Resistance patterns of nosocomial urinary tract infections in urology departments: 8-year results of the global prevalence of infections in urology study (original) (raw)

Abstract

Objective

To present the worldwide antibiotic resistance rates of uropathogens reported in nosocomial urinary tract infections (NAUTI) during the period of 2003–2010.

Materials and methods

Data from the Global Prevalence Study of Infections in Urology from the period of 2003–2010 were analyzed to evaluate the resistance rates of pathogens causing NAUTI. The web-based application was used to record data of investigators from urology departments participating in the study every year during the days allocated in November. Each center was allowed to enter data on a single day of the study. The point prevalence data was used to find differences among geographic regions and years by utilizing multiple logistic regression analysis.

Results

A total of 19,756 patients were hospitalized during the study period, and in 1,866 of them, NAUTI was reported. Proof of infection was reported in 1,395 patients. Resistance rates of all antibiotics tested other than imipenem against the total bacterial spectrum were higher than 10 % in all regions. Resistance to almost all pathogens was lowest in North Europe, and there is no single year where an outbreak of resistance has been detected.

Conclusion

The resistance rates of most of the uropathogens against the antibiotics tested did not show significant trends of increase or decrease with Asia exhibiting the highest rates in general. The only antibiotic tested with an overall resistance rate below 10 % was imipenem. Knowledge of regional and local resistance data and prudent use of antibiotics are necessary to optimize antibiotic therapy in urological patients with NAUTI.

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Acknowledgments

This study was organized by the board of the ESIU and endorsed and sponsored by the EAU and performed in collaboration with the Asian Association of UTI and STD, the International Society of Chemotherapy for Infection and Cancer, and the Interregional Association of Clinical Microbiology and Antimicrobial Chemotherapy. We thank the EAU central office for administrative and secretarial assistance. The GPIU study group is most grateful to the altruistic contributions of the GPIU investigators (see supplementary material).

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Urology, Taksim Teaching Hospital, Istanbul, Turkey
    Zafer Tandogdu
  2. Department of Urology, Trakya Medical School, Edirne, Turkey
    Mete Cek
  3. Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie, Universitätsklinikum Giessen und Marburg GmbH, Justus-Liebig-Universität Giessen, Giessen, Germany
    Florian Wagenlehner
  4. Technical University of Munich, Munich, Germany
    Kurt Naber
  5. Urology, South Pest Teaching Hospital, Budapest, Hungary
    Peter Tenke
  6. European Association of Urology, Arheim, The Netherlands
    Edgar van Ostrum
  7. Institute of clinical medicine, Aarhus University Hospital, Aarhus, Denmark
    Truls Bjerklund Johansen

Authors

  1. Zafer Tandogdu
  2. Mete Cek
  3. Florian Wagenlehner
  4. Kurt Naber
  5. Peter Tenke
  6. Edgar van Ostrum
  7. Truls Bjerklund Johansen

Corresponding author

Correspondence toZafer Tandogdu.

Additional information

Zafer Tandogdu and Mete Cek authors have equally contributed.

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Tandogdu, Z., Cek, M., Wagenlehner, F. et al. Resistance patterns of nosocomial urinary tract infections in urology departments: 8-year results of the global prevalence of infections in urology study.World J Urol 32, 791–801 (2014). https://doi.org/10.1007/s00345-013-1154-8

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