A dopamine transport inhibitor with markedly low abuse liability suppresses cocaine self-administration in the rat (original) (raw)
Agoston GE, Wu JH, Izenwasser S, George C, Katz J, Kline RH, Newman AH (1997) Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter. J Med Chem 40:4329–4339 ArticleCASPubMed Google Scholar
Ahmed SH, Koob GF (2004) Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake. Psychopharmacology (Berl) 172:450–454 ArticleCAS Google Scholar
Beecher MD, Jackson DE (1976) Rate-dependent effect of amphetamine in rats: extension to between-subjects effect. Psychopharmacologia 46:307–309 ArticleCASPubMed Google Scholar
Beuming T, Kniazeff J, Bergmann ML, Shi L, Gracia L, Raniszewska K, Newman AH, Javitch JA, Weinstein H, Gether U, Loland CJ (2008) The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nat Neurosci 11:780–789 ArticleCASPubMed Google Scholar
Botly LC, Burton CL, Rizos Z, Fletcher PJ (2008) Characterization of methylphenidate self-administration and reinstatement in the rat. Psychopharmacology (Berl) 199:55–66 ArticleCAS Google Scholar
Briscoe RJ, Vanecek SA, Vallett M, Baird TJ, Holloway FA, Gauvin DV (1998) Reinforcing effects of caffeine, ephedrine, and their binary combination in rats. Pharmacol Biochem Behav 60:685–693 ArticleCASPubMed Google Scholar
Carrigan KA, Dykstra LA (2007) Behavioral effects of morphine and cocaine in M1 muscarinic acetylcholine receptor-deficient mice. Psychopharmacology (Berl) 191:985–993 ArticleCAS Google Scholar
Chen N, Reith ME (2007) Substrates and inhibitors display different sensitivity to expression level of the dopamine transporter in heterologously expressing cells. J Neurochem 101:377–388 ArticleCASPubMed Google Scholar
Chen N, Zhen J, Reith ME (2004) Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine. J Neurochem 89:853–864 ArticleCASPubMed Google Scholar
Crespo JA, Sturm K, Saria A, Zernig G (2006) Activation of muscarinic and nicotinic acetylcholine receptors in the nucleus accumbens core is necessary for the acquisition of drug reinforcement. J Neurosci 26:6004–6010 ArticleCASPubMed Google Scholar
Dar DE, Mayo C, Uhl GR (2005) The interaction of methylphenidate and benztropine with the dopamine transporter is different than other substrates and ligands. Biochem Pharmacol 70:461–469 ArticleCASPubMed Google Scholar
Davids E, Gastpar M (2004) Buprenorphine in the treatment of opioid dependence. Eur Neuropsychopharmacol 14:209–216 ArticleCASPubMed Google Scholar
Desai RI, Kopajtic TA, French D, Newman AH, Katz JL (2005a) Relationship between in vivo occupancy at the dopamine transporter and behavioral effects of cocaine, GBR 12909 [1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and benztropine analogs. J Pharmacol Exp Ther 315:397–404 ArticleCASPubMed Google Scholar
Desai RI, Kopajtic TA, Koffarnus M, Newman AH, Katz JL (2005b) Identification of a dopamine transporter ligand that blocks the stimulant effects of cocaine. J Neurosci 25:1889–1893 ArticleCASPubMed Google Scholar
Dutta AK, Zhang S, Kolhatkar R, Reith ME (2003) Dopamine transporter as target for drug development of cocaine dependence medications. Eur J Pharmacol 479:93–106 ArticleCASPubMed Google Scholar
Gorelick DA, Gardner EL, Xi ZX (2004) Agents in development for the management of cocaine abuse. Drugs 64:1547–1573 ArticleCASPubMed Google Scholar
Grabowski J, Roache JD, Schmitz JM, Rhoades H, Creson D, Korszun A (1997) Replacement medication for cocaine dependence: methylphenidate. J Clin Psychopharmacol 17:485–488 ArticleCASPubMed Google Scholar
Grabowski J, Shearer J, Merrill J, Negus SS (2004) Agonist-like, replacement pharmacotherapy for stimulant abuse and dependence. Addict Behav 29:1439–1464 ArticlePubMed Google Scholar
Harris RA, Snell D, Loh HH (1978) Effects of d-amphetamine, monomethoxyamphetamines and hallucinogens on schedule-controlled behavior. J Pharmacol Exp Ther 204:103–117 CASPubMed Google Scholar
Hiranita T, Soto PL, Newman AH, Katz JL (2009) Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors. J Pharmacol Exp Ther 329:677–686 ArticleCASPubMed Google Scholar
Huang X, Zhan CG (2007) How dopamine transporter interacts with dopamine: insights from molecular modeling and simulation. Biophys J 93:3627–3639 ArticleCASPubMed Google Scholar
Karila L, Gorelick D, Weinstein A, Noble F, Benyamina A, Coscas S, Blecha L, Lowenstein W, Martinot JL, Reynaud M, Lepine JP (2008) New treatments for cocaine dependence: a focused review. Int J Neuropsychopharmacol 11:425–438 ArticleCASPubMed Google Scholar
Katz JL, Newman AH, Izenwasser S (1997) Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine. Pharmacol Biochem Behav 57:505–512 ArticleCASPubMed Google Scholar
Katz JL, Agoston GE, Alling KL, Kline RH, Forster MJ, Woolverton WL, Kopajtic TA, Newman AH (2001) Dopamine transporter binding without cocaine-like behavioral effects: synthesis and evaluation of benztropine analogs alone and in combination with cocaine in rodents. Psychopharmacology (Berl) 154:362–374 ArticleCAS Google Scholar
Katz JL, Kopajtic TA, Agoston GE, Newman AH (2004) Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands. J Pharmacol Exp Ther 309:650–660 ArticleCASPubMed Google Scholar
Koob GF, Le HT, Creese I (1987) The D1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rat. Neurosci Lett 79:315–320 ArticleCASPubMed Google Scholar
Levin FR, Evans SM, Brooks DJ, Garawi F (2007) Treatment of cocaine dependent treatment seekers with adult ADHD: double-blind comparison of methylphenidate and placebo. Drug Alcohol Depend 87:20–29 ArticleCASPubMed Google Scholar
Li SM, Newman AH, Katz JL (2005) Place conditioning and locomotor effects of N-substituted, 4′, 4″-difluorobenztropine analogs in rats. J Pharmacol Exp Ther 313:1223–1230 ArticleCASPubMed Google Scholar
Lile JA, Morgan D, Birmingham AM, Davies HM, Nader MA (2004) Effects of the dopamine reuptake inhibitor PTT on reinstatement and on food- and cocaine-maintained responding in rhesus monkeys. Psychopharmacology (Berl) 174:246–253 ArticleCAS Google Scholar
Lile JA, Wang Z, Woolverton WL, France JE, Gregg TC, Davies HM, Nader MA (2003) The reinforcing efficacy of psychostimulants in rhesus monkeys: the role of pharmacokinetics and pharmacodynamics. J Pharmacol Exp Ther 307:356–366 ArticleCASPubMed Google Scholar
Loland CJ, Desai RI, Zou MF, Cao J, Grundt P, Gerstbrein K, Sitte HH, Newman AH, Katz JL, Gether U (2008) Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors. Mol Pharmacol 73:813–823 ArticleCASPubMed Google Scholar
Minozzi S, Amato L, Davoli M, Farrell M, Lima Reisser AA, Pani PP, Silva de LM, Soares B, Vecchi S (2008) Anticonvulsants for cocaine dependence. Cochrane Database Syst Rev CD006754
Negus SS, Mello NK, Lamas X, Mendelson JH (1996) Acute and chronic effects of flupenthixol on the discriminative stimulus and reinforcing effects of cocaine in rhesus monkeys. J Pharmacol Exp Ther 278:879–890 CASPubMed Google Scholar
Negus SS, Mello NK, Kimmel HL, Howell LL, Carroll FI (2008) Effects of the monoamine uptake inhibitors RTI-112 and RTI-113 on cocaine- and food-maintained responding in rhesus monkeys. Pharmacol.Biochem.Behav
Newman AH, Agoston GE (1998) Novel benztropine [3a-(diphenylmethoxy)tropane] analogs as probes for the dopamine transporter. Curr Med Chem 5:305–319 CASPubMed Google Scholar
Orson FM, Kinsey BM, Singh RA, Wu Y, Gardner T, Kosten TR (2008) Substance abuse vaccines. Ann NY Acad Sci 1141:257–269 ArticleCASPubMed Google Scholar
Preti A (2000) Vanoxerine National Institute on Drug Abuse. Curr Opin Investig Drugs 1:241–251 CASPubMed Google Scholar
Raje S, Cao J, Newman AH, Gao H, Eddington ND (2003) Evaluation of the blood-brain barrier transport, population pharmacokinetics, and brain distribution of benztropine analogs and cocaine using in vitro and in vivo techniques. J Pharmacol Exp Ther 307:801–808 ArticleCASPubMed Google Scholar
Raje S, Cornish J, Newman AH, Cao J, Katz JL, Eddington ND (2005) Pharmacodynamic assessment of the benztropine analogues AHN-1055 and AHN-2005 using intracerebral microdialysis to evaluate brain dopamine levels and pharmacokinetic/pharmacodynamic modeling. Pharm Res 22:603–612 ArticleCASPubMed Google Scholar
Richardson NR, Roberts DC (1996) Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy. J Neurosci Methods 66:1–11 ArticleCASPubMed Google Scholar
Roberts DC (1993) Self-administration of GBR 12909 on a fixed ratio and progressive ratio schedule in rats. Psychopharmacology (Berl) 111:202–206 ArticleCAS Google Scholar
Rothman RB, Baumann MH, Prisinzano TE, Newman AH (2008) Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction. Biochem Pharmacol 75:2–16 ArticleCASPubMed Google Scholar
Rush CR, Essman WD, Simpson CA, Baker RW (2001) Reinforcing and subject-rated effects of methylphenidate and d-amphetamine in non-drug-abusing humans. J Clin Psychopharmacol 21:273–286 ArticleCASPubMed Google Scholar
Sagvolden T, Slatta K, Arntzen E (1988) Low doses of methylphenidate (Ritalin) may alter the delay-of-reinforcement gradient. Psychopharmacology (Berl) 95:303–312 ArticleCAS Google Scholar
Sanger DJ, Blackman DE (1976) Rate-dependent effects of drugs: a review of the literature. Pharmacol Biochem Behav 4:73–83 ArticleCASPubMed Google Scholar
Sofuoglu M, Kosten TR (2005) Novel approaches to the treatment of cocaine addiction. CNS Drugs 19:13–25 ArticleCASPubMed Google Scholar
Stafford D, Rice KC, Lewis DB, Glowa JR (2000) Response requirements and unit dose modify the effects of GBR 12909 on cocaine-maintained behavior. Exp Clin Psychopharmacol 8:539–548 ArticleCASPubMed Google Scholar
Uchtenhagen A (2003) Substitution management in opioid dependence. J Neural Transm Suppl 33–60
Ukairo OT, Bondi CD, Newman AH, Kulkarni SS, Kozikowski AP, Pan S, Surratt CK (2005) Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. J Pharmacol Exp Ther 314:575–583 ArticleCASPubMed Google Scholar
Vaughan RA, Agoston GE, Lever JR, Newman AH (1999) Differential binding of tropane-based photoaffinity ligands on the dopamine transporter. J Neurosci 19:630–636 CASPubMed Google Scholar
Woolverton WL, Hecht GS, Agoston GE, Katz JL, Newman AH (2001) Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys. Psychopharmacology (Berl) 154:375–382 ArticleCAS Google Scholar