CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones (original) (raw)

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• Published: 16 April 1992

Nature volume 356, pages 607–609 (1992)Cite this article

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Abstract

OCCUPANCY of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is required1. Exposure of T-cell clones to complexes of antigen with major histocompatibility complex molecules in the absence of the co-stimulatory signal induces a state of clonal anergy. This requirement for two stimuli for T-cell activation could have an important role in vivo in establishing peripheral tolerance to antigens not encountered in the thymus1,2. The receptor on T cells required for the co-stimulatory stimulus involved in the prevention of anergy has not been identified. The human T-cell antigen CD28 provides a signal that can synergize with T-cell antigen receptor stimulation in activating T cells to proliferate and secrete lymphokines3–6. Here we report that a monoclonal antibody against the murine homologue of CD28 (ref. 7; J.A.G. et al., manuscript in preparation) can provide a co-stimulatory signal to naive CD4+ T cells and to T-cell clones. Moreover, we demonstrate that this co-stimulatory signal can block the induction of anergy in T-cell clones.

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Authors and Affiliations

1. Division of Immunology, Department of Molecular and Cell Biology and The Cancer Research Laboratory, University of California, Berkeley, California, 94720, USA
   Fiona A. Harding, James G. McArthur, David H. Raulet & James P. Allison
2. Department of Immunology SL-05, University of Washington, Seattle, Washington, 98185, USA
   Jane A. Gross
3. These two authors contributed equally to this work,
   Fiona A. Harding & James G. McArthur

Authors

1. Fiona A. Harding
2. James G. McArthur
3. Jane A. Gross
4. David H. Raulet
5. James P. Allison

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Harding, F., McArthur, J., Gross, J. et al. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones.Nature 356, 607–609 (1992). https://doi.org/10.1038/356607a0

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• Received: 13 November 1991
• Accepted: 17 February 1992
• Issue Date: 16 April 1992
• DOI: https://doi.org/10.1038/356607a0

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