Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training (original) (raw)
Wild S, Roglic G, Green A et al (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047–1053 ArticlePubMed Google Scholar
Bloomgarden ZT (2004) Type 2 diabetes in the young: the evolving epidemic. Diabetes Care 27:998–1010 ArticlePubMed Google Scholar
McCarthy SN, Harrington KE, Kiely M et al (2001) Analyses of the anthropometric data from the North/South Ireland Food Consumption Survey. Public Health Nutr 4:1099–1106 ArticleCASPubMed Google Scholar
Lissau I, Overpeck MD, Ruan WJ et al (2004) Body mass index and overweight in adolescents in 13 European countries, Israel, and the United States. Arch Pediatr Adolesc Med 158:27–33 ArticlePubMed Google Scholar
No authors listed (2003) The National Health and Lifestyle Surveys. Survey of lifestyle, attitudes and nutrition (SLAN) & The Irish Health Behaviour in School-Aged Children Survey (HBSC). Health Promotion Unit, Department of Health and Children, Dublin
Hatunic M, Burns N, Finucane F et al (2005) Contrasting clinical and cardiovascular risk status between early and later onset type 2 diabetes. Diab Vasc Dis Res 2:73–75 ArticlePubMed Google Scholar
McQuaid S, O’Gorman DJ, Yousif O et al (2005) Early-onset insulin-resistant diabetes in obese Caucasians has features of typical type 2 diabetes, but 3 decades earlier. Diabetes Care 28:1216–1218 ArticlePubMed Google Scholar
Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS Jr (1991) Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 325:147–152 ArticleCASPubMed Google Scholar
Knowler WC, Barrett-Connor E, Fowler SE et al (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393–403 ArticleCASPubMed Google Scholar
Manson JE, Rimm EB, Stampfer MJ et al (1991) Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 338:774–778 ArticleCASPubMed Google Scholar
Pan XR, Li GW, Hu YH et al (1997) Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 20:537–544 ArticleCASPubMed Google Scholar
Tuomilehto J, Lindstrom J, Eriksson JG et al (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343–1350 ArticleCASPubMed Google Scholar
DeFronzo RA, Sherwin RS, Kraemer N (1987) Effect of physical training on insulin action in obesity. Diabetes 36:1379–1385 ArticleCASPubMed Google Scholar
Hughes VA, Fiatarone MA, Fielding RA et al (1993) Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. Am J Physiol 264:E855–E862 CASPubMed Google Scholar
O’Gorman DJ, Karlsson HK, McQuaid S et al (2006) Exercise training increases insulin-stimulated glucose disposal and GLUT 4 (SLC2A4) protein content in patients with type 2 diabetes. Diabetologia 49:2983–2992 ArticleCASPubMed Google Scholar
Houmard JA, Tanner CJ, Slentz CA et al (2004) Effect of the volume and intensity of exercise training on insulin sensitivity. J Appl Physiol 96:101–106 ArticleCASPubMed Google Scholar
Burstein R, Polychronakos C, Toews CJ et al (1985) Acute reversal of the enhanced insulin action in trained athletes. Association with insulin receptor changes. Diabetes 34:756–760 ArticleCASPubMed Google Scholar
Dela F, Larsen JJ, Mikines KJ et al (1995) Insulin-stimulated muscle glucose clearance in patients with NIDDM. Effects of one-legged physical training. Diabetes 44:1010–1020 ArticleCASPubMed Google Scholar
Heath GW, Gavin JR 3rd, Hinderliter JM et al (1983) Effects of exercise and lack of exercise on glucose tolerance and insulin sensitivity. J Appl Physiol 55:512–517 CASPubMed Google Scholar
Schneider SH, Amorosa LF, Khachadurian AK, Ruderman NB (1984) Studies on the mechanism of improved glucose control during regular exercise in type 2 (non-insulin-dependent) diabetes. Diabetologia 26:355–360 ArticleCASPubMed Google Scholar
Ludvik B, Nolan JJ, Baloga J et al (1995) Effect of obesity on insulin resistance in normal subjects and patients with NIDDM. Diabetes 44:1121–1125 ArticleCASPubMed Google Scholar
Nolan JJ, Freidenberg G, Henry R et al (1994) Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity. J Clin Endocrinol Metab 78:471–477 ArticleCASPubMed Google Scholar
Nolan JJ, Ludvik B, Baloga J et al (1997) Mechanisms of the kinetic defect in insulin action in obesity and NIDDM. Diabetes 46:994–1000 ArticleCASPubMed Google Scholar
Mari A, Schmitz O, Gastaldelli A et al (2002) Meal and oral glucose tests for assessment of beta-cell function: modeling analysis in normal subjects. Am J Physiol Endocrinol Metab 283:E1159–E1166 CASPubMed Google Scholar
Mari A, Tura A, Gastaldelli A, Ferrannini E (2002) Assessing insulin secretion by modeling in multiple-meal tests: role of potentiation. Diabetes 51(Suppl 1):S221–S226 ArticleCASPubMed Google Scholar
Ferrannini E, Gastaldelli A, Miyazaki Y et al (2005) Beta-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. J Clin Endocrinol Metab 90:493–500 ArticleCASPubMed Google Scholar
Van Cauter E, Mestrez F, Sturis J, Polonsky KS (1992) Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 41:368–377 ArticlePubMed Google Scholar
Elder DA, Prigeon RL, Wadwa RP et al (2006) Beta-cell function, insulin sensitivity, and glucose tolerance in obese diabetic and nondiabetic adolescents and young adults. J Clin Endocrinol Metab 91:185–191 ArticleCASPubMed Google Scholar
Druet C, Tubiana-Rufi N, Chevenne D et al (2006) Characterization of insulin secretion and resistance in type 2 diabetes of adolescents. J Clin Endocrinol Metab 91:401–404 ArticleCASPubMed Google Scholar
Boule NG, Weisnagel SJ, Lakka TA et al (2005) Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. Diabetes Care 28:108–114 ArticlePubMed Google Scholar
Cuff DJ, Meneilly GS, Martin A et al (2003) Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. Diabetes Care 26:2977–2982 ArticlePubMed Google Scholar
Willey KA, Singh MA (2003) Battling insulin resistance in elderly obese people with type 2 diabetes: bring on the heavy weights. Diabetes Care 26:1580–1588 ArticlePubMed Google Scholar
Brage S, Brage N, Franks PW et al (2005) Reliability and validity of the combined heart rate and movement sensor Actiheart. Eur J Clin Nutr 59:561–570 ArticleCASPubMed Google Scholar