Lafferty KJ, Gill RG (1993) The maintenance of self-tolerance. Immunol Cell Biol 71(Pt 3):209 PubMedCAS Google Scholar
Salomon B, Bluestone JA (2001) Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol 19:225 ArticlePubMedCAS Google Scholar
Jenkins MK, Schwartz RH (1987) Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med 165:302 ArticlePubMedCAS Google Scholar
DeSilva DR, Urdahl KB, Jenkins MK (1991) Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J Immunol 147:3261 PubMedCAS Google Scholar
Jenkins MK, Taylor PS, Norton SD, Urdahl KB (1991) CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J Immunol 147:2461 PubMedCAS Google Scholar
Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP (1992) CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607 ArticlePubMedCAS Google Scholar
Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 174:561 ArticlePubMedCAS Google Scholar
Linsley PS, Wallace PM, Johnson J, Gibson MG, Greene JL, Ledbetter JA, Singh C, Tepper MA (1992) Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 257:792 ArticlePubMedCAS Google Scholar
Lenschow DJ, Zeng Y, Thistlethwaite JR, Montag A, Brady W, Gibson MG, Linsley PS, Bluestone JA (1992) Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg. Science 257:789 ArticlePubMedCAS Google Scholar
Larsen CP, Elwood ET, Alexander DZ, Ritchie SC, Hendrix R, Tucker-Burden C, Cho HR, Aruffo A, Hollenbaugh D, Linsley PS, Winn KJ, Pearson TC (1996) Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 381:434 ArticlePubMedCAS Google Scholar
Finck BK, Linsley PS, Wofsy D (1994) Treatment of murine lupus with CTLA4Ig. Science 265:1225 ArticlePubMedCAS Google Scholar
Nishikawa K, Linsley PS, Collins AB, Stamenkovic I, McCluskey RT, Andres G (1994) Effect of CTLA-4 chimeric protein on rat autoimmune anti-glomerular basement membrane glomerulonephritis. Eur J Immunol 24:1249 PubMedCAS Google Scholar
Chu CQ, Londei M (1996) Induction of Th2 cytokines and control of collagen-induced arthritis by nondepleting anti-CD4 Abs. J Immunol 157:2685 PubMedCAS Google Scholar
Daikh DI, Finck BK, Linsley PS, Hollenbaugh D, Wofsy D (1997) Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways. J Immunol 159:3104 PubMedCAS Google Scholar
Daikh DI, Wofsy D (2001) Cutting edge: reversal of murine lupus nephritis with CTLA4Ig and cyclophosphamide. J Immunol 166:2913 PubMedCAS Google Scholar
Oliveira-dos-Santos AJ, Ho A, Tada Y, Lafaille JJ, Tonegawa S, Mak TW, Penninger JM (1999) CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis. J Immunol 162:4490 PubMedCAS Google Scholar
London CA, Lodge MP, Abbas AK (2000) Functional responses and costimulator dependence of memory CD4+ T cells. J Immunol 164:265 PubMedCAS Google Scholar
Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH (1995) B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707 ArticlePubMedCAS Google Scholar
Girvin AM, Dal Canto MC, Rhee L, Salomon B, Sharpe A, Bluestone JA, Miller SD (2000) A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade. J Immunol 164:136 PubMedCAS Google Scholar
Beiske K, Clark EA, Holte H, Ledbetter JA, Smeland EB, Godal T (1988) Triggering of neoplastic B cells via surface IgM and the cell surface antigens CD20 and CDw40. Responses differ from normal blood B cells and are restricted to certain morphologic subsets. Int J Cancer 42:521 PubMedCAS Google Scholar
Valle A, Zuber CE, Defrance T, Djossou O, De Rie M, Banchereau J (1989) Activation of human B lymphocytes through CD40 and interleukin 4. Eur J Immunol 19:1463 PubMedCAS Google Scholar
van Kooten C, Banchereau J (1997) Functions of CD40 on B cells, dendritic cells and other cells. Curr Opin Immunol 9:330 ArticlePubMed Google Scholar
Quezada SA, Jarvinen LZ, Lind EF, Noelle RJ (2004) CD40/CD154 interactions at the interface of tolerance and immunity. Annu Rev Immunol 22:307 ArticlePubMedCAS Google Scholar
Vogel LA, Noelle RJ (1998) CD40 and its crucial role as a member of the TNFR family. Semin Immunol 10:435 ArticlePubMedCAS Google Scholar
Watts TH (2005) TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 23:23 ArticlePubMedCAS Google Scholar
Burkly LC (2001) CD40 pathway blockade as an approach to immunotherapy. Adv Exp Med Biol 489:135 PubMedCAS Google Scholar
Desai-Mehta A, Lu L, Ramsey-Goldman R, Datta SK (1996) Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production. J Clin Invest 97:2063 ArticlePubMedCAS Google Scholar
Higuchi T, Aiba Y, Nomura T, Matsuda J, Mochida K, Suzuki M, Kikutani H, Honjo T, Nishioka K, Tsubata T (2002) Cutting edge: ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease. J Immunol 168:9 PubMedCAS Google Scholar
Wang X, Huang W, Schiffer LE, Mihara M, Akker K, Davidson A (2003) Effects of anti-CD154 treatment on B cells in murine systemic lupus erythematosus. Arthritis Rheum 48:495 ArticlePubMedCAS Google Scholar
Wang X, Huang W, Mihara M, Sinha J, Davidson A (2002) Mechanism of action of combined short-term CTLA4Ig and anti-CD40 ligand in murine systemic lupus erythematosus. J Immunol 168:2046 PubMedCAS Google Scholar
Gescuk BD, Davis JC Jr (2002) Novel therapeutic agents for systemic lupus erythematosus. Curr Opin Rheumatol 14:515 ArticlePubMedCAS Google Scholar
Kalunian KC, Davis JC Jr, Merrill JT, Totoritis MC, Wofsy D (2002) Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 46:3251 ArticlePubMedCAS Google Scholar
Boumpas DT, Furie R, Manzi S, Illei GG, Wallace DJ, Balow JE, Vaishnaw A (2003) A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum 48:719 ArticlePubMedCAS Google Scholar
Daoussis D, Andonopoulos AP, Liossis SN (2004) Targeting CD40 L: a promising therapeutic approach. Clin Diagn Lab Immunol 11:635 ArticlePubMedCAS Google Scholar
Buchner K, Henn V, Grafe M, de Boer OJ, Becker AE, Kroczek RA (2003) CD40 ligand is selectively expressed on CD4+ T cells and platelets: implications for CD40-CD40 L signalling in atherosclerosis. J Pathol 201:288 ArticlePubMed Google Scholar
Pollok KE, Kim YJ, Zhou Z, Hurtado J, Kim KK, Pickard RT, Kwon BS (1993) Inducible T cell antigen 4-1BB. Analysis of expression and function. J Immunol 150:771 PubMedCAS Google Scholar
Melero I, Johnston JV, Shufford WW, Mittler RS, Chen L (1998) NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell Immunol 190:167 ArticlePubMedCAS Google Scholar
Schwarz H, Valbracht J, Tuckwell J, von Kempis J, Lotz M (1995) ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages. Blood 85:1043 PubMedCAS Google Scholar
Reali C, Curto M, Sogos V, Scintu F, Pauly S, Schwarz H, Gremo F (2003) Expression of CD137 and its ligand in human neurons, astrocytes, and microglia: modulation by FGF-2. J Neurosci Res 74:67 ArticlePubMedCAS Google Scholar
Heinisch IV, Bizer C, Volgger W, Simon HU (2001) Functional CD137 receptors are expressed by eosinophils from patients with IgE-mediated allergic responses but not by eosinophils from patients with non-IgE-mediated eosinophilic disorders. J Allergy Clin Immunol 108:21 ArticlePubMedCAS Google Scholar
Pauly S, Broll K, Wittmann M, Giegerich G, Schwarz H (2002) CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers. J Leukoc Biol 72:35 PubMedCAS Google Scholar
Nishimoto H, Lee SW, Hong H, Potter KG, Maeda-Yamamoto M, Kinoshita T, Kawakami Y, Mittler RS, Kwon BS, Ware CF, Croft M, Kawakami T (2005) Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor. Blood 106:4241 ArticlePubMedCAS Google Scholar
Wilcox RA, Chapoval AI, Gorski KS, Otsuji M, Shin T, Flies DB, Tamada K, Mittler RS, Tsuchiya H, Pardoll DM, Chen L (2002) Cutting edge: expression of functional CD137 receptor by dendritic cells. J Immunol 168:4262 PubMedCAS Google Scholar
Futagawa T, Akiba H, Kodama T, Takeda K, Hosoda Y, Yagita H, Okumura K (2002) Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells. Int Immunol 14:275 ArticlePubMedCAS Google Scholar
Saito K, Ohara N, Hotokezaka H, Fukumoto S, Yuasa K, Naito M, Fujiwara T, Nakayama K (2004) Infection-induced up-regulation of the costimulatory molecule 4-1BB in osteoblastic cells and its inhibitory effect on M-CSF/RANKL-induced in vitro osteoclastogenesis. J Biol Chem 279:13555 ArticlePubMedCAS Google Scholar
Shuford WW, Klussman K, Tritchler DD, Loo DT, Chalupny J, Siadak AW, Brown TJ, Emswiler J, Raecho H, Larsen CP, Pearson TC, Ledbetter JA, Aruffo A, Mittler RS (1997) 4-1BB costimulatory signals preferentially induce CD8+T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med 186:47 ArticlePubMedCAS Google Scholar
Goodwin RG, Din WS, Davis-Smith T, Anderson DM, Gimpel SD, Sato TA, Maliszewski CR, Brannan CI, Copeland NG, Jenkins NA et al (1993) Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur J Immunol 23:2631 PubMedCAS Google Scholar
Wang J, Guo Z, Dong Y, Kim O, Hart J, Adams A, Larsen CP, Mittler RS, Newell KA (2003) Role of 4-1BB in allograft rejection mediated by CD8+ T cells. Am J Transplant 3:543 ArticlePubMedCAS Google Scholar
Cho HR, Kwon B, Yagita H, La S, Lee EA, Kim JE, Akiba H, Kim J, Suh JH, Vinay DS, Ju SA, Kim BS, Mittler RS, Okumura K, Kwon BS (2004) Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival. Transpl Int 17:351–361 ArticlePubMedCAS Google Scholar
Melero I, Shuford WW, Newby SA, Aruffo A, Ledbetter JA, Hellstrom KE, Mittler RS, Chen L (1997) Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 3:682 ArticlePubMedCAS Google Scholar
Mittler RS, Bailey TS, Klussman K, Trailsmith MD, Hoffmann MK (1999) Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy. J Exp Med 190:1535 ArticlePubMedCAS Google Scholar
Foell J, McCausland M, Burch J, Corriazzi N, Yan XJ, Suwyn C, O’Neil SP, Hoffmann MK, Mittler RS (2003) CD137-mediated T cell co-stimulation terminates existing autoimmune disease in SLE-prone NZB/NZW F1 mice. Ann N Y Acad Sci 987:230 ArticlePubMedCAS Google Scholar
Foell J, Strahotin S, O’Neil SP, McCausland MM, Suwyn C, Haber M, Chander PN, Bapat AS, Yan XJ, Chiorazzi N, Hoffmann MK, Mittler RS (2003) CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice. J Clin Invest 111:1505 ArticlePubMedCAS Google Scholar
Foell JL, Diez-Mendiondo BI, Diez OH, Holzer U, Ruck P, Bapat AS, Hoffmann MK, Mittler RS, Dannecker GE (2004) Engagement of the CD137 (4-1BB) costimulatory molecule inhibits and reverses the autoimmune process in collagen-induced arthritis and establishes lasting disease resistance. Immunology 113:89 ArticlePubMedCAS Google Scholar
Sun Y, Chen HM, Subudhi SK, Chen J, Koka R, Chen L, Fu YX (2002) Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nat Med 8:1405 ArticlePubMedCAS Google Scholar
Seo SK, Choi JH, Kim YH, Kang WJ, Park HY, Suh JH, Choi BK, Vinay DS, Kwon BS (2004) 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat Med 10:1088 ArticlePubMedCAS Google Scholar
Myers L, Takahashi C, Mittler RS, Rossi RJ, Vella AT (2003) Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering. Proc Natl Acad Sci USA 100:5348 ArticlePubMedCAS Google Scholar
Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP (1999) Tumor necrosis factor receptor and Fas signaling mechanisms. Annu Rev Immunol 17:331 ArticlePubMedCAS Google Scholar
Moskophidis D, Laine E, Zinkernagel RM (1993) Peripheral clonal deletion of antiviral memory CD8+ T cells. Eur J Immunol 23:3306 PubMedCAS Google Scholar