2785–2794 ArticlePubMedCAS Google Scholar
Harwood E, Sigurdsson S, Edfeldt N, Reid B, Hopkins PB (1999) Chemical synthesis and preliminary structural characterization of a nitrous acid interstrand cross-linked duplex DNA. J Am Chem Soc 121:5081–5082 ArticleCAS Google Scholar
Hong IS, Greenberg MM (2005) Efficient DNA interstrand cross-link formation from a nucleotide radical. J Am Chem Soc 127:3692–3693 ArticlePubMedCAS Google Scholar
Hong IS, Ding H, Greenberg MM (2006) Oxygen independent DNA interstrand cross-link formation by a nucleotide radical. J Am Chem Soc 128:485–491 ArticlePubMedCAS Google Scholar
Cole R (1973) Repair of DNA containing interstrand crosslinks in Escherichia coli: sequential excision and recombination. Proc Natl Acad Sci USA 70:1064–1068 ArticlePubMedCAS Google Scholar
Cole R, Levitan D, Sinden R (1976) Removal of psoralen interstrand cross-links from DNA of Escherichia coli: mechanism and genetic control. J Mol Biol 103:39–59 ArticlePubMedCAS Google Scholar
Akkari Y, Bateman R, Reifsteck C, Olson S, Grompe M (2000) DNA replication is required to elicit cellular responses to psoralen-induced DNA interstrand cross-links. Mol Cell Biol 20:8283–8289 ArticlePubMedCAS Google Scholar
Hoy CA, Thompson LH, Mooney CL, Salazar EP (1985) Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents. Cancer Res 45:1737–1743 PubMedCAS Google Scholar
De Silva IU, McHugh PJ, Clingen PH, Hartley JA (2000) Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells. Mol Cell Biol 20:7980–7990 ArticlePubMed Google Scholar
Niedernhofer LJ, Odijk H, Budzowska M, van Drunen E, Maas A, Theil AF, de Wit J, Jaspers NGJ, Beverloo HB, Hoeijmakers JHJ, Kanaar R (2004) The structure-specific endonuclease Ercc1–Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol Cell Biol 24:5776–5787 ArticlePubMedCAS Google Scholar
Hanada K, Budzowska M, Modesti M, Maas A, Wyman C, Essers J, Kanaar R (2006) The structure-specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks. EMBO J 25:4921–4932 ArticlePubMedCAS Google Scholar
Hanada K, Budzowska M, Davies S, van Drunen E, Onizawa H, Beverloo HB, Maas A, Essers J, Hickson I, Kanaar R (2007) The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks. Nat Struct Mol Biol 14:1096–1104 ArticlePubMedCAS Google Scholar
Simpson LJ, Sale JE (2003) Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line. EMBO J 22:1654–1664 ArticlePubMedCAS Google Scholar
Niedzwiedz W, Mosedale G, Johnson M, Ong C, Pace P, Patel KJ (2004) The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. Mol Cell 15:607–620 ArticlePubMedCAS Google Scholar
Gan GN, Wittschieben JP, Wittschieben BØ, Wood RD (2008) DNA polymerase zeta (pol zeta) in higher eukaryotes. Cell Res 18:174–183 ArticlePubMedCAS Google Scholar
Essers J, Hendriks RW, Swagemakers SM, Troelstra C, de Wit J, Bootsma D, Hoeijmakers JH, Kanaar R (1997) Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination. Cell 89:195–204 ArticlePubMedCAS Google Scholar
Liu N, Lamerdin JE, Tebbs RS, Schild D, Tucker JD, Shen MR, Brookman KW, Siciliano MJ, Walter CA, Fan W, Narayana LS, Zhou ZQ, Adamson AW, Sorensen KJ, Chen DJ, Jones NJ, Thompson LH (1998) XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. Mol Cell 1:783–793 ArticlePubMedCAS Google Scholar
Niedernhofer LJ, Lalai AS, Hoeijmakers JHJ (2005) Fanconi anemia (cross)linked to DNA repair. Cell 123:1191–1198 ArticlePubMedCAS Google Scholar
Wang W (2007) Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins. Nat Rev Genet 8:735–748 ArticlePubMedCAS Google Scholar
Moldovan G-L, D’Andrea AD (2009) How the Fanconi anemia pathway guards the genome. Annu Rev Genet 43:223–249 ArticlePubMedCAS Google Scholar
Walter J, Sun L, Newport J (1998) Regulated chromosomal DNA replication in the absence of a nucleus. Mol Cell 1:519–529 ArticlePubMedCAS Google Scholar
Yan Z, Delannoy M, Ling C, Daee D, Osman F, Muniandy PA, Shen X, Oostra AB, Du H, Steltenpool J, Lin T, Schuster B, Décaillet C, Stasiak A, Stasiak AZ, Stone S, Hoatlin ME, Schindler D, Woodcock CL, Joenje H, Sen R, de Winter JP, Li L, Seidman MM, Whitby MC, Myung K, Constantinou A, Wang W (2010) A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol Cell 37:865–878 ArticlePubMedCAS Google Scholar
Singh TR, Saro D, Ali AM, Zheng X-F, Du C-h, Killen MW, Sachpatzidis A, Wahengbam K, Pierce AJ, Xiong Y, Sung P, Meetei AR (2010) MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Mol Cell 37:879–886 ArticlePubMedCAS Google Scholar
Meetei AR, Medhurst AL, Ling C, Xue Y, Singh TR, Bier P, Steltenpool J, Stone S, Dokal I, Mathew CG, Hoatlin M, Joenje H, de Winter JP, Wang W (2005) A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat Genet 37:958–963 ArticlePubMedCAS Google Scholar
Ciccia A, Ling C, Coulthard R, Yan Z, Xue Y, Meetei AR, Laghmani EH, Joenje H, McDonald N, de Winter JP, Wang W, West SC (2007) Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell 25:331–343 ArticlePubMedCAS Google Scholar
Collis SJ, Ciccia A, Deans AJ, Horejsí Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ, West SC, Boulton SJ (2008) FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell 32:313–324 ArticlePubMedCAS Google Scholar
Meetei A, de Winter JP, Medhurst A, Wallisch M, Waisfisz Q, van de Vrugt H, Oostra A, Yan Z, Ling C, Bishop C, Hoatlin M, Joenje H, Wang W (2003) A novel ubiquitin ligase is deficient in Fanconi anemia. Nat Genet 35:165–170 ArticlePubMedCAS Google Scholar
Cole AR, Lewis LPC, Walden H (2010) The structure of the catalytic subunit FANCL of the Fanconi anemia core complex. Nat Struct Mol Biol 17:294–298 ArticlePubMedCAS Google Scholar
Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn M, Timmers C, Hejna J, Grompe M, D’Andrea AD (2001) Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell 7:249–262 ArticlePubMedCAS Google Scholar
Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald E, Hurov K, Luo J, Ballif B, Gygi S, Hofmann K, D’Andrea AD, Elledge S (2007) Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell 129:289–301 ArticlePubMedCAS Google Scholar
Knipscheer P, Räschle M, Smogorzewska A, Enoiu M, Ho TV, Schärer OD, Walter JC, Elledge SJ (2009) The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science 326:1698–1701 ArticlePubMedCAS Google Scholar
Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J (2009) Checkpoint signaling from a single DNA interstrand crosslink. Mol Cell 35:704–715 ArticlePubMedCAS Google Scholar
Shen X, Do H, Li Y, Chung W-H, Tomasz M, de Winter JP, Xia B, Elledge SJ, Wang W, Li L (2009) Recruitment of Fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication. Mol Cell 35:716–723 ArticlePubMedCAS Google Scholar
McHugh P, Sones W, Hartley J (2000) Repair of intermediate structures produced at DNA interstrand cross-links in Saccharomyces cerevisiae. Mol Cell Biol 20:3425–3433 ArticlePubMedCAS Google Scholar
Dendouga N, Gao H, Moechars D, Janicot M, Vialard J, McGowan CH (2005) Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. Mol Cell Biol 25:7569–7579 ArticlePubMedCAS Google Scholar
Ciccia A, McDonald N, West S (2008) Structural and functional relationships of the XPF/MUS81 family of proteins. Annu Rev Biochem 77:259–287 ArticlePubMedCAS Google Scholar
Rothfuss A, Grompe M (2004) Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway. Mol Cell Biol 24:123–134 ArticlePubMedCAS Google Scholar
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D’Andrea A, Niedernhofer LJ, McHugh PJ (2009) XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair. Mol Cell Biol 29:6427–6437 ArticlePubMedCAS Google Scholar
McCabe KM, Hemphill A, Akkari Y, Jakobs PM, Pauw D, Olson SB, Moses RE, Grompe M (2008) ERCC1 is required for FANCD2 focus formation. Mol Genet Metab 95:66–73 ArticlePubMedCAS Google Scholar
Bergstralh DT, Sekelsky J (2008) Interstrand crosslink repair: can XPF-ERCC1 be let off the hook? Trends Genet 24:70–76 ArticlePubMedCAS Google Scholar
Fekairi S, Scaglione S, Chahwan C, Taylor ER, Tissier A, Coulon S, Dong M-Q, Ruse C, Yates JR, Russell P, Fuchs RP, McGowan CH, Gaillard P-HL (2009) Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. Cell 138:78–89 ArticlePubMedCAS Google Scholar
Svendsen JM, Smogorzewska A, Sowa ME, O’Connell BC, Gygi SP, Elledge SJ, Harper JW (2009) Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell 138:63–77 ArticlePubMedCAS Google Scholar
Muñoz IM, Hain K, Déclais A-C, Gardiner M, Toh GW, Sanchez-Pulido L, Heuckmann JM, Toth R, Macartney T, Eppink B, Kanaar R, Ponting CP, Lilley DMJ, Rouse J (2009) Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol Cell 35:116–127 ArticlePubMedCAS Google Scholar
Andersen SL, Bergstralh DT, Kohl KP, LaRocque JR, Moore CB, Sekelsky J (2009) Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination. Mol Cell 35:128–135 ArticlePubMedCAS Google Scholar
Yang W, Woodgate R (2007) What a difference a decade makes: insights into translesion DNA synthesis. Proc Natl Acad Sci USA 104:15591–15598 ArticlePubMed Google Scholar
Prakash S, Johnson RE, Prakash L (2005) Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function. Annu Rev Biochem 74:317–353 ArticlePubMedCAS Google Scholar
Yamanaka K, Minko IG, Takata K-I, Kolbanovskiy A, Kozekov ID, Wood RD, Rizzo CJ, Lloyd RS (2010) Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA–peptide and DNA–DNA cross-links. Chem Res Toxicol 23:689–695 ArticlePubMedCAS Google Scholar
Hinz JM (2010) Role of homologous recombination in DNA interstrand crosslink repair. Environ Mol Mutagen 51:582–603 Google Scholar
Muniandy PA, Liu J, Majumdar A, Liu S-t, Seidman MM (2010) DNA interstrand crosslink repair in mammalian cells: step by step. Crit Rev Biochem Mol Biol 45:23–49 ArticlePubMedCAS Google Scholar
Sarkar S, Davies AA, Ulrich HD, McHugh PJ (2006) DNA interstrand crosslink repair during G1 involves nucleotide excision repair and DNA polymerase zeta. EMBO J 25:1285–1294 ArticlePubMedCAS Google Scholar
Wang X, Peterson C, Zheng H, Nairn R, Legerski R, Li L (2001) Involvement of nucleotide excision repair in a recombination-independent and error-prone pathway of DNA interstrand cross-link repair. Mol Cell Biol 21:713–720 ArticlePubMedCAS Google Scholar
Shen X, Jun S, O’Neal LE, Sonoda E, Bemark M, Sale J, Li L (2006) REV3 and REV1 play major roles in recombination-independent repair of DNA interstrand cross-links mediated by monoubiquitinated proliferating cell nuclear antigen (PCNA). J Biol Chem 281:13869–13872 ArticlePubMedCAS Google Scholar
Hlavin EM, Smeaton MB, Miller PS (2010) Initiation of DNA interstrand cross-link repair in mammalian cells. Environ Mol Mutagen 51:604–624 Google Scholar
Nojima K, Hochegger H, Saberi A, Fukushima T, Kikuchi K, Yoshimura M, Orelli B, Bishop D, Hirano S, Ohzeki M, Ishiai M, Yamamoto K, Takata M, Arakawa H, Buerstedde J, Yamazoe M, Kawamoto T, Araki K, Takahashi J, Hashimoto N, Takeda S, Sonoda E (2005) Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells. Cancer Res 65:11704–11711 ArticlePubMedCAS Google Scholar
Gillet LCJ, Schärer OD (2006) Molecular mechanisms of mammalian global genome nucleotide excision repair. Chem Rev 106:253–276 ArticlePubMedCAS Google Scholar
Hanawalt P, Spivak G (2008) Transcription-coupled DNA repair: two decades of progress and surprises. Nat Rev Mol Cell Biol 9:958–970 ArticlePubMedCAS Google Scholar
Muniandy PA, Thapa D, Thazhathveetil AK, Liu S-t, Seidman MM (2009) Repair of laser-localized DNA interstrand cross-links in G1 phase mammalian cells. J Biol Chem 284:27908–27917 ArticlePubMedCAS Google Scholar
Zamble DB, Mu D, Reardon JT, Sancar A, Lippard SJ (1996) Repair of cisplatin—DNA adducts by the mammalian excision nuclease. Biochemistry 35:10004–10013 ArticlePubMedCAS Google Scholar
Min J-H, Pavletich NP (2007) Recognition of DNA damage by the Rad4 nucleotide excision repair protein. Nature 449:570–575 ArticlePubMedCAS Google Scholar
Schärer OD (2007) Achieving broad substrate specificity in damage recognition by binding accessible nondamaged DNA. Mol Cell 28:184–186 ArticlePubMedCAS Google Scholar
Maillard O, Camenisch U, Blagoev KB, Naegeli H (2008) Versatile protection from mutagenic DNA lesions conferred by bipartite recognition in nucleotide excision repair. Mutat Res 658:271–286 ArticlePubMedCAS Google Scholar
Zhao J, Jain A, Iyer RR, Modrich PL, Vasquez KM (2009) Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks. Nucleic Acids Res 37:4420–4429 ArticlePubMedCAS Google Scholar
Zhang Y, Wu X, Guo D, Rechkoblit O, Geacintov NE, Wang Z (2002) Two-step error-prone bypass of the (+)- and (−)-trans-anti-BPDE-N2-dG adducts by human DNA polymerases eta and kappa. Mutat Res 510:23–35 PubMedCAS Google Scholar
Bessho T, Mu D, Sancar A (1997) Initiation of DNA interstrand cross-link repair in humans: the nucleotide excision repair system makes dual incisions 5′ to the cross-linked base and removes a 22- to 28-nucleotide-long damage-free strand. Mol Cell Biol 17:6822–6830 PubMedCAS Google Scholar
Mu D, Bessho T, Nechev LV, Chen DJ, Harris TM, Hearst JE, Sancar A (2000) DNA interstrand cross-links induce futile repair synthesis in mammalian cell extracts. Mol Cell Biol 20:2446–2454 ArticlePubMedCAS Google Scholar
Martin LP, Hamilton TC, Schilder RJ (2008) Platinum resistance: the role of DNA repair pathways. Clin Cancer Res 14:1291–1295 ArticlePubMedCAS Google Scholar
Spanswick VJ, Hartley JM, Hartley JA (2010) Measurement of DNA interstrand crosslinking in individual cells using the single cell gel electrophoresis (Comet) assay. Methods Mol Biol 613:267–282 ArticlePubMedCAS Google Scholar
Farmer H, McCabe N, Lord CJ, Tutt ANJ, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, Martin NMB, Jackson SP, Smith GCM, Ashworth A (2005) Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434:917–921 ArticlePubMedCAS Google Scholar
Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ, Helleday T (2005) Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434:913–917 ArticlePubMedCAS Google Scholar
Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, Mortimer P, Swaisland H, Lau A, O’Connor MJ, Ashworth A, Carmichael J, Kaye SB, Schellens JHM, de Bono JS (2009) Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 361:123–134 ArticlePubMedCAS Google Scholar
Gallmeier E, Calhoun ES, Rago C, Brody JR, Cunningham SC, Hucl T, Gorospe M, Kohli M, Lengauer C, Kern SE (2006) Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options. Gastroenterology 130:2145–2154 ArticlePubMedCAS Google Scholar
Gallmeier E, Kern SE (2007) Targeting Fanconi anemia/BRCA2 pathway defects in cancer: the significance of preclinical pharmacogenomic models. Clin Cancer Res 13:4–10 ArticlePubMedCAS Google Scholar
Chirnomas D, Taniguchi T, de la Vega M, Vaidya AP, Vasserman M, Hartman A-R, Kennedy R, Foster R, Mahoney J, Seiden MV, D’Andrea AD (2006) Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway. Mol Cancer Ther 5:952–961 ArticlePubMedCAS Google Scholar
Landais I, Sobeck A, Stone S, LaChapelle A, Hoatlin ME (2009) A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway. Int J Cancer 124:783–792 ArticlePubMedCAS Google Scholar
Kowal P, Gurtan AM, Stuckert P, D’Andrea AD, Ellenberger T (2007) Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex. J Biol Chem 282:2047–2055 ArticlePubMedCAS Google Scholar
Orelli B, McClendon TB, Tsodikov OV, Ellenberger TE, Niedernhofer LJ, Schärer OD (2010) The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways. J Biol Chem 285:3705–3712 ArticlePubMedCAS Google Scholar