Immunotherapeutic potential of DISC-HSV and OX40L in cancer (original) (raw)

References

  1. Ahmad M, Rees RC, Ali SA (2004) Escape from immunotherapy: possible mechanisms that influence tumor regression/progression. Cancer Immunol Immunother 53:844
    Article PubMed Google Scholar
  2. Ahmad M, Rees RC, McArdle SE, Li G, Mian S, Entwisle C, Loudon P, Ali SA (2005) Regulation of CTL responses to MHC-restricted class I peptide of the gp70 tumour antigen by splenic parenchymal CD4(+) T cells in mice failing immunotherapy with DISC-mGM-CSF. Int J Cancer. February 18 Epub ahead of print
  3. Ali SA, Lynam J, McLean CS, Entwisle C, Loudon P, Rojas JM, McArdle SE, Li G, Mian S, Rees RC (2002) Tumor regression induced by intratumor therapy with a disabled infectious single cycle (DISC) herpes simplex virus (HSV) vector, DISC/HSV/murine granulocyte-macrophage colony-stimulating factor, correlates with antigen-specific adaptive immunity. J Immunol 168:3512
    PubMed CAS Google Scholar
  4. Ali SA, Rees RC, Anderson DQ, Reed MW, Goepel JR, Brown NJ (2000) Trafficking of ‘immune’ CD4(+)/CD8(+)T-lymphocytes into the RENCA tumour microcirculation in vivo in mice. Br J Cancer 83:1061
    Article PubMed CAS Google Scholar
  5. Ali S, Ahmad M, Lynam J, Rees RC, Brown N (2004) Trafficking of tumor peptide-specific cytotoxic T lymphocytes into the tumor microcirculation. Int J Cancer 110:239
    Article PubMed CAS Google Scholar
  6. Ali SA, Ahmad M, Lynam J, McLean CS, Entwisle C, Loudon P, Choolun E, McArdle SE, Li G, Mian S, Rees RC (2004) Anti-tumour therapeutic efficacy of OX40L in murine tumour model. Vaccine 22:3585
    Article PubMed CAS Google Scholar
  7. Almand B, Clark JI, Nikitina E, van Beynen J, English NR, Knight SC, Carbone DP, Gabrilovich DI (2001) Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J Immunol 166:678
    PubMed CAS Google Scholar
  8. Bonnet MC, Tartaglia J, Verdier F, Kourilsky P, Lindberg A, Klein M, Moingeon P (2000) Recombinant viruses as a tool for therapeutic vaccination against human cancers. Immunol Lett 74:11
    Article PubMed CAS Google Scholar
  9. Boon T, Cerottini JC, Van den Eynde B, van der Bruggen P, Van Pel A (1994) Tumor antigens recognized by T lymphocytes. Annu Rev Immunol 12:337
    Article PubMed CAS Google Scholar
  10. Bronte V, Apolloni E, Cabrelle A, Ronca R, Serafini P, Zamboni P, Restifo NP, Zanovello P (2000) Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. Blood 96:3838
    PubMed CAS Google Scholar
  11. Casares N, Arribillaga L, Sarobe P, Dotor J, Lopez-Diaz de Cerio A, Melero I, Prieto J, Borras-Cuesta F, Lasarte JJ (2003) CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination. J Immunol 171:5931
    PubMed CAS Google Scholar
  12. Chen AI, McAdam AJ, Buhlmann JE, Scott S, Lupher ML Jr, Greenfield EA, Baum PR, Fanslow WC, Calderhead DM, Freeman GJ, Sharpe AH (1999) OX40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Immunity 11:689
    Article PubMed CAS Google Scholar
  13. Dilloo D, Rill D, Entwistle C, Boursnell M, Zhong W, Holden W, Holladay M, Inglis S, Brenner M (1997) A novel herpes vector for the high-efficiency transduction of normal and malignant human hematopoietic cells. Blood 89:119
    PubMed CAS Google Scholar
  14. Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD (2002) Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 3:991
    Article PubMed CAS Google Scholar
  15. Egilmez NK, Hess SD, Chen FA, Takita H, Conway TF, Bankert RB (2002) Human CD4+ effector T cells mediate indirect interleukin-12- and interferon-gamma-dependent suppression of autologous HLA-negative lung tumor xenografts in severe combined immunodeficient mice. Cancer Res 62:2611
    PubMed CAS Google Scholar
  16. Ford CE, Faedo M, Crouch R, Lawson JS, Rawlinson WD (2004) Progression from normal breast pathology to breast cancer is associated with increasing prevalence of mouse mammary tumor virus-like sequences in men and women. Cancer Res 64:4755
    Article PubMed CAS Google Scholar
  17. Gabrilovich DI, Velders MP, Sotomayor EM, Kast WM (2001) Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells. J Immunol 166:5398
    PubMed CAS Google Scholar
  18. Godfrey DI, Hammond KJ, Poulton LD, Smyth MJ, Baxter AG (2000) NKT cells: facts, functions and fallacies. Immunol Today 21:573
    Article PubMed CAS Google Scholar
  19. Gri G, Gallo E, Di Carlo E, Musiani P, Colombo MP (2003) OX40 ligand-transduced tumor cell vaccine synergizes with GM-CSF and requires CD40-APC signaling to boost the host T cell antitumor response. J Immunol 170:99
    PubMed CAS Google Scholar
  20. Gross D, Graff-Dubois S, Opolon P, Cornet S, Alves P, Bennaceur-Griscelli A, Faure O, Guillaume P, Firat H, Chouaib S, Lemonnier F, Davoust J, Miconnet I, Vonderheide R, Kosmatopoulos K (2004) High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy. J Clin Invest 113:425
    Article PubMed CAS Google Scholar
  21. Hamatsu T, Rikimaru T, Yamashita Y, Aishima S, Tanaka S, Shirabe K, Shimada M, Toh Y, Sugimachi K (2003) The role of MTA1 gene expression in human hepatocellular carcinoma. Oncol Rep 10:599
    PubMed CAS Google Scholar
  22. Hicklin DJ, Wang Z, Arienti F, Rivoltini L, Parmiani G, Ferrone S (1998) beta2-Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma. J Clin Invest 101:2720
    Article PubMed CAS Google Scholar
  23. Hickling JK, Chishlom SE, Duncan IE, Taylor EJ, Boswell C, McLean CS, Uttridge J, Roberts JS, Tomasi A, Stanberry L, Bernstein DI, Boursnell M, Inglis SC (1998) Immunogenicity of a disabled infectious single cycle HSV-2 vaccine in phase I clinical trials in HSV-2 seropositive and seronegative volunteers. In: 18th international congress on infectious diseases, Boston, Abs 22.008
  24. Hofer M, Menke A, Genze F, Gierschik P, Giehl K (2004) Expression of MTA1 promotes motility and invasiveness of PANC-1 pancreatic carcinoma cells. Br J Cancer 90:455
    Article PubMed CAS Google Scholar
  25. Kanangat S, Thomas J, Gangappa S, Babu JS, Rouse BT (1996) Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression. Implications in immunopathogenesis and protection. J Immunol 156:1110
    PubMed CAS Google Scholar
  26. Kjaergaard J, Tanaka J, Kim JA, Rothchild K, Weinberg A, Shu S (2000) Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth. Cancer Res 60:5514
    PubMed CAS Google Scholar
  27. Kjaergaard J, Peng L, Cohen PA, Drazba JA, Weinberg AD, Shu S (2001) Augmentation versus inhibition: effects of conjunctional OX-40 receptor monoclonal antibody and IL-2 treatment on adoptive immunotherapy of advanced tumor. J Immunol 167:6669
    PubMed CAS Google Scholar
  28. Krackhardt AM, Witzens M, Harig S, Hodi FS, Zauls AJ, Chessia M, Barrett P, Gribben JG (2000) Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX. Blood 100:2123
    Article CAS Google Scholar
  29. Kumar R, Wang RA, Mazumdar A, Talukder AH, Mandal M, Yang Z, Bagheri-Yarmand R, Sahin A, Hortobagyi G, Adam L, Barnes CJ, Vadlamudi RK (2002) A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm. Nature 418:654
    Article PubMed CAS Google Scholar
  30. Kusmartsev SA, Li Y, Chen SH (2000) Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation. J Immunol 165:779
    PubMed CAS Google Scholar
  31. Kusmartsev S, Cheng F, Yu B, Nefedova Y, Sotomayor E, Lush R, Gabrilovich D (2003) All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination. Cancer Res 63:4441
    PubMed CAS Google Scholar
  32. Li G, Miles A, Line A, Rees RC (2004) Identification of tumour antigens by serological analysis of cDNA expression cloning. Cancer Immunol Immunother 53:139
    Article PubMed CAS Google Scholar
  33. Li Q, Pan PY, Gu P, Xu D, Chen SH (2004) Role of immature myeloid Gr-1+ cells in the development of antitumor immunity. Cancer Res 64:1130
    Article PubMed CAS Google Scholar
  34. Loudon PT, McLean CS, Martin G, Curry J, Leigh Shaw M, Hoogstraten C, Verdegaal E, Osanto S (2003) Preclinical evaluation of DISC–GMCSF for the treatment of breast carcinoma. J Gene Med 5:407
    Article PubMed CAS Google Scholar
  35. Mahoney M, Simpson A, Jost M, Noe M, Kari C, Pepe D, Choi Y, Uitto J, Rodeck U (2002) Metastasis-associated protein (MTA)1 enhances migration, invasion, and anchorage-independent survival of immortalized human keratinocytes. Oncogene 21:2161
    Article PubMed CAS Google Scholar
  36. Marks P, Rifkind R, Richon V, Breslow R, Miller T, Kelly W (2001) Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer 1:194
    Article PubMed CAS Google Scholar
  37. Matzinger P (1994) Tolerance, danger, and the extended family. Annu Rev Immunol 12:991
    PubMed CAS Google Scholar
  38. Maxwell JR, Weinberg A, Prell RA, Vella AT (2000) Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion. J Immunol 164:107
    PubMed CAS Google Scholar
  39. Moodycliffe AM, Nghiem D, Clydesdale G, Ullrich SE (2000) Immune suppression and skin cancer development: regulation by NKT cells. Nat Immunol 1:521
    Article PubMed CAS Google Scholar
  40. Morris A, Vetto JT, Ramstad T, Funatake CJ, Choolun E, Entwisle C, Weinberg AD (2001) Induction of anti-mammary cancer immunity by engaging the OX-40 receptor in vivo. Breast Cancer Res Treat 67:71
    Article PubMed CAS Google Scholar
  41. Mu J, Zou JP, Yamamoto N, Tsutsui T, Tai XG, Kobayashi M, Herrmann S, Fujiwara H, Hamaoka T (1995) Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes. Cancer Res 55:4404
    PubMed CAS Google Scholar
  42. Murakami T, Tokunaga N, Waku T, Gomi S, Kagawa S, Tanaka N, Fujiwara T (2004) Antitumor effect of intratumoral administration of bone marrow-derived dendritic cells transduced with wild-type p53 gene. Clin Cancer Res 10:3871
    Article PubMed CAS Google Scholar
  43. Muster T, Waltenberger A, Grassauer A, Hirschl S, Caucig P, Romirer I, Fodinger D, Seppele H, Schanab O, Magin-Lachmann C, Lower R, Jansen B, Pehamberger H, Wolff K (2003) An endogenous retrovirus derived from human melanoma cells. Cancer Res 63:8735
    PubMed CAS Google Scholar
  44. Nawa A, Nishimori K, Lin P, Maki Y, Moue K, Sawada H, Toh Y, Fumitaka K, Nicolson GL (2000) Tumor metastasis-associated human MTA1 gene: its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides. J Cell Biochem 79:202
    Article PubMed CAS Google Scholar
  45. Nicolson GL, Moustafa AS (1998) Metastasis-associated genes and metastatic tumor progression. In Vivo 12:579
    PubMed CAS Google Scholar
  46. Nicolson G, Nawa A, Toh Y, Taniguchi S, Nishimori K, Moustafa A (2003) Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation. Clin Exp Metastasis 20:19
    Article PubMed CAS Google Scholar
  47. Pan PY, Zang Y, Weber K, Meseck ML, Chen SH (2002) OX40 ligation enhances primary and memory cytotoxic T lymphocyte responses in an immunotherapy for hepatic colon metastases. Mol Ther 6:528
    Article PubMed CAS Google Scholar
  48. Parkinson RJ, Mian S, Bishop MC, Gray T, Li G, McArdle SE, Ali S, Rees RC (2003) Disabled infectious single cycle herpes simplex virus (DISC-HSV) is a candidate vector system for gene delivery/expression of GM-CSF in human prostate cancer therapy. Prostate 56:65
    Article PubMed CAS Google Scholar
  49. Qin Z, Blankenstein T (2000) CD4+ T cell–mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells. Immunity 12:677
    Article PubMed CAS Google Scholar
  50. Rainov NG (2000) A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum Gene Ther 11:2389
    Article PubMed CAS Google Scholar
  51. Rees RC, McArdle S, Mian S, Li G, Ahmad M, Parkinson R, Ali SA (2002) Disabled infectious single cycle-herpes simplex virus (DISC-HSV) as a vector for immunogene therapy of cancer. Curr Opin Mol Ther 4:49
    PubMed Google Scholar
  52. Reker S, Meier A, Holten-Andersen L, Svane I, Becker J, Straten Pt P, Andersen M (2004) Identification of novel survivin-derived CTL epitopes. Cancer Biol Ther 3:173
    PubMed CAS Google Scholar
  53. Sasaki H, Moriyama S, Nakashima Y, Kobayashi Y, Yukiue H, Kaji M, Fukai I, Kiriyama M, Yamakawa Y, Fujii Y (2002) Expression of the MTA1 mRNA in advanced lung cancer. Lung Cancer 35:149
    Article PubMed Google Scholar
  54. Simpson A, Uitto J, Rodeck U, Mahoney M (2001) Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3. Gene 273:29
    Article PubMed CAS Google Scholar
  55. Smyth M, Thia K, Street S, Cretney E, Trapani J, Taniguchi M, Kawano T, Pelikan S, Crowe N, Godfrey D (2000) Differential tumor surveillance by natural killer (NK) and NKT cells. J Exp Med 191:661
    Article PubMed CAS Google Scholar
  56. Stuber E, Strober W (1996) The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response. J Exp Med 183:979
    Article PubMed CAS Google Scholar
  57. Sugamura K, Ishii N, Weinberg AD (2004) Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. Nat Rev Immunol 4:420
    Article PubMed CAS Google Scholar
  58. Takeda K, Hayakawa Y, Atsuta M, Hong S, Van Kaer L, Kobayashi K, Ito M, Yagita H, Okumura K (2000) Relative contribution of NK and NKT cells to the anti-metastatic activities of IL-12. Int Immunol 12:909
    Article PubMed CAS Google Scholar
  59. Tang Q, Ji W, Pan Z, Zheng Y, Guan C (2003) Expression of the metastasis-associated gene 1 in laryngeal squamous cell carcinoma: correlation with cervical lymph node metastasis. Zhonghua Er Bi Yan Hou Ke Za Zhi 38:213
    PubMed Google Scholar
  60. Terabe M, Matsui S, Noben-Trauth N, Chen H, Watson C, Donaldson DD, Carbone DP, Paul WE, Berzofsky JA (2000) NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat Immunol 1:515
    Article PubMed CAS Google Scholar
  61. Terabe M, Matsui S, Park JM, Mamura M, Noben-Trauth N, Donaldson DD, Chen W, Wahl SM, Ledbetter S, Pratt B, Letterio JJ, Paul WE, Berzofsky JA (2003) Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence. J Exp Med 198:1741
    Article PubMed CAS Google Scholar
  62. Todryk S, McLean C, Ali S, Entwistle C, Boursnell M, Rees R, Vile R (1999) Disabled infectious single-cycle herpes simplex virus as an oncolytic vector for immunotherapy of colorectal cancer. Hum Gene Ther 10:2757
    Article PubMed CAS Google Scholar
  63. Toh Y, Pencil S, Nicolson G (1994) A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses. J Biol Chem 269:22958
    PubMed CAS Google Scholar
  64. Toh Y, Oki E, Oda S, Tokunaga E, Ohno S, Maehara Y, Nicolson GL, Sugimachi K (1997) Overexpression of the MTA1 gene in gastrointestinal carcinomas: correlation with invasion and metastasis. Int J Cancer 74:459
    Article PubMed CAS Google Scholar
  65. Toh Y, Kuninaka S, Endo K, Oshiro T, Ikeda Y, Nakashima H, Baba H, Kohnoe S, Okamura T, Nicolson G, Sugimachi K (2000) Molecular analysis of a candidate metastasis-associated gene, MTA1: possible interaction with histone deacetylase 1. J Exp Clin Cancer Res 19:105
    PubMed CAS Google Scholar
  66. Toh Y, Ohga T, Endo K, Adachi E, Kusumoto H, Haraguchi M, Okamura T, Nicolson G (2004) Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas. Int J Cancer 110:362
    Article PubMed CAS Google Scholar
  67. Vierboom M, Nijman H, Offringa R, van der Voort E, van Hall T, van den Broek L, Fleuren G, Kenemans P, Kast W, Melief C (1997) Tumor eradication by wild-type p53-specific cytotoxic T lymphocytes. J Exp Med 186:695
    Article PubMed CAS Google Scholar
  68. Yao YL, Yang WM (2003) The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. J Biol Chem 278:42560
    Article PubMed CAS Google Scholar
  69. Yi S, Guangqi H, Guoli H (2003) The association of the expression of MTA1, nm23H1 with the invasion, metastasis of ovarian carcinoma. Chin Med Sci J 18:87
    PubMed Google Scholar

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